Article
Pharmacology & Pharmacy
Nandini Ravikumar Jayakumari, Raji Sasikala Rajendran, Ashok Sivasailam, Sulfath Thottungal Parambil, Anand Chellappan Reghuvaran, Harikrishnan Vijayakumar Sreelatha, Srinivas Gopala
Summary: The active ingredient honokiol in Magnolia tree bark extract can improve cardiac mitochondrial function in type 2 diabetes patients by regulating fatty acid respiration and expression of oxidant response factors.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Cell Biology
Jiuzhou Huo, Vikram Prasad, Kelly M. Grimes, Davy Vanhoutte, N. Scott Blair, Suh-Chin Lin, Michael J. Bround, Donald M. Bers, Jeffery D. Molkentin
Summary: MCUb is an inducible control point that regulates skeletal muscle mitochondrial Ca2+ levels and substrate utilization, impacting overall metabolic balance.
Review
Biochemistry & Molecular Biology
Panpan Liu, Zhuli Yang, Youjun Wang, Aomin Sun
Summary: The heart relies on glucose and fatty acids as major energy substrates, and their shift in preference is associated with cardiac diseases. STIM1, a calcium sensor, has been identified as a critical player in cardiac hypertrophy and diabetic cardiomyopathy, and its involvement in energy metabolism and the molecular mechanisms are not well understood. Understanding the role of STIM1 in regulating energy substrate preference could provide insights into novel therapeutic targets for cardiac metabolic diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Ele Ferrannini, Simona Baldi, Tiziana Scozzaro, Vasilis Tsimihodimos, Fisseha Tesfaye, Wayne Shaw, Norman Rosenthal, Gemma A. Figtree, Bruce Neal, Kenneth W. Mahaffey, Vlado Perkovic, Michael K. Hansen
Summary: This study examines the relationship between the circulating substrate mix and the incidence of heart failure and cardiovascular mortality. The results suggest that a higher lipolysis metabolic setup may be beneficial in delaying or preventing heart failure, and canagliflozin treatment may reinforce this influence by stimulating further lipolysis.
Review
Immunology
Mark R. Boothby, Shawna K. Brookens, Ariel L. Raybuck, Sung Hoon Cho
Summary: This article discusses the molecular programming of antibody-secreting cells and how they adapt to become specialized factories for antibody secretion. It emphasizes the impact of nutrient supply and sensor mechanisms on the development of plasma cells and their adaptations.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Zhu Qiao, Que Kong, Wan Ting Tee, Audrey R. Q. Lim, Miao Xuan Teo, Vincent Olieric, Pui Man Low, Yuzhou Yang, Guoliang Qian, Wei Ma, Yong-Gui Gao
Summary: The study reveals the DNA-binding mechanism of WRI1, a crucial transcription factor involved in plant oil biosynthesis. The structure of Arabidopsis WRI1 with its cognate dsDNA was determined, showing a previously unidentified structural fold and DNA-binding mode. Mutations in key DNA-interacting residues of WRI1 affected its binding affinity and oil biosynthesis, while overexpression of an AtWRI1 variant enhanced seed oil content. These findings provide a structural basis for WRI1 recognition and binding of DNA and suggest a potential strategy for increasing oil yield in crops through WRI1 bioengineering.
Article
Multidisciplinary Sciences
Xudong Huang, Ling Pan, Zhixiang Zuo, Mei Li, Lingxing Zeng, Rui Li, Ying Ye, Jialiang Zhang, Guandi Wu, Ruihong Bai, Lisha Zhuang, Lusheng Wei, Yanfen Zheng, Jiachun Su, Junge Deng, Shuang Deng, Shaoping Zhang, Shihao Zhu, Xu Che, Chengfeng Wang, Chen Wu, Rufu Chen, Dongxin Lin, Jian Zheng
Summary: LINC00842 plays a role in promoting the malignancy of pancreatic ductal adenocarcinoma by regulating the acetylation status of PGC-1 alpha, leading to metabolic reprogramming in cancer cells.
NATURE COMMUNICATIONS
(2021)
Review
Cell Biology
Baigalmaa Lkhagva, Ting-Wei Lee, Yung-Kuo Lin, Yao-Chang Chen, Cheng-Chih Chung, Satoshi Higa, Yi-Jen Chen
Summary: The article discusses the high prevalence and mortality rates of atrial fibrillation in diabetes, emphasizing the importance of understanding the pathophysiological mechanisms of atrial fibrillation and the development of new therapeutic approaches.
