pH Signaling in Human Fungal Pathogens: a New Target for Antifungal Strategies

Candida albicans biofilms: building a heterogeneous, drug-tolerant environment

(2013) Julie Bonhomme et al.   CURRENT OPINION IN MICROBIOLOGY

Elucidating the immunological function of theCryptococcus neoformanscapsule

(2013) Anna Vecchiarelli et al.   Future Microbiology

Profiling of Candida albicans Gene Expression During Intra-abdominal Candidiasis Identifies Biologic Processes Involved in Pathogenesis

(2013) Shaoji Cheng et al.   JOURNAL OF INFECTIOUS DISEASES

An encapsulation of iron homeostasis and virulence in Cryptococcus neoformans

(2013) James W. Kronstad et al.   TRENDS IN MICROBIOLOGY

Cryptococcus neoformans Rim101 Is Associated with Cell Wall Remodeling and Evasion of the Host Immune Responses

(2013) T. R. O'Meara et al.   mBio

Targeting Iron Acquisition Blocks Infection with the Fungal Pathogens Aspergillus fumigatus and Fusarium oxysporum

(2013) Sixto M. Leal et al.   PLoS Pathogens

Candida and Host Determinants of Susceptibility to Invasive Candidiasis

(2013) Michail S. Lionakis et al.   PLoS Pathogens

Receptor-mediated signaling in Aspergillus fumigatus

(2013) C. M. Grice et al.   Frontiers in Microbiology

Conservation inAspergillus fumigatusof pH-signaling seven transmembrane domain and arrestin proteins, and implications for drug discovery

(2012) Elaine M. Bignell   Annals of the New York Academy of Sciences

The Cryptococcus neoformans Capsule: a Sword and a Shield

(2012) T. R. O'Meara et al.   CLINICAL MICROBIOLOGY REVIEWS

Importance of the Candida albicans cell wall during commensalism and infection

(2012) Neil AR Gow et al.   CURRENT OPINION IN MICROBIOLOGY

The β-Arrestin-Like Protein Rim8 Is Hyperphosphorylated and Complexes with Rim21 and Rim101 To Promote Adaptation to Neutral-Alkaline pH

(2012) Jonathan Gomez-Raja et al.   EUKARYOTIC CELL

Two cation transporters Ena1 and Nha1 cooperatively modulate ion homeostasis, antifungal drug resistance, and virulence of Cryptococcus neoformans via the HOG pathway

(2012) Kwang-Woo Jung et al.   FUNGAL GENETICS AND BIOLOGY

Cryptococcus neoformans Requires the ESCRT Protein Vps23 for Iron Acquisition from Heme, for Capsule Formation, and for Virulence

(2012) Guanggan Hu et al.   INFECTION AND IMMUNITY

Membrane Protein Rim21 Plays a Central Role in Sensing Ambient pH inSaccharomyces cerevisiae

(2012) Keisuke Obara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An ordered pathway for the assembly of fungal ESCRT-containing ambient pH signalling complexes at the plasma membrane

(2012) A. Galindo et al.   JOURNAL OF CELL SCIENCE

Identification of a complex genetic network underlyingSaccharomyces cerevisiaecolony morphology

(2012) Karin Voordeckers et al.   MOLECULAR MICROBIOLOGY

Hidden Killers: Human Fungal Infections

(2012) G. D. Brown et al.   Science Translational Medicine

Iron – A Key Nexus in the Virulence of Aspergillus fumigatus

(2012) Hubertus Haas   Frontiers in Microbiology

Coordination of hypoxia adaptation and iron homeostasis in human pathogenic fungi

(2012) Dawoon Chung et al.   Frontiers in Microbiology

pH Response Pathways in Fungi: Adapting to Host-derived and Environmental Signals

(2012) Kyla Selvig et al.   MYCOBIOLOGY

Comparative genomics allowed the identification of drug targets against human fungal pathogens

(2011) Ana Karina R Abadio et al.   BMC GENOMICS

Cryptococcal Titan Cell Formation Is Regulated by G-Protein Signaling in Response to Multiple Stimuli

(2011) Laura H. Okagaki et al.   EUKARYOTIC CELL

Current perspectives on echinocandin class drugs

(2011) David S Perlin   Future Microbiology

The Deferasirox–AmBisome Therapy for Mucormycosis (DEFEAT Mucor) study: a randomized, double-blinded, placebo-controlled trial

(2011) Brad Spellberg et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Growth of Candida albicans hyphae

(2011) Peter E. Sudbery   NATURE REVIEWS MICROBIOLOGY

Candida albicans morphogenesis and host defence: discriminating invasion from colonization

(2011) Neil A. R. Gow et al.   NATURE REVIEWS MICROBIOLOGY

Nonlytic Exocytosis of Cryptococcus neoformans from Macrophages Occurs In Vivo and Is Influenced by Phagosomal pH

(2011) A. M. Nicola et al.   mBio

Trailing or Paradoxical Growth of Candida albicans When Exposed to Caspofungin Is Not Associated with Microsatellite Genotypes

(2010) M. Khlif et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Characterization of thepalHGene fromAspergillus oryzae

(2010) Mitsuko DOHMOTO et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

The Candida albicans ESCRT Pathway Makes Rim101-Dependent and -Independent Contributions to Pathogenesis

