Article
Cell Biology
Fan Li, Huizhi Sun, Yihui Yu, Na Che, Jiyuan Han, Runfen Cheng, Nan Zhao, Yuhong Guo, Chongbiao Huang, Danfang Zhang
Summary: In this study, it was found that RIPK1-dependent necroptosis promoted vasculogenic mimicry (VM) formation in triple-negative breast cancer (TNBC). The activation of RIPK1/p-AKT/eIF4E signaling pathway played a role in this process. Furthermore, eIF4E promoted epithelial-mesenchymal transition (EMT) and MMP2 expression and activity, contributing to VM formation. The findings suggest potential therapeutic targets for TNBC through necroptosis-mediated VM.
CELL DEATH & DISEASE
(2023)
Review
Oncology
Xinyu Lin, Sheng Long, Congcong Yan, Xiaofeng Zou, Guoxi Zhang, Junrong Zou, Gengqing Wu
Summary: Angiogenesis is a crucial process in cancer growth and metastasis, but its inhibition can lead to acquired resistance. Vasculogenic mimicry is an alternative mechanism of tumor angiogenesis and is associated with poor prognosis. Inhibiting vasculogenic mimicry may be an effective therapeutic strategy to overcome the limitations of anti-angiogenic treatment when used in combination with other anti-tumor therapies.
FRONTIERS IN ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ana K. Herrera-Vargas, Eduardo Garcia-Rodriguez, Monserrat Olea-Flores, Miguel A. Mendoza-Catalan, Eugenia Flores-Alfaro, Napoleon Navarro-Tito
Summary: The ability of leptin to induce angiogenesis and vasculogenic mimicry in different types of cancer has been studied, with significant relationships observed in breast cancer. Leptin activates multiple pathways to promote the expression of angiogenic factors and vasculogenic mimicry, suggesting its potential role as a therapeutic target for tumor survival and metastasis.
CYTOKINE & GROWTH FACTOR REVIEWS
(2021)
Article
Cell Biology
Ran Fu, Wenwen Du, Zongli Ding, Yi Wang, Yue Li, Jianjie Zhu, Yuanyuan Zeng, Yulong Zheng, Zeyi Liu, Jian-an Huang
Summary: This study revealed the role of the HIF-1 alpha/NRP1 axis in mediating lung adenocarcinoma metastasis and VM formation. High expression of HIF-1 alpha and NRP1 was associated with poor prognosis, highlighting the potential therapeutic value of targeting NRP1 to suppress lung adenocarcinoma metastasis and progression.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Hongyuan Lu, Cen Wu, Xiao-wen Jiang, Qingchun Zhao
Summary: This study found that the ADAM-17 inhibitor ZLDI-8 significantly inhibits angiogenesis and vasculogenic mimicry (VM) in drug-resistant NSCLC by suppressing the Notch1-HIF1αVEGF signaling pathway. This study lays the foundation for the discovery of drugs that inhibit angiogenesis and VM in drug-resistant NSCLC.
Review
Oncology
Elena Andreucci, Silvia Peppicelli, Jessica Ruzzolini, Francesca Bianchini, Lido Calorini
Summary: Tumour vascularisation is crucial for cancer sustainment, with vasculogenic mimicry (VM) gaining increasing interest as a potential target for cancer treatment. Unlike healthy tissue vessels, tumour vasculature is heterogeneous and tortuous, hindering efficient chemotherapy delivery and facilitating cancer cell metastasis. The disorganisation of tumour vessels contributes to a self-reinforcing vicious circle, promoting cancer malignancy and progression. Hypoxia and acidosis within tumours, which are hallmark features of cancer, induce vascularisation and create a permissive microenvironment for cancer progression and dissemination. Targeting hypoxia and acidosis may represent a potential strategy to treat VM and impede tumour perfusion and cancer cell sustainment.
