Article
Endocrinology & Metabolism
Yongjing Cheng, Jianhui Xu, Ruixin Zeng, Xi Zhao, Wenmin Gao, Junru Quan, Xiaosong Hu, Ziling Shen, Jie Zhang
Summary: The enzymes COX-2 and mPGES-1 were upregulated in the LPBN, and pharmacological inhibition attenuated LPS-induced fever. Direct administration of PGE(2) in the LPBN induced a febrile response with increased EE, BAT thermogenesis, and shivering. Neurons in different LPBN subnuclei showed varied responses to PGE(2) modulation, indicating its role in LPS-induced fever.
NEUROENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Janin Henkel, Julia Klauder, Meike Statz, Anne-Sophie Wohlenberg, Sonja Kuipers, Madita Vahrenbrink, Gerhard Paul Pueschel
Summary: The study found that a mix of palmitate, insulin, and PGE(2) in dysfunctional adipose tissue can induce the production of the pro-inflammatory cytokine IL-8. Insulin and PGE(2) amplify the effect of palmitate on IL-8 induction, exacerbating inflammation and insulin resistance.
Article
Endocrinology & Metabolism
Yongjing Cheng, Jianhui Xu, Ruixin Zeng, Xi Zhao, Wenmin Gao, Junru Quan, Xiaosong Hu, Ziling Shen, Jie Zhang
Summary: The LPBN plays a role in fever induced by LPS through the upregulation of COX-2 and mPGES-1, with PGE(2) mediating fever by modulating the firing rate of neurons in different LPBN subnuclei.
NEUROENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yanxia Li, Jing Zhao, Yuan Yin, Ke Li, Chenchen Zhang, Yajuan Zheng
Summary: Fibrosis is a detrimental outcome of most chronic inflammatory disorders, and IL-6 plays a significant role in these diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Medicine, Research & Experimental
Hui Cheng, Haoyan Huang, Zhikun Guo, Ying Chang, Zongjin Li
Summary: PGE2 plays a crucial role in tissue regeneration by promoting the regeneration of various organ systems through activation of endogenous stem cells, immune regulation, and angiogenesis. Understanding the modulation of tissue regeneration by PGE2 and enhancing its regenerative efficiency are crucial for tissue repair and regeneration processes.
Article
Biochemistry & Molecular Biology
Yifan Tu, Xiaodong Li, Yuanzheng Fu, Yunyun Chen, Hui Fang, Yuan Li, Ying Gu, Jiawei Zhang
Summary: Isocorydine (ICD), an isoquinoline alkaloid, shows potential effects in reducing IL-6 expression and protecting mice from acute lung injury by attenuating the phosphorylation of p65 and JNK in BMDMs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Weixuan Wang, Mingjie Liang, Lexun Wang, Weijian Bei, Xianglu Rong, Jianqin Xu, Jiao Guo
Summary: Atherosclerosis, a trigger of cardiovascular disease, is a serious threat to human health. Abnormal phenotypic regulation of macrophages is considered the pathological basis of atherosclerosis. Recent studies have shown that PGE2 promotes anti-inflammatory M2 macrophage polarization and mitigates atherosclerosis progression, but the mechanisms by which PGE2 acts remain unclear.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Weibing Tang, Minjian Chen, Xuejiang Guo, Kun Zhou, Zechao Wen, Fengli Liu, Xiang Liu, Xiaohua Mao, Xiaowei He, Weiyue Hu, Xian Sun, Junwei Tang, Hongxing Li, Richard Allen I. I. I. I. White, Wei Lv, Pin Wang, Bo Hang, Rongli Sun, Xinru Wang, Yankai Xia
Summary: This study found that levels of PGE2, expression of EP2 receptor, and PTGS1 and PTGES synthesis enzyme genes increased in HSCR colon tissues, while the synthesis of PGE2-related byproducts decreased. In vivo, pregnant mice treated with PGE2 gave birth to offspring with reduced ganglion cells in their colon and impaired gut function; in vitro, blocking EP2 reversed PGE2-inhibited cell migration.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Nutrition & Dietetics
Kyeong-Min Kim, So-Yeon Kim, Tamanna Jahan Mony, Ho Jung Bae, Sang-Deok Han, Eun-Seok Lee, Seung-Hyuk Choi, Sun Hee Hong, Sang-Deok Lee, Se Jin Park
Summary: The study demonstrates that Dracocephalum moldavica ethanol extract (DMEE) exerts anti-inflammatory effects on LPS-stimulated RAW 264.7 macrophages and anti-septic effects in septic mouse models through inhibition of the ERK/JNK/NF-kappa B signaling cascades and IL-6 production.