(2010) Julie M. Wolf et al.   EUKARYOTIC CELL

Candida albicans Als3, a Multifunctional Adhesin and Invasin

(2010) Yaoping Liu et al.   EUKARYOTIC CELL

Problems and hopes in the development of drugs targeting the fungal cell wall

(2010) Vishukumar Aimanianda et al.   Expert Review of Anti-Infective Therapy

Functional analysis of the pH responsive pathway Pal/Rim in the phytopathogenic basidiomycete Ustilago maydis

(2010) Cervantes-Chávez José Antonio et al.   FUNGAL GENETICS AND BIOLOGY

Receptor-independent Ambient pH Signaling by Ubiquitin Attachment to Fungal Arrestin-like PalF

(2010) América Hervás-Aguilar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Candida albicans Tpk1p and Tpk2p isoforms differentially regulate pseudohyphal development, biofilm structure, cell aggregation and adhesins expression

(2010) Romina Giacometti et al.   YEAST

PKC Signaling Regulates Drug Resistance of the Fungal Pathogen Candida albicans via Circuitry Comprised of Mkc1, Calcineurin, and Hsp90

(2010) Shantelle L. LaFayette et al.   PLoS Pathogens

Interaction of Cryptococcus neoformans Rim101 and Protein Kinase A Regulates Capsule

(2010) Teresa R. O'Meara et al.   PLoS Pathogens

Cryptococcal Cell Morphology Affects Host Cell Interactions and Pathogenicity

(2010) Laura H. Okagaki et al.   PLoS Pathogens

Analysis of the dual function of the ESCRT-III protein Snf7 in endocytic trafficking and in gene expression

(2009) Peter Weiss et al.   BIOCHEMICAL JOURNAL

How human pathogenic fungi sense and adapt to pH: the link to virulence

(2009) Dana A Davis   CURRENT OPINION IN MICROBIOLOGY

Aspergillus fumigatus Survival in Alkaline and Extreme Zinc-Limiting Environments Relies on the Induction of a Zinc Homeostasis System Encoded by thezrfCandaspf2Genes

(2009) Jorge Amich et al.   EUKARYOTIC CELL

Antifungal drug resistance mechanisms in fungal pathogens from the perspective of transcriptional gene regulation

(2009) Dominique Sanglard et al.   FEMS YEAST RESEARCH

Fungal echinocandin resistance

(2009) Louise A. Walker et al.   FUNGAL GENETICS AND BIOLOGY

Mutational Analysis of Candida albicans SNF7 Reveals Genetically Separable Rim101 and ESCRT Functions and Demonstrates Divergence in bro1-Domain Protein Interactions

(2009) J. M. Wolf et al.   GENETICS

The iron chelator deferasirox enhances liposomal amphotericin B efficacy in treating murine invasive pulmonary aspergillosis

(2009) A. S. Ibrahim et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Transcriptional profiling reveals genes in the human pathogen Trichophyton rubrum that are expressed in response to pH signaling

(2009) Henrique C.S. Silveira et al.   MICROBIAL PATHOGENESIS

Recruitment of the ESCRT Machinery to a Putative Seven-Transmembrane-Domain Receptor Is Mediated by an Arrestin-Related Protein

(2009) A. Herrador et al.   MOLECULAR AND CELLULAR BIOLOGY

Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease

(2009) Leah E. Cowen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The homologue of the Saccharomyces cerevisiae RIM9 gene is required for ambient pH signalling in Candida albicans

(2009) Muriel Cornet et al.   RESEARCH IN MICROBIOLOGY

A Phenotypic Profile of the Candida albicans Regulatory Network

(2009) Oliver R. Homann et al.   PLoS Genetics

Hsp90 Orchestrates Stress Response Signaling Governing Fungal Drug Resistance

(2009) Leah E. Cowen   PLoS Pathogens

Hsp90 Governs Echinocandin Resistance in the Pathogenic Yeast Candida albicans via Calcineurin

(2009) Sheena D. Singh et al.   PLoS Pathogens

Systemic analysis of the response of Aspergillus niger to ambient pH

(2009) Mikael R Andersen et al.   GENOME BIOLOGY

Systematic Genetic Analysis of Virulence in the Human Fungal Pathogen Cryptococcus neoformans

(2008) Oliver W. Liu et al.   CELL

Stress, Drugs, and Evolution: the Role of Cellular Signaling in Fungal Drug Resistance

(2008) Leah E. Cowen et al.   EUKARYOTIC CELL

Candida albicansFerric Reductases Are Differentially Regulated in Response to Distinct Forms of Iron Limitation by the Rim101 and CBF Transcription Factors

(2008) Yong-Un Baek et al.   EUKARYOTIC CELL

Physiological Involvement in pH Signaling of Vps24-mediated Recruitment ofAspergillusPalB Cysteine Protease to ESCRT-III

(2008) Olga Rodríguez-Galán et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ambient pH signalling in the yeast Yarrowia lipolytica involves YlRim23p/PalC, which interacts with Snf7p/Vps32p, but does not require the long C terminus of YlRim9p/PalI

(2008) S. Blanchin-Roland et al.   MICROBIOLOGY-SGM

The evolution of fungal drug resistance: modulating the trajectory from genotype to phenotype

(2008) Leah E. Cowen   NATURE REVIEWS MICROBIOLOGY

Prokaryote-eukaryote interactions identified by using Caenorhabditis elegans

(2008) A. Y. Peleg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ambient pH gene regulation in fungi: making connections

(2008) Miguel A. Peñalva et al.   TRENDS IN MICROBIOLOGY

Sub-Telomere Directed Gene Expression during Initiation of Invasive Aspergillosis

(2008) Andrew McDonagh et al.   PLoS Pathogens