Article
Biochemistry & Molecular Biology
Katri Vaparanta, Anne Jokilammi, Ilkka Paatero, Johannes A. Merilahti, Juho Heliste, Karthik Amudhala Hemanthakumar, Riikka Kivela, Kari Alitalo, Pekka Taimen, Klaus Elenius
Summary: In this study, it is demonstrated that Neuregulin-1 (NRG-1) regulates myocardial growth through the STAT5b pathway. Disruption of the NRG-1/ERBB4 pathway or inhibition of Dynamin-2 reduces STAT5b activation and cardiomyocyte hypertrophy. Activation of Stat5 is also observed in NRG-1-induced myocardial growth in zebrafish embryos, and knockdown of stat5b leads to reduced myocardial growth and cardiac function. Furthermore, the NRG-1/ERBB4/STAT5b pathway is differentially regulated in patients with pathological cardiac hypertrophy.
Review
Dermatology
Qi Yin, Albert Wolkerstorfer, Oren Lapid, Frank B. Niessen, Paul P. M. Van Zuijlen, Susan Gibbs
Summary: Keloid tissues contain inflammatory cells and upregulated pro-inflammatory cytokines. The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway mediate cellular responses to these cytokines. Preclinical studies indicate a role for the JAK-STAT pathway in keloid pathogenesis and a potential role for JAK-STAT inhibitors in keloid treatment. Further investigation on relevant biomarkers in a human keloid skin model and in clinical studies is needed.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Obstetrics & Gynecology
Hiroaki Inui, Takako Kawakita, Misaki Murayama, Tomotaka Nakagawa, Hikari Sasada, Ayaka Shinohara, Ryousuke Aragaki, Tomohiro Kagawa, Yuri Kadota, Takeshi Kato, Masato Nishimura, Takeshi Iwasa
Summary: STAT inhibitors have a therapeutic effect on endometriosis.
REPRODUCTIVE SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Ines Roger, Javier Milara, Paula Montero, Julio Cortijo
Summary: Pulmonary hypertension is a group of diseases characterized by an increase in pulmonary vascular resistance, leading to right ventricular failure and premature death. Current treatments for PH are limited to vasodilatory agents, prompting the search for new drugs that target pulmonary artery remodeling. Activation of the JAK/STAT pathway plays a critical role in pulmonary artery remodeling and PH progression, suggesting it as a potential target for future treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Xuelian Chen, Yunzheng Zhang, Junjian He, Yibing Li
Summary: This study identified the importance of STAT5B in endometrial carcinoma (EC) and its correlation with clinical outcomes. STAT5B and STAT6 expression predicted favorable clinical outcomes, while STAT1 and STAT2 expression predicted poor clinical outcomes in EC. The STAT family was found to be involved in apoptosis pathway activation, cell cycle disruption, and epithelial-mesenchymal transition. STAT5B expression was also correlated with clinicopathological characteristics, immune cell infiltration, and specific signaling pathways.
Review
Biochemistry & Molecular Biology
Jia Liu, Faping Wang, Fengming Luo
Summary: There are four members of the JAK family and seven of the STAT family in mammals. The JAK/STAT molecular pathway can be activated by various hormones, cytokines, growth factors, etc. The JAK/STAT signaling pathway extensively mediates various biological processes such as cell proliferation, differentiation, migration, apoptosis, and immune regulation.
