Article
Environmental Sciences
Kefeng Yang, Cheng Chen, Qi Yan, Xiuhua Shen, Linlei Jiang, Rui Ma, Liping Lu, Jie Zhu, Ying Tian, Wei Cai, Mary E. D'Alton, Jun Zhang, Ka Kahe
Summary: This study aimed to investigate the association between prenatal LCn3PUFAs, Hg, Se and infant cognitive performance. It was found that infants with higher LCn3PUFA concentrations and lower Hg levels had better performance in gross motor skills. Additionally, differential methylation was observed in certain CpG sites between high and low LCn3PUFA groups.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Min Jing, Dan Lin, Pianpian Wu, Martin J. Kainz, Kevin Bishop, Haiyu Yan, Qiuhua Li, Xinbin Feng
Summary: The bioaccumulation of mercury and polyunsaturated fatty acids in zoobenthos varies in Chinese reservoirs and Swedish lakes, with higher levels observed in Chinese reservoirs. In Swedish lakes, environmental factors such as pH and dissolved organic carbon influence mercury content, while in Chinese reservoirs, mercury content is more related to algal diet sources. Additionally, EPA and DHA contents in zoobenthos are associated with different factors in Chinese reservoirs and Swedish lakes.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Anran Cai, Lutzen Portengen, Eva Govarts, Laura Rodriguez Martin, Greet Schoeters, Juliette Legler, Roel Vermeulen, Virissa Lenters, Sylvie Remy
Summary: This study used data from two Belgian cohorts and found that prenatal exposure to persistent organic pollutants (POPs) may affect infant growth, particularly in terms of changes in body mass index (BMI) during the first two years after birth. However, there were no clear effects on longer-term growth trajectories during childhood. No evidence of effect modification by child sex was found.
Review
Nutrition & Dietetics
Steven Saavedra, Angeles Fernandez-Recamales, Ana Sayago, Antonio Cervera-Barajas, Raul Gonzalez-Dominguez, Juan D. Gonzalez-Sanz
Summary: This review evaluated the clinical repercussions of maternal exposure to methyl mercury on the health of fetuses, neonates, and children up to 8 years old, finding that mercury exposure was associated with lower birth weight and poorer neuropsychological and developmental outcomes.
Article
Pediatrics
Kathleen M. Gustafson, Danielle N. Christifano, Dirk Hoyer, Alexander Schmidt, Susan E. Carlson, John Colombo, Nicole B. Mathis, Scott A. Sands, Lynn Chollet-Hinton, Alexandra R. Brown, Dinesh Pal Mudaranthakam, Byron J. Gajewski
Summary: This study aimed to investigate the effect of maternal DHA supplementation on maternal-infant DHA equilibrium and fetal neurodevelopment. The results showed that pregnant women who received a higher dose of DHA were more likely to achieve maternal-infant DHA equilibrium at delivery, but this equilibrium status did not significantly impact fetal neurodevelopment.
PEDIATRIC RESEARCH
(2022)
Article
Environmental Sciences
Anna V. Oppenheimer, David C. Bellinger, Brent A. Coull, Marc G. Weisskopf, Susan A. Korrick
Summary: Working memory is crucial for behavioral and psychiatric disorders, and environmental factors such as organochlorines and metals can impact it. This study found a negative association between a chemical mixture and verbal working memory, as well as an adverse effect of prenatal manganese exposure on working memory.
ENVIRONMENTAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Shaojie Cui, Glenn Simmons, Goncalo Vale, Yaqin Deng, Jungyeon Kim, Hyeonwoo Kim, Ruihui Zhang, Jeffrey G. McDonald, Jin Ye
Summary: This study reveals that Fas-associated factor 1 (FAF1) interacts directly with free polyunsaturated fatty acids (PUFAs) and this interaction is crucial for protecting cells from ferroptosis. FAF1 assembles a globular structure that sequesters free PUFAs into a hydrophobic core, preventing PUFA peroxidation and ultimately inhibiting ferroptosis initiation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Environmental Sciences
Marua Abu Risha, Asghar Ali, Puntita Siengdee, Nares Trakooljul, Dirk Dannenberger, Klaus Wimmers, Siriluck Ponsuksili
Summary: Climate change-induced temperature fluctuations have detrimental effects on the health and productivity of farm animals. This study investigates the impact of temperature stress on muscle cell differentiation, growth, and membrane fatty acid composition, revealing changes in molecular pathways related to lipid metabolism and fatty acid elongation.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Clinical Neurology
Yuxi Jia, Ping Li, Fei Wu, Fanjie Zeng, Beilin Zhang, Jinpeng Wang
Summary: This study investigated the potential influences of n-3/n-6 polyunsaturated fatty acids (PUFAs) as supplements in VPA-induced autistic rat model. The results showed that supplementation with n-3/n-6 PUFA (1:5) reduced repetitive stereotyped behaviors and social deficits in neonatal rats exposed to VPA, likely due to improved inflammatory responses through the alteration of STAT3 signaling. This study provides evidence for the use of n-3/n-6 PUFAs in the treatment of autism in humans.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2022)
Article
Medicine, General & Internal
Maaike E. Straat, Lucas Jurado-Fasoli, Zhixiong Ying, Kimberly J. Nahon, Laura G. M. Janssen, Mariette R. Boon, Gernot F. Grabner, Sander Kooijman, Robert Zimmermann, Martin Giera, Patrick C. N. Rensen, Borja Martinez-Telleza
Summary: The application of cold exposure has shown to enhance lipid catabolism in the human body. However, the effect of cold exposure on the lipidome varies depending on the intensity and duration of exposure. Through sequential lipidomic profiling, this study found that cold exposure gradually increased circulating free fatty acids in humans, while temporarily decreasing total triacylglycerols (TAGs) at 30 minutes. Different TAG species showed varying responses, with the initial decrease in unsaturated and polyunsaturated TAG species with <= 5 double bonds, followed by a significant increase in polyunsaturated TAG species with >= 6 double bonds after 120 minutes. A mechanistic study in mice revealed that the increase in polyunsaturated TAGs induced by cold exposure was largely prevented by blocking adipose triglyceride lipase. These findings suggest that cold exposure promotes the utilization of TAG-derived fatty acids for thermogenesis, resulting in a decrease in circulating TAG species and an increased production of polyunsaturated TAG species by the liver.
