Article
Oncology
Yin Zhang, Lei Zhang, Kexia Fan, Yajun Gou, Zhenle Zang, Xiao Ding, Hui Yang, Song Li
Summary: The invasiveness and high proliferation rate of growth hormone-secreting pituitary adenomas (GHPAs) are associated with abnormal mitochondrial dynamics. In this study, it was found that invasive GHPA samples had decreased numbers, volumes, and membrane areas of mitochondria compared to noninvasive samples. Downregulation of Drp1 protein may contribute to this abnormal mitochondrial dynamics, leading to enhanced invasion and proliferation of tumor cells. Mitochondrial hypofission might activate the STAT3 pathway to regulate tumor cell functions.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Petros Stefanidis, Georgios Kyriakopoulos, Andreas Miltiadis Seretis, Stefanos Korfias, Stamatios Theocharis, Anna Angelousi
Summary: This study evaluated the expression of Ki-67, CD-56, Cyclin-D1, and E-Cadherin in pituitary adenomas (PAs) and their association with clinical manifestation, tumor size, invasiveness, and risk of recurrence. Cyclin-D1 and Ki-67 were found to be positively correlated with tumor size, recurrence, extension beyond the sellar region, and invasion of the cavernous sinus. However, there was no correlation between CD-56 and E-Cadherin expression and the parameters mentioned above. Cyclin-D1 and Ki-67 may be promising markers in predicting the behavior and recurrence of PAs, but further studies are needed to confirm their role in routine evaluation of PAs.
Article
Clinical Neurology
Georgios Mantziaris, Stylianos Pikis, Tomas Chytka, Roman Liscak, Kimball Sheehan, Darrah Sheehan, Selcuk Peker, Yavuz Samanci, Shray K. Bindal, Ajay Niranjan, L. Dade Lunsford, Rupinder Kaur, Renu Madan, Manjul Tripathi, Dhiraj J. Pangal, Ben A. Strickland, Gabriel Zada, Anne-Marie Langlois, David Mathieu, Ronald E. Warnick, Samir Patel, Zayda Minier, Herwin Speckter, Zhiyuan Xu, Rithika Kormath Anand, Jason P. Sheehan
Summary: This study analyzed 375 patients with residual nonfunctioning pituitary adenomas (NFPAs) who were treated with stereotactic radiosurgery (SRS) and compared the outcomes between early treatment and treatment at progression. The results showed that there was no significant difference in tumor control and preservation of hormonal/visual function between SRS at residual NFPA progression and adjuvant SRS. Deferring radiosurgical management to the time of radiological progression could prolong the onset of radiosurgically induced pituitary dysfunction.
JOURNAL OF NEUROSURGERY
(2023)
Article
Endocrinology & Metabolism
Jiun-Lin Yan, Mao-Yu Chen, Yao-Liang Chen, Chi-Cheng Chuang, Peng-Wei Hsu, Kuo-Chen Wei, Chen-Nen Chang
Summary: This study evaluated the outcomes of the endoscopic transsphenoidal approach as the primary treatment for somatotroph adenomas and investigated patients with suboptimal surgical results. Factors such as tumor size, preoperative GH level, and residual tumors were found to be associated with surgical failure. Octreotide showed good outcomes for treating DGSA patients, while SRS/EXRT generated good results for patients receiving secondary treatments when remission could not be reached after 6 months of TSA operation.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Seung Woo Hong, Se Hoon Kim, Seung Hoon Lim, Eun Jig Lee, Sun Ho Kim, Cheol Ryong Ku, Eui Hyun Kim
Summary: The study evaluated the clinical relevance of the new cell lineage-based classification system for pituitary adenomas proposed by WHO, finding that it mostly matched with the traditional classification but discrepancies between TF and pituitary hormone stains exist in some cases. Null cell adenomas may be more prevalent than reported and are clinically more aggressive than gonadotroph adenomas.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Wei Dong, Wenjian Shi, Yongliang Liu, Jingwu Li, Yu Zhang, Guilan Dong, Xiaoliu Dong, Hua Gao
Summary: This study investigated the impact of CHST7 methylation status on the proliferation and differentiation of pituitary adenomas (PAs). Results showed that CHST7 levels were associated with the differentiation and cell adhesion of PAs, with low CHST7 levels linked to SF-1 lineage and optic chiasm compression. The study also revealed correlations between CHST7 and the eIF2/ATF4 pathway and mitochondrion-related genes.
