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miR signatures and the role of miRs in acute myeloid leukaemia

EUROPEAN JOURNAL OF CANCER (2010)

期刊

EUROPEAN JOURNAL OF CANCER

卷 46, 期 9, 页码 1520-1527

出版社

ELSEVIER SCI LTD

DOI: 10.1016/j.ejca.2010.03.031

关键词

MicroRNAs; miRs; miR signatures; RNAi; Leukaemia; AML

类别

Oncology

资金

FCT [SFRH/BD/47428/2008]
FCT, Portugal
European Social Fund
Fundacao Calouste Gulbenkian
FCT, the Portuguese Foundation for Science and Technology

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Protocol

Reagent

摘要

Acute myeloid leukaemia (AML) is a hematopoietic stem cell disorder in which neoplastic myeloblasts are arrested in an immature stage of differentiation. Recent publications have underlined the involvement of non-coding RNAs in cancer and particularly in AML development, with several studies regarding their possible contribution to the evolution of the disease. MicroRNAs (miRs) are a class of single-stranded non-coding RNAs that bind to the 3'-untranslated region of target mRNAs and thus negatively regulate gene expression, by translation repression or mRNA degradation. Abnormal expression of miRs in AML has been described and we here review the current data from miR expression profiles. Additionally, we review the current knowledge on the biological function of individual miRs in the development of AML. (C) 2010 Elsevier Ltd. All rights reserved.