Article
Multidisciplinary Sciences
Oleksi Petrenko, Jinyu Li, Velasco Cimica, Patricio Mena-Taboada, Ha Youn Shin, Stephen D'Amico, Nancy C. Reich
Summary: IL-6 is a critical tumor promoter in early stages of B cell lymphomagenesis, inhibiting tumor suppressors BIM and PTEN to advance MYC-driven B cell tumorigenesis.
Article
Multidisciplinary Sciences
Coral Garcia-Pastor, Selma Benito-Martinez, Ricardo J. Bosch, Ana B. Fernandez-Martinez, Francisco J. Lucio-Cazana
Summary: Proximal tubular cells (PTC) are vulnerable to hypoxia-induced apoptosis, which may be a crucial factor in kidney diseases. Research has shown that apoptosis under hypoxia is mediated by COX-2-dependent production of PGE(2), suggesting potential new therapeutic targets for preventing hypoxia-dependent lesions in renal diseases.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Lisa Z. Fang, Victoria Linehan, Maria Licursi, Christian O. Alberto, Jacob L. Power, Matthew P. Parsons, Michiru Hirasawa
Summary: Hypothalamic inflammation can exacerbate obesity and fatty liver by stimulating appetite-promoting neurons.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Anders Blomqvist
Summary: We have recently shown that prostaglandin production in brain endothelial cells is essential for fever generation during systemic immune challenge. In this discussion, I examine the implications of this finding in relation to previous studies and highlight unresolved issues.
DNA AND CELL BIOLOGY
(2023)
Article
Reproductive Biology
Lea Magdalena Rempel, Hanna Korber, Iris M. Reichler, Orsolya Balogh, Sandra Goericke-Pesch
Summary: The study found no significant difference in PGE2 production and signaling between PUI and OD, indicating that altered uterine PTGES, PTGER2, PTGER4, HPGD, and PGT expression may not be the cause of PUI. However, higher PTGES expression in PUI-N compared to OD may point to a potential role of PGE2 during parturition, while higher PTGES expression in PUI-N compared to PUI-S/L suggests an influence of litter size.
Article
Multidisciplinary Sciences
Jessica A. Osterhout, Vikrant Kapoor, Stephen W. Eichhorn, Eric Vaughn, Jeffrey D. Moore, Ding Liu, Dean Lee, Laura A. DeNardo, Liqun Luo, Xiaowei Zhuang, Catherine Dulac
Summary: This study identifies a previously uncharacterized population of neurons in the brain that are activated after infection, playing a crucial role in generating fever response and other sickness symptoms. By examining gene expression and electrophysiological measurements, the researchers uncover a mechanism where these neurons are influenced by immune signals released by non-neuronal cells during infection and are functionally connected to brain areas controlling body temperature and appetite.
