Article
Cell Biology
John Dou, Muraly Puttabyatappa, Vasantha Padmanabhan, Kelly M. Bakulski
Summary: Prenatal testosterone-treated female sheep show disruptions in gene expression related to adiposity, inflammation, differentiation and vascular function in different adipose tissues, suggesting that dysregulation in gene expression underlies functional differences among adipose depots and metabolic dysfunction.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Rebecka Amodei, Sonnet S. Jonker, William Whitler, Charles T. Estill, Charles E. Roselli
Summary: GnRH plays a critical role in brain sexual differentiation in sheep fetuses, and pharmacological inhibition of GnRH leads to suppressed LH secretion and affected plasma T levels, which may have long-term consequences on adult sexual behaviors and fertility.
Article
Endocrinology & Metabolism
Nadia Saadat, Muraly Puttabyatappa, Venkateswaran R. Elangovan, John Dou, Joseph N. Ciarelli, Robert C. Thompson, Kelly M. Bakulski, Vasantha Padmanabhan
Summary: This study investigates the transcriptional changes and transcriptome signature of prenatal testosterone excess-induced hepatic and muscle-specific metabolic disruptions. The findings suggest that downregulation of mitochondria, lipid catabolism, and PPAR signaling genes in the liver and dysregulation of mitochondrial and ncRNA gene pathways in muscle contribute to lipotoxic and insulin-resistant hepatic and muscle phenotype.
Article
Cell Biology
John Dou, Soundara Viveka Thangaraj, Muraly Puttabyatappa, Venkateswaran Ramamoorthi Elangovan, Kelly Bakulski, Vasantha Padmanabhan
Summary: Inappropriate developmental exposure to steroids, such as prenatal testosterone excess or bisphenol A (BPA), has been linked to metabolic disorders. This study sequenced non-coding RNA (ncRNA) from different adipose depots of animals treated with prenatal testosterone and BPA, and found depot-specific changes in ncRNA that are consistent with depot-specific mRNA expression. These changes are associated with insulin resistance, adipocyte differentiation, and cardiac hypertrophy.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2023)
Article
Psychology, Developmental
Kumari Anshu, Ajay Kumar Nair, Shoba Srinath, T. Rao Laxmi
Summary: This article investigates early indicators of Autism Spectrum Disorder and identifies sex-specific developmental delays in an animal model. The authors develop a composite score that effectively distinguishes between Autism Spectrum Disorder and control groups, providing a reliable measurement for early intervention studies.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2023)
Article
Cell Biology
Muraly Puttabyatappa, Joseph N. Ciarelli, Adam G. Chatoff, Vasantha Padmanabhan
Summary: The study suggests that prenatal testosterone excess may lead to insulin resistance, mainly due to mitochondrial and endoplasmic reticulum dysfunction in muscle. Additionally, fibrosis and premature senescence may occur in the liver, while changes in mitochondrial function and ER stress in different adipose tissues are depot-specific.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Review
Developmental Biology
Daniel A. Dumesic, Luis R. Hoyos, Gregorio D. Chazenbalk, Rajanigandha Naik, Vasantha Padmanabhan, David H. Abbott
Article
Biochemistry & Molecular Biology
Chantal A. Vella, O. Lynne Nelson, Heiko T. Jansen, Charles T. Robbins, Andrew E. Jensen, Silvana Constantinescu, Marcia J. Abbott, Lorraine P. Turcotte
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2020)
Article
Endocrinology & Metabolism
Muraly Puttabyatappa, Margaret Banker, Lixia Zeng, Jaclyn M. Goodrich, Steven E. Domino, Dana C. Dolinoy, John D. Meeker, Subramaniam Pennathur, Peter X. K. Song, Vasantha Padmanabhan
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2020)
Review
Obstetrics & Gynecology
Amy M. Padula, Catherine Monk, Patricia A. Brennan, Ann Borders, Emily S. Barrett, Cindy T. McEvoy, Sophie Foss, Preeya Desai, Akram Alshawabkeh, Renee Wurth, Carolyn Salafia, Raina Fichorova, Julia Varshavsky, Amii Kress, Tracey J. Woodruff, Rachel Morello-Frosch, D. K. Benjamin, P. B. Smith, K. L. Newby, L. P. Jacobson, C. B. Parker, R. Gershon, D. Cella, S. L. Teitelbaum, R. O. Wright, K. M. Aldous, T. Fennell, S. S. Hecht, L. Peterson, B. O'Brien, J. Y. Lee, J. Snowden, J. L. Aschner, A. A. Litonjua, F. P. Perera, M. R. Karagas, C. J. Newschaffer, A. L. Dunlop, P. A. Brennan, E. J. Corwin, P. K. Gregersen, B. Diamond, E. Oken, K. P. Kleinman, A. Ferrara, L. A. Croen, C. A. Camargo, J. E. Vena, R. Wapner, S. Deoni, H. G. Mueller, N. Paneth, C. Barone, G. E. Copeland, M. R. Elliott, D. M. Ruden, C. S. Duarte, G. J. Canino, C. E. Monk, J. E. Posner, C. B. Blair, L. Trasande, C. T. McEvoy, E. R. Spindel, A. N. Alshawabkeh, A. J. Elliott, B. Eskenazi, I Hertz-Picciotto, D. H. Bennett, J. B. Schweitzer, E. C. Claud, D. Dabelea, S. L. Schantz, L. D. Leve, J. L. Lewis, D. MacKenzie, M-G Begay, M. O'Shea, R. Fry, A. E. Hipwell, K. E. Keenan, T. G. O'Connor, C. Buss, R. K. Miller, P. D. Wadhwa, F. D. Gilliland, C. Breton, J. B. Stanford, E. B. Clark, C. Porucznik, C. Karr, N. R. Bush, K. Z. Lewinn, J. Gern, B. Lester, D. Gold, S. T. Weiss, R. T. Schultz, N. Hershey, R. Miller, J. B. Herbstman, C. J. Marsit, J. M. Ganiban, C. Johnson, D. Ownby, E. Zoratti, A. Stroustrup, K. Huddleston, H. E. Volk, R. J. Landa, K. Hunt, J. M. Neiderhiser, S. Sathyanarayana, F. Martinez, A. Wright, R. Keller, T. J. Woodruff, R. J. Schmidt, S. Ozonoff, B. Andrews, D. S. Messinger, V Padma-nabhan, J. Piven, H. N. Simhan, G. Pryhuber, F. A. Tylaysky, S. R. Dager, D. Maycock, W. L. Stone, D. Jackson, C. Seroogy, T. Hartert, P. Moore, L. Bacharier, K. N. Botteron
