Editorial Material
Immunology
Ana Paula Streling, Mohanad M. Al Obaidi, William D. Lainhart, Tirdad Zangeneh, Ayesha Khan, An Q. Dinh, Blake Hanson, Cesar A. Arias, William R. Miller
Summary: A study reported the emergence of non-susceptibility to cefiderocol in a subpopulation of Pseudomonas aeruginosa recovered from a patient without prior exposure to the antibiotic. Whole genome sequencing revealed mutations in major iron transport pathways linked to cefiderocol uptake, highlighting the importance of susceptibility testing before therapy with siderophore cephalosporins.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Engineering, Environmental
Daniel W. Smith, Mahfuza Islam, Kirin E. Furst, Shobnom Mustaree, Yoshika S. Crider, Nazrin Akter, Syed Anjerul Islam, Sonia Sultana, Zahid H. Mahmud, Mahbubur Rahman, William A. Mitch, Jennifer Davis
Summary: The taste of chlorinated water can impact people's acceptance of drinking water treatment, leading to increased microbiological exposure if individuals reject chlorinated water in favor of untreated water. Therefore, taste acceptability should be a critical consideration when establishing chlorination dosing guidelines.
Article
Infectious Diseases
Alexandre Tetard, Susie Gaillot, Eline Dubois, Soumaya Aarras, Benoit Valot, Gilles Phan, Patrick Plesiat, Catherine Llanes
Summary: Research has found that Pseudomonas aeruginosa is able to adapt to the strong electrophilic molecule cinnamaldehyde (CNA) by upregulating its intrinsic efflux pump and through other pleiotropic changes, leading to increased resistance. Further evaluation is needed to assess whether multidrug-resistant mutants can emerge in patients using cinnamon essential oil as self-medication.
Article
Biochemistry & Molecular Biology
Adeline Cezard, Delphine Fouquenet, Virginie Vasseur, Katy Jeannot, Fabien Launay, Mustapha Si-Tahar, Virginie Herve
Summary: By using scanning electron microscopy and fluorometry test, this study demonstrated that poly-L-lysine can enhance the bactericidal effects of commonly used antibiotics against drug-resistant Pseudomonas aeruginosa. The synergistic effects of the combination were confirmed in vitro and ex vivo, suggesting that pLK could be a potential adjuvant antibiotherapy against drug-resistant strains.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Environmental
Chong Liu, Yang Sun, Vicente Mustieles, Ying-Jun Chen, Li-Li Huang, Yan-Ling Deng, Yi-Xin Wang, Wen-Qing Lu, Carmen Messerlian
Summary: The study found that prenatal exposure to certain disinfection byproducts is associated with reduced fetal abdominal circumference, especially in the first trimester.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Chelsey M. VanDrisse, Rosalie Lipsh-Sokolik, Olga Khersonsky, Sarel J. Fleishman, Dianne K. Newman
Summary: This study demonstrates that by engineering the structure of PodA protein and combining it with tobramycin, the killing effect on P. aeruginosa can be enhanced, especially on biofilms that are resistant to conventional antibiotic treatment.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Environmental Sciences
Zhao-Xi Ye, Kai-Li Shao, Huang Huang, Xin Yang
Summary: The study indicates that tetracycline antibiotics form DBPs including DCAcAm during chlorination and chloramination, with DCAcAm being a main contributor to the yields and cytotoxicity of the measured DBPs.
Article
Immunology
Wenlu Zhang, Shasha Li, Bo Deng, Pengfei Wu, Yingbin Shui, Jiaming Zhang, Zhongjie Li
Summary: This study used RNA-sequencing to analyze sRNAs in antibiotic-resistant PAO1, finding a large number of differentially expressed sRNAs. Target gene prediction and pathway analysis revealed the potential roles of these differentially expressed sRNAs in regulating antibiotic resistance.
MICROBIAL PATHOGENESIS
(2022)
Article
Multidisciplinary Sciences
Maria Victoria Pepe, Celeste Dea, Camila Genskowsky, Dario Capasso, Mara Sabrina Roset, Adriana Valeria Jager, Fernando Peruani, Arlinet Kierbel
Summary: The formation of long-lived bacterial clusters is crucial in the development of many bacterial diseases. This study reveals that Pseudomonas aeruginosa can form permanent bacterial clusters on polarized MDCK epithelium without requiring irreversible adhesion, cell proliferation, or a phenotypic transition. By combining experiments and a mathematical model, the researchers demonstrate that the formation process is mediated by type IV pili and that it involves a stochastic process of reversible attachment.
Article
Biochemistry & Molecular Biology
Felix Wong, Jonathan M. Stokes, Sarah C. Bening, Charles Vidoudez, Sunia A. Trauger, James J. Collins
Summary: This study found that bactericidal antibiotics still have killing effect under anaerobic conditions. By affecting the energy demands of cells, antibiotics generate reactive metabolic byproducts, particularly reactive electrophilic species, which leads to bacterial death.