Article
Biochemistry & Molecular Biology
Elahe Mirrasekhian, Johan L. A. Nilsson, Kiseko Shionoya, Anders Blomgren, Peter M. Zygmunt, David Engblom, Edward D. Hoegestaett, Anders Blomqvist
Article
Medicine, Research & Experimental
Anna Mathia Klawonn, Michael Fritz, Anna Nilsson, Jordi Bonaventura, Kiseko Shionoya, Elahe Mirrasekhian, Urban Karlsson, Maarit Jaarola, Bjorn Granseth, Anders Blomqvist, Michael Michaelides, David Engblom
JOURNAL OF CLINICAL INVESTIGATION
(2018)
Review
Clinical Neurology
Anders Blomqvist, David Engblom
Article
Immunology
Joanna Zajdel, Adriano Zager, Anders Blomqvist, David Engblom, Kiseko Shionoya
BRAIN BEHAVIOR AND IMMUNITY
(2019)
Article
Biochemistry & Molecular Biology
Claus Brandt, Hendrik Nolte, Sinika Henschke, Linda Engstroem Ruud, Motoharu Awazawa, Donald A. Morgan, Paula Gabel, Hans-Georg Sprenger, Martin E. Hess, Stefan Guenther, Thomas Langer, Kamal Rahmouni, Henning Fenselau, Marcus Krueger, Jens C. Bruening
Article
Endocrinology & Metabolism
Fredrik Anesten, Devesh Mishra, Adria Dalmau Gasull, Linda Engstroem-Ruud, Jakob Bellman, Vilborg Palsdottir, Fuping Zhang, Stefan Trapp, Karolina P. Skibicka, Matti Poutanen, John-Olov Jansson
NEUROENDOCRINOLOGY
(2019)
Article
Immunology
Lea Chaskiel, Adrian D. Bristow, Rose-Marie Bluthe, Robert Dantzer, Anders Blomqvist, Jan Pieter Konsman
BRAIN BEHAVIOR AND IMMUNITY
(2019)
Article
Cell Biology
Johan Ruud, Jens Alber, Anna Tokarska, Linda Engstroem Ruud, Hendrik Nolte, Nasim Biglari, Rachel Lippert, Anne Lautenschlager, Przemyslaw E. Ciealak, Lukasz Szumiec, Martin E. Hess, Hella S. Broenneke, Marcus Krueger, Hans Nissbrandt, Tatiana Korotkova, Gilad Silberberg, Jan Rodriguez Parkitna, Jens C. Bruening
Article
Multidisciplinary Sciences
Linda Engstroem Ruud, Mafalda M. A. Pereira, Alain J. de Solis, Henning Fenselau, Jens C. Bruening
NATURE COMMUNICATIONS
(2020)
Article
Chemistry, Medicinal
Johan L. A. Nilsson, Christophe Mallet, Kiseko Shionoya, Anders Blomgren, Anders P. Sundin, Lars Grundemar, Ludivine Boudieu, Anders Blomqvist, Alain Eschalier, Ulf J. Nilsson, Peter M. Zygmunt
Summary: Research suggests that analgesics and antipyretics without liver toxicity can be derived from paracetamol, showing potential for future applications. Paracetamol exhibits separate mechanisms for producing antipyretic and analgesic effects, which may lead to better therapeutic benefits for various conditions.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Neurosciences
Anna Eskilsson, Kiseko Shionoya, David Engblom, Anders Blomqvist
Summary: The study found that fever during localized inflammation is not mediated by neural signaling, but rather relies on humoral signaling involving interleukin actions on brain endothelial cells, potentially facilitating PGE(2) entry into the brain from the circulation, representing a mechanism distinct from that during systemic inflammation.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Karin H. Nilsson, Petra Henning, Maha El Shahawy, Maria Nethander, Thomas Levin Andersen, Charlotte Ejersted, Jianyao Wu, Karin L. Gustafsson, Antti Koskela, Juha Tuukkanen, Pedro P. C. Souza, Jan Tuckermann, Mattias Lorentzon, Linda Engstrom Ruud, Terho Lehtimaki, Jon H. Tobias, Sirui Zhou, Ulf H. Lerner, J. Brent Richards, Sofia Moverare-Skrtic, Claes Ohlsson
Summary: Genetic association signals at the RSPO3 locus are linked to fracture risk in humans. Studies show that the fracture-reducing allele at the RSPO3 locus leads to increased RSPO3 expression, reducing the risk of fractures.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Anders Blomqvist
Summary: We have recently shown that prostaglandin production in brain endothelial cells is essential for fever generation during systemic immune challenge. In this discussion, I examine the implications of this finding in relation to previous studies and highlight unresolved issues.
DNA AND CELL BIOLOGY
(2023)
Biographical-Item
Neurosciences
Anders Blomqvist, Henry C. Evrard, Jonathan O. Dostrovsky, Irina A. Strigo, Wilfrid Jaenig
Summary: Bud Craig, an exceptional neuroscientist, made unique contributions to the fields of pain and interoception. His research challenged major dogmas and provided powerful explanations for central pain and subjective awareness of feelings, significantly impacting our understanding of consciousness.
NATURE NEUROSCIENCE
(2023)
Article
Cell Biology
Celine E. Riera, Eva Tsaousidou, Jonathan Halloran, Patricia Follett, Oliver Hahn, Mafalda M. A. Pereira, Linda Engstroem Ruud, Jens Alber, Kevin Tharp, Courtney M. Anderson, Hella Broenneke, Brigitte Hampel, Carlos Daniel de Magalhaes Filho, Andreas Stahl, Jens C. Bruening, Andrew Dillin