Review
Immunology
Payal Grover, Peeyush N. Goel, Mark I. Greene
Summary: T regulatory cells employ various immunosuppressive mechanisms to limit immune responses, including secretion of cytokines, cell cytolysis, metabolic perturbation, guiding antigen-presenting cell function, etc.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Yuzhi Lu, Ni Xia, Xiang Cheng
Summary: Regulatory T cells (Tregs) play a crucial role in the development of chronic heart failure, suppressing excessive inflammatory responses and promoting stable scar formation in the early stage of heart injury. However, in chronic heart failure, the functions and phenotypes of Tregs change, transforming into a cell type that is harmful to the heart.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Nicolas Krause, Joerg Mengwasser, Elpida Phithak, Francisca Beato, Marc Appis, Edgar Louis Milford, Johan Pratschke, Igor Sauer, Anja Kuehl, Arndt Vogel, Michael Goodyear, Linda Hammerich, Frank Tacke, Johanna Faith Haas, Tobias Mueller, Nalan Utku
Summary: IR1 cells are a subset of T regulatory cells that have immune suppressive functions and can inhibit proliferation in mixed lymphocyte reactions. They deliver regulatory signals by binding to their ligand, HLA-DR alpha 2, and have the potential to modulate immune dysregulation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Paola de Candia, Claudio Procaccini, Claudia Russo, Maria Teresa Lepore, Giuseppe Matarese
Summary: Regulatory T cells, as key metabolic sensors, play a crucial role in controlling immune state and have promising therapeutic potential for autoimmune and metabolic disorders.
Review
Immunology
Chen Dong
Summary: T lymphocytes play a key role in cellular immunity, with significant heterogeneity in CD4(+) T cells leading to the identification of various subsets with unique roles in immunity and pathology. Understanding cytokine regulation and function has provided innovative treatment options for many human diseases.
ANNUAL REVIEW OF IMMUNOLOGY, VOL 39
(2021)
Review
Immunology
Jingli Lu, Yan Liang, Haiyang Meng, Ailing Zhang, Junjie Zhao, Chengliang Zhang
Summary: The article discusses the metabolic and epigenetic features of Treg cells, as well as the impact of metabolites on epigenetic changes in Treg cells, which in turn affect the activation, differentiation, and function of Treg cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Christina E. Zielinski
Summary: Sodium chloride has been proposed to have potent effects on T cell responses in the context of autoimmune, allergic, and infectious tissue inflammation in both mouse models and humans. It is stringently regulated in the blood by the kidneys but displays differential deposition patterns in peripheral tissues, which may be influenced by dietary intake and intentional behavior. Its downstream cellular activities represent a potential therapeutic target given its effects on T cell cytokine production.
Article
Fisheries
Jiafeng Cao, Haoyue Xu, Yongyao Yu, Zhen Xu
Summary: This article reviews the relationship between cytokines and T and B cells in fish, and the regulatory roles of cytokines in these two lymphocyte types. It provides important information for the development of adaptive immunity-based vaccines and immunostimulants in vertebrates.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Review
Immunology
Meihong Da, Luxia Chen, Alexander Enk, Sabine Ring, Karsten Mahnke
Summary: Adenosine (Ado) has immunosuppressive effects, and the ectoenzyme CD73 is crucial for the production of extracellular Ado. CD73 is highly expressed in regulatory T cells (Tregs) and upregulated after activation. Ado generated by CD73(+) Tregs plays a role in immune suppression of dendritic cells, monocytes, and T cells, making CD73 a novel checkpoint inhibitor in immunosuppressive environments such as tumors. Therapeutic intervention targeting CD73 is currently under investigation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pathology