Article
Environmental Sciences
Anna Oppenheimer, David C. Bellinger, Brent A. Coull, Marc G. Weisskopf, Michele Zemplenyi, Susan A. Korrick
Summary: This study investigated the association between adolescent inhibition and prenatal exposure to organochlorines and metals. The findings suggest a potential adverse joint association between exposure to a five-chemical mixture and verbal inhibition, with exposure to Mn potentially driving this overall association.
Article
Agricultural Engineering
Anil Kumar Patel, Ajeet Singh Chauhan, Prashant Kumar, Philippe Michaud, Vijai Kumar Gupta, Jo-Shu Chang, Chiu-Wen Chen, Cheng-Di Dong, Reeta Rani Singhania
Summary: This article provides an update on the production of essential fatty acids from potential microbes and explores novel strategies to promote the accumulation of omega-3 and omega-6 through engineering and omics approaches.
BIORESOURCE TECHNOLOGY
(2022)
Article
Fisheries
Wei Zhu, Ruonan Dong, Leilei Ge, Qigang Yang, Na Lu, Hui Li, Zhengfu Feng
Summary: This study aimed to investigate the effects of dietary arachidonic acid (ARA) and linoleic acid (LA) on the growth, fatty acid composition, antioxidant capacity, and immunity of Litopenaeus vannamei. The results showed that appropriate levels of LA (9.5 g kg(-1)) or ARA (3.8 g kg(-1)) had positive effects on the growth, EPA biosynthesis, antioxidant capacity, and immunity of L. vannamei.
AQUACULTURE REPORTS
(2023)
Article
Engineering, Environmental
Juan Zhang, Wen-Hao Zhang, Christophe Morisseau, Min Zhang, Hong-Jun Dong, Qi-Meng Zhu, Xiao-Kui Huo, Cheng-Peng Sun, Bruce D. Hammock, Xiao-Chi Ma
Summary: PM2.5 is closely related to respiratory diseases and lung inflammation. sEH and epoxy fatty acids play a vital role in this inflammation. In a mouse model of PM2.5-mediated lung injury, the cytochrome P450 oxidase/sEH metabolic pathway was found to be involved. The inhibition of sEH protected against lung injury by increasing levels of EETs and inactivating pulmonary macrophages.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Haruhiko Jimbo, Koki Yuasa, Kensuke Takagi, Takashi Hirashima, Sumie Keta, Makiko Aichi, Hajime Wada
Summary: Our study showed that PUFAs accelerate the photodamage to PSII in Synechocystis cells, while monounsaturated fatty acids do not have this effect. PUFAs are specifically incorporated into the sn-2 position of PG molecules, a process that requires the involvement of acyl-ACP synthetase.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Psychiatry
Beatrice Decaluwe, Sandra W. Jacobson, Marie-Andree Poirier, Nadine Forget-Dubois, Joseph L. Jacobson, Gina Muckle
AMERICAN JOURNAL OF ORTHOPSYCHIATRY
(2015)
Article
Environmental Sciences
Youssef Oulhote, Emilie Tremblay, Tye E. Arbuckle, William D. Fraser, Jean-Pascal Lemelin, Jean R. Seguin, Emmanuel Ouellet, Nadine Forget-Dubois, Pierre Ayotte, Michel Boivin, Ginette Dionne, Bruce P. Lanphear, Gina Muckle
ENVIRONMENT INTERNATIONAL
(2018)
Article
Psychiatry
Christie L. Burton, Laura S. Park, Elizabeth C. Corfield, Nadine Forget-Dubois, Annie Dupuis, Vanessa M. Sinopoli, Janet Shan, Tara Goodale, S. -M. Shaheen, Jennifer Crosbie, Russell J. Schachar, Paul D. Arnold
TRANSLATIONAL PSYCHIATRY
(2018)
Article
Behavioral Sciences
Genevieve Morneau-Vaillancourt, Ginette Dionne, Mara Brendgen, Frank Vitaro, Bei Feng, Jeffrey Henry, Nadine Forget-Dubois, Richard Tremblay, Michel Boivin
Article
Environmental Sciences
Sylvaine Cordier, Nadine Forget-Dubois, Mireille Desrochers-Couture, Florence Rouget, Leah Michineau, Christine Monfort, Jean Pierre Thome, Philippe Kadhel, Luc Multigner, Gina Muckle
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2020)
Article