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Catz, Claudia Cavadas, Federica Cavaliere, Gabriella Cavallini, Maria Cavinato, Maria L. Cayuela, Paula Cebollada Rica, Valentina Cecarini, Francesco Cecconi, Marzanna Cechowska-Pasko, Simone Cenci, Victoria Ceperuelo-Mallafre, Joao J. Cerqueira, Janete M. Cerutti, Davide Cervia, Vildan Bozok Cetintas, Silvia Cetrullo, Han-Jung Chae, Andrei S. Chagin, Chee-Yin Chai, Gopal Chakrabarti, Oishee Chakrabarti, Tapas Chakraborty, Trinad Chakraborty, Mounia Chami, Georgios Chamilos, David W. Chan, Edmond Y. W. Chan, Edward D. Chan, H. Y. Edwin Chan, Helen H. Chan, Hung Chan, Matthew T. Chan, Yau Sang Chan, Partha K. Chandra, Chih-Peng Chang, Chunmei Chang, Hao-Chun Chang, Kai Chang, Jie Chao, Tracey Chapman, Nicolas Charlet-Berguerand, Samrat Chatterjee, Shail K. Chaube, Anu Chaudhary, Santosh Chauhan, Edward Chaum, Frederic Checler, Michael E. Cheetham, ChangShi Chen, Guang-Chao Chen, Jian-Fu Chen, Liam L. Chen, Leilei Chen, Lin Chen, Mingliang Chen, MuKuan Chen, Ning Chen, Quan Chen, Ruey-Hwa Chen, Shi Chen, Wei Chen, Weiqiang Chen, XinMing Chen, Xiong-Wen Chen, Xu Chen, Yan Chen, Ye-Guang Chen, Yingyu Chen, Yongqiang Chen, YuJen Chen, Yue-Qin Chen, Zhefan Stephen Chen, Zhi Chen, Zhi-Hua Chen, Zhijian J. Chen, Zhixiang Chen, Hanhua Cheng, Jun Cheng, Shi-Yuan Cheng, Wei Cheng, Xiaodong Cheng, Xiu-Tang Cheng, Yiyun Cheng, Zhiyong Cheng, Zhong Chen, Heesun Cheong, Jit Kong Cheong, Boris Chernyak, Sara Cherry, Chi Fai Randy Cheung, Chun Hei Antonio Cheung, King-Ho Cheung, Eric Chevet, Richard J. Chi, Alan Kwok Shing Chiang, Ferdinando Chiaradonna, Roberto Chiarelli, Mario Chiariello, Nathalia Chica, Susanna Chiocca, Mario Chiong, Shih-Hwa Chiou, Abhilash Chiramel, Valerio Chiurchiu, Dong-Hyung Cho, Seong-Kyu Choe, Augustine M. K. Choi, Mary E. Choi, Kamalika Roy Choudhury, Norman S. Chow, Charleen T. Chu, Jason P. Chua, John Jia En Chua, Hyewon Chung, Kin Pan Chung, Seockhoon Chung, So-Hyang Chung, Yuen-Li Chung, Valentina Cianfanelli, Iwona A. Ciechomska, Mariana Cifuentes, Laura Cinque, Sebahattin Cirak, Mara Cirone, Michael J. Clague, Robert Clarke, Emilio Clementi, Eliana M. Coccia, Patrice Codogno, Ehud Cohen, Mickael M. Cohen, Tania Colasanti, Fiorella Colasuonno, Robert A. Colbert, Anna Colell, Nuria S. Coll, Mark O. Collins, Maria Colombo, Daniel A. Colon-Ramos, Lydie Combaret, Sergio Comincini, Marcia R. Cominetti, Antonella Consiglio, Andrea Conte, Fabrizio Conti, Viorica Raluca Contu, Mark R. Cookson, Kevin M. Coombs, Isabelle Coppens, Maria Tiziana Corasaniti, Dale P. Corkery, Nils Cordes, Katia Cortese, Maria do Carmo Costa, Sarah Costantino, Paola Costelli, Ana Coto-Montes, Peter J. Crack, Jose L. Crespo, Alfredo Criollo, Valeria Crippa, Riccardo Cristofani, Tamas Csizmadia, Antonio Cuadrado, Bing Cui, Jun Cui, Yixian Cui, Yong Cui, Emmanuel Culetto, Andrea C. Cumino, Andrey Cybulsky, Mark J. Czaja, Stanislaw J. Czuczwar, Stefania D'Adamo, Marcello D'Amelio, Daniela D'Arcangelo, Andrew C. D'Lugos, Gabriella D'Orazi, James A. da Silva, Hormos Salimi Dafsari, Ruben K. Dagda, Yasin Dagdas, Maria Daglia, Xiaoxia Dai, Yun Dai, Yuyuan Dai, Jessica Dal Col, Paul Dalhaimer, Luisa Dalla Valle, Tobias Dallenga, Guillaume Dalmasso, Markus Damme, Ilaria Dando, Nico P. Dantuma, April L. Darling, Hiranmoy Das, Srinivasan Dasarathy, Santosh K. Dasari, Srikanta Dash, Oliver Daumke, Adrian N. Dauphinee, Jeffrey S. Davies, Valeria A. Davila, Roger J. Davis, Tanja Davis, Sharadha Dayalan Naidu, Francesca De Amicis, Karolien De Bosscher, Francesca De Felice, Lucia De Franceschi, Chiara De Leonibus, Mayara G. de Mattos Barbosa, Guido R. Y. De Meyer, Angelo De Milito, Cosimo De Nunzio, Clara De Palma, Mauro De Santi, Claudio De Virgilio, Daniela De Zio, Jayanta Debnath, Brian J. DeBosch, JeanPaul Decuypere, Mark A. Deehan, Gianluca Deflorian, James DeGregori, Benjamin Dehay, Gabriel Del Rio, Joe R. Delaney, Lea M. D. Delbridge, Elizabeth Delorme-Axford, M. Victoria Delpino, Francesca Demarchi, Vilma Dembitz, Nicholas D. Demers, Hongbin Deng, Zhiqiang Deng, Joern Dengjel, Paul Dent, Donna Denton, Melvin L. DePamphilis, Channing J. Der, Vojo Deretic, Albert Descoteaux, Laura Devis, Sushil Devkota, Olivier Devuyst, Grant Dewson, Mahendiran Dharmasivam, Rohan Dhiman, Diego di Bernardo, Manlio Di Cristina, Fabio Di Domenico, Pietro Di Fazio, Alessio Di Fonzo, Giovanni Di Guardo, Gianni M. Di Guglielmo, Luca Di Leo, Chiara Di Malta, Alessia Di Nardo, Martina Di Rienzo, Federica Di Sano, George Diallinas, Jiajie Diao, Guillermo Diaz-Araya, Ines Diaz-Laviada, Jared M. Dickinson, Marc Diederich, Melanie Dieude, Ivan Dikic, Shiping Ding, Wen-Xing Ding, Luciana Dini, Miroslav Dinic, Albena T. Dinkova-Kostova, Marc S. Dionne, Jorg H. W. Distler, Abhinav Diwan, Ian M. C. Dixon, Mojgan Djavaheri-Mergny, Ina Dobrinski, Oxana Dobrovinskaya, Radek Dobrowolski, Renwick C. J. Dobson, Serap