Article
Cell Biology
Marina Rodriguez-Munoz, Martina Serrat, David Soler, Anna Genesca, Teresa Anglada
Summary: Chromosome bridges in cancer cells are often formed and may break during mitosis, with a direct correlation between the distance between bridge kinetochores and bridge breakage. The mechanisms responsible for chromosome bridge breakage during mitosis may depend on the separation between the bridge kinetochores. Previous studies have suggested mechanical stress or biochemical digestion as possible causes of bridge breakage in interphase cells, suggesting a multifactorial model for bridge breakage.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Joshua Victor, Jamie Deutsch, Annalis Whitaker, Erica N. Lamkin, Anthony March, Pei Zhou, Jason W. Botten, Nimrat Chatterjee
Summary: SARS-CoV-2 infection may trigger a DNA damage response in host cells, leading to telomere shortening and reduced expression of the TRF2 shelterin-protein complex.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Cell Biology
Mattia La Torre, Eleonora Centofante, Carmine Nicoletti, Romina Burla, Alessandro Giampietro, Federica Cannistra, Leonardo Schirone, Valentina Valenti, Sebastiano Sciarretta, Antonio Musaro, Isabella Saggio
Summary: DNA damage is emerging as a key factor in the development of heart disease. This study investigates the role of Ft1 deficiency in cardiac defects and compares the impact of DNA damage targeted to vasculature smooth muscle cells versus diffuse damage. The results show that both Ft1ko and Ft1sm22ko mice display cardiac defects, but Ft1 deficiency targeted to smooth muscle cells exacerbates age-related pathological traits. Additionally, depletion of the DNA damage sensor p53 rescues the defects caused by Ft1 deficiency in the left ventricle and functional heart.
Review
Biology
Susan M. Bailey, Jared J. Luxton, Miles J. McKenna, Lynn E. Taylor, Kerry A. George, Sameer G. Jhavar, Gregory P. Swanson
Summary: Space exploration has made significant progress in the past half century, with the current goal being to journey to the moon and Mars. As the number and diversity of space travelers increase, understanding the effects of long-duration spaceflight on human health is crucial. Individual differences in response are important in developing personalized approaches for evaluating human health effects and long-term outcomes associated with radiation exposures.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2022)
Editorial Material
Cell Biology
Pawel Kordowitzki
Summary: Research has shown that the pool of oocytes in females starts to decline before birth, and as women age, characteristics such as chromosomal abnormalities, decreased mitochondrial function, and telomere shortening become more common. This may contribute to higher rates of miscarriage and chromosomal non-disjunction in older women who choose to delay pregnancy.
Review
Oncology
Sebastian Omar Siri, Julieta Martino, Vanesa Gottifredi
Summary: Chromosome instability (CIN) involves increased numerical and structural changes in chromosomes, playing a pivotal role in tumor progression and potential therapeutic targeting. The review delves into the origins of structural CIN, cellular mechanisms, relationships between different CIN phenotypes, and the consequences of structural CIN in cells. The discussion also explores strategies to either prevent or amplify CIN for tumor treatment.
Review
Medicine, Research & Experimental
Shihui Guo, Xiao Zhu, Ziyuan Huang, Chuzhong Wei, Jiaao Yu, Lin Zhang, Jinghua Feng, Mingdong Li, Zesong Li
Summary: Genetic instability can be caused by external factors and is related to intracellular damage. Research has shown the connection between genomic stability and tumors, which is a crucial factor in tumor treatment. The mechanisms of genomic stability and tumorigenesis development are complex, but researchers have been making progress in these areas. This review introduces various aspects related to genomic stability, tumor development drivers, characteristics of tumor cells, tumor metastasis, and tumor treatment. Immunotherapy plays a significant role in tumor treatment as it can effectively inhibit tumor spread and eliminate tumor cells. Advances in tumorigenesis development studies and discoveries in tumor metastasis provide new therapeutic techniques that can prevent tumor spread and improve the cure rate of tumors.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Medicine, Research & Experimental
Qiang Liu, Qiu Peng, Bin Zhang, Yueqiu Tan
Summary: Genomic instability is a common feature of tumors, and the XRCC gene family plays an important role in tumor development and therapeutic sensitivity. Studying XRCC can help us better understand the mechanisms of tumor formation and potential treatments.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Cell Biology
Laura L. Thompson, Kailee A. Rutherford, Chloe C. Lepage, Kirk J. McManus
Summary: SKP1 plays a central role in regulating essential cellular processes, and its aberrant expression and function may lead to genome instability and cancer pathogenesis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Omkar Suhas Vinchure, Kurt Whittemore, Deependra Kushwah, Maria A. Blasco, Ritu Kulshreshtha
Summary: miR-490 targets multiple genes to regulate telomere maintenance in GBM, exerting tumor suppressive effects, impacting stemness and senescence, activating DNA damage response, and potentially holding therapeutic significance in GBM treatment.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Renee C. Duardo, Federico Guerra, Simona Pepe, Giovanni Capranico
Summary: Non-canonical secondary structures (NCSs) are alternative nucleic acid structures that differ from the canonical B-DNA conformation. NCSs play important roles in physiological processes and have crucial implications for genome stability.
