The Scribble–Dlg–Lgl polarity module in development and cancer: from flies to man

Aberrant Overexpression of the Cell Polarity Module Scribble in Human Cancer

(2011) Valentina Vaira et al.   AMERICAN JOURNAL OF PATHOLOGY

The Hippo pathway and apico–basal cell polarity

(2011) Alice Genevet et al.   BIOCHEMICAL JOURNAL

Loss of the Drosophila cell polarity regulator Scribbled promotes epithelial tissue overgrowth and cooperation with oncogenic Ras-Raf through impaired Hippo pathway signaling

(2011) Karen Doggett et al.   BMC DEVELOPMENTAL BIOLOGY

The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on Breast Cancer Cells

(2011) Michelangelo Cordenonsi et al.   CELL

Yap1 Acts Downstream of α-Catenin to Control Epidermal Proliferation

(2011) Karin Schlegelmilch et al.   CELL

Epithelial polarity and morphogenesis

(2011) Daniel St Johnston et al.   CURRENT OPINION IN CELL BIOLOGY

Principles of planar polarity in animal development

(2011) L. V. Goodrich et al.   DEVELOPMENT

Planar polarity pathway and Nance-Horan syndrome-like 1b have essential cell-autonomous functions in neuronal migration

(2011) G. S. Walsh et al.   DEVELOPMENT

Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila

(2011) B. G. Fernandez et al.   DEVELOPMENT

Lgl1 Activation of Rab10 Promotes Axonal Membrane Trafficking Underlying Neuronal Polarization

(2011) Tong Wang et al.   DEVELOPMENTAL CELL

Planar Cell Polarity: Coordinating Morphogenetic Cell Behaviors with Embryonic Polarity

(2011) Ryan S. Gray et al.   DEVELOPMENTAL CELL

Modulating F-actin organization induces organ growth by affecting the Hippo pathway

(2011) Leticia Sansores-Garcia et al.   EMBO JOURNAL

Scribble-mediated membrane targeting of PHLPP1 is required for its negative regulation of Akt

(2011) Xin Li et al.   EMBO REPORTS

Mutations in the planar cell polarity genesCELSR1andSCRIBare associated with the severe neural tube defect craniorachischisis

(2011) Alexis Robinson et al.   HUMAN MUTATION

The Structure of the PDZ3-SH3-GuK Tandem of ZO-1 Protein Suggests a Supramodular Organization of the Membrane-associated Guanylate Kinase (MAGUK) Family Scaffold Protein Core

(2011) Lifeng Pan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia

(2011) Helen B. Pearson et al.   JOURNAL OF CLINICAL INVESTIGATION

Deciphering tumor-suppressor signaling in flies: Genetic link between Scribble/Dlg/Lgl and the Hippo pathways

(2011) Masato Enomoto et al.   Journal of Genetics and Genomics

Mammalian Llgl2 Is Necessary for Proper Branching Morphogenesis during Placental Development

(2011) S. Sripathy et al.   MOLECULAR AND CELLULAR BIOLOGY

Asymmetric cell divisions promote Notch-dependent epidermal differentiation

(2011) Scott E. Williams et al.   NATURE

Loss of PI3K blocks cell-cycle progression in a Drosophila tumor model

(2011) M Willecke et al.   ONCOGENE

An ENU-Mutagenesis Screen in the Mouse: Identification of Novel Developmental Gene Functions

(2011) Carolien Wansleeben et al.   PLoS One

 -Catenin Is a Tumor Suppressor That Controls Cell Accumulation by Regulating the Localization and Activity of the Transcriptional Coactivator Yap1

(2011) M. R. Silvis et al.   Science Signaling

Novel insights into epithelial polarity proteins in Drosophila

(2011) Patrick Laprise et al.   TRENDS IN CELL BIOLOGY

The lethal giant larvae tumour suppressor mutation requires dMyc oncoprotein to promote clonal malignancy

(2010) Francesca Froldi et al.   BMC BIOLOGY

The novel mouse mutant, chuzhoi, has disruption of Ptk7 protein and exhibits defects in neural tube, heart and lung development and abnormal planar cell polarity in the ear

(2010) Anju Paudyal et al.   BMC DEVELOPMENTAL BIOLOGY

Ras and Raf pathways in epidermis development and carcinogenesis

(2010) F Kern et al.   BRITISH JOURNAL OF CANCER

Cell Polarity in Eggs and Epithelia: Parallels and Diversity

(2010) Daniel St Johnston et al.   CELL

Lgl, the SWH pathway and tumorigenesis: It’s a matter of context and competition!