CANCER AND METASTASIS REVIEWS
(2022)
Article
Oncology
Bochao Geng, Yuanzhang Zhu, Yingying Yuan, Jingyi Bai, Zhizhi Dou, Aihua Sui, Wenjuan Luo
Summary: The study found that the traditional antimalarial drug artesunate (ART) eliminated vasculogenic mimicry (VM) formation in choroidal melanoma (CM) cells by inhibiting the Wnt5a/CaMKII signaling pathway, as well as downregulated the expression levels of angiogenesis and VM-related proteins, leading to decreased angiogenesis and VM formation. Furthermore, ART also inhibited the proliferation, migration, and invasion of CM cells.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Kelsey Maddison, Nikola A. Bowden, Moira C. Graves, Paul A. Tooney
Summary: This study aimed to determine the markers consistently attributed to vasculogenic mimicry (VM) and tumour to endothelial transdifferentiation in glioblastoma. It was found that VM lacks expression of CD34 and/or CD31, while tumour to endothelial transdifferentiation expresses CD34 and/or CD31 in addition to other endothelial, stem cell, or tumour cell markers. Further research and characterization of this process are needed.
Article
Oncology
Ronghan Zhang, Xiaogang Chen, Shengwen Chen, Jiajia Tang, Feng Chen, Yong Lin, Peter Sol Reinach, Xiyun Yan, LiLi Tu, Hongxia Duan, Jia Qu, Qiang Hou
Summary: CD146 is a novel target for inhibiting the progression of uveal melanoma by regulating both angiogenesis and vasculogenic mimicry. Inhibition of CD146 leads to declines in tube formation and migration in endothelial cells, as well as tube-like structure formation, migration, and invasion in uveal melanoma cells. CD146 exerts its effects through VEGFR/AKT/p38/NF-kappa B and FAK/VE-cadherin signaling pathways. Blockade of CD146 with siRNA or AA98 also inhibits migration, invasion, and EMT process in uveal melanoma cells, and suppresses tumor growth, angiogenesis, and vasculogenic mimicry induced by implantation of uveal melanoma cells.
Review
Biochemistry & Molecular Biology
Xiaoxu Wei, Yunhua Chen, Xianjie Jiang, Miao Peng, Yiduo Liu, Yongzhen Mo, Daixi Ren, Yuze Hua, Boyao Yu, Yujuan Zhou, Qianjin Liao, Hui Wang, Bo Xiang, Ming Zhou, Xiaoling Li, Guiyuan Li, Yong Li, Wei Xiong, Zhaoyang Zeng
Summary: Overall, the use of VM inhibitors in combination with conventional anti-angiogenesis treatments is a promising strategy for improving the effectiveness of targeted angiogenesis treatments; further, considering the importance of hypoxia in tumor invasion and metastasis, drugs targeting the hypoxia signaling pathway seem to achieve good results.
Article
Oncology
Wan-Yi Shie, Pin-Hsuan Chu, Mark Yen-Ping Kuo, Huei-Wen Chen, Meng-Tie Lin, Xuan-Jie Su, Yi-Ling Hong, Han-Yi Elizabeth Chou
Summary: Acidosis is a characteristic of the tumor microenvironment that promotes tumor metastatic colonization. Acidosis remodels the extracellular matrix and upregulates the expression of integrin subunit alpha-4 (ITGA4) gene. ITGA4 is also upregulated in primary tumors with metastatic capability and retained in corresponding secondary tumors. Acidosis induces the enrichment of side population cells, enhancing resistance to the tumor microenvironment.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2023)
Article
Peripheral Vascular Disease
Kailiang Qiao, Yantao Liu, Zheng Xu, Haohao Zhang, Heng Zhang, Chao Zhang, Zhi Chang, Xinyan Lu, Zhongwei Li, Ce Luo, Yanrong Liu, Cheng Yang, Tao Sun
Summary: This study revealed that m6A methylation plays a key role in vasculogenic mimicry (VM) formation in hepatocellular carcinoma (HCC), and METTL3 and YAP1 could be potential therapeutic targets for anti-metastatic strategies by impairing VM formation.