JOURNAL OF PERINATOLOGY
(2020)
Article
Environmental Sciences
Wenhui Song, Muraly Puttabyatappa, Lixia Zeng, Delia Vazquez, Subramaniam Pennathur, Vasantha Padmanabhan
Article
Cell Biology
Muraly Puttabyatappa, Joseph N. Ciarelli, Adam G. Chatoff, Kanakadurga Singer, Vasantha Padmanabhan
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2020)
Review
Cell Biology
Vasantha Padmanabhan, Rodolfo C. Cardoso
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2020)
Correction
Biology
Heiko T. Jansen, Shawn Trojahn, Michael W. Saxton, Corey R. Quackenbush, Brandon D. Evans Hutzenbiler, O. Lynne Nelson, Omar E. Cornejo, Charles T. Robbins, Joanna L. Kelley
COMMUNICATIONS BIOLOGY
(2020)
Article
Biology
Heiko T. Jansen, Brandon Evans Hutzenbiler, Hannah R. Hapner, Madeline L. McPhee, Anthony M. Carnahan, Joanna L. Kelley, Michael W. Saxton, Charles T. Robbins
Summary: Feeding glucose to hibernating bears partially restores metabolic parameters to active season levels, with some indicators remaining incomplete due to the suppression of circulating free fatty acids. The study provides a controlled model to examine the relationship between nutrient availability and metabolism on the hibernation phenotype in bears.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2021)
Article
Veterinary Sciences
Marc Cattet, David M. Janz, Luciene Kapronczai, Joy A. Erlenbach, Heiko T. Jansen, O. Lynne Nelson, Charles T. Robbins, Gordon B. Stenhouse
Summary: The study showed that injecting cosyntropin into captive grizzly bears caused a significant increase in blood cortisol levels within a short period, but did not have a noticeable effect on hair cortisol concentration. This suggests that the spike in cortisol induced by cosyntropin may not be sufficient to explain the stress response of free-ranging bears when captured. Further research with a larger sample of captive bears is recommended to better simulate the adrenocortical response in these animals.
VETERINARY MEDICINE AND SCIENCE
(2021)
Article
Evolutionary Biology
Richard J. Wang, Yadira Pena-Garcia, Madeleine G. Bibby, Muthuswamy Raveendran, R. Alan Harris, Heiko T. Jansen, Charles T. Robbins, Jeffrey Rogers, Joanna L. Kelley, Matthew W. Hahn
Summary: This study examines the per-generation mutation rate in a brown bear pedigree and finds that both male bias and per-generation mutation rates are similar to that of non-hibernating species, contradicting previous theories. These findings provide new evidence for the determinants of mutation rates and mutation biases.
GENOME BIOLOGY AND EVOLUTION
(2022)
Article
Physiology
Ellery P. Vincent, Blair W. Perry, Joanna L. Kelley, Charles T. Robbins, Heiko T. Jansen
Summary: Hibernation and circadian rhythms play important roles in energy conservation for brown bears. The study shows that culturing cells at hibernation body temperature delays ATP production peak and alters the timing and amplitudes of mitochondrial gene transcription and circadian gene transcripts. Key metabolic genes linked to the circadian system and energy balance also show changes.
JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMS AND ENVIRONMENTAL PHYSIOLOGY
(2023)
Article
Cell Biology
Blair W. Perry, Anna L. Mcdonald, Shawn Trojahn, Michael W. Saxton, Ellery P. Vincent, Courtney Lowry, Brandon D. Evans Hutzenbiler, Omar E. Cornejo, Charles T. Robbins, Heiko T. Jansen, Joanna L. Kelley
Summary: Hibernation in bears involves changes in gene expression in multiple tissues, including insulin resistance, and feeding bears glucose during hibernation can partially restore active season physiological phenotypes. This study analyzes gene expression in adipose, liver, and muscle tissues to identify genes that respond to midhibernation glucose feeding and drive metabolic and physiological shifts. The results suggest that peroxisome proliferator-activated receptor gamma (PPARG) and other regulators of insulin sensitivity play a role in shifting metabolic phenotypes between hibernation and active states.
PHYSIOLOGICAL GENOMICS
(2023)
Article
Cell Biology
Xingzi Guo, Muraly Puttabyatappa, Steven E. Domino, Vasantha Padmanabhan
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2020)
Article
Environmental Sciences
John F. Dou, Muraly Puttabyatappa, Vasantha Padmanabhan, Kelly M. Bakulski