Article
Chemistry, Multidisciplinary
Karin Mannerstedt, Narendra Kumar Mishra, Ebbe Engholm, Morten Lundh, Charlotte S. Madsen, Philip J. Pedersen, Priska Le-Huu, Soren L. Pedersen, Nina Buch-Manson, Bjorn Borgstrom, Thomas Brimert, Lisbeth N. Fink, Keld Fosgerau, Niels Vrang, Knud J. Jensen
Summary: A glucose responsive insulin (GRI) has been developed using glucose cleavable linkers based on hydrazone and thiazolidine structures, demonstrating glucose responsiveness in vitro, particularly for thiazolidines. Clamp studies confirmed increased glucose infusion at hyperglycemic conditions for one GRI, indicating a true glucose response. The glucose responsive cleavable linker in these GRIs drives the release of active insulin from a circulating depot in response to changes in glucose levels.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Materials Science, Biomaterials
Zhaoyang Guo, Haiyang Liu, Zhekun Shi, Lulu Lin, Yinping Li, Miao Wang, Guoqing Pan, Yifeng Lei, Longjian Xue
Summary: In this study, a glucose-responsive insulin-releasing hydrogel microneedle dressing was developed for diabetic wound healing. The microneedle dressing exhibited mechanical stability, biocompatibility, glucose-responsive insulin release, and improved blood glucose control, making it effective for diabetic wound management and potentially useful for other chronic skin injuries.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Chemistry, Physical
Xiaomin Xu, Yani Xu, Yuai Li, Min Li, Leilei Wang, Qiang Zhang, Bingjie Zhou, Qing Lin, Tao Gong, Xun Sun, Zhirong Zhang, Ling Zhang
Summary: In this study, a glucose-responsive system mimicking erythrocytes was designed by coupling glucose-responsive nanoparticles to red blood cells, allowing for long-term response to hyperglycemia and potential application in diabetes treatment.
Article
Engineering, Biomedical
Lisa R. Volpatti, Matthew A. Bochenek, Amanda L. Facklam, Delaney M. Burns, Corina MacIsaac, Alexander Morgart, Benjamin Walters, Robert Langer, Daniel G. Anderson
Summary: This study develops biodegradable, partially oxidized alginate carriers for glucose-responsive insulin delivery and islet cell transplantation therapy. The results demonstrate that these carriers can achieve glycemic control and reduce the volume of nondegradable material implanted.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Biomedical
Lisa R. Volpatti, Amanda L. Facklam, Abel B. Cortinas, Yen-Chun Lu, Morgan A. Matranga, Corina MacIsaac, Michael C. Hill, Robert Langer, Daniel G. Anderson
Summary: A glucose-responsive insulin delivery system was developed using encapsulated nanoparticles and microgels, showing extended glycemic control in diabetic mice and a similar response to glucose challenge compared to healthy animals in animal studies.
Review
Materials Science, Biomaterials
Avha R. Mohanty, Akhila Ravikumar, Nicholas A. Peppas
Summary: There have been significant advancements in glucose sensing and insulin delivery for treating type I diabetes mellitus in the past few decades. The introduction of closed-loop insulin delivery systems has shifted the research focus in this field. In this contribution, recent advancements over the last 5 years are discussed, along with persisting issues in these technologies.
REGENERATIVE BIOMATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Yanfang Wang, Pengbo Chen, Wei Liu, Xiangqian Wei, Juan Zhang, Xinwei Wei, Yun Liu, Luxuan Rao, Shiming Zhang, Jicheng Yu, Xiao Ye, Jinqiang Wang, Zhen Gu
Summary: Researchers have developed a novel insulin nanocarrier system that can effectively and safely control blood glucose levels in type 1 diabetes patients for an extended period of time.
Article
Biochemistry & Molecular Biology
Gwangho Yoon, Yeong-Hwan Lim, Danbi Jo, Juhee Ryu, Juhyun Song, Young-Kook Kim
Summary: Metabolic syndromes, including obesity, result in neuropathophysiological changes in the brain leading to cognitive deficits. A recently identified obesity-linked circRNA, circTshz2-2, was found to affect neuronal cell cycle and spatial memory. Dysregulation of circTshz2-2 alters gene expression related to cell division, impacts cell cycle progression, and influences memory function, highlighting a potential link between metabolic syndromes and cognitive impairments.