Dokmeci Emre, Massimo Donadelli, Bo Dong, Xiaonan Dong, Zhiwu Dong, Gerald W. Dorn Ii, Volker Dotsch, Huan Dou, Juan Dou, Moataz Dowaidar, Sami Dridi, Liat Drucker, Ailian Du, Caigan Du, Guangwei Du, Hai-Ning Du, Li-Lin Du, Andre du Toit, Shao-Bin Duan, Xiaoqiong Duan, Sonia P. Duarte, Anna Dubrovska, Elaine A. Dunlop, Nicolas Dupont, Raul Duran, Bilikere S. Dwarakanath, Sergey A. Dyshlovoy, Darius Ebrahimi-Fakhari, Leopold Eckhart, Charles L. Edelstein, Thomas Efferth, Eftekhar Eftekharpour, Ludwig Eichinger, Nabil Eid, Tobias Eisenberg, N. Tony Eissa, Sanaa Eissa, Miriam Ejarque, Abdeljabar El Andaloussi, Nazira El-Hage, Shahenda El-Naggar, Anna Maria Eleuteri, Eman S. El-Shafey, Mohamed Elgendy, Aristides G. Eliopoulos, Maria M. Elizalde, Philip M. Elks, Hans-Peter Elsasser, Eslam S. Elsherbiny, Brooke M. Emerling, N. C. Tolga Emre, Christina H. Eng, Nikolai Engedal, Anna-Mart Engelbrecht, Agnete S. T. Engelsen, Jorrit M. Enserink, Ricardo Escalante, Audrey Esclatine, Mafalda Escobar-Henriques, Eeva-Liisa Eskelinen, Lucile Espert, Makandjou-Ola Eusebio, Gemma Fabrias, Cinzia Fabrizi, Antonio Facchiano, Francesco Facchiano, Bengt Fadeel, Claudio Fader, Alex C. Faesen, W. Douglas Fairlie, Alberto Falco, Bjorn H. Falkenburger, Daping Fan, Jie Fan, Yanbo Fan, Evandro F. Fang, Yanshan Fang, Yognqi Fang, Manolis Fanto, Tamar Farfel-Becker, Mathias Faure, Gholamreza Fazeli, Anthony O. Fedele, Arthur M. Feldman, Du Feng, Jiachun Feng, Lifeng Feng, Yibin Feng, Yuchen Feng, Wei Feng, Thais Fenz Araujo, Thomas A. Ferguson, Jose C. Fernandez-Checa, Sonia FernandezVeledo, Alisdair R. Fernie, Anthony W. Ferrante, Alessandra Ferraresi, Merari F. Ferrari, Julio C. B. Ferreira, Susan Ferro-Novick, Antonio Figueras, Riccardo Filadi, Nicoletta Filigheddu, Eduardo FilippiChiela, Giuseppe Filomeni, Gian Maria Fimia, Vittorio Fineschi, Francesca Finetti, Steven Finkbeiner, Edward A. Fisher, Paul B. Fisher, Flavio Flamigni, Steven J. Fliesler, Trude H. Flo, Ida Florance, Oliver Florey, Tullio Florio, Erika Fodor, Carlo Follo, Edward A. Fon, Antonella Forlino, Francesco Fornai, Paola Fortini, Anna Fracassi, Alessandro Fraldi, Brunella Franco, Rodrigo Franco, Flavia Franconi, Lisa B. Frankel, Scott L. Friedman, Leopold F. Frohlich, Gema Fruhbeck, Jose M. Fuentes, Yukio Fujiki, Naonobu Fujita, Yuuki Fujiwara, Mitsunori Fukuda, Simone Fulda, Luc Furic, Norihiko Furuya, Carmela Fusco, Michaela U. Gack, Lidia Gaffke, Sehamuddin Galadari, Alessia Galasso, Maria F. Galindo, Sachith Gallolu Kankanamalage, Lorenzo Galluzzi, Vincent Galy, Noor Gammoh, Boyi Gan, Ian G. Ganley, Feng Gao, Hui Gao, Minghui Gao, Ping Gao, Shou-Jiang Gao, Wentao Gao, Xiaobo Gao, Ana Garcera, Maria Noe Garcia, Veronica E. Garcia, Francisco Garcia-Del Portillo, Vega Garcia-Escudero, Aracely GarciaGarcia, Marina Garcia-Macia, Diana Garcia-Moreno, Carmen Garcia-Ruiz, Patricia Garcia-Sanz, Abhishek D. Garg, Ricardo Gargini, Tina Garofalo, Robert F. Garry, Nils C. Gassen, Damian Gatica, Liang Ge, Wanzhong Ge, Ruth Geiss-Friedlander, Cecilia Gelfi, Pascal Genschik, Ian E. Gentle, Valeria Gerbino, Christoph Gerhardt, Kyla Germain, Marc Germain, David A. Gewirtz, Elham Ghasemipour Afshar, Saeid Ghavami, Alessandra Ghigo, Manosij Ghosh, Georgios Giamas, Claudia Giampietri, Alexandra Giatromanolaki, Gary E. Gibson, Spencer B. Gibson, Vanessa Ginet, Edward Giniger, Carlotta Giorgi, Henrique Girao, Stephen E. Girardin, Mridhula Giridharan, Sandy Giuliano, Cecilia Giulivi, Sylvie Giuriato, Julien Giustiniani, Alexander Gluschko, Veit Goder, Alexander Goginashvili, Jakub Golab, David C. Goldstone, Anna Golebiewska, Luciana R. Gomes, Rodrigo Gomez, Ruben Gomez-Sanchez, Maria Catalina Gomez-Puerto, Raquel Gomez-Sintes, Qingqiu Gong, Felix M. Goni, Javier Gonzalez-Gallego, Tomas Gonzalez-Hernandez, Rosa A. Gonzalez-Polo, Jose A. Gonzalez-Reyes, Patricia Gonzalez-Rodriguez, Ing Swie Goping, Marina S. Gorbatyuk, Nikolai Gorbunov, Roxana M. Gorojod, Sharon M. Gorski, Sandro Goruppi, Cecilia Gotor, Roberta A. Gottlieb, Illana Gozes, Devrim Gozuacik, Martin Graef, Markus H. Graler, Veronica Granatiero, Daniel Grasso, Joshua P. Gray, Douglas R. Green, Alexander Greenhough, Stephen L. Gregory, Edward F. Griffin, Mark W. Grinstaff, Frederic Gros, Charles Grose, Angelina S. Gross, Florian Gruber, Paolo Grumati, Tilman Grune, Xueyan Gu, Jun-Lin Guan, Carlos M. Guardia, Kishore Guda, Flora Guerra, Consuelo Guerri, Prasun Guha, Carlos Guillen, Shashi Gujar, Anna Gukovskaya, Ilya Gukovsky, Jan Gunst, Andreas Gunther, Anyonya R. Guntur, Chuanyong Guo, Chun Guo, Hongqing Guo, Lian-Wang Guo, Ming Guo, Pawan Gupta, Alvaro F. Fernandez, Shashi Kumar Gupta, Swapnil Gupta, Veer Bala Gupta, Vivek Gupta, Asa B. Gustafsson, David D. Gutterman, H. B. Ranjitha, Annakaisa Haapasalo, James E. Haber, Shinji Hadano, Anders J. Hafren, Mansour Haidar, Belinda S. Hall, Gunnel Hallden, Anne Hamacher-Brady, Andrea