Article
Biochemistry & Molecular Biology
Sara Peri, Alessio Biagioni, Giampaolo Versienti, Elena Andreucci, Fabio Staderini, Giuseppe Barbato, Lisa Giovannelli, Francesco Coratti, Nicola Schiavone, Fabio Cianchi, Laura Papucci, Lucia Magnelli
Summary: Chemotherapy is widely used in gastric cancer treatment as an adjuvant when surgery is not feasible or in the presence of metastasis. Chemoresistance is a major challenge in cancer therapy, leading to tumor recurrence and treatment failure. Despite known mechanisms of chemoresistance, a universal marker for chemoresistant cancer cells has not yet been identified.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Jianguo Wang, Yan Liu, Yuanbin Zhang, Xiaoyang Li, Min Fang, Dong Qian
Summary: This study investigated the function and mechanism of a targeting exosome system (iRGD-exo-antagomiR) against vasculogenic mimicry (VM) and angiogenesis in nasopharyngeal carcinoma (NPC) and provided new approaches for NPC treatment.
Article
Chemistry, Medicinal
Songtao Dong, Zhongyuan Chen, Li Wang, Yankai Liu, Dimitrios Stagos, Xiukun Lin, Ming Liu
Summary: BTDE, a marine algae-derived compound, demonstrates anti-angiogenesis effects by inhibiting endothelial cell activity and affecting functions of tumor cells, indicating its potential value in anti-cancer therapy through targeting angiogenesis.
Article
Oncology
Dhiraj Kumar, Saikat Haldar, Mahadeo Gorain, Santosh Kumar, Fayaj A. Mulani, Amit S. Yadav, Lucio Miele, Hirekodathakallu V. Thulasiram, Gopal C. Kundu
Article
Oncology
Margarite D. Matossian, Hope E. Burks, Annie C. Bowles, Steven Elliott, Van T. Hoang, Rachel A. Sabol, Nicholas C. Pashos, Benjamen O'Donnell, Kristin S. Miller, Bahia M. Wahba, Bruce A. Bunnell, Krzysztof Moroz, Arnold H. Zea, Steven D. Jones, Augusto C. Ochoa, Amir A. Al-Khami, Fokhrul Hossain, Adam I. Riker, Lyndsay V. Rhodes, Elizabeth C. Martin, Lucio Miele, Matthew E. Burow, Bridgette M. Collins-Burow
BREAST CANCER RESEARCH AND TREATMENT
(2018)
Article
Cell & Tissue Engineering
Jianghong Man, Xingjiang Yu, Haidong Huang, Wenchao Zhou, Chaomei Xiang, Haohao Huang, Lucio Miele, Zhenggang Liu, Gurkan Bebek, Shideng Bao, Jennifer S. Yu
Article
Oncology
Deep Shah, Debra Wyatt, Andrew T. Baker, Patricia Simms, Daniel S. Peiffer, Michelle Fernandez, Emad Rakha, Andrew Green, Alexandra Filipovic, Lucio Miele, Clodia Osipo
CLINICAL CANCER RESEARCH
(2018)
Article
Oncology
Lu Dai, Charles D. Smith, Maryam Foroozesh, Lucio Miele, Zhiqiang Qin
INTERNATIONAL JOURNAL OF CANCER
(2018)
Article
Biochemistry & Molecular Biology
Karthik Chandiran, Rebecca Lawlor, Antonio Pannuti, Gabriela Gonzalez Perez, Janani Srinivasan, Todd E. Golde, Lucio Miele, Barbara A. Osborne, Lisa M. Minter
MOLECULAR IMMUNOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Andrew Baker, Debra Wyatt, Maurizio Bocchetta, Jun Li, Aleksandra Filipovic, Andrew Green, Daniel S. Peiffer, Suzanne Fuqua, Lucio Miele, Kathy S. Albain, Clodia Osipo
Article
Environmental Sciences
Tarun K. K. Mamidi, Jiande Wu, Paul B. Tchounwou, Lucio Miele, Chindo Hicks
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2018)
Review
Biotechnology & Applied Microbiology
Samarpan Majumder, Judy S. Crabtree, Todd E. Golde, Lisa M. Minter, Barbara A. Osborne, Lucio Miele
Summary: The Notch pathway in cancer has multifaceted roles, acting as both an oncogene and a tumor suppressor depending on the context. Despite potential, developing safe and effective Notch-targeting agents for clinical use remains challenging.
