Article
Multidisciplinary Sciences
Wael Abu Dayyih, Raghad Layth, Mohammad Hailat, Bayan Alkhawaja, Lina Al Tamimi, Zainab Zakaraya, Aseel Aburumman, Nisreen Al Dmour, Mohamed J. Saadh, Hisham Al-Matubsi, Saed M. Aldalaen
Summary: In this study, it was found that administering date molasses to rats significantly decreased the pharmacokinetic parameters of levetiracetam, which could increase the risk of epileptic seizures.
SCIENTIFIC REPORTS
(2023)
Article
Nutrition & Dietetics
Cinzia Ferraris, Erika Meroni, Maria Cristina Casiraghi, Anna Tagliabue, Valentina De Giorgis, Daniela Erba
Summary: This study found that one month of ketogenic diet (KD) significantly reduced the production of short chain fatty acids (SCFA) in epileptic patients, while slightly decreasing the toxicity of fecal water. These results suggest a new avenue for investigation into the effects of KD on gut health.
FRONTIERS IN NUTRITION
(2021)
Article
Microbiology
Kitty Reemst, Sebastian Tims, Kit-Yi Yam, Mona Mischke, Jan Knol, Stanley Brul, Lidewij Schipper, Aniko Korosi
Summary: Early-life stress and dietary polyunsaturated fatty acids have an impact on the gut microbiota, which is related to cognitive, metabolic, and fatty acid profiles.
Review
Biochemistry & Molecular Biology
Ara Ko, Hye Eun Kwon, Heung Dong Kim
Summary: The ketogenic diet is a high-fat, low-carbohydrate diet that utilizes ketone bodies as an energy source and has shown effectiveness in treating drug-resistant epilepsy. Recent clinical and scientific knowledge supports its use for its anti-seizure efficacy, safety, and tolerability. It is also being explored as a potential treatment option for other neurological disorders.
BIOMEDICAL JOURNAL
(2022)
Article
Clinical Neurology
Mala Manral, Rekha Dwivedi, Sheffali Gulati, Kirandeep Kaur, Ashima Nehra, Ravindra Mohan Pandey, Ashish Datt Upadhyay, Savita Sapra, Manjari Tripathi
Summary: This study investigated whether Modified Atkins diet (MAD) combined with standard drug therapy (SDT) was more effective than SDT alone in reducing seizure frequency and improving psychological outcomes in adolescents and adults with drug-resistant epilepsy (DRE). The results showed that the MAD group had significant improvements in seizure frequency and behavioral problems compared to the control group.
Article
Nutrition & Dietetics
Simone Perna, Cinzia Ferraris, Monica Guglielmetti, Tariq A. Alalwan, Alaa M. Mahdi, Davide Guido, Anna Tagliabue
Summary: This study assessed the efficacy and side effects of the classic ketogenic diet (cKD) in children with drug-resistant epilepsy in Bahrain. The results showed that cKD was effective in reducing seizure rates, with a significant increase in triglycerides and albumin levels. Although there were some increases in cholesterol and alanine transaminase levels, they were not statistically significant. Adherence to the diet was influenced by the duration of cKD and age at cKD initiation. Close monitoring and emphasis on healthy fats are important when using cKD as a treatment for epilepsy.
Article
Medicine, Research & Experimental
Chunlong Mu, Naghmeh Nikpoor, Thomas A. Tompkins, Anamika Choudhary, Melinda Wang, Wendie N. Marks, Jong M. Rho, Morris H. Scantlebury, Jane Shearer
Summary: Targeted microbiota manipulation, mimicking changes induced by the ketogenic diet, reduces seizure frequency and improves locomotor activity in a rodent model of infantile spasms syndrome. This study suggests that microbiota manipulation could be a potential therapeutic avenue for pediatric epileptic encephalopathies.
Article
Nutrition & Dietetics
Francesca Felicia Operto, Angelo Labate, Salvatore Aiello, Cristina Perillo, Valeria de Simone, Rosetta Rinaldi, Giangennaro Coppola, Grazia Maria Giovanna Pastorino
Summary: The aim of this study was to evaluate parental stress after 6 and 12 months of a ketogenic diet, considering demographic and clinical variables. A standardized questionnaire was administered to assess parental stress. The results showed a significant increase in parental stress after 6 and 12 months of dietary treatment. Assessment of parental stress can help improve adherence to the ketogenic diet therapy.