Review
Endocrinology & Metabolism
Yasuhiro Onogi, Siegfried Ussar
Summary: Brown adipose tissue (BAT) is a tightly controlled regulator of body temperature and nutrient balance, influenced by complex hormonal and nervous inputs. This article provides an overview of key regulatory circuits, including diurnal rhythms and the interdependency of nutrient utilization in thermogenesis. It also discusses additional factors mediating sympathetic BAT activation and limitations of glucose-based BAT activity measurements.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Abel M. Mengeste, Parmeshwar Katare, Andrea Dalmao Fernandez, Jenny Lund, Hege G. Bakke, David Baker, Stefano Bartesaghi, Xiao-Rong Peng, Arild C. Rustan, G. Hege Thoresen, Eili Tranheim Kase
Summary: This study investigated the role of sarcolipin (SLN) in substrate metabolism in human skeletal muscle cells. The findings showed that depletion of SLN affected glucose and oleic acid metabolism, reduced mitochondrial function, and decreased gene expression levels. Additionally, SLN knockdown resulted in increased accumulation of complex lipids and free fatty acids. The study highlights the importance of SLN in maintaining metabolic homeostasis in human skeletal muscle and suggests that targeting SLN-mediated futile cycling of SERCA may have therapeutic implications for obesity and associated metabolic disorders.
MOLECULAR BIOLOGY REPORTS
(2022)
Review
Pharmacology & Pharmacy
N. P. Syamprasad, Siddhi Jain, Bishal Rajdev, Neethu Prasad, Ravindra Kallipalli, V. G. M. Naidu
Summary: It is established that metabolic reprogramming plays a crucial role in the development and progression of various cancers, but a common biomarker linking dysregulated metabolism and cancer progression has yet to be identified. Recent studies suggest that aldose reductase (AR) is involved in cancer metabolism. AR-mediated glucose metabolism leads to a Warburg-like effect and an acidic tumor microenvironment, while AR overexpression is associated with mitochondrial impairment and accumulation of free fatty acids. AR-mediated reduction of lipid aldehydes and chemotherapeutics activates factors promoting proliferation and chemo-resistance. Understanding cancer metabolism and the role of AR could potentially lead to the use of AR inhibitors as metabolic modulating agents for cancer therapy.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Sport Sciences
S. E. A. N. A. NEWSOM, H. A. R. R. I. S. O. N. D. STIERWALT, S. A. R. A. H. E. EHRLICHER, M. A. T. T. H. E. W. M. ROBINSON
Summary: In sedentary adults, a single bout of moderate-intensity cycling induces modest increases in intrinsic mitochondrial oxidative phosphorylation that are consistent across multiple substrates.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2021)
Article
Nutrition & Dietetics
Jiapeng Huang, Takashi Tagawa, Sihui Ma, Katsuhiko Suzuki
Summary: The study found that a single administration of black ginger extract (KPE) can significantly prolong the endurance time of mice, possibly through promoting cellular energy metabolism and substrate utilization.