NATURE REVIEWS DRUG DISCOVERY
(2021)
Article
Oncology
Akshita B. Bhatt, Thomas D. Wright, Van Barnes, Suravi Chakrabarty, Margarite D. Matossian, Erin Lexner, Deniz A. Ucar, Lucio Miele, Patrick T. Flaherty, Matthew E. Burow, Jane E. Cavanaugh
Summary: The epithelial to mesenchymal transition (EMT) and mesenchymal to epithelial transition (MET) play key roles in breast cancer metastasis, with the ERK1/2 and ERK5 pathways linked to patient prognosis. Pharmacological interventions targeting these pathways can alter cell morphology and gene expression, impacting cancer cell migration and growth.
TRANSLATIONAL ONCOLOGY
(2021)
Review
Oncology
Fokhrul Hossain, Samarpan Majumder, Justin David, Lucio Miele
Summary: The implementation of precision medicine is set to revolutionize cancer treatment paradigms, offering hope for patients with triple-negative breast cancer. However, challenges remain as oncologists navigate the complexities of tumor heterogeneity and evolution in designing personalized treatment plans.
Article
Nutrition & Dietetics
Fokhrul Hossain, Samarpan Majumder, Justin David, Bruce A. Bunnell, Lucio Miele
Summary: The study investigates how obesity modulates the gut microbiome in a TNBC mouse model, finding that obesity decreases alpha diversity. Obesity was the only significant factor explaining the similarity of bacterial communities. In functional profile analysis, obesity, tumor presence, and obesity-tumor interaction were significant in explaining variation, with obesity having the strongest correlation.
Article
Public, Environmental & Occupational Health
Susanna L. Lamers, David J. Nolan, Tessa M. LaFleur, Benjamin N. Lain, Samual R. Moot, Christopher R. Huston, Chad D. Neilsen, Amy K. Feehan, Lucio Miele, Rebecca Rose
Summary: This study utilized genomic surveillance to confirm two viral strains infecting offshore workers and suggested that changes in quarantine protocols contributed to outbreaks. The findings support that industrial hygiene quarantine/testing protocols limited viral transmissions, halted offshore outbreaks, and prevented the spread of a variant of interest.
AMERICAN JOURNAL OF INFECTION CONTROL
(2022)
Article
Oncology
Peter T. Katzmarzyk, Justin C. Brown, Shengping Yang, Emily F. Mire, Xiao-Cheng Wu, Lucio Miele, Augusto C. Ochoa, Jovanny Zabaleta
Summary: This study found that both abdominal visceral adipose tissue (VAT) and total fat mass (FM) are associated with cancer incidence and mortality. The association between VAT and cancer incidence is largely independent of total FM. These results suggest that more direct measures of adiposity may be needed in assessing obesity-related cancer risk.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Oncology
Michele Vigolo, Charlotte Urech, Sebastien Lamy, Giulia Monticone, Jovanny Zabaleta, Fokhrul Hossain, Dorota Wyczechowska, Luis Del Valle, Ruth M. O'Regan, Lucio Miele, Rajwinder Lehal, Samarpan Majumder
Summary: Notch signaling is involved in treatment resistance and cancer stem cell maintenance in breast cancer. CB-103 is a novel pan-Notch inhibitor with improved safety and efficacy compared to first-generation inhibitors. The study demonstrates that CB-103 in combination with fulvestrant or paclitaxel exhibits promising therapeutic potential in endocrine-resistant and triple negative breast cancers.