Environmental Sciences
Mireille Desrochers-Couture, Yohann Courtemanche, Nadine Forget-Dubois, Richard E. Belanger, Olivier Boucher, Pierre Ayotte, Sylvaine Cordier, Joseph L. Jacobson, Sandra W. Jacobson, Gina Muckle
ENVIRONMENTAL RESEARCH
(2019)
Article
Environmental Sciences
Youssef Oulhote, Bruce Lanphear, Joseph M. Braun, Glenys M. Webster, Tye E. Arbuckle, Taylor Etzel, Nadine Forget-Dubois, Jean R. Seguin, Maryse F. Bouchard, Amanda MacFarlane, Emmanuel Ouellet, William Fraser, Gina Muckle
ENVIRONMENTAL HEALTH PERSPECTIVES
(2020)
Article
Public, Environmental & Occupational Health
Maude Bradette-Laplante, Yohann Courtemanche, Mireille Desrochers-Couture, Nadine Forget-Dubois, Richard E. Belanger, Pierre Ayotte, Joseph L. Jacobson, Sandra W. Jacobson, Gina Muckle
PUBLIC HEALTH NUTRITION
(2020)
Article
Environmental Sciences
Emad Tahir, Sylvaine Cordier, Yohann Courtemanche, Nadine Forget-Dubois, Mireille Desrochers-Couture, Richard E. Belanger, Pierre Ayotte, Joseph L. Jacobson, Sandra W. Jacobson, Gina Muckle
ENVIRONMENTAL RESEARCH
(2020)
Article
Psychology, Developmental
Genevieve Morneau-Vaillancourt, Till F. M. Andlauer, Isabelle Ouellet-Morin, Stephane Paquin, Mara R. Brendgen, Frank Vitaro, Jean-Philippe Gouin, Jean R. Seguin, Eloi Gagnon, Rosa Cheesman, Nadine Forget-Dubois, Guy A. Rouleau, Gustavo Turecki, Richard E. Tremblay, Sylvana M. Cote, Ginette Dionne, Michel Boivin
Summary: This study revealed distinct associations between polygenic scores, social wariness, and preference for solitude. The loneliness polygenic score significantly predicted the high trajectory for social wariness, while the general mental health genetic risk score factor was associated with the trajectory depicting high-chronic preference for solitude.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2021)
Article
Developmental Biology
Genevieve Morneau-Vaillancourt, Isabelle Ouellet-Morin, Sandra Pouliot, Natalia Poliakova, Bei Feng, Lysandre Provost, Nadine Forget-Dubois, Celia Matte-Gagne, Amelie Petitclerc, Mara R. Brendgen, Frank Vitaro, Richard E. Tremblay, Ginette Dionne, Michel Boivin
Summary: Social wariness and preference for solitude, two dimensions of social withdrawal, are associated with various socioemotional difficulties in childhood. This study examines early predictors of these dimensions and finds that social inhibition and emotion regulation play important roles in predicting social wariness and preference for solitude.
DEVELOPMENTAL PSYCHOBIOLOGY
(2022)
Article
Education & Educational Research
Peter Twining, Deirdre Butler, Petra Fisser, Margaret Leahy, Chris Shelton, Nadine Forget-Dubois, Michel Lacasse
Summary: The paper discusses the importance of national curricula reflecting external changes, highlights the complexity of achieving quality curriculum in a technological era, and emphasizes the crucial alignment between policies and practices. The three key issues underlying alignment are stakeholders engagement, teacher professionalism, and summative assessment, all of which are linked with the issue of trust.
ETR&D-EDUCATIONAL TECHNOLOGY RESEARCH AND DEVELOPMENT
(2021)
Article
Education & Educational Research
Caroline Bouchard, Audette Sylvestre, Nadine Forget-Dubois
EDUCATIONAL PSYCHOLOGY
(2020)
Article
Public, Environmental & Occupational Health
Camille Pepin, Gina Muckle, Caroline Moisan, Nadine Forget-Dubois, Mylene Riva
INTERNATIONAL JOURNAL OF CIRCUMPOLAR HEALTH
(2018)
Meeting Abstract
Clinical Neurology
Paul Arnold, Laura Park, Annie Dupuis, Vanessa Sinopoli, Christie Burton, Janet Shan, Nadine Forget-Dubois, Jennifer Crosbie, Russell Schachar
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2017)