Article
Endocrinology & Metabolism
Giuseppe Giuffrida, Valeria D'Argenio, Francesco Ferrau, Vito Alessandro Lasorsa, Francesca Polito, Federica Aliquo, Marta Ragonese, Oana Ruxandra Cotta, Ylenia Alessi, Rosaria Oteri, Federica Di Maggio, Alessio Asmundo, Petronilla Daniela Romeo, Federica Spagnolo, Lucio Pastore, Filippo Flavio Angileri, Mario Capasso, Salvatore Cannavo, M'Hammed Aguennouz
Summary: The study found that there are complex epigenetic modifications, mainly methylation and miRNA activity, in pituitary adenomas. Nonfunctioning tumors (NFPAs) showed higher methylation levels compared to GH-omas, with 178 differentially methylated regions (DMRs) mainly located in noncoding and intronic sequences. Additionally, the study identified three hypermethylated genes involved in tumorigenesis processes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Beata Rak, Maria Maksymowicz, Monika Pekul, Grzegorz Zielinski
Summary: The study found that densely granulated corticotroph adenomas occurred at a younger age, were more commonly microadenomas compared to sparsely granulated tumors, less frequently had invasive features, and more commonly achieved immediate postsurgical hormonal remission. This highlights the importance of accurately differentiating between densely granulated and sparsely granulated subtypes in the pathomorphological diagnosis of corticotropic tumors, especially in invasive PitNETs.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Amy A. Swanson, Dana Erickson, Diane Mary Donegan, Sarah M. Jenkins, Jamie J. Van Gompel, John L. D. Atkinson, Bradley J. Erickson, Caterina Giannini
Summary: This study analyzed histologic subtypes of growth hormone-producing pituitary adenomas in acromegaly patients and found that histologic subtype did not predict surgical outcome, while absence of invasion and lower pre-operative IGF-1 index were significantly associated with post-surgical remission.
Article
Endocrinology & Metabolism
Lijun Heng, Xiaoyan Liu, Dong Jia, Wei Guo, Shuo Zhang, Guodong Gao, Li Gong, Yan Qu
Summary: This study aimed to establish a preoperative prediction method for distinguishing sparsely granulated (SG) growth hormone (GH)-secreting pituitary adenoma in acromegaly patients. The study found that SG tumors tend to occur in younger patients with larger diameters and volumes, higher Knosp grades, lower GH indexes, and lower incremental GH% after octreotide treatment.Combining tumor size, Knosp grade, GH index, and GH% increment after octreotide treatment, a grading scale with an AUC of 0.84 was established for predicting SG GH-secreting pituitary adenomas.
CLINICAL ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Na Yu, Lian Duan, Fang Hu, Shengmin Yang, Jie Liu, Meiping Chen, Yong Yao, Kan Deng, Feng Feng, Xin Lian, Xinxin Mao, Huijuan Zhu
Summary: This study retrospectively analyzed the clinical characteristics, diagnosis, and treatment experience of 21 patients with GH/TSH cosecreting pituitary adenoma. The average age of symptom onset was 41.6 years, and delayed diagnosis occurred in 57.1% of patients. The most common complaint was thyrotoxicosis. Comprehensive treatment strategies were used, and one-third of cases achieved complete remission of both hormones.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Qizhi Zhang, Ying Wang, Yinting Zhou, Qiujuan Zhang, Chuan Xu
Summary: The abnormal expression of miRNAs has been closely linked to tumor development. This study found significantly lower levels of miRNA-26b, miRNA-138, miRNA-206, and miRNA-let-7e in the peripheral serum of NFPA patients compared to normal subjects. These miRNAs may play a role in the occurrence and progression of NFPAs, providing a basis for further exploration of tumor markers in pituitary adenomas.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Review
Endocrinology & Metabolism
Mengqi Chang, Chengxian Yang, Xinjie Bao, Renzhi Wang
Summary: This passage discusses the classification of pituitary adenomas and significant progresses in understanding their molecular biological characteristics, focusing on genetic and epigenetic variations. It also mentions several tumor predisposition syndromes related to pituitary adenomas and specific genetic mutations associated with different hormone-secreting types of adenomas.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Bahadir Koylu, Busra Firlatan, Suleyman Nahit Sendur, Seda Hanife Oguz, Selcuk Dagdelen, Tomris Erbas
Summary: The characteristics and treatment outcomes of giant GH-secreting pituitary adenomas differ from non-giant macroadenomas. Patients with giant adenomas have higher numbers of surgeries and treatment modalities, as well as lower hormonal remission rates.
