期刊
CLINICAL INFECTIOUS DISEASES
卷 62, 期 6, 页码 770-773出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/civ995
关键词
paradoxical reaction; autoantibodies; interferon-gamma; disseminated tuberculosis; IRIS
资金
- Intramural Research Program of the National Institute of Allergy and Infectious Diseases at the National Institutes of Health [ZO1-AI00647-06]
Interferon-gamma (IFN gamma) neutralizing autoantibodies are associated with disseminated nontuberculous mycobacterial infections. We report a previously healthy Thai woman with disseminated tuberculosis and high-titer IFN gamma-neutralizing autoantibodies, who developed a severe inflammatory reaction during anti-tuberculosis treatment. IFN gamma contributes to host control of tuberculosis but appears inessential for tuberculosis paradoxical reactions.
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