Review
Endocrinology & Metabolism
Robert C. C. Osorio, Jun Y. Y. Oh, Nikita Choudhary, Meeki Lad, Luis Savastano, Manish K. K. Aghi
Summary: This review examines the prevalence of cerebrovascular disease in patients with pituitary adenomas. The research shows that patients with pituitary adenomas have a higher mortality rate from cerebrovascular diseases compared to healthy populations. The mechanisms behind cerebrovascular disease in different subpopulations of pituitary adenomas are less understood and require further research.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Mengqi Chang, Chengxian Yang, Xinjie Bao, Renzhi Wang
Summary: This passage discusses the classification of pituitary adenomas and significant progresses in understanding their molecular biological characteristics, focusing on genetic and epigenetic variations. It also mentions several tumor predisposition syndromes related to pituitary adenomas and specific genetic mutations associated with different hormone-secreting types of adenomas.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Mengqi Chang, Shenzhong Jiang, Xiaopeng Guo, Jun Gao, Peng Liu, Xinjie Bao, Ming Feng, Renzhi Wang
Summary: Exosomes are small vesicles that carry various molecules, including RNAs, and play important roles in cell communication and drug delivery. In this review, the impact of exosomal RNAs on pituitary adenoma and their potential as clinical therapies are discussed. Potential biomarkers and therapeutic applications of exosomes in pituitary adenoma are examined.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Neurosciences
Domenico Solari, Luigi Maria Cavallo, Chiara Graziadio, Sergio Corvino, Ilaria Bove, Felice Esposito, Paolo Cappabianca
Summary: Giant pituitary adenomas present a surgical challenge due to their growth patterns and locations. There is no consensus on the optimal surgical strategy, but transcranial or transsphenoidal approaches are commonly used. Endoscopic endonasal approach is preferred, but transcranial approach is more suitable when the tumor has significant intracranial extension. Accurate preoperative evaluation and individualized treatment plans are crucial for long-term effectiveness.
Article
Radiology, Nuclear Medicine & Medical Imaging
Waiel A. Bashari, Russell Senanayake, James MacFarlane, Daniel Gillett, Andrew S. Powlson, Angelos Kolias, Richard J. Mannion, Olympia Koulouri, Mark Gurnell
Summary: For most patients with suspected or confirmed pituitary adenomas, MRI is usually sufficient for clinical decision making, but additional MR sequences may be needed for certain patients. There is a subgroup of patients for whom MRI cannot accurately localize the tumor site, leading to limited intervention options. Emerging evidence suggests that hybrid imaging, combining molecular and cross-sectional modalities, can improve tumor detection and localization for targeted intervention, potentially reducing the need for long-term high-cost therapies.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Review
Endocrinology & Metabolism
Odelia Cooper, Vivien Bonert, Ning-Ai Liu, Adam N. Mamelak
Summary: Management of aggressive pituitary adenomas is challenging due to lack of rigorous evidence supporting treatment approaches; recent guidelines emphasize maximizing standard therapies and using temozolomide and radiation therapy for recurrence; multidisciplinary, individualized approach is crucial, but timing and rationale for surgery, radiation therapy, medication need to be discussed within evidence-based guidelines for effective management.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Clinical Neurology
Alexander Micko, Matthew S. Agam, Andrew Brunswick, Ben A. Strickland, Martin J. Rutkowski, John D. Carmichael, Mark S. Shiroishi, Gabriel Zada, Engelbert Knosp, Stefan Wolfsberger
Summary: The aim of this study is to assess the treatment strategies and outcomes of giant pituitary adenomas (GPAs) in the era of endoscopic transsphenoidal surgery (ETS). The study found that the extent of resection is dependent on the morphology of the GPA. Treatment strategies for residual pituitary adenoma include early transcranial reoperation, delayed endoscopic transsphenoidal/transcranial reoperation, and adjuvant radiosurgery.
JOURNAL OF NEUROSURGERY
(2022)
Article
Biochemistry & Molecular Biology
Yu Cai, Peiyong Chen, Hui Xu, Shanglai Li, Bingru Zhao, Yixuan Fan, Feng Wang, Yanli Zhang
Summary: In this study, it was found that EZH2 gene knockdown in sheep pituitary cells led to decreased cell proliferation, increased apoptosis, and reduced FSH secretion. These effects were mediated through the modulation of the AKT/ERK signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agriculture, Dairy & Animal Science
Guohua Song, Yixuan Jiang, Yaling Wang, Mingkun Song, Xuanmin Niu, Huifen Xu, Ming Li
Summary: CTSS plays a crucial role in regulating hormone secretion, cell proliferation, and apoptosis in rabbit granulosa cells. Overexpression of CTSS promotes progesterone and estrogen secretion, while enhancing cell proliferation and reducing apoptosis. These findings provide insights for better understanding the molecular mechanisms of rabbit reproduction.