(2010) Nicola A Grzeschik et al.   CELL CYCLE

LGL Can Partition the Cortex of One-Cell Caenorhabditis elegans Embryos into Two Domains

(2010) Carsten Hoege et al.   CURRENT BIOLOGY

Lgl, aPKC, and Crumbs Regulate the Salvador/Warts/Hippo Pathway through Two Distinct Mechanisms

(2010) Nicola A. Grzeschik et al.   CURRENT BIOLOGY

Polarity protein alterations in carcinoma: a focus on emerging roles for polarity regulators

(2010) Ling Huang et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The C. elegans homolog of Drosophila Lethal giant larvae functions redundantly with PAR-2 to maintain polarity in the early embryo

(2010) A. Beatty et al.   DEVELOPMENT

Hippo signaling: growth control and beyond

(2010) G. Halder et al.   DEVELOPMENT

Epidermal Wound Repair Is Regulated by the Planar Cell Polarity Signaling Pathway

(2010) Jacinta Caddy et al.   DEVELOPMENTAL CELL

Lgl/aPKC and Crb regulate the Salvador/Warts/Hippo pathway

(2010) Linda M Parsons et al.   FLY

The planar cell polarity gene Vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation

(2010) Laura L. Yates et al.   HUMAN MOLECULAR GENETICS

The Nance–Horan syndrome protein encodes a functional WAVE homology domain (WHD) and is important for co-ordinating actin remodelling and maintaining cell morphology

(2010) Simon P. Brooks et al.   HUMAN MOLECULAR GENETICS

The Dual Role of Zonula Occludens (ZO) Proteins

(2010) H. Bauer et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Spatially defined Dsh-Lgl interaction contributes to directional tissue morphogenesis

(2010) N. A. Kaplan et al.   JOURNAL OF CELL SCIENCE

The cell polarity regulator hScrib controls ERK activation through a KIM site-dependent interaction

(2010) K Nagasaka et al.   ONCOGENE

hScrib, a Human Homolog of Drosophila Neoplastic Tumor Suppressor, Is Involved in the Progress of Endometrial Cancer

(2010) Zhuo Ouyang et al.   ONCOLOGY RESEARCH

Polarity and endocytosis: reciprocal regulation

(2010) Jessica M. Shivas et al.   TRENDS IN CELL BIOLOGY

Tumor Suppressor Scribble Regulates Assembly of Tight Junctions in the Intestinal Epithelium

(2009) Andrei I. Ivanov et al.   AMERICAN JOURNAL OF PATHOLOGY

scribble mutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs

(2009) Gregory R Leong et al.   BMC BIOLOGY

aPKC Phosphorylates Miranda to Polarize Fate Determinants during Neuroblast Asymmetric Cell Division

(2009) Scott X. Atwood et al.   CURRENT BIOLOGY

The exocyst complex in polarized exocytosis

(2009) Bing He et al.   CURRENT OPINION IN CELL BIOLOGY

Lgl2 and E-cadherin act antagonistically to regulate hemidesmosome formation during epidermal development in zebrafish

(2009) M. Sonawane et al.   DEVELOPMENT

The apical/basal-polarity determinant Scribble cooperates with the PCP core factor Stbm/Vang and functions as one of its effectors

(2009) Jean-Remy Courbard et al.   DEVELOPMENTAL BIOLOGY

Phosphatidylinositol 3-kinase: a key regulator in adherens junction formation and function

(2009) Nathalie Rivard   Frontiers in Bioscience-Landmark

The Crumbs complex: from epithelial-cell polarity to retinal degeneration

(2009) N. A. Bulgakova et al.   JOURNAL OF CELL SCIENCE

Cell polarity protein Lgl2 is lost or aberrantly localized in gastric dysplasia and adenocarcinoma: an immunohistochemical study

(2009) Mikhail Lisovsky et al.   MODERN PATHOLOGY

Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis

(2009) Courtney M Karner et al.   NATURE GENETICS

Defective expression of polarity protein PAR-3 gene (PARD3) in esophageal squamous cell carcinoma