Hamann, Maho Hamasaki, Weidong Han, Malene Hansen, Phyllis Hanson, Zijian Hao, Masaru Harada, Ljubica Harhaji-Trajkovic, Nirmala Hariharan, Nigil Haroon, James Harris, Takafumi Hasegawa, Noor Hasima Nagoor, Jeffrey A. Haspel, Volker Haucke, Wayne D. Hawkins, Bruce A. Hay, Cole M. Haynes, Soren B. Hayrabedyan, Thomas S. Hays, Congcong He, Qin He, RongRong He, You-Wen He, Yu-Ying He, Yasser Heakal, Alexander M. Heberle, J. Fielding Hejtmancik, Gudmundur Vignir Helgason, Vanessa Henkel, Marc Herb, Alexander Hergovich, Anna Herman-Antosiewicz, Agustin Hernandez, Carlos Hernandez, Sergio Hernandez-Diaz, Virginia Hernandez-Gea, Amaury Herpin, Judit Herreros, Javier H. Hervas, Daniel Hesselson, Claudio Hetz, Volker T. Heussler, Yujiro Higuchi, Sabine Hilfiker, Joseph A. Hill, William S. Hlavacek, Emmanuel A. Ho, Idy H. T. Ho, Philip Wing-Lok Ho, ShuLeong Ho, Wan Yun Ho, G. Aaron Hobbs, Mark Hochstrasser, Peter H. M. Hoet, Daniel Hofius, Paul Hofman, Annika Hohn, Carina Holmberg, Jose R. Hombrebueno, Chang-Won Hong, Yi-Ren Hong, Lora Hooper, Thorsten Hoppe, Rastislav Horos, Yujin Hoshida, I-Lun Hsin, Hsin-Yun Hsu, Bing Hu, Dong Hu, Li-Fang Hu, Ming Chang Hu, Ronggui Hu, Wei Hu, Yu-Chen Hu, Zhuo-Wei Hu, Fang Hua, Jinlian Hua, Yingqi Hua, Chongmin Huan, Canhua Huang, Chuanshu Huang, Chuanxin Huang, Chunling Huang, Haishan Huang, Kun Huang, Michael L. H. Huang, Rui Huang, Shan Huang, Tianzhi Huang, Xing Huang, Yuxiang Jack Huang, Tobias B. Huber, Virginie Hubert, Christian A. Hubner, Stephanie M. Hughes, William E. Hughes, Magali Humbert, Gerhard Hummer, James H. Hurley, Sabah Hussain, Salik Hussain, Patrick J. Hussey, Martina Hutabarat, Hui-Yun Hwang, Seungmin Hwang, Antonio Ieni, Fumiyo Ikeda, Yusuke Imagawa, Yuzuru Imai, Carol Imbriano, Masaya Imoto, Denise M. Inman, Ken Inoki, Juan Iovanna, Renato Iozzo, Giuseppe Ippolito, Javier E. Irazoqui, Pablo Iribarren, Mohd Ishaq, Makoto Ishikawa, Nestor Ishimwe, Ciro Isidoro, Nahed Ismail, Shohreh Issazadeh-Navikas, Eisuke Itakura, Daisuke Ito, Davor Ivankovic, Saska Ivanova, Anand Krishnan Iyer, Jose M. Izquierdo, Masanori Izumi, Marja Jaattela, Majid Sakhi Jabir, William T. Jackson, Nadia Jacobo-Herrera, Anne-Claire Jacomin, Elise Jacquin, Pooja Jadiya, Hartmut Jaeschke, Chinnaswamy Jagannath, Arjen J. Jakobi, Johan Jakobsson, Bassam Janji, Pidder JansenDurr, Patric J. Jansson, Jonathan Jantsch, Slawomir Januszewski, Alagie Jassey, Steve Jean, Helene JeltschDavid, Pavla Jendelova, Andreas Jenny, Thomas E. Jensen, Niels Jessen, Jenna L. Jewell, Jing Ji, Lijun Jia, Rui Jia, Liwen Jiang, Qing Jiang, Richeng Jiang, Teng Jiang, Xuejun Jiang, Yu Jiang, Maria Jimenez-Sanchez, Eun-Jung Jin, Fengyan Jin, Hongchuan Jin, Li Jin, Luqi Jin, Meiyan Jin, Si Jin, Eun-Kyeong Jo, Carine Joffre, Terje Johansen, Gail V. W. Johnson, Simon A. Johnston, Eija Jokitalo, Mohit Kumar Jolly, Leo A. B. Joosten, Joaquin Jordan, Bertrand Joseph, Dianwen Ju, Jeong-Sun Ju, Jingfang Ju, Esmeralda Juarez, Delphine Judith, Gabor Juhasz, Youngsoo Jun, Chang Hwa Jung, SungChul Jung, Yong Keun Jung, Heinz Jungbluth, Johannes Jungverdorben, Steffen Just, Kai Kaarniranta, Allen Kaasik, Tomohiro Kabuta, Daniel Kaganovich, Alon Kahana, Renate Kain, Shinjo Kajimura, Maria Kalamvoki, Manjula Kalia, Danuta S. Kalinowski, Nina Kaludercic, Ioanna Kalvari, Joanna Kaminska, Vitaliy O. Kaminskyy, Hiromitsu Kanamori, Keizo Kanasaki, Chanhee Kang, Rui Kang, Sang Sun Kang, Senthilvelrajan Kaniyappan, Tomotake Kanki, Thirumala-Devi Kanneganti, Anumantha G. Kanthasamy, Arthi Kanthasamy, Marc Kantorow, Orsolya Kapuy, Michalis Karamouzis, Md Razaul Karim, Parimal Karmakar, Rajesh G. Katare, Masaru Kato, Stefan H. E. Kaufmann, Anu Kauppinen, Gur P. Kaushal, Susmita Kaushik, Kiyoshi Kawasaki, Kemal Kazan, Po-Yuan Ke, Damien J. Keating, Ursula Keber, John H. Kehrl, Kate E. Keller, Christian W. Keller, Jongsook Kim Kemper, Candia M. Kenific, Oliver Kepp, Stephanie Kermorgant, Andreas Kern, Robin Ketteler, Tom G. Keulers, Boris Khalfin, Hany Khalil, Bilon Khambu, Shahid Y. Khan, Vinoth Kumar Megraj Khandelwal, Rekha Khandia, Widuri Kho, Noopur Khobrekar, Sataree Khuansuwan, Mukhran Khundadze, Samuel A. Killackey, Dasol Kim, Deok Ryong Kim, Do-Hyung Kim, Dong-Eun Kim, Eun Young Kim, Eun-Kyoung Kim, HakRim Kim, Hee-Sik Kim, Hyung-Ryong Kim, Jeong Hun Kim, Jin Kyung Kim, Jin-Hoi Kim, Joungmok Kim, Ju Hwan Kim, Keun Il Kim, Peter K. Kim, Seong-Jun Kim, Scot R. Kimball, Adi Kimchi, Alec C. Kimmelman, Tomonori Kimura, Matthew A. King, Kerri J. Kinghorn, Conan G. Kinsey, Vladimir Kirkin, Lorrie A. Kirshenbaum, Sergey L. Kiselev, Shuji Kishi, Katsuhiko Kitamoto, Yasushi Kitaoka, Kaio Kitazato, Richard N. Kitsis, Josef T. Kittler, Ole Kjaerulff, Peter S. Klein, Thomas Klopstock, Jochen Klucken, Helene Knovelsrud, Roland L. Knorr, Ben C. B. Ko, Fred Ko, JiunnLiang Ko, Hotaka Kobayashi, Satoru Kobayashi, Ina Koch, Jan C. Koch, Ulrich