Review
Nutrition & Dietetics
Kaleem Imdad, Turki Abualait, Ammara Kanwal, Ziyad Tareq AlGhannam, Shahab Bashir, Anum Farrukh, Sahir Hameed Khattak, Raidah Albaradie, Shahid Bashir
Summary: This article discusses the role of the ketogenic diet (KD) in the treatment of epilepsy, suggesting that ketone bodies can regulate neuronal metabolic activities, decrease seizure rate, and have significant therapeutic effects on epilepsy and related metabolic disorders.
Article
Microbiology
Isabelle Bourdeau-Julien, Sophie Castonguay-Paradis, Gabrielle Rochefort, Julie Perron, Benoit Lamarche, Nicolas Flamand, Vincenzo Di Marzo, Alain Veilleux, Frederic Raymond
Summary: This study aimed to investigate the effects of a lead-in diet on the response to a short-term dietary intervention. The results showed that dietary changes had an immediate and reversible modulation on gut microbiota composition, endocannabinoidome mediators, short-chain fatty acids, and branched-chain fatty acids. The response of gut microbiota composition was more influenced by the lead-in diet, while the endocannabinoidome response was not affected. Higher initial microbiome diversity favored the stability of gut microbiota in response to dietary changes.
Article
Multidisciplinary Sciences
Shaojie Cui, Glenn Simmons, Goncalo Vale, Yaqin Deng, Jungyeon Kim, Hyeonwoo Kim, Ruihui Zhang, Jeffrey G. McDonald, Jin Ye
Summary: This study reveals that Fas-associated factor 1 (FAF1) interacts directly with free polyunsaturated fatty acids (PUFAs) and this interaction is crucial for protecting cells from ferroptosis. FAF1 assembles a globular structure that sequesters free PUFAs into a hydrophobic core, preventing PUFA peroxidation and ultimately inhibiting ferroptosis initiation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Environmental Sciences
Marua Abu Risha, Asghar Ali, Puntita Siengdee, Nares Trakooljul, Dirk Dannenberger, Klaus Wimmers, Siriluck Ponsuksili
Summary: Climate change-induced temperature fluctuations have detrimental effects on the health and productivity of farm animals. This study investigates the impact of temperature stress on muscle cell differentiation, growth, and membrane fatty acid composition, revealing changes in molecular pathways related to lipid metabolism and fatty acid elongation.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Medicine, General & Internal
Chunlong Mu, Naghmeh Nikpoor, Thomas A. Tompkins, Jong M. Rho, Morris H. Scantlebury, Jane Shearer
Summary: In this study using a rat model, it was found that infants with infantile spasms syndrome who were on a ketogenic diet (KD) had severe hepatic steatosis, which could be prevented by a specific probiotic blend. These probiotics protected the liver by improving signaling pathways and promoting lipid oxidation, potentially reducing the risk of hepatic side effects in children receiving KD treatment.
Article
Nutrition & Dietetics
Chunlong Mu, Angela Pochakom, Raylene A. Reimer, Anamika Choudhary, Melinda Wang, Jong M. Rho, Morris H. Scantlebury, Jane Shearer
Summary: The ketogenic diet is an effective treatment for infantile spasms syndrome. This study investigated the effect of adding a prebiotic fiber to the diet, and found that it improved metabolic parameters and gut microbiota diversity. However, it had no impact on spasms or developmental outcomes.
Article
Agricultural Engineering
Anil Kumar Patel, Ajeet Singh Chauhan, Prashant Kumar, Philippe Michaud, Vijai Kumar Gupta, Jo-Shu Chang, Chiu-Wen Chen, Cheng-Di Dong, Reeta Rani Singhania
Summary: This article provides an update on the production of essential fatty acids from potential microbes and explores novel strategies to promote the accumulation of omega-3 and omega-6 through engineering and omics approaches.
BIORESOURCE TECHNOLOGY
(2022)
Editorial Material
Physiology
Fredrik Elinder
Article
Multidisciplinary Sciences
Marie Jakesova, Malin Silvera Ejneby, Vedran Derek, Tony Schmidt, Maciej Gryszel, Johan Brask, Rainer Schindl, Daniel T. Simon, Magnus Berggren, Fredrik Elinder, Eric Daniel Glowacki
Article
Physiology
Mark A. Skarsfeldt, Sara I. Liin, Hans P. Larsson, Bo H. Bentzen
Article
Physiology
Johan E. Larsson, Urban Karlsson, Xiongyu Wu, Sara Liin
JOURNAL OF GENERAL PHYSIOLOGY
(2020)
Article
Biology
Briana M. Bohannon, Alicia de la Cruz, Xiaoan Wu, Jessica J. Jowais, Marta E. Perez, Sara Liin, H. Peter Larsson
Correction
Biology
Briana M. Bohannon, Alicia de la Cruz, Xiaoan Wu, Jessica J. Jowais, Marta E. Perez, Derek M. Dykxhoorn, Sara I. Liin, H. Peter Larsson
Article
Physiology
Malin Silvera Ejneby, Arina Gromova, Nina E. Ottosson, Stina Borg, Argel Estrada-Mondragon, Samira Yazdi, Panagiotis Apostolakis, Fredrik Elinder, Lucie Delemotte
Summary: Voltage-gated potassium channels can be opened by resin acids and their derivatives, with different binding sites potentially leading to varying effects. The specific binding dynamics of resin acids and their interactions with proteins may determine their ability to activate and influence the voltage-gated channels.