MOLECULAR PSYCHIATRY
(2021)
Article
Chemistry, Multidisciplinary
Lisa R. Volpatti, Delaney M. Burns, Arijit Basu, Robert Langer, Daniel G. Anderson
Summary: This study presents the development of electrostatic complexes for glucose-responsive insulin delivery, demonstrating the potential to mimic healthy mice's glycemic profile in diabetic animals.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Multidisciplinary
Jinqiang Wang, Zejun Wang, Guojun Chen, Yanfang Wang, Tianyuan Ci, Hongjun Li, Xiangsheng Liu, Daojia Zhou, Anna R. Kahkoska, Zhuxian Zhou, Huan Meng, John B. Buse, Zhen Gu
Summary: This study introduces a glucose-responsive cationic polymer for constructing polymer-insulin complexes, which shows potential for glucose-stimulated insulin delivery. The effects of different parameters on the insulin release kinetics were studied to evaluate the blood glucose regulation ability in type 1 diabetic mice.
Article
Chemistry, Multidisciplinary
Yun Liu, Yanfang Wang, Yuejun Yao, Juan Zhang, Wei Liu, Kangfan Ji, Xinwei Wei, Yuanwu Wang, Xiangsheng Liu, Shiming Zhang, Jinqiang Wang, Zhen Gu
Summary: Lipid nanoparticle-based drug delivery systems have a significant impact on nucleic acid-based therapy and vaccination. We designed phenylboronic acid-based quaternary amine-type cationic lipids that can self-assemble into spherical lipid nanoparticles. Mixing insulin with the lipid nanoparticles immediately forms a heterostructured insulin complex, and in a hyperglycemia-relevant glucose solution, the lipid nanoparticles gradually become less positively charged, leading to insulin release.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Endocrinology & Metabolism
Mark A. Jarosinski, Balamurugan Dhayalan, Nischay Rege, Deepak Chatterjee, Michael A. Weiss
Summary: Insulin replacement therapy for diabetes aims to minimize blood glucose fluctuations using smart systems or insulin analogues that provide hormone activity proportional to blood glucose levels. Current strategies for optimization include coupling continuous glucose monitoring with delivery devices, glucose-responsive polymer encapsulation of insulin, and mechanism-based hormone modifications.
Article
Polymer Science
Yangyang Lu, Haojie Yu, Li Wang, Di Shen, Jian Liu
Summary: Researchers have developed a glucose-responsive microneedle system based on phenylboronic acid, which can painlessly deliver insulin and regulate its release according to blood glucose levels. The microneedles are derived from glucose-responsive hydrogels and have demonstrated effective insulin release in animal experiments.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Nanoscience & Nanotechnology
Biswanath Maity, Hariharan Moorthy, Thimmaiah Govindaraju
Summary: This article presents a glucose-responsive smart hydrogel platform based on phenylboronic acid-functionalized natural silk fibroin protein for regulated insulin delivery. The platform provides controlled insulin release and restores blood glucose levels in diabetic conditions.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Multidisciplinary
Guohongfang Tan, Fujian Jiang, Tianshuo Jia, Zhenzhen Qi, Tieling Xing, Subhas C. Kundu, Shenzhou Lu
Summary: This study reports the use of polylysine-modified cationized silk fibroin (SF) to prepare microneedles (MNs) for responsive transdermal insulin delivery. The MNs were well arranged and formed an array with 0.5 mm pitch, and had a length of approximately 430 μm. They exhibited pH and glucose-responsive properties, rapidly releasing insulin as pH decreased and glucose concentration increased. In vivo experiments showed that the insulin release from cationized SF MNs was significantly lower in diabetic rats compared to normal rats. Therefore, cationized SF MNs hold promise as a new modality for diabetes treatment, replacing subcutaneous injections of insulin.
Review
Cell Biology
Silvia Rodriguez-Fernandez, Lidia Almenara-Fuentes, David Perna-Barrull, Bruna Barneda, Marta Vives-Pi
Summary: Type 1 diabetes is a chronic metabolic disease caused by the autoimmune destruction of insulin-producing beta-cells. While scientific advancements have led to the development of antigen-specific immunotherapies, the results of prevention and reversal trials have been disappointing, prompting the need for further optimization.