Sulieman Ibraheem Shelash Al-Hawary, Khadisha Kashikova, Elena M. Ioffe, Almaral Izbasarova, Ahmed Hjazi, Nahla A. Tayyib, Ali Alsalamy, Beneen M. Hussien, Mohamood Hameed, Mays Jassim Abdalkareem
Summary: Regulatory T cells (Tregs) play a crucial role in the pathogenesis of various diseases, and long non-coding RNAs (lncRNAs) have emerged as important regulators in the differentiation and immune cell balance of Tregs. By regulating gene expression at multiple levels, lncRNAs can impact biological processes such as cell proliferation, apoptosis, and differentiation.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Biochemistry & Molecular Biology
Natalia M. Krajewska, Remi Fiancette, Ye H. Oo
Summary: Immune-mediated cholangiopathies are characterized by the destruction of bile ducts, leading to liver inflammation and fibrosis. Regulatory T cells (Tregs) play a crucial role in these diseases, but their function can be impaired by the inflamed microenvironment. Mast cells (MCs) are also involved in the pathogenesis by releasing pro-inflammatory mediators. MCs can indirectly influence Treg function and there are also direct interactions between MCs and Tregs. Understanding the crosstalk between Tregs and MCs is important for the progression of autoimmune cholangiopathy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Qi Jiang, Guocan Yang, Qi Liu, Shengjun Wang, Dawei Cui
Summary: Rheumatoid arthritis is a systemic and heterogeneous autoimmune disease characterized by symmetrical polyarthritis, with dysfunction of regulatory T (Treg) cells potentially contributing to the breakdown of self-tolerance. The ideal treatment strategy for RA should focus on re-inducing self-tolerance to prevent obvious tissue injury.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Jing Lu, Taotao Liang, Ping Li, Qingsong Yin
Summary: The tumor microenvironment (TME) plays a crucial role in various aspects of tumor progression and clinical outcomes. Understanding the status of TME, the involvement of immune cells, and the key factors driving T cell dysfunction is essential for developing effective therapies. This study focuses on the regulatory effects of Interferon regulatory factor 4 (IRF4) on immune cells in the TME and highlights its potential as a therapeutic target for reversing T cell exhaustion and promoting anti-tumor immunity.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Lourdes Rocamora-Reverte, Franz Leonard Melzer, Reinhard Wuerzner, Birgit Weinberger
Summary: The immune system is a tightly regulated network, where regulatory T cells play an important role in maintaining immune homeostasis. Different types of T cells have regulatory functions in modulating immune responses, and the aging process can affect the composition of immune cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Shuaifeng Yan, Konstantin Kotschenreuther, Shuya Deng, David M. Kofler
Summary: Rheumatoid arthritis is an autoimmune disease that affects joints and causes systemic inflammation. Regulatory T cells play a crucial role in disease onset, and their functions and frequency are reduced in autoimmune diseases. Therefore, increasing and restoring the functions of these cells is a promising strategy for the treatment of rheumatoid arthritis. Current research in this field focuses on RA patients and animal models.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Hematology
Virginia Sheikh, Brian O. Porter, Rebecca DerSimonian, Stephen B. Kovacs, William L. Thompson, Ainhoa Perez-Diez, Alexandra F. Freeman, Gregg Roby, JoAnn Mican, Alice Pau, Adam Rupert, Joseph Adelsberger, Jeanette Higgins, Jeffrey S. Bourgeois, Stig M. R. Jensen, David R. Morcock, Peter D. Burbelo, Leah Osnos, Irina Maric, Ven Natarajan, Therese Croughs, Michael D. Yao, Jacob D. Estes, Irini Sereti
Editorial Material
Immunology
Denise C. Hsu, Kimberly F. Faldetta, Luxin Pei, Virginia Sheikh, Netanya S. Utay, Gregg Roby, Adam Rupert, Anthony S. Fauci, Irini Sereti
CLINICAL INFECTIOUS DISEASES
(2016)
Article
Immunology
Yingda L. Xie, Lindsey B. Rosen, Irini Sereti, Daniel L. Barber, Ray Y. Chen, Denise C. Hsu, S. Sonia Qasba, Christa S. Zerbe, Steven M. Holland, Sarah K. Browne
CLINICAL INFECTIOUS DISEASES
(2016)
Article
Immunology
Mark N. Polizzotto, Thomas S. Uldrick, Kathleen M. Wyvill, Karen Aleman, Vickie Marshall, Victoria Wang, Denise Whitby, Stefania Pittaluga, Elaine S. Jaffe, Corina Millo, Giovanna Tosato, Richard F. Little, Seth M. Steinberg, Irini Sereti, Robert Yarchoan
CLINICAL INFECTIOUS DISEASES
(2016)
Article
Immunology
Irini Sereti, Shelly J. Krebs, Nittaya Phanuphak, James L. Fletcher, Bonnie Slike, Suteeraporn Pinyakorn, Robert J. O'Connell, Adam Rupert, Nicolas Chomont, Victor Valcour, Jerome H. Kim, Merlin L. Robb, Nelson L. Michael, Daniel C. Douek, Jintanat Ananworanich, Netanya S. Utay
CLINICAL INFECTIOUS DISEASES
(2017)
Review
Dentistry, Oral Surgery & Medicine
C-S Wong, E. S. Richards, L. Pei, I. Sereti
Article
Immunology
Chao Wang, Maria I. Edilova, Lisa E. Wagar, Shariq Mujib, Meromit Singer, Nicole F. Bernard, Therese Croughs, Michael M. Lederman, Irini Sereti, Margaret A. Fischl, Elisabeth Kremmer, Mario Ostrowski, Jean-Pierre Routy, Tania H. Watts
JOURNAL OF IMMUNOLOGY
(2018)
Article
Immunology
Aurelie Gouel-Cheron, Martha Nason, Adam Rupert, Virginia Sheikh, Greg Robby, Gary A. Fahle, Irini Sereti
OPEN FORUM INFECTIOUS DISEASES
(2020)
Article
Immunology
Ornella Sortino, Joana Dias, Megan Anderson, Elizabeth Laidlaw, Edwin Leeansyah, Andrea Lisco, Virginia Sheikh, Johan K. Sandberg, Irini Sereti
Summary: Patients with idiopathic CD4(+) lymphocytopenia (ICL) maintain normal levels and function of MAIT cells compared to healthy controls, with IL-7 treatment expanding the CD8(+) MAIT-cell subset while preserving responsiveness and effector functions.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Ivan Vujkovic-Cvijin, Ornella Sortino, Eveline Verheij, Ferdinand W. Wit, Neeltje A. Kootstra, Brian Sellers, Maarten Schim van der Loeff, Yasmine Belkaid, Peter Reiss, Irini Sereti
Summary: Unbiased plasma proteomics in a matched case-control study of treated people with human immunodeficiency virus (PWH) revealed the complement cascade as being among the top pathways enriched in PWH. Specific complement components, namely C5, associated significantly with non-AIDS comorbidity prevalence, and did so more strongly than previously established predictive biomarkers.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Immunology
Catherine W. Cai, Irini Sereti
Summary: The use of combination antiretroviral therapy has significantly improved morbidity and mortality in people with HIV, but may not fully restore immune function, leading to non-AIDS comorbidities. Early diagnosis and prompt initiation of therapy at high CD4 counts may be the best approach for improved immune recovery in PWH.
SEMINARS IN IMMUNOLOGY
(2021)
Letter
Multidisciplinary Sciences
Irini Sereti, Tomi Akinyemiju, Sara Gianella
Article
Immunology
Kimberly F. Breglio, Caian L. Vinhaes, Maria B. Arriaga, Martha Nason, Gregg Roby, Joseph Adelsberger, Bruno B. Andrade, Virginia Sheikh, Irini Sereti
Summary: This study assessed the predictors of Mycobacterium avium complex (MAC) immune reconstitution inflammatory syndrome (MAC-IRIS) in HIV patients initiating antiretroviral therapy (ART). Results showed that high ALP levels and increased CD8(+) T-cell activation with low CD4 counts at ART initiation were associated with an increased risk of developing MAC-IRIS. Decision tree and logistic regression models suggested that ALP levels and D-dimer could be used as predictors for MAC-IRIS likelihood.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Immunology
Asier Saez-Cirion, Irini Sereti
Summary: Immunometabolism plays a key role in HIV-1 pathogenesis, with the metabolic states of T cells and macrophages determining their susceptibility to infection, metabolism of immune cells shaping their response to infection, and metabolic products driving inflammation during infection.
NATURE REVIEWS IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Ainhoa Perez-Diez, Xiangdong Liu, Virginia Sheikh, Gregg Roby, David F. Stroncek, Irini Sereti