JOURNAL OF GENERAL PHYSIOLOGY
(2021)
Article
Physiology
Samira Yazdi, Johan Nikesjo, Williams Miranda, Valentina Corradi, D. Peter Tieleman, Sergei Yu. Noskov, H. Peter Larsson, Sara I. Liin
Summary: PUFAs directly interact with the KCNQ1 channel via two binding sites, stabilizing the PUFA head group and tail selectively. This study provides insights into the molecular mechanisms of PUFAs on ion channels and potential avenues for drug development.
JOURNAL OF GENERAL PHYSIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Oliya S. Abdullaeva, Ihor Sahalianov, Malin Silvera Ejneby, Marie Jakesova, Igor Zozoulenko, Sara I. Liin, Eric Daniel Glowacki
Summary: A microfabricated ROS modulation device based on controlled faradaic reactions was developed in this research. The device can generate tunable gradients of peroxide and oxygen concentrations, enabling controlled H2O2 delivery. The prototype devices were tested by modulating human H2O2-sensitive channels to demonstrate the potential of PEDOT as an H2O2 delivery system.
Editorial Material
Physiology
Sara Liin
JOURNAL OF GENERAL PHYSIOLOGY
(2022)
Article
Biology
Damon J. A. Frampton, Koushik Choudhury, Johan Nikesjo, Lucie Delemotte, Sara Liin
Summary: The study reveals that polyunsaturated fatty acids (PUFAs) can facilitate the activation of one subtype of potassium channels while inhibiting the activation of another subtype. The response to PUFAs is dependent on the charge of the fatty acids and shows subtype-specific effects.
Article
Biology
Briana M. Bohannon, Jessica J. Jowais, Leif Nyberg, Vanessa Olivier-Meo, Valentina Corradi, D. Peter Tieleman, Sara Liin, H. Peter Larsson
Summary: Voltage-gated potassium (K-V) channels play a vital role in regulating cellular excitability and repolarization of heart and brain. Mutations in K-V channels lead to abnormal cellular excitability, resulting in epilepsy and cardiac arrhythmias. Polyunsaturated fatty acids (PUFAs) and PUFA analogues have the potential to restore K-V channel function and treat arrhythmogenic disorders. Aromatic PUFA analogues with a tyrosine head group have been found to activate the cardiac I-Ks channel, mainly through hydrogen bonding and ionic interactions.
Article
Pharmacology & Pharmacy
Michael Pokl, Akshay Sridhar, Damon J. A. Frampton, Veronika A. A. Linhart, Lucie Delemotte, Sara I. I. Liin
Summary: CBD can modulate the activity of different K(V)7 subtypes, enhancing the activity of K(V)7.2-7.5 subtypes and inhibiting the activity of K(V)7.1 and K(V)7.1/KCNE1 channels. The interaction sites of CBD with these channels are different, and the residues important for CBD effects vary among different subtypes.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Physiology
Jessica J. Jowais, Samira Yazdi, Alessia Golluscio, Vanessa Olivier-Meo, Sara I. Liin, H. Peter Larsson
Summary: The KCNQ1 channel plays a vital role in the repolarization phase of the cardiac action potential. Mutations in KCNQ1 can lead to long QT syndrome (LQTS), causing arrhythmia and sudden cardiac death. Previous research has shown that polyunsaturated fatty acids (PUFAs) and PUFA analogs can activate the KCNQ1 channel, offering potential therapeutics for LQTS treatment. Different binding sites on KCNQ1 are preferred by PUFA analogs, with binding between S3 and S4 resulting in the greatest shift in voltage dependence. Understanding these interactions can aid in the development of drugs for long QT syndrome.
JOURNAL OF GENERAL PHYSIOLOGY
(2023)
Article
Physiology
S. Salari, M. Silvera Ejneby, J. Brask, F. Elinder