Article
Endocrinology & Metabolism
Yifan Tang, Tao Xie, Silin Wu, Qiaoqiao Yang, Tengfei Liu, Chen Li, Shuang Liu, Zhiyong Shao, Xiaobiao Zhang
Summary: This study provides large-scale proteome molecular characteristics of distinct granulation subtypes of somatotroph adenomas. Compared with DG adenomas, The differential protein of SG adenomas mostly enrich in invasive and proliferative functions and pathways at the proteomic level. Cadherin-1 and Catenin beta-1 play key roles in the different biological characteristics of the two tumor subtypes.
Article
Clinical Neurology
Xianchao Zhao, Lijun Heng, Yan Qu, Dong Jia, Jiafeng Ren, Shuyu Sun, Jian Qiu, Jinxiang Cheng, Ting Yang, Junying Zhou, Changjun Su
Summary: The study found a high prevalence of obstructive sleep apnea (OSA) in patients with acromegaly, and the densely granulated (DG) pattern in adenomas may be a risk factor for OSA in acromegaly.
SLEEP AND BREATHING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Waiel A. Bashari, Russell Senanayake, James MacFarlane, Daniel Gillett, Andrew S. Powlson, Angelos Kolias, Richard J. Mannion, Olympia Koulouri, Mark Gurnell
Summary: For most patients with suspected or confirmed pituitary adenomas, MRI is usually sufficient for clinical decision making, but additional MR sequences may be needed for certain patients. There is a subgroup of patients for whom MRI cannot accurately localize the tumor site, leading to limited intervention options. Emerging evidence suggests that hybrid imaging, combining molecular and cross-sectional modalities, can improve tumor detection and localization for targeted intervention, potentially reducing the need for long-term high-cost therapies.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Medical Laboratory Technology
Yuan Ren, Ying Wang, Xinjie Bao, Ming Feng, Bing Xing, Wei Lian, Yong Yao, Renzhi Wang
Summary: Incomplete surgical resection of invasive non-functional pituitary adenomas (NFPAs) carries a risk of subsequent complications. This study examined biomarkers for determining the invasiveness of NFPAs and explored therapeutic targets. The results highlighted the role of MMP1 in tumor invasion and angiogenesis, with exosomes playing a regulatory role.
CLINICA CHIMICA ACTA
(2022)
Review
Medicine, General & Internal
Benjamin Voellger, Zhuo Zhang, Julia Benzel, Junwen Wang, Ting Lei, Christopher Nimsky, Joerg-Walter Bartsch
Summary: Pituitary adenomas (PAs) are mostly benign tumors, but up to 10% exhibit aggressive behavior. This article provides an overview of target structures in aggressive PAs and summarizes current clinical trials for treating PAs. Drug targets in PAs are based on general features of tumor cells and include immune checkpoints and signal pathways involved in tumor cell proliferation, migration, and angiogenesis. Dopamine agonists (DAs) are the first line treatment for prolactinomas and have potential to treat other subtypes of PAs. Targeting the invasive behavior of PAs may improve therapy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Mattia Dalle Nogare, Sarah D'Annunzio, Giovanni Vazza, Daniela Regazzo, Luna Picello, Luca Denaro, Giacomo Voltan, Carla Scaroni, Filippo Ceccato, Gianluca Occhi
Summary: It has been found that aberrant expression of glucose-dependent insulinotropic polypeptide receptor (GIPR) in GH-secreting pituitary adenomas (GH-PAs) can lead to an increase in GH levels after glucose load. This study aimed to investigate if DNA methylation changes in the GIPR locus could contribute to this phenomenon. The results showed differences in methylation levels between GIPR-positive and GIPR-negative GH-PAs, indicating that epigenetic regulation affects GIPR expression. Treatment with 5-aza-2'-deoxycytidine resulted in a reduction in Gipr expression, suggesting a correlation between DNA methylation and Gipr expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Chenglong Cao, Yujing Huang, Aobo Chen, Guozheng Xu, Jian Song
Summary: Cognitive abilities are impaired in patients with pituitary adenoma, with attention processing found to be compromised in preoperative patients but showing signs of improvement after surgery. Hormone levels may play a role in affecting attention processing, as shown by higher P200 component amplitudes in preoperative patients compared to healthy controls and postoperative patients.