IMMUNOLOGY AND CELL BIOLOGY
(2021)
Review
Environmental Sciences
Diana Arabiat, Mohammad AL Jabery, Vivien Kemp, Mark Jenkins, Lisa C. Whitehead, Gary Adams
Summary: Exposure to maternal diabetes during pregnancy is associated with lower motor development in children, particularly in terms of gross and fine motor skills. Other factors such as pre-existing diabetes, gestational comorbidities, and low socioeconomic status also play a role in impacting child development, with those with additional risk factors being more likely to face developmental challenges.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Multidisciplinary Sciences
Judith Grau-Exposito, Nerea Sanchez-Gaona, Nuria Massana, Marina Suppi, Antonio Astorga-Gamaza, David Perea, Joel Rosado, Anna Falco, Cristina Kirkegaard, Ariadna Torrella, Bibiana Planas, Jordi Navarro, Paula Suanzes, Daniel Alvarez-Sierra, Alfonso Ayora, Irene Sansano, Juliana Esperalba, Cristina Andres, Andres Anton, Santiago Ramon y Cajal, Benito Almirante, Ricardo Pujol-Borrell, Vicenc Falco, Joaquin Burgos, Maria J. Buzon, Meritxell Genesca
Summary: The study suggests that lung resident memory T cells play a crucial role in limiting the spread of SARS-CoV-2 and COVID-19. Different clinical outcomes are associated with distinct virus-specific T cell responses, and the persistence of antiviral lung T-RM cells in convalescent patients may help limit reinfection.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Yvonne M. Mueller, Thijs J. Schrama, Rik Ruijten, Marco W. J. Schreurs, Dwin G. B. Grashof, Harmen J. G. van de Werken, Giovanna Jona Lasinio, Daniel Alvarez-Sierra, Caoimhe H. Kiernan, Melisa D. Castro Eiro, Marjan van Meurs, Inge Brouwers-Haspels, Manzhi Zhao, Ling Li, Harm de Wit, Christos A. Ouzounis, Merel E. P. Wilmsen, Tessa M. Alofs, Danique A. Laport, Tamara van Wees, Geoffrey Kraker, Maria C. Jaimes, Sebastiaan Van Bockstael, Manuel Hernandez-Gonzalez, Casper Rokx, Bart J. A. Rijnders, Ricardo Pujol-Borrell, Peter D. Katsikis
Summary: This study demonstrates that by measuring anti-SARS-CoV-2 antibody and cytokine levels at the time of hospital admission and using unsupervised hierarchical clustering/machine learning, it is possible to predict unfavorable outcomes in COVID-19 patients.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Laia Gomez-Munoz, David Perna-Barrull, Josep M. Caroz-Armayones, Marta Murillo, Silvia Rodriguez-Fernandez, Aina Valls, Federico Vazquez, Jacobo Perez, Raquel Corripio, Luis Castano, Joan Bel, Marta Vives-Pi
Summary: The partial remission phase of type 1 diabetes is characterized by specific immunological biomarkers, including changes in the percentages of different types of T lymphocytes and inflammatory cells. In addition, certain immune cell percentages and the insulin dose at diagnosis can predict the occurrence of the partial remission phase.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Aina Teniente-Serra, Eduarda Pizarro, Bibiana Quirant-Sanchez, Marco A. Fernandez, Marta Vives-Pi, Eva M. Martinez-Caceres
Summary: Flow cytometry analysis of lymphocyte subpopulations in adult T1D patients at disease onset and 2 years follow-up reveals changes supporting the migration of effector cells to the pancreas and the persistence of autoimmune process throughout the disease. Multiparametric flow cytometry allows identification of potential biomarkers for T1D.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Emily Toscano-Guerra, Monica Martinez Gallo, Iria Arrese-Munoz, Anna Gine, Noelia Diaz-Troyano, Pablo Gabriel-Medina, Mar Riveiro-Barciela, Moises Labrador-Horrillo, Fernando Martinez-Valle, Adrian Sanchez Montalva, Manuel Hernandez-Gonzalez, Ricardo Pujol Borrell, Francisco Rodriguez-Frias, Roser Ferrer, Timothy M. Thomson, Rosanna Paciucci
Summary: This study analyzed the relationship between serum testosterone levels and immune cell skewing with disease severity in male COVID-19 patients. The study found quantitative differences in biochemical predictors of disease outcome between male and female patients. Longitudinal analyses identified serum testosterone trajectories as the strongest predictor of survival in male COVID-19 patients, and changes in serum luteinizing hormone (LH) and androstenedione levels were inconsistent with physiological feedback patterns.
Article
Endocrinology & Metabolism
David Perna-Barrull, Marta Murillo, Nati Real, Laia Gomez-Munoz, Silvia Rodriguez-Fernandez, Joan Bel, Manel Puig-Domingo, Marta Vives-Pi
Summary: This study aimed to evaluate the association between prenatal exposure to betamethasone and T1D in humans. The results demonstrate that prenatal exposure to betamethasone does not increase T1D susceptibility, and may even be associated with a trend towards decreased risk of developing the disease.
JOURNAL OF DIABETES RESEARCH
(2022)
Article
Medicine, General & Internal
Monica Martinez-Gallo, Juliana Esperalba, Ricardo Pujol-Borrell, Victor Sanda, Iria Arrese-Munoz, Candela Fernandez-Naval, Andres Anton, Victoria Cardona, Moises Labrador-Horrillo, Tomas Pumarola, Manuel Hernandez-Gonzalez
Summary: This study aimed to assess the feasibility of a validated assay of T-cell responses as a complement to antibody tests for evaluating the levels of protection generated by natural infection or SARS-CoV-2 vaccines. The results showed that the IGRA test detected T-cell responses in naturally exposed and vaccinated individuals, and there was a high correlation with specific antibody levels. These findings suggest that the IGRA test could be a promising tool for measuring the state of the immune response to SARS-CoV-2.