Review
Biochemistry & Molecular Biology
Siti A. M. Imran, Muhammad Dain Yazid, Wei Cui, Yogeswaran Lokanathan
Summary: TRF2 plays a crucial role in protecting telomeres and preventing DNA instability and diseases like cancer. Despite its ability to inhibit DNA damage response factors, more research is needed to understand its interactions outside of telomeres.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Rashmi Dahiya, Qing Hu, Peter Ly
Summary: Cancer genomes frequently experience structural chromosomal rearrangements, which can be caused by DNA damage and repair mechanisms as well as errors in cell division. Understanding the mechanisms behind these rearrangements is crucial for studying tumor development in depth.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Baraah Al Ahmad Nachar, Filippo Rosselli
Summary: DNA replication is a crucial process that requires the coordinated action of multiple proteins to permit, initiate, and progress replication forks. However, there are obstacles that can impede replication fork progression. Cells have developed various mechanisms to protect DNA replication and ensure its completion before entering mitosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Chaohui Li, Lingxi Chen, Guangze Pan, Wenqian Zhang, Shuai Cheng Li
Summary: Breakage-fusion-bridge (BFB) is a mechanism that leads to complex genome rearrangements in multiple cancers. The authors developed a computational method for identifying these events, even when further complicated by additional structural variations.
NATURE COMMUNICATIONS
(2023)
Letter
Hematology
M. Rinelli, E. Bellacchio, F. Berardinelli, G. Pascolini, P. Grammatico, A. Sgura, A. P. Iori, L. Quattrocchi, A. Novelli, S. Majore, E. Agolini
ANNALS OF HEMATOLOGY
(2019)
Correction
Hematology
M. Rinelli, E. Bellacchio, F. Berardinelli, G. Pascolini, P. Grammatico, A. Sgura, A. P. Iori, L. Quattrocchi, A. Novelli, S. Majore, E. Agolini
ANNALS OF HEMATOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Ilaria Laudadio, Francesca Orso, Gianluca Azzalin, Carlo Calabro, Francesco Berardinelli, Elisa Coluzzi, Silvia Gioiosa, Daniela Taverna, Antonella Sgura, Claudia Carissimi, Valerio Fulci
Article
Oncology
F. Berardinelli, M. Tanori, D. Muoio, M. Buccarelli, A. di Masi, S. Leone, L. Ricci-Vitiani, R. Pallini, M. Mancuso, A. Antoccia
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2019)
Article
Cell Biology
Marco De Vitis, Francesco Berardinelli, Elisa Coluzzi, Jessica Marinaccio, Roderick J. O'Sullivan, Antonella Sgura
Article
Biochemistry & Molecular Biology
Claudia Tonini, Mayra Colardo, Barbara Colella, Sabrina Di Bartolomeo, Francesco Berardinelli, Giuseppina Caretti, Valentina Pallottini, Marco Segatto
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Cell Biology
Aurora Irene Idilli, Emilio Cusanelli, Francesca Pagani, Francesco Berardinelli, Manuel Bernabe, Maria Luisa Cayuela, Pietro Luigi Poliani, Maria Caterina Mione
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Article
Genetics & Heredity
Roberta Amato, Martina Valenzuela, Francesco Berardinelli, Erica Salvati, Carmen Maresca, Stefano Leone, Antonio Antoccia, Antonella Sgura
Article
Oncology
Aurora Irene Idilli, Francesca Pagani, Emanuela Kerschbamer, Francesco Berardinelli, Manuel Bernabe, Maria Luisa Cayuela, Silvano Piazza, Pietro Luigi Poliani, Emilio Cusanelli, Maria Caterina Mione
Article
Chemistry, Multidisciplinary