Koenig, Donat Kogel, Young Ho Koh, Masato Koike, Sepp D. Kohlwein, Nur M. Kocaturk, Masaaki Komatsu, Jeannette Konig, Toru Kono, Benjamin T. Kopp, Tamas Korcsmaros, Gozde Korkmaz, Viktor Korolchuk, Monica Suarez Korsnes, Ali Koskela, Janaiah Kota, Yaichiro Kotake, Monica L. Kotler, Yanjun Kou, Michael Koukourakis, Evangelos Koustas, Attila L. Kovacs, Tibor Kovacs, Daisuke Koya, Tomohiro Kozako, Claudine Kraft, Dimitri Krainc, Helmut Kramer, Anna D. Krasnodembskaya, Carole Kretz-Remy, Guido Kroemer, Nicholas T. Ktistakis, Kazuyuki Kuchitsu, Sabine Kuenen, Lars Kuerschner, Thomas Kukar, Ajay Kumar, Ashok Kumar, Deepak Kumar, Dhiraj Kumar, Sharad Kumar, Shinji Kume, Caroline Kumsta, Chanakya N. Kundu, Mondira Kundu, Ajaikumar B. Kunnumakkara, Lukasz Kurgan, Tatiana G. Kutateladze, Ozlem Kutlu, SeongAe Kwak, Ho Jeong Kwon, Taeg Kyu Kwon, Yong Tae Kwon, Irene Kyrmizi, Albert La Spada, Patrick Labonte, Sylvain Ladoire, Ilaria Laface, Frank Lafont, Diane C. Lagace, Vikramjit Lahiri, Zhibing Lai, Angela S. Laird, Aparna Lakkaraju, Trond Lamark, Sheng-Hui Lan, Ane Landajuela, Darius J. R. Lane, Jon D. Lane, Charles H. Lang, Carsten Lange, Rupert Langer, Pierre Lapaquette, Jocelyn Laporte, Nicholas F. LaRusso, Isabel Lastres-Becker, Wilson Chun Yu Lau, Gordon W. Laurie, Sergio Lavandero, Betty Yuen Kwan Law, Helen Ka-wai Law, Rob Layfield, Weidong Le, Herve Le Stunff, Alexandre Y. Leary, Jean-Jacques Lebrun, Lionel Y. W. Leck, Jean-Philippe Leduc-Gaudet, Changwook Lee, Chung-Pei Lee, Da-Hye Lee, Edward B. Lee, Erinna F. Lee, Gyun Min Lee, He-Jin Lee, Heung Kyu Lee, Jae Man Lee, Jason S. Lee, Jin-A Lee, Joo-Yong Lee, Jun Hee Lee, Michael Lee, Min Goo Lee, Min Jae Lee, Myung-Shik Lee, Sang Yoon Lee, Seung-Jae Lee, Stella Y. Lee, Sung Bae Lee, Won Hee Lee, Ying-Ray Lee, Yong-ho Lee, Youngil Lee, Christophe Lefebvre, Renaud Legouis, Yu L. Lei, Yuchen Lei, Sergey Leikin, Gerd Leitinger, Leticia Lemus, Shuilong Leng, Olivia Lenoir, Guido Lenz, Heinz Josef Lenz, Paola Lenzi, Yolanda Leon, Andreia M. Leopoldino, Christoph Leschczyk, Stina Leskela, Elisabeth Letellier, Chi-Ting Leung, Po Sing Leung, Jeremy S. Leventhal, Beth Levine, Patrick A. Lewis, Klaus Ley, Bin Li, Da-Qiang Li, Jianming Li, Jing Li, Jiong Li, Ke Li, Liwu Li, Mei Li, Min Li, Min Li, Ming Li, Mingchuan Li, Pin-Lan Li, MingQing Li, Qing Li, Sheng Li, Tiangang Li, Wei Li, Wenming Li, Xue Li, Yi-Ping Li, Yuan Li, Zhiqiang Li, Zhiyong Li, Zhiyuan Li, Jiqin Lian, Chengyu Liang, Qiangrong Liang, Weicheng Liang, Yongheng Liang, YongTian Liang, Guanghong Liao, Lujian Liao, Mingzhi Liao, Yung-Feng Liao, Mariangela Librizzi, Pearl P. Y. Lie, Mary A. Lilly, Hyunjung J. Lim, Thania R. R. Lima, Federica Limana, Chao Lin, Chih-Wen Lin, Dar-Shong Lin, Fu-Cheng Lin, Jiandie D. Lin, Kurt M. Lin, Kwang-Huei Lin, Liang-Tzung Lin, Pei-Hui Lin, Qiong Lin, Shaofeng Lin, Su-Ju Lin, Wenyu Lin, Xueying Lin, Yao-Xin Lin, Yee-Shin Lin, Rafael Linden, Paula Lindner, Shuo-Chien Ling, Paul Lingor, Amelia K. Linnemann, YihCherng Liou, Marta M. Lipinski, Saska Lipovsek, Vitor A. Lira, Natalia Lisiak, Paloma B. Liton, Chao Liu, Ching-Hsuan Liu, Chun-Feng Liu, Cui Hua Liu, Fang Liu, Hao Liu, Hsiao-Sheng Liu, Hua-feng Liu, Huifang Liu, Jia Liu, Jing Liu, Julia Liu, Leyuan Liu, Longhua Liu, Meilian Liu, Qin Liu, Wei Liu, Wende Liu, Xiao-Hong Liu, Xiaodong Liu, Xingguo Liu, Xu Liu, Xuedong Liu, Yanfen Liu, Yang Liu, Yang Liu, Yueyang Liu, Yule Liu, J. Andrew Livingston, Gerard Lizard, Jose M. Lizcano, Senka Ljubojevic-Holzer, Matilde E. LLeonart, David Llobet-Navas, Alicia Llorente, Chih Hung Lo, Damian Lobato-Marquez, Qi Long, Yun Chau Long, Ben Loos, Julia A. Loos, Manuela G. Lopez, Guillermo Lopez-Domenech, Jose Antonio Lopez-Guerrero, Ana T. Lopez-Jimenez, Israel Lopez-Valero, Magdalena J. Lorenowicz, Mar Lorente, Peter Lorincz, Laura Lossi, Sophie Lotersztajn, Penny E. Lovat, Jonathan F. Lovell, Alenka Lovy, Guang Lu, Haocheng Lu, Jia-Hong Lu, Jin-Jian Lu, Mengji Lu, Shuyan Lu, Alessandro Luciani, John M. Lucocq, Paula Ludovico, Micah A. Luftig, Morten Luhr, Diego Luis-Ravelo, Julian J. Lum, Liany Luna-Dulcey, Anders H. Lund, Viktor K. Lund, Jan D. Lunemann, Patrick Luningschror, Honglin Luo, Rongcan Luo, Shouqing Luo, Zhi Luo, Claudio Luparello, Bernhard Luscher, Luan Luu, Alex Lyakhovich, Konstantin G. Lyamzaev, Alf Hakon Lystad, Lyubomyr Lytvynchuk, Alvin C. Ma, Changle Ma, Mengxiao Ma, Ning-Fang Ma, Quan-Hong Ma, Xinliang Ma, Yueyun Ma, Zhenyi Ma, Ormond A. MacDougald, Fernando Macian, Gustavo C. MacIntosh, Jeffrey P. MacKeigan, Kay F. Macleod, Sandra Maday, Frank Madeo, Muniswamy Madesh, Tobias Madl, Julio Madrigal-Matute, Akiko Maeda, Yasuhiro Maejima, Marta Magarinos, Poornima Mahavadi, Emiliano Maiani, Kenneth Maiese, Panchanan Maiti, Maria Chiara Maiuri, Barbara Majello, Michael B. Major, Elena Makareeva, Fayaz Malik, Karthik Mallilankaraman, Walter Malorni, Alina Maloyan, Najiba