Consistent development of bioprocesses from microliter cultures to the industrial scale

Novel dynamic model for aerated shaking bioreactors

(2015) Hamed Osouli Tabrizi et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Fed-batch microbioreactor platform for scale down and analysis of a plasmid DNA production process

(2012) Diana M. Bower et al.   BIOTECHNOLOGY AND BIOENGINEERING

Biopharmaceutical process development - shortcut to market: An interview with Rolf Werner from Boehringer Ingelheim

(2012) Alois Jungbauer et al.   Biotechnology Journal

Exact model reduction of combinatorial reaction networks

(2012) Holger Conzelmann et al.   BMC Systems Biology

Model-integrated process development demonstrated on the optimization of a robotic cation exchange step

(2012) A. Osberghaus et al.   CHEMICAL ENGINEERING SCIENCE

Editorial: Towards faster bioprocess development

(2011) Peter Neubauer   Biotechnology Journal

A two-compartment bioreactor system made of commercial parts for bioprocess scale-down studies: Impact of oscillations on Bacillus subtilis fed-batch cultivations

(2011) Stefan Junne et al.   Biotechnology Journal

An industrial perspective on bioreactor scale-down: What we can learn from combined large-scale bioprocess and model fluid studies

(2011) Henk Noorman   Biotechnology Journal

A new microfluidic concept for parallel operated milliliter-scale stirred tank bioreactors

(2011) Gabi Gebhardt et al.   BIOTECHNOLOGY PROGRESS

Considerations on nonlinear model predictive control techniques

(2011) Flavio Manenti   COMPUTERS & CHEMICAL ENGINEERING

Effect of post-induction substrate oscillation on recombinant alkaline phosphatase production expressed in Escherichia coli

(2011) Mohammadhadi Jazini et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

How implementation of Quality by Design and advances in Biochemical Engineering are enabling efficient bioprocess development and manufacture

(2011) Sunil Chhatre et al.   JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

Reducing conditions are the key for efficient production of active ribonuclease inhibitor in Escherichia coli

(2011) Juozas Šiurkus et al.   Microbial Cell Factories

Heterologous production of active ribonuclease inhibitor in Escherichia coli by redox state control and chaperonin coexpression

(2011) Juozas Šiurkus et al.   Microbial Cell Factories

High-yield production of biologically active recombinant protein in shake flask culture by combination of enzyme-based glucose delivery and increased oxygen transfer

(2011) Kaisa Ukkonen et al.   Microbial Cell Factories

Where process development begins: A multiple case study of front end activities in process firms

(2011) Monika Kurkkio et al.   TECHNOVATION

Downstream bioprocessing: recent advances and future promise

(2011) Steven M Cramer et al.   Current Opinion in Chemical Engineering

Design of experiments on 135 cloned poplar trees to map environmental influence in greenhouse

(2010) Rui Climaco Pinto et al.   ANALYTICA CHIMICA ACTA

Microfluidic biolector-microfluidic bioprocess control in microtiter plates

(2010) Matthias Funke et al.   BIOTECHNOLOGY AND BIOENGINEERING

Application of an aqueous two-phase systems high-throughput screening method to evaluate mAb HCP separation

(2010) Stefan A. Oelmeier et al.   BIOTECHNOLOGY AND BIOENGINEERING

Constructing and maintaining proper process models

(2010) Heinz A. Preisig   COMPUTERS & CHEMICAL ENGINEERING

Scale-down simulators for metabolic analysis of large-scale bioprocesses

(2010) Peter Neubauer et al.   CURRENT OPINION IN BIOTECHNOLOGY

Time-dependent regulation of yeast glycolysis upon nitrogen starvation depends on cell history

(2010) K. van Eunen et al.   IET Systems Biology

Novel approach of high cell density recombinant bioprocess development: Optimisation and scale-up from microlitre to pilot scales while maintaining the fed-batch cultivation mode of E. coli cultures

(2010) Juozas Šiurkus et al.   Microbial Cell Factories

A novel fed-batch based cultivation method provides high cell-density and improves yield of soluble recombinant proteins in shaken cultures

(2010) Mirja Krause et al.   Microbial Cell Factories

Organisational modes for Open Innovation in the bio-pharmaceutical industry: An exploratory analysis

(2010) Mattia Bianchi et al.   TECHNOVATION

Fast dynamic response of the fermentative metabolism ofEscherichia colito aerobic and anaerobic glucose pulses

(2009) Alvaro R. Lara et al.   BIOTECHNOLOGY AND BIOENGINEERING

Robo-Lector – a novel platform for automated high-throughput cultivations in microtiter plates with high information content

(2009) Robert Huber et al.   Microbial Cell Factories

Validation of a high-throughput fermentation system based on online monitoring of biomass and fluorescence in continuously shaken microtiter plates

(2009) Frank Kensy et al.   Microbial Cell Factories

Quality by design for biopharmaceuticals

(2009) Anurag S Rathore et al.   NATURE BIOTECHNOLOGY

Rational and systematic protein purification process development: the next generation

(2009) Beckley K. Nfor et al.   TRENDS IN BIOTECHNOLOGY

Micro biochemical engineering to accelerate the design of industrial-scale downstream processes for biopharmaceutical proteins

(2008) N.J. Titchener-Hooker et al.   BIOTECHNOLOGY AND BIOENGINEERING

High Throughput Screening for the Design and Optimization of Chromatographic Processes – Miniaturization, Automation and Parallelization of Breakthrough and Elution Studies

(2008) M. Wiendahl et al.   CHEMICAL ENGINEERING & TECHNOLOGY

CFD modelling of the fast pyrolysis of biomass in fluidised bed reactors, Part A: Eulerian computation of momentum transport in bubbling fluidised beds

(2008) K. Papadikis et al.   CHEMICAL ENGINEERING SCIENCE

Optimal automatic reaction and species elimination in kinetic mechanisms

(2008) A. Mitsos et al.   COMBUSTION AND FLAME

Efficient moving horizon state and parameter estimation for SMB processes

(2008) Achim Küpper et al.   JOURNAL OF PROCESS CONTROL

Enzyme controlled glucose auto-delivery for high cell density cultivations in microplates and shake flasks

(2008) Johanna Panula-Perälä et al.   Microbial Cell Factories

Protein production and purification

(2008) Susanne Gräslund et al.   NATURE METHODS

Pharmaceutical Quality by Design: Product and Process Development, Understanding, and Control

(2008) Lawrence X. Yu   PHARMACEUTICAL RESEARCH

Design and characterisation of a miniature stirred bioreactor system for parallel microbial fermentations

(2007) N.K. Gill et al.   BIOCHEMICAL ENGINEERING JOURNAL

Model-based design of experiments for parameter precision: State of the art

(2007) Gaia Franceschini et al.   CHEMICAL ENGINEERING SCIENCE

Design strategies for integrated protein purification processes: challenges, progress and outlook

(2007) Beckley K Nfor et al.   JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

High-throughput automated refolding screening of inclusion bodies

(2004) Renaud Vincentelli et al.   PROTEIN SCIENCE