Article
Engineering, Environmental
Min Zhang, Xiao-Ying Liu, Yan-Ling Deng, Chong Liu, Jia-Yue Zeng, Yu Miao, Yang Wu, Cheng-Ru Li, Yang-Juan Li, A-Xue Liu, Qiang Zeng, TREE Study Team
Summary: Toxicological studies have shown that disinfection byproducts (DBPs), specifically haloacetic acids, can have toxic effects on the testicles. However, there is limited and inconclusive evidence from human studies. This study examined the associations between DBP exposures and semen parameters in 1230 reproductive-aged men. The results revealed inverse associations between urinary biomarkers of DBP exposures and sperm count, motility, and overall quality, particularly among leaner men.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Article
Infectious Diseases
Seryoung Kim, Satomi Masai, Keiji Murakami, Momoyo Azuma, Keiko Kataoka, Mayu Sebe, Kazuya Shimizu, Tomoaki Itayama, Niwooti Whangchai, Kanda Whangchai, Ikko Ihara, Hideaki Maseda
Summary: This study established an isolation method to evaluate the infection risk of Pseudomonas aeruginosa in the environment using specific culture conditions and primers. The results showed clear differences between environmental and clinical strains, but both had a high potential resistance risk for non-resistant strains.
Article
Biotechnology & Applied Microbiology
Melanie Grosjean, Sophie Guenard, Caroline Giraud, Cedric Muller, Patrick Plesiat, Paulo Juarez
Summary: Pseudomonas aeruginosa is commonly used to study antibiotic resistance and pathogenesis, but its natural resistance to antibiotics and ability to produce virulence factors hinder its biotechnological potential. By reducing the genome of this bacterium, researchers developed hypovirulent and hypersusceptible recombinant DNA hosts, laying the foundation for further optimization for biotechnological applications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Infectious Diseases
Mizuki Abe, Keiji Murakami, Yuka Hiroshima, Takashi Amoh, Mayu Sebe, Keiko Kataoka, Hideki Fujii
Summary: This study investigated the effects of newly synthesized Pseudomonas aeruginosa quorum-sensing autoinducer analogs on the activity of azithromycin and clarithromycin against P. aeruginosa. The results showed that these analogs enhanced the bactericidal ability of the macrolide antibiotics, improved the killing activity in biofilm cells, and affected antibiotic tolerance by changing bacterial cell surface properties and accelerating antibiotic permeability. The combination therapy of macrolides and these analogs may improve the therapeutic efficacy in treating chronic P. aeruginosa biofilm infections.
Article
Veterinary Sciences
Telma de Sousa, Andreia Garces, Augusto Silva, Ricardo Lopes, Nuno Alegria, Michel Hebraud, Gilberto Igrejas, Patricia Poeta
Summary: This study evaluated the antimicrobial resistance patterns and biofilm production of clinical isolates of pathogenic bacterium Pseudomonas aeruginosa in dogs. The results revealed widespread resistance to beta-lactam antimicrobials, with amikacin and tobramycin being the only effective aminoglycosides. All isolates carried the oprD gene and virulence genes. The study emphasizes the importance of monitoring antimicrobial resistance and responsible antibiotic use in veterinary medicine to prevent multi-drug resistance.
VETERINARY SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Yingying Chen, Jiayuan Sheng, Tao Jiang, Joseph Stevens, Xueyang Feng, Na Wei
BIOTECHNOLOGY FOR BIOFUELS
(2016)
Article
Engineering, Environmental
Jiaqi Lan, Sheikh Mokhlesur Rahman, Na Gou, Tao Jiang, Micheal J. Plewa, Akram Alshawabkeh, April Z. Gu
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2018)
Article
Engineering, Environmental
Yishan Lin, Maria Sevillano-Rivera, Tao Jiang, Guangyu Li, Irmarie Cotto, Solize Vosloo, Corey M. G. Carpenter, Philip Larese-Casanova, Roger W. Giese, Damian E. Helbling, Ingrid Y. Padilla, Zaira Rosario-Pabon, Carmen Velez Vega, Jose F. Cordero, Akram N. Alshawabkeh, Ameet Pinto, April Z. Gu
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2020)
Article
Environmental Sciences
Tao Jiang, Matt Geisler, Weilan Zhang, Yanna Liang
Summary: This study found that ether-PFAS significantly affected the structure and functions of soil microbial communities, especially showing differences at different concentrations.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Tao Jiang, Carlo Alberto Amadei, Yishan Lin, Na Gou, Sheikh Mokhlesur Rahman, Jiaqi Lan, Chad D. Vecitis, April Z. Gu
Summary: This study comprehensively assessed GO toxicity and its dependence on oxidation level, elemental composition, and size, revealing that elemental composition and size do exert impacts on GO toxicity, while oxidation level does not. UV-treated GO showed higher toxicity levels, especially in protein and chemical stress categories, while sonicated GOs displayed increased toxicity levels with decreasing size, suggesting that the covering and subsequent internalization of GO sheets may be the main mode of action in yeast cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Green & Sustainable Science & Technology
Tao Jiang, Sarabjot Singh, Kathleen A. Dunn, Yanna Liang
Summary: This study developed mathematical models for optimal leaching of rare earth elements (REEs) using levulinic acid (LevA) in red mud and spent fluorescent lamp phosphors. The results showed that the organic acid was able to efficiently leach REEs under certain conditions, leading to morphological and compositional changes in the waste materials.