Mammadova, Gene Chi Wai Man, Federico Manai, Joseph D. Mancias, Eva-Maria Mandelkow, Michael A. Mandell, Angelo A. Manfredi, Masoud H. Manjili, Ravi Manjithaya, Patricio Manque, Bella B. Manshian, Raquel Manzano, Claudia Manzoni, Kai Mao, Cinzia Marchese, Sandrine Marchetti, Anna Maria Marconi, Fabrizio Marcucci, Stefania Mardente, Olga A. Mareninova, Marta Margeta, Muriel Mari, Sara Marinelli, Oliviero Marinelli, Guillermo Marino, Sofia Mariotto, Richard S. Marshall, Mark R. Marten, Sascha Martens, Alexandre P. J. Martin, Katie R. Martin, Sara Martin, Shaun Martin, Adrian Martin-Segura, Miguel A. Martin-Acebes, Inmaculada Martin-Burriel, Marcos Martin-Rincon, Paloma Martin-Sanz, Jose A. Martina, Wim Martinet, Aitor Martinez, Ana Martinez, Jennifer Martinez, Moises Martinez Velazquez, Nuria Martinez-Lopez, Marta Martinez-Vicente, Daniel O. Martins, Ulo Lange, Oscar Lopez-Perez, Joilson O. Martins, Waleska K. Martins, Tania Martins-Marques, Emanuele Marzetti, Shashank Masaldan, Celine Masclaux-Daubresse, Douglas G. Mashek, Valentina Massa, Lourdes Massieu, Glenn R. Masson, Laura Masuelli, Anatoliy Masyuk, Tetyana Masyuk, Paola Matarrese, Ander Matheu, Satoaki Matoba, Sachiko Matsuzaki, Pamela Mattar, Alessandro Matte, Domenico Mattoscio, Jose L. Mauriz, Mario Mauthe, Caroline Mauvezin, Emanual Maverakis, Paola Maycotte, Johanna Mayer, Gianluigi Mazzoccoli, Cristina Mazzoni, Joseph R. Mazzulli, Nami McCarty, Christine McDonald, Mitchell R. McGill, Sharon L. McKenna, BethAnn McLaughlin, Fionn McLoughlin, Mark A. McNiven, Thomas G. McWilliams, Fatima Mechta-Grigoriou, Tania Catarina Medeiros, Diego L. Medina, Lynn A. Megeney, Klara Megyeri, Maryam Mehrpour, Jawahar L. Mehta, Alfred J. Meijer, Annemarie H. Meijer, Jakob Mejlvang, Alicia Melendez, Annette Melk, Gonen Memisoglu, Alexandrina F. Mendes, Delong Meng, Fei Meng, Tian Meng, Rubem Menna-Barreto, Manoj B. Menon, Carol Mercer, Anne E. Mercier, Jean-Louis Mergny, Adalberto Merighi, Seth D. Merkley, Giuseppe Merla, Volker Meske, Ana Cecilia Mestre, Shree Padma Metur, Christian Meyer, Hemmo Meyer, Wenyi Mi, Jeanne Mialet-Perez, Junying Miao, Lucia Micale, Yasuo Miki, Enrico Milan, Dana L. Miller, Samuel Miller, Silke Miller, Steven W. Millward, Ira Milosevic, Elena A. Minina, Hamed Mirzaei, Hamid Reza Mirzaei, Mehdi Mirzaei, Amit Mishra, Nandita Mishra, Paras Kumar Mishra, Maja Misirkic Marjanovic, Roberta Misasi, Amit Misra, Gabriella Misso, Claire Mitchell, Geraldine Mitou, Tetsuji Miura, Shigeki Miyamoto, Makoto Miyazaki, Mitsunori Miyazaki, Taiga Miyazaki, Keisuke Miyazawa, Noboru Mizushima, Trine H. Mogensen, Baharia Mograbi, Reza Mohammadinejad, Yasir Mohamud, Abhishek Mohanty, Sipra Mohapatra, Torsten Mohlmann, Asif Mohmmed, Anna Moles, Kelle H. Moley, Maurizio Molinari, Vincenzo Mollace, Andreas Buch Muller, Bertrand Mollereau, Faustino Mollinedo, Costanza Montagna, Mervyn J. Monteiro, Andrea Montella, L. Ruth Montes, Barbara Montico, Vinod K. Mony, Giacomo Monzio Compagnoni, Michael N. Moore, Mohammad A. Moosavi, Ana L. Mora, Marina Mora, David Morales-Alamo, Rosario Moratalla, Paula Moreira, Elena Morelli, Sandra Moreno, Daniel Moreno-Blas, Viviana Moresi, Benjamin Morga, Alwena H. Morgan, Fabrice Morin, Hideaki Morishita, Orson L. Moritz, Mariko Moriyama, Yuji Moriyasu, Manuela Morleo, Eugenia Morselli, Jose F. Moruno-Manchon, Jorge Moscat, Serge Mostowy, Elisa Motori, Andrea Felinto Moura, Naima Moustaid-Moussa, Maria Mrakovcic, Gabriel MucinoHernandez, Anupam Mukherjee, Subhadip Mukhopadhyay, Jean M. Mulcahy Levy, Victoriano Mulero, Sylviane Muller, Christian Munch, Ashok Munjal, Pura Munoz-Canoves, Teresa Munoz-Galdeano, Christian Munz, Tomokazu Murakawa, Claudia Muratori, Brona M. Murphy, J. Patrick Murphy, Aditya Murthy, Timo T. Myohanen, Indira U. Mysorekar, Jennifer Mytych, Seyed Mohammad Nabavi, Massimo Nabissi, Peter Nagy, Jihoon Nah, Aimable Nahimana, Ichiro Nakagawa, Ken Nakamura, Hitoshi Nakatogawa, Shyam S. Nandi, Meera Nanjundan, Monica Nanni, Gennaro Napolitano, Roberta Nardacci, Masashi Narita, Melissa Nassif, Ilana Nathan, Manabu Natsumeda, Ryno J. Naude, Christin Naumann, Olaia Naveiras, Fatemeh Navid, Steffan T. Nawrocki, Taras Y. Nazarko, Francesca Nazio, Florentina Negoita, Thomas Neill, Amanda L. Neisch, Luca M. Neri, Mihai G. Netea, Patrick Neubert, Thomas P. Neufeld, Dietbert Neumann, Albert Neutzner, Phillip T. Newton, Paul A. Ney, Ioannis P. Nezis, Charlene C. W. Ng, Tzi Bun Ng, Hang T. T. Nguyen, Long T. Nguyen, Hong-Min Ni, Cliona Ni Cheallaigh, Zhenhong Ni, M. Celeste Nicolao, Francesco Nicoli, Manuel Nieto-Diaz, Per Nilsson, Shunbin Ning, Rituraj Niranjan, Hiroshi Nishimune, Mireia Niso-Santano, Ralph A. Nixon, Annalisa Nobili, Clevio Nobrega, Takeshi Noda, Uxia Nogueira-Recalde, Trevor M. Nolan, Ivan Nombela, Ivana Novak, Beatriz Novoa, Takashi Nozawa, Nobuyuki Nukina, Carmen Nussbaum-Krammer, Jesper Nylandsted, ,