Article
Oncology
Diego de Miguel-Perez, Edward M. Pickering, Umberto Malapelle, William Grier, Francesco Pepe, Pasquale Pisapia, Gianluca Russo, Joseph A. Pinto, Alessandro Russo, Giancarlo Troncone, Melissa J. Culligan, Katherine A. Scilla, Ranee Mehra, Pranshu Mohindra, Oscar Arrieta, Andres F. Cardona, Marzia Del Re, Ashutosh Sachdeva, Fred R. Hirsch, Andrea Wolf, Joseph S. Friedberg, Christian Rolfo
Summary: In this study, genetic alterations in resectable pleural mesothelioma tissues and blood samples were analyzed, and it was found that high tissue tumor mutational burden, tissue median minor allele frequency, blood tumor mutational burden, and specific mutations were correlated with outcomes in patients with resected PM. These findings suggest that molecular profiling could help identify longer survivors in patients with resected PM.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Davide Melisi, Camilla Zecchetto, Valeria Merz, Giuseppe Malleo, Luca Landoni, Alberto Quinzii, Simona Casalino, Federica Fazzini, Marina Gaule, Camilla Pesoni, Luca Casetti, Alessandro Esposito, Giovanni Marchegiani, Cristiana Piazzola, Mirko D'Onofrio, Riccardo de Robertis, Armando Gabbrielli, Laura Bernardoni, Stefano F. Crino, Silvia Pietrobono, Claudio Luchini, Camillo Aliberti, Guido Martignoni, Stefano Milleri, Giovanni Butturini, Aldo Scarpa, Roberto Salvia, Claudio Bassi
Summary: This study evaluated the safety and activity of liposomal irinotecan in the perioperative treatment of resectable pancreatic ductal adenocarcinoma (rPDAC) patients. The results showed that NALIRIFOX has manageable and active outcomes, and should be further investigated in randomized trials comparing it to standard upfront surgery followed by adjuvant therapy.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Eric Jonasch, Todd M. Bauer, Kyriakos P. Papadopoulos, Elizabeth R. Plimack, Jaime R. Merchan, David F. Mcdermott, M. Dror Michaelson, Leonard J. Appleman, Ananya Roy, Rodolfo F. Perini, Yanfang Liu, Toni K. Choueiri
Summary: After a median follow-up of 41.2 months, belzutifan monotherapy demonstrated durable antitumor activity in patients with advanced ccRCC and acceptable safety.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Patricia A. H. Hamers, Geraldine R. Vink, Marloes A. G. Elferink, Leon M. G. Moons, Cornelis J. A. Punt, Anne M. May, Miriam Koopman
Summary: Screen-detection of the primary tumor is associated with longer overall survival after metachronous metastasis.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Camilla Nero, Nicolo Bizzarri, Stefano Di Berardino, Francesca Sillano, Giuseppe Vizzielli, Francesco Cosentino, Virginia Vargiu, Pierandrea De Iaco, Anna Myriam Perrone, Enrico Vizza, Benito Chiofalo, Stefano Uccella, Fabio Ghezzi, Luigi Carlo Turco, Giacomo Corrado, Diana Giannarelli, Tina Pasciuto, Gian Franco Zannoni, Anna Fagotti, Giovanni Scambia
Summary: This study evaluates the sensitivity and specificity of sentinel-lymph-node mapping compared to systematic lymphadenectomy in detecting lymph node metastasis in early stage ovarian cancer. The results show that sentinel-lymph-node mapping did not reach the expected sensitivity, but ultra-staging protocol improved the accuracy of diagnosis for patients.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Adriana Hepner, Judith M. Versluis, Roslyn Wallace, Clara Allayous, Lauren Julia Brown, Claudia Trojanielloh, Camille Lea Gerardi, Yanina J. L. Jansenj, Prachi Bhave, Bart Neyns, Andrew Haydon, Olivier Michielin, Joanna Manganan Oliver Klein, Alexander N. Shoushtari, Allison Betof Warner, Paolo Antonio Ascierto, Jennifer Leigh McQuade, Matteo S. Carlino, Lisa Zimmer, Celeste Lebbe, Douglas B. Johnson, Shahneen Sandhu, Victoria Atkinson, Christian U. Blank, Serigne N. Lo, Georgina V. Long, Alexander M. Menzies
Summary: Acquired resistance to PD-1 therapy in melanoma is mainly oligometastatic, and patients may have a favorable survival outcome following salvage treatment.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Savannah Roy, Stephanie Lakritz, Anna R. Schreiber, Elizabeth Molina Kuna, Cathy J. Bradley, Lavanya Kondapalli, Jennifer R. Diamond
Summary: This study evaluates major adverse cardiovascular events (MACE) in older women with TNBC treated with anthracycline and taxane-based chemotherapy (ATAX) compared to taxane-based chemotherapy (TAX). The results show that ATAX does not increase the risk of MACE and there is no difference in survival between patients who received TAX and ATAX.
EUROPEAN JOURNAL OF CANCER
(2024)
Letter
Oncology
Pei-Chun Weng, Yau-Li Huang, Chun-Yu Cheng
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Philipp Jansen, Jean Le 'Clerc Arrastia, Daniel Otero Baguer, Maximilian Schmidt, Jennifer Landsberg, Joerg Wenzel, Michael Emberger, Dirk Schadendorf, Eva Hadaschik, Peter Maass, Klaus Georg Griewank
Summary: This study highlights the enormous potential of artificial intelligence in pathology, showing that it can aid in the identification of rare cutaneous adnexal tumors and potentially become a standard tool in routine diagnostics.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Casper W. F. van Eijck, Gaby Strijk, Eveline E. Vietscha, Fleur van der Sijde, Maaike Verheij, Dana A. M. Mustafa, Madelief Vinkc, Joachim G. J. V. Aerts, Casper H. J. van Eijck, Marcella Willemsen
Summary: The study reveals that FOLFIRINOX has immunomodulatory effects, suggesting its potential in immune-based combination therapies for pancreatic cancer. Additionally, certain plasma proteins hold promise as circulating predictive biomarkers for early prediction of FOLFIRINOX response in patients with pancreatic cancer.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Marwan Fakih, Chongkai Wang, Jaideep Sandhu, Jian Ye, Colt Egelston, Xiaochen Li
Summary: This study explores the impact of metastatic sites on treatment outcomes for chemotherapy-refractory colorectal cancer patients. It found that patients with liver or peritoneal metastases had poor treatment outcomes, while those with lung-only metastases showed significant response. The presence of concurrent lymph node or other extrahepatic metastatic disease diminished treatment response in patients with lung metastases. Future checkpoint inhibitor trials should stratify patients based on metastatic locations.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Georgios Christos Tsiatsianis, Candace S. Y. Chan, Ioannis Mouratidis, Nikol Chantzi, Anna Maria Tsiatsiani, Nelson S. Yee, Apostolos Zaravinos, Verena Kantere, Ilias Georgakopoulos-Soares
Summary: The study reveals that nullpeptides can serve as biomarkers for cancer detection and treatment, particularly in highly recurrent cancer patients. These nullpeptides primarily occur in highly expressed genes, particularly in specific loci of oncogenes and tumor suppressors. Recurrent nullpeptides are more likely to be found in neoantigens, which play a significant role in immunotherapy.
EUROPEAN JOURNAL OF CANCER
(2024)