Review
Immunology
Li Xiao, Qiao Wang, Hongling Peng
Summary: Tumor-associated macrophages (TAMs) are a dynamic and heterogeneous cell population of the tumor microenvironment (TME) that plays an essential role in tumor formation and progression. Understanding the metabolic changes in TAMs is crucial for comprehending immune evasion mechanisms in cancer. The metabolic reprogramming of TAMs is a novel method for enhancing their antitumor effects.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Qiao Xiong, Dechao Feng, Ziwei Wang, Yidie Ying, Chuanliang Xu, Qiang Wei, Shuxiong Zeng, Lu Yang
Summary: The study found that fatty acid metabolism genes have potential applications in predicting prognosis and immunotherapy response in bladder cancer. A prognostic model was constructed and key fatty acid metabolism genes were identified in bladder cancer. Fatty acid synthase plays a central role in bladder cancer, and its differential expression is related to survival and muscle invasion. The study also found that the differential expression of fatty acid synthase is significantly related to immune cell infiltration and immunotherapy response.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Physiology
K. S. Rigano, J. L. Gehring, B. D. Evans Hutzenbiler, A. V. Chen, O. L. Nelson, C. A. Vella, C. T. Robbins, H. T. Jansen
JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMS AND ENVIRONMENTAL PHYSIOLOGY
(2017)
Article
Ecology
Jasmine V. Ware, Karyn D. Rode, Jeffrey F. Bromaghin, David C. Douglas, Ryan R. Wilson, Eric V. Regehr, Steven C. Amstrup, George M. Durner, Anthony M. Pagano, Jay Olson, Charles T. Robbins, Heiko T. Jansen
Article
Biodiversity Conservation
Marc Cattet, Gordon B. Stenhouse, David M. Janz, Luciene Kapronczai, Joy Anne Erlenbach, Heiko T. Jansen, O. Lynne Nelson, Charles T. Robbins, John Boulanger
CONSERVATION PHYSIOLOGY
(2017)
Article
Veterinary Sciences
Hilary L. Wright, Annie Chen, Heiko T. Jansen
JOURNAL OF ZOO AND WILDLIFE MEDICINE
(2019)
Article
Biology
Jasmine V. Ware, Karyn D. Rode, Charles T. Robbins, Tanya Leise, Colby R. Weil, Heiko T. Jansen
JOURNAL OF BIOLOGICAL RHYTHMS
(2020)
Correction
Biology
Heiko T. Jansen, Shawn Trojahn, Michael W. Saxton, Corey R. Quackenbush, Brandon D. Evans Hutzenbiler, O. Lynne Nelson, Omar E. Cornejo, Charles T. Robbins, Joanna L. Kelley
COMMUNICATIONS BIOLOGY
(2020)
Article
Biology
Heiko T. Jansen, Brandon Evans Hutzenbiler, Hannah R. Hapner, Madeline L. McPhee, Anthony M. Carnahan, Joanna L. Kelley, Michael W. Saxton, Charles T. Robbins
Summary: Feeding glucose to hibernating bears partially restores metabolic parameters to active season levels, with some indicators remaining incomplete due to the suppression of circulating free fatty acids. The study provides a controlled model to examine the relationship between nutrient availability and metabolism on the hibernation phenotype in bears.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2021)
Article
Veterinary Sciences
Marc Cattet, David M. Janz, Luciene Kapronczai, Joy A. Erlenbach, Heiko T. Jansen, O. Lynne Nelson, Charles T. Robbins, Gordon B. Stenhouse
Summary: The study showed that injecting cosyntropin into captive grizzly bears caused a significant increase in blood cortisol levels within a short period, but did not have a noticeable effect on hair cortisol concentration. This suggests that the spike in cortisol induced by cosyntropin may not be sufficient to explain the stress response of free-ranging bears when captured. Further research with a larger sample of captive bears is recommended to better simulate the adrenocortical response in these animals.
VETERINARY MEDICINE AND SCIENCE
(2021)
Article
Evolutionary Biology
Richard J. Wang, Yadira Pena-Garcia, Madeleine G. Bibby, Muthuswamy Raveendran, R. Alan Harris, Heiko T. Jansen, Charles T. Robbins, Jeffrey Rogers, Joanna L. Kelley, Matthew W. Hahn
Summary: This study examines the per-generation mutation rate in a brown bear pedigree and finds that both male bias and per-generation mutation rates are similar to that of non-hibernating species, contradicting previous theories. These findings provide new evidence for the determinants of mutation rates and mutation biases.
GENOME BIOLOGY AND EVOLUTION
(2022)
Article
Physiology
Ellery P. Vincent, Blair W. Perry, Joanna L. Kelley, Charles T. Robbins, Heiko T. Jansen
Summary: Hibernation and circadian rhythms play important roles in energy conservation for brown bears. The study shows that culturing cells at hibernation body temperature delays ATP production peak and alters the timing and amplitudes of mitochondrial gene transcription and circadian gene transcripts. Key metabolic genes linked to the circadian system and energy balance also show changes.
JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMS AND ENVIRONMENTAL PHYSIOLOGY
(2023)
Article
Cell Biology
Blair W. Perry, Anna L. Mcdonald, Shawn Trojahn, Michael W. Saxton, Ellery P. Vincent, Courtney Lowry, Brandon D. Evans Hutzenbiler, Omar E. Cornejo, Charles T. Robbins, Heiko T. Jansen, Joanna L. Kelley
Summary: Hibernation in bears involves changes in gene expression in multiple tissues, including insulin resistance, and feeding bears glucose during hibernation can partially restore active season physiological phenotypes. This study analyzes gene expression in adipose, liver, and muscle tissues to identify genes that respond to midhibernation glucose feeding and drive metabolic and physiological shifts. The results suggest that peroxisome proliferator-activated receptor gamma (PPARG) and other regulators of insulin sensitivity play a role in shifting metabolic phenotypes between hibernation and active states.
PHYSIOLOGICAL GENOMICS
(2023)
Article
Biology
Heiko T. Janseng, Shawn Trojahn, Michael W. Saxton, Corey R. Quackenbush, Brandon D. Evans Hutzenbiler, O. Lynne Nelson, Omar E. Cornejo, Charles T. Robbins, Joanna L. Kelley
COMMUNICATIONS BIOLOGY
(2019)
Article
Zoology
D. R. Rivet, O. L. Nelson, C. A. Vella, H. T. Jansen, C. T. Robbins
CANADIAN JOURNAL OF ZOOLOGY
(2017)
Article
Information Science & Library Science
Carmen Huening, Heiko Jansen, Vanessa Kauke, Jessica Roschanski, Elmar Schackmann, Silke Schomburg, Michaela Selbach
ZEITSCHRIFT FUR BIBLIOTHEKSWESEN UND BIBLIOGRAPHIE
(2016)
Article
Biochemistry & Molecular Biology
Sang Hyuck Lee, Mi Ae Kim, Young Chang Sohn
Summary: This study characterized the CCAP signaling system in Pacific abalone and revealed its relationship with the calcium/PKC and cAMP/PKA signal transduction pathways. It provides new insights into the evolutionary origins of the NPS and OT/VP signaling systems in protostomes.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Hanna Scheuffele, Erica V. Todd, John A. Donald, Timothy D. Clark
Summary: Global warming is causing an increase in extreme weather events, affecting ecosystems and the behavior of ectotherms. More research is needed to understand the impact of diurnal thermal variability and improve climate change predictions.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Jaakko Haverinen, Ahmed Badr, Markus Eskelinen, Matti Vornanen
Summary: The acclimatization of certain ectothermic vertebrates to winter conditions involves reduced energy consumption, achieved through decreased movement activity, depression of cellular functions, or switching to anaerobic energy production. This study on crucian carp showed that winter-acclimatized fish exhibited lower metabolic rates and a shift to anaerobic energy production during anoxia. Winter dormancy in crucian carp is achieved through active reduction of energy consumption, a slowed metabolic rate, and a direct response to oxygen absence.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Maria Cruz Sueiro, Cynthia A. Awruch, Gustavo M. Somoza, Walter S. Svagelj, Maria G. Palacios
Summary: According to life-history theory, there might be different immunological strategies between reproductive and non-reproductive periods due to limited resources. Our study on two sympatric marine fish species, rockfish and sandperch, found that reproductive individuals showed lower immune function, but higher levels of natural antibodies in rockfish females, compared to their non-reproductive counterparts. On the other hand, reproductively active sandperch males showed lower levels of natural antibodies and higher neutrophil to lymphocyte ratio and spleen index compared to non-reproductive males. The study highlights the species-specific patterns of immunity and the potential influence of resource limitation and abiotic factors on immune trade-offs in fish.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
James B. Cummins, Dane A. Crossley II
Summary: This study focuses on cardiovascular development in altricial bird species, which has been less studied compared to precocial species. The researchers investigated the cholinergic and adrenergic receptor mediated control of arterial blood pressure and heart rate in the neotropic cormorant. The findings suggest that both cholinergic and adrenergic tone play a role in cardiovascular regulation in embryonic birds.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Ru Xia, Hong-Kang Liu, Xi-Feng Liu, Xin Deng, Chuan-Jie Qin, Yuan-Fa He, Shi-Mei Lin, Yong-Jun Chen
Summary: This study cloned the genes encoding glucokinase and glucose-6-phosphatase catalytic subunit in largemouth bass, revealing their distribution and transcriptional regulation. The results showed that the functions of G6pc and Gck in LMB were highly conserved in evolution, and the interconversion of glucose and G6P in the liver was well regulated at the transcript level under high starch diet, but a futile cycle was induced after a glucose load.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2024)