Article
Medicine, Research & Experimental
Zhuo Zhang, Agnes Schaefer, Benjamin Voellger, Jun-Wen Wang, Ting Lei, Christopher Nimsky, Jorg W. Bartsch
Summary: This study demonstrates that the downregulation of miRNA-149 is associated with the invasiveness of PA cells, and it exerts its effects by regulating the expression of ADAM12 and MMP-14.
CURRENT MEDICAL SCIENCE
(2022)
Article
Oncology
Suresh Sivakumar, Sonja Lieber, Damiano Librizzi, Corinna Keber, Leah Sommerfeld, Florian Finkernagel, Katrin Roth, Silke Reinartz, Joerg W. Bartsch, Johannes Graumann, Sabine Mueller-Bruesselbach, Rolf Mueller
Summary: Different forms of BCAM protein are associated with metastasis and poor prognosis in ovarian cancer. The soluble form of BCAM inhibits tumor cell adhesion and migration, but promotes the dispersion and invasion of tumor cell spheroids. These findings provide new insights for the treatment of ovarian cancer.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Clinical Neurology
Panagiota-Eleni Tsalouchidou, Johann Philipp Zoellner, Annika Kirscht, Christina Julia Mueller, Christopher Nimsky, Maximilian Schulze, Elke Hattingen, Georgios Chatzis, Thomas M. Freiman, Adam Strzelczyk, Sven Fuest, Katja Menzler, Felix Rosenow, Susanne Knake
Summary: This study aimed to identify coexisting structural lesions in patients with epilepsy and known temporal encephaloceles (TEs). Results showed that TEs can occur with other lesions, potentially impacting surgical evaluation and approach. Additionally, TEs may be associated with malformations of cortical development.
Article
Oncology
Maren Nicole Stillger, Chia-Yi Chen, Zon Weng Lai, Mujia Li, Agnes Schaefer, Axel Pagenstecher, Christopher Nimsky, Joerg Walter Bartsch, Oliver Schilling
Summary: This study found that the expression of calcium-dependent protease calpain-2 is increased in glioblastoma. Treatment with a calpain inhibitor increased the sensitivity of primary glioblastoma cells to TMZ. The knockdown of calpain-2 resulted in DNA damage and disrupted TP53 signaling. Therefore, calpain-2 may serve as a prognostic factor for GBM outcome.
CANCER CELL INTERNATIONAL
(2023)
Article
Clinical Neurology
Stefanie T. Jost, Agni Konitsioti, Philipp A. Loehrer, Keyoumars Ashkan, Alexandra Rizos, Anna Sauerbier, Maria Gabriela dos Santos Ghilardi, Franz Rosenkranz, Lena Strobel, Alexandra Gronostay, Michael T. Barbe, Julian Evans, Veerle Visser-Vandewalle, Christopher Nimsky, Gereon R. Fink, Monty Silverdale, Rubens G. Cury, Erich T. Fonoff, Angelo Antonini, K. Ray Chaudhuri, Lars Timmermann, Pablo Martinez-Martin, Haidar S. Dafsari
Summary: This study suggests that patients with 'postural instability and gait difficulty' (PIGD) may experience more beneficial non-motor effects compared to patients with 'tremor-dominant' symptoms undergoing deep brain stimulation (DBS) for Parkinson's disease (PD). These differences in clinical efficacy on non-motor aspects should be taken into consideration when advising and monitoring PD patients undergoing DBS.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Andreas Schulze-Bonhage, Martin Hirsch, Susanne Knake, Elisabeth Kaufmann, Josua Kegele, Michael Rademacher, Kristl Vonck, Volker Arnd Coenen, Martin Glaser, Carolin Jenkner, Yaroslav Winter, Sergiu Groppa, EASEE Study Grp
Summary: A pooled analysis of two clinical trials showed that a novel stimulation device could effectively reduce seizure frequency in patients with drug-refractory focal epilepsy, providing a promising treatment option for patients with a predominant epileptic focus.
Article
Neurosciences
Lara Evers, Agnes Schaefer, Raffaella Pini, Kai Zhao, Susanne Stei, Christopher Nimsky, Joerg W. Bartsch
Summary: This study explored changes in miRNA expression profiles in patient-derived glioblastoma stem-like cells (GSCs) upon differentiation into glial fiber acid protein (GFAP)-expressing astrocytic tumor cells. The results showed that miR-17-5p and miR-425-5p were downregulated, while miR-223-3p and let-7-5p were upregulated in differentiated cells. Among them, miR-425-5p consistently showed the highest downregulation in all GSCs. Transfection of a 425-5p miRNA mimic demonstrated downregulation of GFAP protein in differentiated patient-derived GBM cells, suggesting direct regulation of miRNAs in the GSC/GBM cell transition.