Summary: The guidelines presented in this article aim to assist researchers in selecting and interpreting methods to examine autophagy, as well as to help reviewers provide constructive critiques of reports focused on these processes. It emphasizes that no single assay is perfect for every situation, and multiple techniques may be needed to properly monitor autophagy in different experimental settings. The article also highlights the importance of targeting multiple autophagy-related genes in genetic approaches to block autophagy effectively.

AUTOPHAGY (2021)

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Article Oncology

Genomic profiling of tissue and blood predicts survival outcomes in patients with resected pleural mesothelioma

Diego de Miguel-Perez, Edward M. Pickering, Umberto Malapelle, William Grier, Francesco Pepe, Pasquale Pisapia, Gianluca Russo, Joseph A. Pinto, Alessandro Russo, Giancarlo Troncone, Melissa J. Culligan, Katherine A. Scilla, Ranee Mehra, Pranshu Mohindra, Oscar Arrieta, Andres F. Cardona, Marzia Del Re, Ashutosh Sachdeva, Fred R. Hirsch, Andrea Wolf, Joseph S. Friedberg, Christian Rolfo

Summary: In this study, genetic alterations in resectable pleural mesothelioma tissues and blood samples were analyzed, and it was found that high tissue tumor mutational burden, tissue median minor allele frequency, blood tumor mutational burden, and specific mutations were correlated with outcomes in patients with resected PM. These findings suggest that molecular profiling could help identify longer survivors in patients with resected PM.

EUROPEAN JOURNAL OF CANCER (2024)

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Article Oncology

Perioperative NALIRIFOX in patients with resectable pancreatic ductal adenocarcinoma: The open-label, multicenter, phase II nITRO trial

Davide Melisi, Camilla Zecchetto, Valeria Merz, Giuseppe Malleo, Luca Landoni, Alberto Quinzii, Simona Casalino, Federica Fazzini, Marina Gaule, Camilla Pesoni, Luca Casetti, Alessandro Esposito, Giovanni Marchegiani, Cristiana Piazzola, Mirko D'Onofrio, Riccardo de Robertis, Armando Gabbrielli, Laura Bernardoni, Stefano F. Crino, Silvia Pietrobono, Claudio Luchini, Camillo Aliberti, Guido Martignoni, Stefano Milleri, Giovanni Butturini, Aldo Scarpa, Roberto Salvia, Claudio Bassi

Summary: This study evaluated the safety and activity of liposomal irinotecan in the perioperative treatment of resectable pancreatic ductal adenocarcinoma (rPDAC) patients. The results showed that NALIRIFOX has manageable and active outcomes, and should be further investigated in randomized trials comparing it to standard upfront surgery followed by adjuvant therapy.

EUROPEAN JOURNAL OF CANCER (2024)

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Article Oncology

Phase I LITESPARK-001 study of belzutifan for advanced solid tumors: Extended 41-month follow-up in the clear cell renal cell carcinoma cohort

Eric Jonasch, Todd M. Bauer, Kyriakos P. Papadopoulos, Elizabeth R. Plimack, Jaime R. Merchan, David F. Mcdermott, M. Dror Michaelson, Leonard J. Appleman, Ananya Roy, Rodolfo F. Perini, Yanfang Liu, Toni K. Choueiri

Summary: After a median follow-up of 41.2 months, belzutifan monotherapy demonstrated durable antitumor activity in patients with advanced ccRCC and acceptable safety.

EUROPEAN JOURNAL OF CANCER (2024)

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Article Oncology

Impact of colorectal cancer screening on survival after metachronous metastasis

Patricia A. H. Hamers, Geraldine R. Vink, Marloes A. G. Elferink, Leon M. G. Moons, Cornelis J. A. Punt, Anne M. May, Miriam Koopman

Summary: Screen-detection of the primary tumor is associated with longer overall survival after metachronous metastasis.