Article
Environmental Sciences
Tao Jiang, Weilan Zhang, Yanna Liang
Summary: This study investigated the distribution of PFAS in a soil-microbe-soybean system and its impacts on genes involved in the nitrogen cycle. The results showed that PFAS mixtures had a synergistic uptake by soybean shoots and significantly affected the abundance of nitrification and denitrification genes in the soil, as well as the expression of N fixation gene in soybean nodules. This work provides valuable insights into the distribution of PFAS and their impacts on the N cycle, and contributes to assessing the risks of PFAS to soybean.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Multidisciplinary Sciences
Tao Jiang, Qiantao Shi, Zheng Wei, Kevin Shah, Haralabos Efstathiadis, Xiaoguang Meng, Yanna Liang
Summary: This study compared two eco-friendly leaching methods, chemical leaching and bioleaching, for the recovery of Li, Ni, Co, and Mn from waste lithium-ion batteries. The results showed that complete leaching of the target metals was achieved using 6.86M levulinic acid under optimal conditions in chemical leaching. In bioleaching, pretreatment of the waste batteries significantly improved the extraction efficiency. The comparison of these two methods provides technical details for further cost and environmental impact analysis.
Article
Environmental Sciences
Aswin Kumar Ilango, Tao Jiang, Weilan Zhang, Jeremy I. Feldblyum, Haralabos Efstathiadis, Yanna Liang
Summary: The researchers synthesized and tested alginate and chitosan based fibers/aerogels, as well as poly-ethyleneimine functionalized fibers/aerogels, for the adsorption of 12 PFASs from water. The ALGPEI-3 and GTH CTNPEI aerogels showed the best sorption performance, with hydrophobic interaction being the dominant mechanism. These aerogels exhibited fast and superior sorption of hydrophobic PFASs and retained their shape even at extreme pH conditions. The maximum adsorption capacity of ALGPEI-3 and GTH-CTNPEI aerogels for total PFASs removal was found to be 3045 and 12,133 mg/g, respectively. A rating of 8 out of 10 is given for the importance of this study.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Aswin Kumar Ilango, Tao Jiang, Weilan Zhang, Md. Nahid Pervez, Jeremy I. Feldblyum, Haralabos Efstathiadis, Yanna Liang
Summary: Chemical modifications of activated carbon are necessary for enhanced removal of PFAS in water. The study found that modified powdered activated carbon exhibited excellent adsorption performance, which was attributed to its powdered nature and electrostatic and hydrophobic interactions.
Article
Engineering, Environmental
Weilan Zhang, Tao Jiang, Yanna Liang
Summary: This study demonstrates the positive effect of sorbent addition in decreasing PFAS leaching in sludge, with RemBind® 100X showing the best stabilization performance. The dose of sorbents plays a crucial role in stabilizing PFAS in sludge.
JOURNAL OF HAZARDOUS MATERIALS ADVANCES
(2022)
Article
Engineering, Environmental
Maria Sevillano, Solize Vosloo, Irmarie Cotto, Zihan Dai, Tao Jiang, Jose M. Santiago Santana, Ingrid Y. Padilla, Zaira Rosario-Pabon, Carmen Velez Vega, Jose F. Cordero, Akram Alshawabkeh, April Gu, Ameet J. Pinto
Summary: This study analyzed the microbial composition of drinking water in nine systems in Puerto Rico after Hurricane Maria, and found that while bacterial concentrations decreased, there was no significant and sustained deterioration in biological quality of the water. This suggests that disruptions caused by the hurricane did not have a major impact on the drinking water quality.
Article
Engineering, Environmental
Tao Jiang, Yishan Lin, Carlo Alberto Amadei, Na Gou, Sheikh Mokhlesur Rahman, Jiaqi Lan, Chad D. Vecitis, April Z. Gu
Summary: This study comprehensively evaluated and compared the potential toxicological effects and mechanisms of seven carbon-based nanomaterials in three representative types, revealing DNA damage, oxidative stress, and protein stress as major mechanisms of action. The toxicity of CNMs was concentration-dependent, with similarities within the same structural group and distinctiveness among different CNMs. Size and structure were found to have a remarkable impact on toxicity, and protein biomarkers captured main cellular effects associated with adverse phenotypic outcomes.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Tao Jiang, Carlo Alberto Amadei, Na Gou, Yishan Lin, Jiaqi Lan, Chad D. Vecitis, April Z. Gu
ENVIRONMENTAL SCIENCE-NANO
(2020)