FRONTIERS IN NEUROLOGY
(2021)
Article
Endocrinology & Metabolism
Luis G. Perez-Rivas, Marily Theodoropoulou, Troy H. Puar, Julia Fazel, Mareike R. Stieg, Francesco Ferrau, Guillaume Assie, Monica R. Gadelha, Timo Deutschbein, Maria C. Fragoso, Benno Kusters, Wolfgang Saeger, Juergen Honegger, Michael Buchfelder, Marta Korbonits, Jerome Bertherat, Guenter K. Stalla, Ad R. Hermus, Felix Beuschlein, Martin Reincke
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2018)
Article
Endocrinology & Metabolism
Adriana Albani, Luis G. Perez-Rivas, Christina Dimopoulou, Stephanie Zopp, Paula Colon-Bolea, Sigrun Roeber, Juergen Honegger, Joerg Flitsch, Walter Rachinger, Michael Buchfelder, Guenter K. Stalla, Jochen Herms, Martin Reincke, Marily Theodoropoulou
CLINICAL ENDOCRINOLOGY
(2018)
Review
Endocrinology & Metabolism
Adriana Albani, Luis G. Perez-Rivas, Martin Reincke, Marily Theodoropoulou
ENDOCRINE PRACTICE
(2018)
Article
Oncology
Paraskevi Xekouki, Emily J. Lodge, Jakob Matschke, Alice Santambrogio, John R. Apps, Ariane Sharif, Thomas S. Jacques, Simon Aylwin, Vincent Prevot, Ran Li, Joerg Flitsch, Stefan R. Bornstein, Marily Theodoropoulou, Cynthia L. Andoniadou
ENDOCRINE-RELATED CANCER
(2019)
Review
Endocrinology & Metabolism
Marily Theodoropoulou, Martin Reincke
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2019)
Review
Endocrinology & Metabolism
German Rubinstein, Andrea Osswald, Stephanie Zopp, Katrin Ritzel, Marily Theodoropoulou, Felix Beuschlein, Martin Reincke
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
(2019)
Article
Endocrinology & Metabolism
Christof Schoefl, Bernhard Mayr, Nicole Maison, Felix Beuschlein, Gesine Meyer, Klaus Badenhoop, Tina Kienitz, Marcus Quinkler
CLINICAL ENDOCRINOLOGY
(2019)
Article
Oncology
Silviu Sbiera, Luis Gustavo Perez-Rivas, Lyudmyla Taranets, Isabel Weigand, Joerg Flitsch, Elisabeth Graf, Camelia-Maria Monoranu, Wolfgang Saeger, Christian Hagel, Juergen Honegger, Guillaume Assie, Ad R. Hermus, Guenter K. Stalla, Sabine Herterich, Cristina L. Ronchi, Timo Deutschbein, Martin Reincke, Tim M. Strom, Nikita Popov, Marily Theodoropoulou, Martin Fassnacht
Article
Endocrinology & Metabolism
Denis Ciato, Ran Li, Jose Luis Monteserin Garcia, Lilia Papst, Sarah D'Annunzio, Michael Hristov, Maria A. Tichomirowa, Zhanna Belaya, Liudmila Rozhinskaya, Michael Buchfelder, Marily Theodoropoulou, Marcelo Paez-Pereda, Guenter Karl Stalla
NEUROENDOCRINOLOGY
(2019)
Review
Endocrinology & Metabolism
Guenter K. Stalla, Christina Dimopoulou, Caroline Jung-Sievers, Eduardo Arzt, Marcelo Paez Pereda, Marily Theodoropoulou, Denis Ciato, Ulrich Renner
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2020)
Review
Pathology
C. Villa, A. Vasiljevic, M. L. Jaffrain-Rea, O. Ansorge, S. Asioli, V. Barresi, L. Chinezu, M. P. Gardiman, A. Lania, A. M. Lapshina, L. Poliani, L. Reiniger, A. Righi, W. Saeger, J. Soukup, M. Theodoropoulou, S. Uccella, J. Trouillas, F. Roncaroli
Article
Biochemistry & Molecular Biology
Kristin Lucia, Yonghe Wu, Jose Monteserin Garcia, Anne Barlier, Michael Buchfelder, Wolfgang Saeger, Ulrich Renner, Guenter K. Stalla, Marily Theodoropoulou
Article
Endocrinology & Metabolism
Adriana Albani, Marily Theodoropoulou
Summary: Transsphenoidal surgery is the main treatment for Cushing's disease, yet incomplete tumor resection and misdiagnosis can lead to persistent disease. A multidisciplinary approach is necessary to minimize potential pitfalls and provide optimal care for patients who have undergone unsuccessful surgery.
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
(2021)
Article
Endocrinology & Metabolism
Daniela Regazzo, Marina Paola Gardiman, Marily Theodoropoulou, Carla Scaroni, Gianluca Occhi, Filippo Ceccato
ENDOCRINOLOGY DIABETES AND METABOLISM CASE REPORTS
(2018)
Review
Endocrinology & Metabolism
Adriana Albani, Marily Theodoropoulou, Martin Reincke
CLINICAL ENDOCRINOLOGY
(2018)