Article
Medicine, General & Internal
Malgorzata Galecka, Janusz Szemraj, Kuan-Pin Su, Angelos Halaris, Michael Maes, Aleksandra Skiba, Piotr Galecki, Katarzyna Blizniewska-Kowalska
Summary: This study found that there is increased expression of JAK3 and decreased expression of STAT1 in depressed patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Sarah M. M. AL-Qabbaa, Samaher I. I. Qaboli, Tahani K. K. Alshammari, Maha A. A. Alamin, Haya M. M. Alrajeh, Lama A. A. Almuthnabi, Rana R. R. Alotaibi, Asma S. S. Alonazi, Anfal F. F. Bin Dayel, Nawal M. M. Alrasheed, Nouf M. M. Alrasheed
Summary: This study examined the therapeutic effects of sitagliptin, a dipeptidyl peptidase inhibitor, on diabetic nephropathy (DN). The results showed that sitagliptin can reduce inflammation and improve DN by inhibiting PTP1B and modulating the JAK/STAT signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Amr Allam, Marina Yakou, Lokman Pang, Matthias Ernst, Jennifer Huynh
Summary: This article discusses the relationship between cancer-associated fibroblasts (CAFs) and signal transducer and activator of transcription 3 (STAT3) in the tumor microenvironment, as well as their impact on tumor growth, immune suppression, and metastatic spread. Research suggests that CAF-intrinsic STAT3 activity is closely associated with tumor progression.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Lena Puigdevall, Camille Michiels, Clara Stewardson, Laure Dumoutier
Summary: A subset of cytokines triggers the JAK-STAT pathway to exert various functions such as inflammation and immune responses. There are alternative modes of STAT activation, including association between the tyrosine-free region of cytokine receptors and STATs, and direct interaction between JAK and STAT proteins. These noncanonical mechanisms by cytokine receptors suggest their importance and are discussed in this review.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Review
Genetics & Heredity
Abdolmajid Ghasemian, Hadeel A. Omear, Yaser Mansoori, Pardis Mansouri, Xinpei Deng, Farzaneh Darbeheshti, Elham Zarenezhad, Maryam Kohansal, Babak Pezeshki, Zhangling Wang, Hailin Tang
Summary: Colorectal cancer is a fatal cancer, and lncRNAs play regulatory roles in cell proliferation and immune responses via the JAK/STAT signaling pathway, making them potential biomarkers and therapeutic targets.
FRONTIERS IN GENETICS
(2023)
Article
Pharmacology & Pharmacy
N. P. Syamprasad, Nitin Madje, Jayasri Bachannagari, Arun Kumar Jannu, Siddhi Jain, Kalyani Tene, P. A. Shantanu, V. G. M. Naidu, Naveen Chella
Summary: The current therapy for gastrointestinal stromal tumors is limited in its efficacy and resistance. In this study, the potential of the signal transducer and activator of transcription 3 (STAT3) inhibitor, niclosamide, to treat gastrointestinal stromal tumors was explored. Nanocrystals of niclosamide were developed to improve solubility and bioavailability. The study demonstrated that niclosamide induced dose-dependent cytotoxicity, mitochondrial damage, and apoptotic-like cell death in gastrointestinal stromal tumor cells. Niclosamide nanocrystals showed enhanced anticancer activity compared to pure niclosamide. Furthermore, niclosamide nanocrystals exhibited better tumor suppression, indicating higher bioavailability. This study suggests that nanocrystals could be a promising delivery strategy for niclosamide in treating gastrointestinal stromal tumors.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Immunology
I-Hsin Huang, Wen-Hung Chung, Po-Chien Wu, Chun-Bing Chen
Summary: Atopic dermatitis is a chronic, inflammatory, pruritic skin disease that significantly affects patients' quality of life. The JAK-STAT pathway plays a crucial role in the pathogenesis of AD, and targeting this pathway may alleviate inflammation and itchiness. Topical and oral JAK inhibitors offer promising therapeutic options for AD treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Grace L. Wong, Sara G. Manore, Daniel L. Doheny, Hui-Wen Lo
Summary: Breast cancer is a common and deadly disease in women, and the STAT family of transcription factors, especially STAT3, plays a critical role in its development and progression. Targeting STAT proteins for cancer treatment presents significant opportunities and challenges.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Sun Young Moon, Kwang Dong Kim, Jiyun Yoo, Jeong-Hyung Lee, Cheol Hwangbo
Summary: Inflammatory bowel disease (IBD) encompasses Crohn's disease (CD) and ulcerative colitis (UC), with cytokines playing a crucial role in the pathological processes of IBD through the JAK and STAT signaling pathways. Small molecules inhibiting JAK have been used in clinical trials, and phytochemicals have shown potential as new drugs for IBD treatment.