Article
Immunology
Adrian Sanchez-Montalva, Daniel Alvarez-Sierra, Monica Martinez-Gallo, Janire Perurena-Prieto, Iria Arrese-Munoz, Juan Carlos Ruiz-Rodriguez, Juan Espinosa-Pereiro, Pau Bosch-Nicolau, Xavier Martinez-Gomez, Andres Anton, Ferran Martinez-Valle, Mar Riveiro-Barciela, Albert Blanco-Grau, Francisco Rodriguez-Frias, Pol Castellano-Escuder, Elisabet Poyatos-Canton, Jordi Bas-Minguet, Eva Martinez-Caceres, Alex Sanchez-Pla, Coral Zurera-Egea, Aina Teniente-Serra, Manuel Hernandez-Gonzalez, Ricardo Pujol-Borrell
Summary: Currently used laboratory tests for clinical management of COVID-19 patients have limited predictive power due to redundancy. This limitation could be overcome by adding immunological tests with independent predictive power.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
David Perna-Barrull, Laia Gomez-Munoz, Silvia Rodriguez-Fernandez, Anna Gieras, Rosa M. Ampudia-Carrasco, Lidia Almenara-Fuentes, Ruth M. Risueno, Sergi Querol, Eva Tolosa, Marta Vives-Pi
Summary: The use of the powerful glucocorticoid betamethasone can improve discarded umbilical cord blood by enhancing the engraftment capacities of its stem cells, leading to faster immune system recovery and increased survival of the transplanted cells.
ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
(2023)
Review
Biochemistry & Molecular Biology
Gara Arteaga-Henriquez, Jorge Lugo-Marin, Laura Gisbert, Imanol Setien-Ramos, Monica Martinez-Gallo, Ricardo Pujol-Borrell, Josep Antoni Ramos-Quiroga
Summary: Individuals with Autism spectrum disorder (ASD) exhibit differences in immune cell levels and inflammation markers compared to typically developing (TD) controls.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nanoscience & Nanotechnology
Lidia Almenara-Fuentes, Silvia Rodriguez-Fernandez, Estela Rosell-Mases, Katerina Kachler, Axel You, Miriam Salvado, Darja Andreev, Ulrike Steffen, Holger Bang, Aline Bozec, Georg Schett, Rozen Le Panse, Joan Verdaguer, Marti Dalmases, Silvia Rodriguez-Vidal, Bruna Barneda-Zahonero, Marta Vives-Pi
Summary: This study demonstrates the therapeutic potential of using phosphatidylserine (PS)-liposomes encapsulating autoantigens to treat various autoimmune diseases. These specific PS-liposomes have shown preventive and therapeutic efficacy in restoring self-tolerance and immunoregulation.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2023)
Article
Multidisciplinary Sciences
Roser Salvia, Laura G. Rico, Jolene A. Bradford, Michael D. Ward, Michael W. Olszowy, Cristina Martinez, Alvaro Domingo Madrid-Aris, Joan R. Grifols, Agueda Ancochea, Laia Gomez-Munoz, Marta Vives-Pi, Eva Martinez-Caceres, Marco A. Fernandez, Marc Sorigue, Jordi Petriz
Summary: Plastic pollution is a global problem, with potential health consequences for animals and humans who ingest and inhale plastic particles. Nanoplastics (NPs), ranging from 1 nm to 1000 nm, are particles formed from the erosion or breakage of larger plastic debris and can vary in physical properties and composition. The exposure to NPs may lead to alterations in xenobiotic and energy metabolism, nutrients absorption, cytotoxicity, and behavior. Our study prospectively investigated the presence of NPs in human peripheral blood using fluorescence techniques and nanocytometry, demonstrating the accurate detection of NPs with flow cytometry.
Article
Biochemistry & Molecular Biology
Laia Gomez-Munoz, David Perna-Barrull, Marta Murillo, Maria Pilar Armengol, Marta Alcalde, Marti Catala, Silvia Rodriguez-Fernandez, Sergi Sunye, Aina Valls, Jacobo Perez, Raquel Corripio, Marta Vives-Pi
Summary: The partial remission phase of type 1 diabetes is characterized by endogenous insulin production and downregulated autoimmunity. This study identifies and validates a unique miRNA signature during this phase and demonstrates the immunomodulatory role of miR-30d-5p. Inhibition of miR-30d-5p results in increased regulatory T cells and changes in immune cell populations in vivo. This miRNA signature provides potential biomarkers and enhances understanding of the mechanisms driving the partial remission phase.