Francesca Brero, Martin Albino, Antonio Antoccia, Paolo Arosio, Matteo Avolio, Francesco Berardinelli, Daniela Bettega, Paola Calzolari, Mario Ciocca, Maurizio Corti, Angelica Facoetti, Salvatore Gallo, Flavia Groppi, Andrea Guerrini, Claudia Innocenti, Cristina Lenardi, Silvia Locarno, Simone Manenti, Renato Marchesini, Manuel Mariani, Francesco Orsini, Emanuele Pignoli, Claudio Sangregorio, Ivan Veronese, Alessandro Lascialfari
Article
Biochemistry & Molecular Biology
Piergiorgio La Rosa, Sara Petrillo, Riccardo Turchi, Francesco Berardinelli, Tommaso Schirinzi, Gessica Vasco, Daniele Lettieri-Barbato, Maria Teresa Fiorenza, Enrico S. Bertini, Katia Aquilano, Fiorella Piemonte
Summary: Ferroptosis is a form of iron-dependent cell death that may be involved in Friedreich's Ataxia. Nrf2 signaling plays a crucial role in ferroptosis, suggesting it as a potential target to combat neurodegenerative diseases.
Review
Oncology
Sara Pescatori, Francesco Berardinelli, Jacopo Albanesi, Paolo Ascenzi, Maria Marino, Antonio Antoccia, Alessandra di Masi, Filippo Acconcia
Summary: 17 beta-estradiol (E2) has a dual nature as both a regulator of human physiology and a genotoxic substance, which can induce DNA damages and potentially lead to the initiation of cellular transformation. E2's ability to control DNA stability while also posing a risk factor for cancer development challenges the conventional understanding of hormones, highlighting the delicate balance between its physiological and harmful effects in maintaining human body homeostasis.
Review
Oncology
Martina Valenzuela, Roberta Amato, Antonella Sgura, Antonio Antoccia, Francesco Berardinelli
Summary: The ATRX gene is emerging as one of the most important oncosuppressive genes in the human genome, with diverse activities such as regulating epigenetic stability, maintaining telomere function, responding to replicative stress, and suppressing transposable elements and viral genomes.
Article
Biochemistry & Molecular Biology
Alessandra Palma, Sveva Grande, Anna Maria Luciani, Lucia Ricci-Vitiani, Mariachiara Buccarelli, Roberto Pallini, Alice Triveri, Valentina Pirota, Filippo Doria, Quintino Giorgio D'Alessandris, Francesco Berardinelli, Antonio Antoccia, Antonella Rosi
Summary: The study revealed differences in response to different types of radiation by different GSC lines, and showed that a new RHPS4 derivative, #190, can reduce cardiotoxicity while analyzing metabolites using MR spectroscopy. The statistical significance of changes in metabolites was higher in line #1 compared to line #83, but no synergistic effects were observed in combination treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Francesca Brero, Paola Calzolari, Martin Albino, Antonio Antoccia, Paolo Arosio, Francesco Berardinelli, Daniela Bettega, Mario Ciocca, Angelica Facoetti, Salvatore Gallo, Flavia Groppi, Claudia Innocenti, Anna Laurenzana, Cristina Lenardi, Silvia Locarno, Simone Manenti, Renato Marchesini, Manuel Mariani, Francesco Orsini, Emanuele Pignoli, Claudio Sangregorio, Francesca Scavone, Ivan Veronese, Alessandro Lascialfari
Summary: This study investigates the effects of proton therapy combined with hyperthermia and magnetic fluid hyperthermia using magnetic nanoparticles on BxPC3 pancreatic cancer cells. The cells' response to the combined treatment was evaluated through various analyses. The results showed that the combination therapy had a stronger inhibitory effect on the survival of cancer cells compared to single irradiation treatment, suggesting a new and effective approach for treating pancreatic tumors. The presence of magnetic nanoparticles and hyperthermia also played a role in enhancing the therapeutic effects.