Immune-mediated β-cell death in type 1 diabetes: lessons from human β-cell lines

Configuration of electrofusion-derived human insulin-secreting cell line as pseudoislets enhances functionality and therapeutic utility

(2012) Hong Guo-Parke et al.   JOURNAL OF ENDOCRINOLOGY

Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients

(2012) Ken T. Coppieters et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structural basis for the killing of human beta cells by CD8+ T cells in type 1 diabetes

(2012) Anna M Bulek et al.   NATURE IMMUNOLOGY

Induction of the intrinsic apoptosis pathway in insulin-secreting cells is dependent on oxidative damage of mitochondria but independent of caspase-12 activation

(2011) Ilir Mehmeti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Inhibitory Effect of Unsaturated Fatty Acids on Saturated Fatty Acid-Induced Apoptosis in Human Pancreatic β-Cells: Activation of Caspases and ER Stress Induction

(2011) Vlasta Němcová-Fürstová et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

TCF7L2 splice variants have distinct effects on β-cell turnover and function

(2011) Olivier Le Bacquer et al.   HUMAN MOLECULAR GENETICS

Cytokines Tumor Necrosis Factor-α and Interferon-γ Induce Pancreatic β-Cell Apoptosis through STAT1-mediated Bim Protein Activation

(2011) Jenny Barthson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Development and Functional Characterization of Insulin-releasing Human Pancreatic Beta Cell Lines Produced by Electrofusion

(2011) Jane T. McCluskey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A genetically engineered human pancreatic β cell line exhibiting glucose-inducible insulin secretion

(2011) Philippe Ravassard et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of the Mitochondria in Immune-Mediated Apoptotic Death of the Human Pancreatic β Cell Line βLox5

(2011) Yaíma L. Lightfoot et al.   PLoS One

Insulitis in human type 1 diabetes

(2011) Peter In't Veld   Islets

Simultaneous Detection of Circulating Autoreactive CD8+ T-Cells Specific for Different Islet Cell-Associated Epitopes Using Combinatorial MHC Multimers

(2010) J. H. Velthuis et al.   DIABETES

Characterisation of the NES2Y cell line and its use in the production of human glucose-responsive insulin producing (hGRIP) cell lines by cell-cell fusion

(2010) Gary G. Adams et al.   Islets

Prediction and prevention of Type 1 diabetes mellitus

(2010) Li ZHANG et al.   Journal of Diabetes

Insulitis in Human Type 1 Diabetes

(2009) Toshiaki Hanafusa et al.   Annals of the New York Academy of Sciences

Proinflammatory Cytokines Activate the Intrinsic Apoptotic Pathway in  -Cells

(2009) L. G. Grunnet et al.   DIABETES

Rituximab, B-Lymphocyte Depletion, and Preservation of Beta-Cell Function

(2009) Mark D. Pescovitz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Analysis of islet inflammation in human type 1 diabetes

(2008) A. Willcox et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Cytotoxic T-lymphocyte–mediated killing of human pancreatic islet cells in vitro

(2008) Peter D. Campbell et al.   HUMAN IMMUNOLOGY

Insulinoma CM cell line as in vitro model for beta-cell

(2008) Maria Gisella Cavallo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The CM cell line derived from liver metastasis of malignant human insulinoma is not a valid beta cell model for in vitro studies

(2008) Claudia Gragnoli   JOURNAL OF CELLULAR PHYSIOLOGY

Comparison of the effect of individual saturated and unsaturated fatty acids on cell growth and death induction in the human pancreatic β-cell line NES2Y

(2008) Vlasta Fürstova et al.   LIFE SCIENCES