(2009) K Zen et al.   ONCOGENE

A role for the TGF -Par6 polarity pathway in breast cancer progression

(2009) A. M. Viloria-Petit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Scribble participates in Hippo signaling and is required for normal zebrafish pronephros development

(2009) K. Skouloudaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Line up and listen: Planar cell polarity regulation in the mammalian inner ear

(2009) Padmashree C.G. Rida et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Planar Cell Polarity Signaling: The Developing Cell's Compass

(2009) E. K. Vladar et al.   Cold Spring Harbor Perspectives in Biology

Lgl2 Executes Its Function as a Tumor Suppressor by Regulating ErbB Signaling in the Zebrafish Epidermis

(2009) Sven Reischauer et al.   PLoS Genetics

Planar Cell Polarity Signaling: From Fly Development to Human Disease

(2008) Matias Simons et al.   Annual Review of Genetics

PTEN and the PI3-Kinase Pathway in Cancer

(2008) Nader Chalhoub et al.   Annual Review of Pathology-Mechanisms of Disease

Role of the Polarity Determinant Crumbs in Suppressing Mammalian Epithelial Tumor Progression

(2008) C. M. Karp et al.   CANCER RESEARCH

The Polarity Protein Par6 Induces Cell Proliferation and Is Overexpressed in Breast Cancer

(2008) M. E. Nolan et al.   CANCER RESEARCH

Linking Cell Cycle to Asymmetric Division: Aurora-A Phosphorylates the Par Complex to Regulate Numb Localization

(2008) Frederik Wirtz-Peitz et al.   CELL

Deregulation of Scribble Promotes Mammary Tumorigenesis and Reveals a Role for Cell Polarity in Carcinoma

(2008) Lixing Zhan et al.   CELL

Mechanisms of Asymmetric Stem Cell Division

(2008) Juergen A. Knoblich   CELL

Cdc42, Par6, and aPKC Regulate Arp2/3-Mediated Endocytosis to Control Local Adherens Junction Stability

(2008) Marios Georgiou et al.   CURRENT BIOLOGY

Drosophila Cip4 and WASp Define a Branch of the Cdc42-Par6-aPKC Pathway Regulating E-Cadherin Endocytosis

(2008) Andrea Leibfried et al.   CURRENT BIOLOGY

Regulation of the hDlg/hScrib/Hugl-1 tumour suppressor complex

(2008) Paola Massimi et al.   EXPERIMENTAL CELL RESEARCH

Role of Lgl/Dlg/Scribble in the regulation of epithelial junction, polarity and growth

(2008) Tomoyuki Yamanaka   Frontiers in Bioscience-Landmark

Basolateral Junctions Utilize Warts Signaling to Control Epithelial-Mesenchymal Transition and Proliferation Crucial For Migration and Invasion of Drosophila Ovarian Epithelial Cells

(2008) M. Zhao et al.   GENETICS

Scrib regulates PAK activity during the cell migration process

(2008) Sébastien Nola et al.   HUMAN MOLECULAR GENETICS

Cdc42 and Par proteins stabilize dynamic adherens junctions in theDrosophilaneuroectoderm through regulation of apical endocytosis

(2008) Kathryn P. Harris et al.   JOURNAL OF CELL BIOLOGY

Control of tumourigenesis by the Scribble/Dlg/Lgl polarity module

(2008) P O Humbert et al.   ONCOGENE

Loss of human Scribble cooperates with H-Ras to promote cell invasion through deregulation of MAPK signalling

(2008) L E Dow et al.   ONCOGENE

Polarity proteins in migration and invasion

(2008) S Etienne-Manneville   ONCOGENE

Cell polarity proteins: common targets for tumorigenic human viruses

(2008) R T Javier   ONCOGENE

Human papillomaviruses, cervical cancer and cell polarity

(2008) M Thomas et al.   ONCOGENE

The Coffin-Lowry syndrome-associated protein RSK2 is implicated in calcium-regulated exocytosis through the regulation of PLD1

(2008) M. Zeniou-Meyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human T-cell leukemia virus type 1 Tax induces an aberrant clustering of the tumor suppressor Scribble through the PDZ domain-binding motif dependent and independent interaction

(2008) Masaaki Okajima et al.   VIRUS GENES

Polarity complex proteins

(2007) Emeline Assémat et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES