Article
Obstetrics & Gynecology
Takashi Takeda
Summary: Premenstrual disorders (PMDs), including premenstrual syndrome and premenstrual dysphoric disorder, are proposed as a continuum. The exact etiology of PMDs is unknown, but hormonal fluctuations and involvement of neurotransmitters in the brain are clear. Current treatments, such as serotonin reuptake inhibitors and oral contraceptives, are insufficient, and there is a discrepancy between research and clinical practice. This review focuses on promising new therapies.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2023)
Review
Psychiatry
Mingzhou Gao, Hao Zhang, Changlin Wang, Xiangyu Mou, Qingjun Zhu, Jieqiong Wang, Dongmei Gao
Summary: This study conducted bibliometric analysis on premenstrual syndrome/premenstrual dysphoric disorder (PMS/PMDD) to identify research hot spots and trends. The findings revealed that epidemiology and steroid pathogenesis have become the main research focus, with potential areas of future research including GABAA receptor delta subunits and double-blind placebo-controlled trials.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Public, Environmental & Occupational Health
Mingzhou Gao, Dongmei Gao, Hui Sun, Xunshu Cheng, Li An, Mingqi Qiao
Summary: The global scientific output of research on PMS and PMDD has been increasing from 1945 to 2018, with menstrual cycle, depression, and ovarian hormones identified as research hotspots, while prevalence, systematic review, anxiety and depression, and young women are considered the research frontiers.
FRONTIERS IN PUBLIC HEALTH
(2021)
Review
Psychiatry
Bethany Sander, Jennifer L. Gordon
Summary: Recent findings suggest that early menopause transition may exacerbate existing MRMDs due to hormonal changes, leading to depressive mood in some women. There is also evidence that some women with MRMD may have increased mood sensitivity to ovarian hormone withdrawal during late menopause transition and early postmenopausal phase. Further research is needed to clarify the trajectory of premenstrual dysphoria in the menopause transition and to be vigilant for potential worsening of symptoms in perimenopause for women with past or current premenstrual dysphoric disorder.
CURRENT PSYCHIATRY REPORTS
(2021)
Article
Nutrition & Dietetics
Ajna Hamidovic, Shahd Smadi, John Davis
Summary: This study aimed to investigate whether food cravings vary across the menstrual cycle according to abdominal obesity type and PMDD diagnosis, and whether it is related to affective symptomatology. The results showed that women with abdominal obesity and PMDD displayed higher levels of food cravings in certain phases of the menstrual cycle, and irritability and depression were correlated with food cravings.
Article
Cell Biology
Yu-Wei Chang, Taichi Hatakeyama, Chia-Wei Sun, Masugi Nishihara, Keitaro Yamanouchi, Takashi Matsuwaki
Summary: We developed a methodology using machine learning to identify the pathogenic factors of PMDD, a disease that causes emotional and physical symptoms in women before menstruation. By analyzing gene expression levels and behavior in pseudopregnant rats, we successfully built a diagnostic model for PMDD using supervised machine learning. This methodology could potentially be applied for clinical diagnosis of PMDD using blood samples in the future.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2023)
Article
Cell Biology
Mingzhou Gao, Hao Zhang, Zhan Gao, Ya Sun, Guanghao Xu, Fengqin Wei, Jieqiong Wang, Dongmei Gao
Summary: A rat model of premenstrual irritability in PMDD was induced using the resident-intruder paradigm. The model demonstrated similar symptoms of premenstrual irritability and anxiety as seen in PMDD, which were dependent on the estrous cycle. The study also found that abnormal changes in 5-HT, NE, GABA, P, ALLO, and GABRA4 may be critical biomarkers during the pathogenesis of PMDD.
Article
Clinical Neurology
Mitchel Kappen, Sofie Raeymakers, Steven Weyers, Marie -Anne Vanderhasselt
Summary: This study investigated the relationship between PMS symptom severity and depression, anxiety, stress, and rumination. The results showed that participants with higher severity of PMS symptoms had higher scores on depressive symptoms, anxiety, stress, and rumination. The study also found that momentary stress and stress-related perseverative rumination increased with increased PMS symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychology, Biological
Eva-Maria Hartmann, Miriam Gade, Marco Steinhauser
Summary: This study investigates whether conflict and adaptive control in working memory (WM) are reflected by the same neural markers as in selective attention tasks. The results suggest that conflict and adaptive control in WM show similarities to those observed in selective attention tasks, as indicated by event-related potentials (ERPs).
Article
Medicine, General & Internal
Qian Yang, Edda Bjork Pordardottir, Arna Hauksdottir, Thor Aspelund, Johanna Jakobsdottir, Thorhildur Halldorsdottir, Gunnar Tomasson, Harpa Runarsdottir, Hilda Bjork Danielsdottir, Elizabeth R. Bertone-Johnson, Arvid Sjolander, Fang Fang, Donghao Lu, Unnur Anna Valdimarsdottir
Summary: This study found a dose-dependent association between childhood adverse experiences and premenstrual disorders (including premenstrual syndrome and premenstrual dysphoric disorder), emphasizing the importance of early intervention to reduce the risk of these disorders and other morbidities in adulthood.
Article
Health Care Sciences & Services
Pai-Cheng Lin, Chih-Hung Ko, Ju-Yu Yen
Summary: The study showed that women with PMDD had impaired executive function during the late luteal phase, with cognitive reappraisal positively correlated with executive function and negatively associated with depression. In the late luteal phase, PMDD patients experienced higher levels of inattention, insomnia, and fatigue, which were correlated with depression and functional impairment. Inattention was identified as the most associated factor with PMDD and functional impairment.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Environmental Sciences
Pai-Cheng Lin, Chih-Hung Ko, Yen-Ju Lin, Ju-Yu Yen
Summary: The study found that women with PMDD experience more severe symptoms of insomnia, inattention, and fatigue compared to those without PMDD. These symptoms worsen in the late luteal phase of the menstrual cycle and are correlated with functional impairment.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Psychology, Social
Nicole Poladian, Angela Maron, Tania Ghazarian, Yadi Fernandez-Sweeny, Anita L. Nelson
Summary: Analyzing posts and comments on Reddit, the study identified emotional responses, unanswered questions, impact on relationships, and recommendations as the main concerns of women with PMDD.
CYBERPSYCHOLOGY BEHAVIOR AND SOCIAL NETWORKING
(2022)
Article
Psychology, Multidisciplinary
Samantha J. Booth, Laura J. E. Brown, Jason R. Taylor, Gorana Pobric
Summary: This study aimed to investigate the effects of training schedule on the performance of working memory training (WMT) and its transfer tasks in healthy older adults. The results showed that participants were able to successfully perform the cognitively demanding intervention using their own devices at home, and comparable training effects were observed regardless of the intensity of the training schedule. However, while the WMT group showed significant improvement in the WMT task, there was no evidence of near or far transfer effects.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Pharmacology & Pharmacy
Kimberly A. Yonkers, Margaret Altemus, Kathryn Gilstad-Hayden, Susan G. Kornstein, Ralitza Gueorguieva
Summary: This clinical trial found that daily treatment with sertraline at symptom onset improved functional impairment, particularly in relationship functioning, among individuals with PMDD. Anger/irritability likely mediated the improvements in relationship interference. Replication of these results in other datasets is needed.
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
(2023)
Letter
Obstetrics & Gynecology
I-Chieh Sung, Ching-Ju Shen, Cheng-Yu Long
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2022)
Article
Engineering, Biomedical
Kun-Ling Lin, Shih-Hsiang Chou, Zi-Xi Loo, Yi-Yin Liu, Jung-Chien Cheng, Cheng-Yu Long
Summary: This study investigated the effects of vulvovaginal erbium laser on the genitourinary syndrome of menopause (GSM) and sexual function of post-menopausal women. The results showed a significant improvement in GSM and sexual function after vulvovaginal laser treatment, with no serious adverse effects observed up to 1 year post-treatment.
LASERS IN MEDICAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Kuang-Shun Chueh, Kuan-Hua Huang, Jian-He Lu, Tai-Jui Juan, Shu-Mien Chuang, Rong-Jyh Lin, Yi-Chen Lee, Cheng-Yu Long, Mei-Chen Shen, Ting-Wei Sun, Yung-Shun Juan
Summary: This study demonstrates that intravesical instillation of platelet-rich plasma (PRP) can decrease bladder inflammation and ameliorate bladder hyperactivity in a ketamine ulcerative cystitis (KIC) rat model. PRP treatment reduces inflammatory fibrosis, attenuates oxidative stress, promotes urothelial cell regeneration, and enhances angiogenesis and neurogenesis, thereby recovering bladder dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Letter
Obstetrics & Gynecology
Chun-Hsiang Yang, Cheng-Yu Long
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2022)
Article
Nursing
Hui-Fen Hsu, Hung-Pin Tu, Kuei-Min Chen, Frank Belcastro
Summary: This study examined the association between the number of chronic medications and the risk of mortality in older adults using population data from the National Health Insurance Research Database in Taiwan. The results showed a significant association between medication use and high mortality risk. This highlights the importance of recognizing the potential adverse effects of polypharmacy in optimizing drug regimens.
Article
Biology
Sithembiso Tiyandza Dlamini, Kyaw Moe Htet, Ei Chue Chue Theint, Wei-Ming Li, Hsin-Wen Chang, Hung-Pin Tu
Summary: This study investigated the role of vitamin D in the risk of tuberculosis among patients with end-stage kidney disease (ESKD). The results showed an increased risk of tuberculosis in kidney disease and ESKD patients, and vitamin D did not provide any benefit to ESKD patients.
Article
Oncology
Ying-Wen Wang, Yu-Che Ou, Hao Lin, Kun-Siang Huang, Hung-Chun Fu, Chen-Hsuan Wu, Ying-Yi Chen, Szu-Wei Huang, Hung-Pin Tu, Ching-Chou Tsai
Summary: Cancer-related fatigue (CRF) is common in gynecological cancer patients and often goes unnoticed. This study aimed to explore the prevalence and clinical characteristics of CRF in these patients. The results showed that 77.9% of patients had received fatigue management, and a predictive model was developed to help identify high-risk patients.
Article
Oncology
Ching-Hu Wu, Chien-Wei Feng, Chiu-Lin Wang, Zhi-Hong Wen, Cheng-Yu Long, Feng-Hsiang Tang
Summary: Our data showed that cisplatin treatment induces production of reactive oxygen species (ROS) that regulate apoptotic protein expression and stimulate anti-oxidative signal, inhibiting cell migration. The intervention of Zfp90 enhanced apoptosis pathway and inhibited migrative pathway, thus regulating the sensitivity of ovarian cancer cells to cisplatin. This study suggests that loss of Zfp90 function promotes cisplatin sensitization in ovarian cancer cells through the regulation of Nrf2/HO-1 pathway, enhancing cell apoptosis and inhibiting migration.
Review
Cell Biology
Albert Min-Shan Ko, Hung-Pin Tu, Ying-Chin Ko
Summary: Betel quid and areca nut are complex mixture carcinogens, but little is known about whether their derived single-agent arecoline or arecoline N-oxide (ANO) is carcinogenic, and the underlying mechanisms remain unclear. In this systematic review, recent studies on the roles of arecoline and ANO in cancer and strategies to block carcinogenesis were analyzed. The findings suggest that both arecoline and ANO are likely carcinogenic to humans and their mechanisms and pathways of carcinogenesis are useful indicators for cancer therapy and prognosis.
Article
Environmental Sciences
Kuei-Hau Luo, Chih-Hsien Wu, Chen-Cheng Yang, Tzu-Hua Chen, Hung-Pin Tu, Cheng-Hong Yang, Hung-Yi Chuang
Summary: This research used machine learning to investigate the relationships between metal mixture in blood and kidney function, as well as tumor necrosis factor alpha (TNF-alpha). The study found that certain metals were associated with TNF-alpha and kidney function, and machine learning models could accurately predict these outcomes in a multi-metal exposure scenario.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Clinical Neurology
Ching-Hu Wu, Kun-Ling Lin, Cheng-Yu Long, Chien-Wei Feng
Summary: Parkinson's disease is a highly influential disease worldwide, and current medications only provide relief for symptoms without slowing down disease progression. However, the plant-derived compound isotetrandrine (ITD) has been found to possess neuroprotective activity both in vitro and in vivo. ITD inhibits inflammatory-related protein and mRNA expression, improves locomotor deficiency, and reduces apoptosis in zebrafish models of PD. The neuroprotective effects of ITD may be mediated through anti-neuroinflammation and antiapoptosis pathways involving PI3K, ERK, and HO-1.
PARKINSONS DISEASE
(2023)
Article
Medicine, General & Internal
Cheng-Yu Long, Zi-Xi Loo, Ching-Hu Wu, Kun-Ling Lin, Chang-Lin Yeh, Chien-Wei Feng, Pei-Chi Wu
Summary: This study aimed to evaluate the correlation between the overall rest-stress distance measured by transperineal ultrasound (TPUS) and Q-tip test angle in women with urodynamic stress incontinence (USI), and determine the optimal cut-off value for predicting urethral hypermobility (UH). The results showed a strong correlation between the overall rest-stress distance in TPUS and Q-tip test angle, and a rest-stress distance of more than 13.3 mm was found to be an optimal cut-off value for predicting UH in women with USI.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Te-Yu Chen, Szu-Chia Chen, Chih-Wen Wang, Hung-Pin Tu, Pei-Shih Chen, Stephen Chu-Sung Hu, Chiu-Hui Li, Da-Wei Wu, Chih-Hsing Hung, Chao-Hung Kuo
Summary: This study evaluated the associations among chronic lung diseases, air pollution, and meteorological factors. The results showed that high temperature, high humidity, and low rainfall increased the risk of obstructive lung disease. Furthermore, synergistic effects were observed among temperature, SO2, and PM2.5/PM10.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Dermatology
Sebastian Yu, Yu-Hsiang Tsao, Hung-Pin Tu, Cheng-Che E. Lan
Summary: The study investigated the 5-year drug survival of biologic agents in patients with psoriatic arthritis. The results showed that ustekinumab and etanercept had higher 5-year survival rates for psoriatic disease compared to adalimumab. This suggests that the therapeutic response of biologic agents may differ between different ethnic groups.
DERMATOLOGICA SINICA
(2022)
Article
Medicine, General & Internal
Duurenjargal Tseeleesuren, Hui-Hua Hsiao, Rajni Kant, Yu-Chuen Huang, Hung-Pin Tu, Chih-Chung Lai, Shiu-Feng Huang, Chia-Hung Yen
Summary: The study found that CD133 overexpression was associated with poor survival in HCC patients, while NRF2 and its signaling components were not correlated with survival. Combination marker analysis indicated that co-expression of NQO1 and CD133 was associated with poor outcome in TAE/TACE-treated HCC patients.
MEDICINA-LITHUANIA
(2022)