EUROPEAN JOURNAL OF CANCER (2024)

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Article Oncology

Sentinel-node biopsy in apparent early stage ovarian cancer: final results of a prospective multicentre study (SELLY)

Camilla Nero, Nicolo Bizzarri, Stefano Di Berardino, Francesca Sillano, Giuseppe Vizzielli, Francesco Cosentino, Virginia Vargiu, Pierandrea De Iaco, Anna Myriam Perrone, Enrico Vizza, Benito Chiofalo, Stefano Uccella, Fabio Ghezzi, Luigi Carlo Turco, Giacomo Corrado, Diana Giannarelli, Tina Pasciuto, Gian Franco Zannoni, Anna Fagotti, Giovanni Scambia

Summary: This study evaluates the sensitivity and specificity of sentinel-lymph-node mapping compared to systematic lymphadenectomy in detecting lymph node metastasis in early stage ovarian cancer. The results show that sentinel-lymph-node mapping did not reach the expected sensitivity, but ultra-staging protocol improved the accuracy of diagnosis for patients.

EUROPEAN JOURNAL OF CANCER (2024)

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Article Oncology

The features and management of acquired resistance to PD1-based therapy in metastatic melanoma

Adriana Hepner, Judith M. Versluis, Roslyn Wallace, Clara Allayous, Lauren Julia Brown, Claudia Trojanielloh, Camille Lea Gerardi, Yanina J. L. Jansenj, Prachi Bhave, Bart Neyns, Andrew Haydon, Olivier Michielin, Joanna Manganan Oliver Klein, Alexander N. Shoushtari, Allison Betof Warner, Paolo Antonio Ascierto, Jennifer Leigh McQuade, Matteo S. Carlino, Lisa Zimmer, Celeste Lebbe, Douglas B. Johnson, Shahneen Sandhu, Victoria Atkinson, Christian U. Blank, Serigne N. Lo, Georgina V. Long, Alexander M. Menzies

Summary: Acquired resistance to PD-1 therapy in melanoma is mainly oligometastatic, and patients may have a favorable survival outcome following salvage treatment.

EUROPEAN JOURNAL OF CANCER (2024)

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Article Oncology

Major cardiovascular adverse events in older adults with early-stage triple-negative breast cancer treated with adjuvant taxane plus anthracycline versus taxane-based chemotherapy regimens: A SEER-medicare study

Savannah Roy, Stephanie Lakritz, Anna R. Schreiber, Elizabeth Molina Kuna, Cathy J. Bradley, Lavanya Kondapalli, Jennifer R. Diamond

Summary: This study evaluates major adverse cardiovascular events (MACE) in older women with TNBC treated with anthracycline and taxane-based chemotherapy (ATAX) compared to taxane-based chemotherapy (TAX). The results show that ATAX does not increase the risk of MACE and there is no difference in survival between patients who received TAX and ATAX.

EUROPEAN JOURNAL OF CANCER (2024)

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Letter Oncology

Osimertinib-induced urticarial vasculitis in a patient with lung cancer: A rare cutaneous toxicity

Pei-Chun Weng, Yau-Li Huang, Chun-Yu Cheng

EUROPEAN JOURNAL OF CANCER (2024)

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Article Oncology

Deep learning based histological classification of adnex tumors

Philipp Jansen, Jean Le 'Clerc Arrastia, Daniel Otero Baguer, Maximilian Schmidt, Jennifer Landsberg, Joerg Wenzel, Michael Emberger, Dirk Schadendorf, Eva Hadaschik, Peter Maass, Klaus Georg Griewank

Summary: This study highlights the enormous potential of artificial intelligence in pathology, showing that it can aid in the identification of rare cutaneous adnexal tumors and potentially become a standard tool in routine diagnostics.

EUROPEAN JOURNAL OF CANCER (2024)

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Article Oncology

FOLFIRINOX chemotherapy modulates the peripheral immune landscape in pancreatic cancer: Implications for combination therapies and early response prediction

Casper W. F. van Eijck, Gaby Strijk, Eveline E. Vietscha, Fleur van der Sijde, Maaike Verheij, Dana A. M. Mustafa, Madelief Vinkc, Joachim G. J. V. Aerts, Casper H. J. van Eijck, Marcella Willemsen

Summary: The study reveals that FOLFIRINOX has immunomodulatory effects, suggesting its potential in immune-based combination therapies for pancreatic cancer. Additionally, certain plasma proteins hold promise as circulating predictive biomarkers for early prediction of FOLFIRINOX response in patients with pancreatic cancer.

EUROPEAN JOURNAL OF CANCER (2024)

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Article Oncology

Immunotherapy response in microsatellite stable metastatic colorectal cancer is influenced by site of metastases

Marwan Fakih, Chongkai Wang, Jaideep Sandhu, Jian Ye, Colt Egelston, Xiaochen Li

Summary: This study explores the impact of metastatic sites on treatment outcomes for chemotherapy-refractory colorectal cancer patients. It found that patients with liver or peritoneal metastases had poor treatment outcomes, while those with lung-only metastases showed significant response. The presence of concurrent lymph node or other extrahepatic metastatic disease diminished treatment response in patients with lung metastases. Future checkpoint inhibitor trials should stratify patients based on metastatic locations.

EUROPEAN JOURNAL OF CANCER (2024)

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Article Oncology

Peptide absent sequences emerging in human cancers

Georgios Christos Tsiatsianis, Candace S. Y. Chan, Ioannis Mouratidis, Nikol Chantzi, Anna Maria Tsiatsiani, Nelson S. Yee, Apostolos Zaravinos, Verena Kantere, Ilias Georgakopoulos-Soares

Summary: The study reveals that nullpeptides can serve as biomarkers for cancer detection and treatment, particularly in highly recurrent cancer patients. These nullpeptides primarily occur in highly expressed genes, particularly in specific loci of oncogenes and tumor suppressors. Recurrent nullpeptides are more likely to be found in neoantigens, which play a significant role in immunotherapy.

EUROPEAN JOURNAL OF CANCER (2024)

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