Article
Oncology
Tarek M. A. Abdel-Fatah, Reuben J. Broom, Jun Lu, Paul M. Moseley, Baiqu Huang, Lili Li, Suling Liu, Longxin Chen, Runlin Z. Ma, Wenming Cao, Xiaojia Wang, Yan Li, Jo K. Perry, Mohammed Aleskandarany, Christopher C. Nolan, Emad A. Rakha, Peter E. Lobie, Stephen Y. T. Chan, Ian O. Ellis, Le-Ann Hwang, David P. Lane, Andrew R. Green, Dong-Xu Liu
BRITISH JOURNAL OF CANCER
(2019)
Article
Biotechnology & Applied Microbiology
Elsie C. Jacobson, Ralph S. Grand, Jo K. Perry, Mark H. Vickers, Ada L. Olins, Donald E. Olins, Justin M. O'Sullivan
Article
Genetics & Heredity
Elsie C. Jacobson, Lekha Jain, Mark H. Vickers, Ada L. Olins, Donald E. Olins, Jo K. Perry, Justin M. O'Sullivan
G3-GENES GENOMES GENETICS
(2019)
Article
Biochemical Research Methods
Yue Wang, Ries J. Langley, Kyle Tamshen, Stephen M. Jamieson, Man Lu, Heather D. Maynard, Jo K. Perry
BIOCONJUGATE CHEMISTRY
(2020)
Article
Biochemical Research Methods
Kyle Tamshen, Yue Wang, Stephen M. F. Jamieson, Jo K. Perry, Heather D. Maynard
BIOCONJUGATE CHEMISTRY
(2020)
Article
Clinical Neurology
William Schierding, Sophie Farrow, Tayaza Fadason, Oscar E. E. Graham, Toni L. Pitcher, Sara Qubisi, Alan J. Davidson, Jo K. Perry, Tim J. Anderson, Martin A. Kennedy, Antony Cooper, Justin M. O'Sullivan
MOVEMENT DISORDERS
(2020)
Editorial Material
Endocrinology & Metabolism
Mark H. Vickers, Jo K. Perry
Article
Biochemistry & Molecular Biology
Yue Wang, Ries J. Langley, Kyle Tamshen, Julia Harms, Martin J. Middleditch, Heather D. Maynard, Stephen M. F. Jamieson, Jo K. Perry
Summary: The study successfully generated a novel PEGylated GHR antagonist by site-specific attachment of mPEG maleimide at an introduced cysteine residue, effectively reducing serum IGF-I levels in vivo.
Article
Biology
Daniel Ho, Denis M. Nyaga, William Schierding, Richard Saffery, Jo K. Perry, John A. Taylor, Mark H. Vickers, Andreas W. Kempa-Liehr, Justin M. O'Sullivan
Summary: A machine learning approach was developed to rank tissue-specific gene regulatory effects for T1D SNPs, identifying an eQTL associated with changes to AP4B1-AS1 transcript levels in lung tissue as making the largest gene regulatory contribution to T1D risk. The strongest tissue-specific eQTL effects were observed in lung tissue, potentially explaining associations between respiratory infections and risk of islet autoantibody seroconversion in young children.
COMMUNICATIONS BIOLOGY
(2021)
Review
Oncology
Michael Pudjihartono, Jo K. Perry, Cris Print, Justin M. O'Sullivan, William Schierding
Summary: This study reviews the research on non-coding mutations and emphasizes the importance of interpreting and prioritizing different regulatory data types to deepen our understanding of novel mechanisms driving cancer.
CLINICAL EPIGENETICS
(2022)
Review
Oncology
Yue Wang, Stephen M. F. Jamieson, Jo K. Perry
Summary: Published research supports the role of growth hormone in cancer, leading to increasing interest in targeting growth hormone in oncology. Growth hormone receptor antagonists have shown efficacy in xenograft studies as single agents or in combination with other anticancer therapies. However, there are challenges in using growth hormone receptor antagonists in preclinical models, such as identifying predictive biomarkers for selecting patients and monitoring drug efficacy.
ENDOCRINE-RELATED CANCER
(2023)
Article
Cell Biology
Lekha Jain, Mark H. Vickers, Bincy Jacob, Martin J. Middleditch, Daria A. Chudakova, Austen R. D. Ganley, Justin M. O'Sullivan, Jo K. Perry
Summary: Growth hormone (GH) activates downstream signalling by binding to its cell-surface receptor, the GH receptor (GHR). However, nuclear localization of GHR has been observed and linked to increased cancer cell proliferation. In this study, the authors investigated the functional implications of GHR nuclear translocation in two cancer cell lines and identified potential interactions with chromatin factors. The findings suggest that GHR nuclear translocation might mediate GH actions by influencing downstream transcriptional programs.
JOURNAL OF CELL COMMUNICATION AND SIGNALING
(2023)
Review
Biochemistry & Molecular Biology
Man Lu, Jack U. Flanagan, Ries J. Langley, Michael P. Hay, Jo K. Perry
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2019)
Review
Public, Environmental & Occupational Health
E. Jacobson, M. H. Vickers, J. K. Perry, J. M. O'Sullivan
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2018)
Review
Endocrinology & Metabolism
Shutan Liao, Mark H. Vickers, Joanna L. Stanley, Philip N. Baker, Jo K. Perry