Article
Oncology
Biao Xing, Zhuowei Lei, Zihan Wang, Quanji Wang, Qian Jiang, Zhuo Zhang, Xiaojin Liu, Yiwei Qi, Sihan Li, Xiang Guo, Yanchao Liu, Xingbo Li, Kai Shu, Huaqiu Zhang, Joerg Walter Bartsch, Christopher Nimsky, Yimin Huang, Ting Lei
Summary: This study found that ADAM22 is overexpressed in pituitary adenoma (PA) and promotes its growth and invasion through activating the ITGB1 signaling pathway. It also revealed that PKA may regulate ADAM22 levels through phosphorylation and delaying degradation. ITGB1 may be a potential therapeutic target for PA.
Article
Oncology
Miguel Cosenza-Contreras, Agnes Schafer, Justin Sing, Lena Cook, Maren N. Stillger, Chia-Yi Chen, Jose Villacorta Hidalgo, Niko Pinter, Larissa Meyer, Tilman Werner, Darleen Bug, Zeno Haberl, Oliver Kuebeck, Kai Zhao, Susanne Stei, Anca Violeta Gafencu, Radu Ionita, Felix M. Brehar, Jaime Ferrer-Lozano, Gloria Ribas, Leo Cerda-Alberich, Luis Marti-Bonmati, Christopher Nimsky, Alexis Van Straaten, Martin L. Biniossek, Melanie Foll, Nina Cabezas-Wallscheid, Jorg Buscher, Hannes Rost, Armelle Arnoux, Jorg W. Bartsch, Oliver Schilling
Summary: This study utilized proteomics and lipidomics to analyze patient-matched initial and recurrent glioblastoma specimens, revealing increased immune cell infiltration and extracellular matrix reorganization in recurrent glioblastoma. ASAH1 and SYNM were identified as potential plasma markers for the progression of recurrent glioblastoma.
Article
Clinical Neurology
Alexander Calvano, Laura Beccaria, Lars Timmermann, Miriam H. A. Bopp, Marko Gjorgjevski, Christopher Nimsky, David J. Pedrosa
Summary: Personalized structural considerations, particularly using patient-specific connectome analysis, can provide important insights for the treatment of secondary myoclonus-dystonia syndromes.
FRONTIERS IN NEUROLOGY
(2023)
Article
Medicine, General & Internal
Corinna Keil, Siegmund Koehler, Benjamin Sass, Maximilian Schulze, Gerald Kalmus, Michael Belfort, Nicolas Schmitt, Daniele Diehl, Alice King, Stefanie Gross, Caitlin D. Sutton, Luc Joyeux, Mirjam Wege, Christopher Nimsky, Wiliam E. Whitehead, Eberhard Uhl, Thierry A. G. M. Huisman, Bernd A. Neubauer, Stefanie Weber, Helmut Hummler, Roland Axt-Fliedner, Ivonne Bedei
Summary: Open spina bifida (OSB) is a congenital malformation that can be treated through prenatal fetal therapy. The University of Giessen and Marburg (UKGM) has successfully performed a three-port, three-layer fetoscopic repair of OSB via laparotomy-assisted approach. The transfer of technique to a different setting is possible with experienced centers and intensive multidisciplinary preparation and training.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Ziyu Qi, Miriam H. A. Bopp, Christopher Nimsky, Xiaolei Chen, Xinghua Xu, Qun Wang, Zhichao Gan, Shiyu Zhang, Jingyue Wang, Haitao Jin, Jiashu Zhang
Summary: This study proposes a novel registration method for mixed reality navigation (MRN) using a laser crosshair simulator, which achieves low user dependency, high accuracy, and clinical applicability. The method was successfully implemented and showed promising results in efficiency and intuitiveness. It marks a valuable advancement in low-cost, easy-to-use MRN systems and has the potential to improve surgical outcomes.
BIOENGINEERING-BASEL
(2023)
Article
Health Care Sciences & Services
Rosita Rupa, Tim Vladimirov, Mirza Pojskic, Christopher Nimsky, Benjamin Voellger
Summary: During the COVID-19 pandemic, our neurosurgical department maintained an open-door policy and admitted more neurotrauma patients from outside our district compared to previous years. There was a significant increase in the number of patients admitted in 2020 and 2021. During high COVID-19 caseload weeks, we observed an increased number of neurotrauma patients from densely populated areas in our catchment area, with no higher in-house mortality observed.
