Article
Thermodynamics
Y. Xia, T. Liu, W. Gao, W. Lin, Q. Li, X. Ding
Summary: This study numerically investigates the behavior of weak axisymmetric fountains in homogeneous fluid with coexistent temperature and concentration effects. The results show that the maximum fountain height, fountain upflow width, and whole fountain width decrease with increasing buoyancy ratio representing the relative contribution of concentration to density. However, when the Froude number defined with temperature only becomes larger, these parameters increase due to reduced overall negative buoyancy. The Reynolds number has a strong effect on these parameters, with larger values leading to increased values. Additionally, the existing scaling relations for the maximum fountain height are applicable for fountains with density coming from both temperature and concentration when the overall Froude number is less than or similar to 2.0.
CASE STUDIES IN THERMAL ENGINEERING
(2022)
Article
Thermodynamics
Liqiang Dong, Wenxian Lin, Mehdi Khatamifar
Summary: This study analyzed the long-term behavior of weak round fountains in a cylindrical container using numerical simulation, identifying different development stages and key parameters involved. Fr = 1 and 2 were determined as critical values to distinguish behaviors, while Re = 200 was identified as a critical value to distinguish the influence of Reynolds number.
CASE STUDIES IN THERMAL ENGINEERING
(2021)
Article
Green & Sustainable Science & Technology
Madison D. Horgan, H. Alex Hsain, Jacob L. Jones, Khara D. Grieger
Summary: Analysis of the environmental, health, and societal impacts of lead-free piezoelectrics is crucial for materials development. The screening-level EMRA approach proposed in this paper is used to compare mining and processing routes for hafnia, a potential replacement for PZT, and identify the more sustainable route.
SUSTAINABLE MATERIALS AND TECHNOLOGIES
(2023)
Review
Psychology, Multidisciplinary
Rene Tanious, Pierre Gerain, Wolfgang Jacquet, Elke Van Hoof
Summary: This article provides a scoping review on life skills development and transfer in emerging adults. The findings indicate limited research on the definition and transfer of life skills, with a focus on vulnerable populations. The most frequently mentioned life skills include budgeting/finances, communication, problem-solving, decision-making, and emotional regulation.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Mathematics, Applied
Robert Steglinski
Summary: The paper discusses a double phase problem in R-N space, provides a new functional setting, and proves the existence of infinitely many solutions using the Fountain and Dual Fountain Theorem. The results extend recent work in the field.
NONLINEAR ANALYSIS-THEORY METHODS & APPLICATIONS
(2022)
Review
Chemistry, Multidisciplinary
Yu Ding, Zhenqian Pang, Kai Lan, Yuan Yao, Guido Panzarasa, Lin Xu, Marco Lo Ricco, Douglas R. Rammer, J. Y. Zhu, Ming Hu, Xuejun Pan, Teng Li, Ingo Burgert, Liangbing Hu
Summary: The building sector is responsible for a significant amount of global energy-related CO2 emissions. Developing carbon-storage materials and novel designs using wood has the potential to address sustainability challenges and mitigate climate change.
Article
Environmental Sciences
Panpan Cheng, Qiang Jin
Summary: This article evaluates the environmental and economic performance of four common technologies used in rural sewage treatment facilities in China. The results suggest that the anaerobic-anoxic-oxic process is the optimal scheme for lower environmental impact and cost-effectiveness. Electricity consumption during the operation phase was found to be the main contributor to environmental impact. Scenario analysis indicates that measures like reusing treated water and adjusting power structure could promote sustainable development of rural water environments.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Review
Food Science & Technology
Piotr Kulawik, Dani Dordevic
Summary: Sushi meals have been gaining popularity globally, leading to the emergence of new sushi production plants. However, the sushi industry faces challenges related to microbiological hazards. Research suggests that using novel minimal processing technologies can improve the shelf-life and quality of sushi meals while reducing microbiological risks.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Engineering, Electrical & Electronic
Zijun Qin, Zesong Fei, Jingxuan Huang, Yeliang Wang, Ming Xiao, Jinhong Yuan
Summary: In this paper, we investigate the application of reinforcement learning (RL) in online fountain codes and propose two schemes to reduce the overhead of full recovery with limited feedback. The first scheme, RL-based degree determination (RL-DD), uses RL to determine the optimal degree of coded symbols based on theoretical analysis. The second scheme, online fountain codes with no build-up phase using sectioned distribution (OFCNB-SD), eliminates the build-up phase and improves the decoder to utilize non-immediately decodable coded symbols. The simulation results demonstrate that our proposed schemes achieve lower full-recovery overhead compared to existing schemes.
IEEE TRANSACTIONS ON COMMUNICATIONS
(2023)
Article
Biology
Scott L. Nuismer, Andrew J. Basinski, Courtney Schreiner, Alexander Whitlock, Christopher H. Remien
Summary: The ecology and life history of wild animals influence their potential to harbor infectious disease. Average lifespan and viral mutation rate play a crucial role in the likelihood of animals serving as reservoirs for human infectious disease. Persistent infections and transient immune responses within the reservoir are more likely to lead to the emergence of viral pathogens.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Stephen C. Newbold, Madison Ashworth, David Finnoff, Jason F. Shogren, Linda Thunstroem
Summary: Two strategies for controlling an emerging epidemic are physical distancing and regular testing with self-isolation. Comparing the performance of these strategies in an integrated epidemiological and economic model, an optimized testing strategy was found to outperform an optimized distancing strategy, especially in the presence of superspreading events.
SCIENTIFIC REPORTS
(2023)
Article
Thermodynamics
Liqiang Dong, Wenxian Lin, Mehdi Khatamifar
Summary: The study investigates the behavior of 'fountain filling box' flow resulting from releasing a round fountain in a cylindrical container using high-speed cameras and flow visualization techniques. Results show the transition of the flow behavior from laminar to turbulent with increasing Fr, and the strengthening of turbulence with increasing Re. Additionally, the non-dimensionalized time-scale for the intrusion front to impinge upon the sidewall remains constant for Re greater than or similar to 500.
INTERNATIONAL JOURNAL OF HEAT AND FLUID FLOW
(2021)
Article
Computer Science, Information Systems
Muyun Yuan, Yue Qiao, Yusun Fu, Jinhui Tang
Summary: This article uses fountain code as application-layer coding to provide high-reliability low-latency deterministic communication for industrial cloud control systems (ICCSs). Simulation results show that the fountain code scheme, especially RaptorQ code, significantly improves communication reliability. Based on the performance difference of fountain codes between time-critical and non-time-critical use cases, a self-adaptive coding parameter selection method is proposed to better meet communication requirements and reduce coding cost.
IEEE INTERNET OF THINGS JOURNAL
(2023)
Article
Psychology, Multidisciplinary
Beatriz Soucase, Joaquin Garcia-Alandete, Cesar Rubio-Belmonte
Summary: The feeling of meaning in life is important for optimal psychological functioning. This study examined the relationship between presence and search for meaning and positive psychological variables in emerging adults, as well as gender differences. The results showed that presence of meaning was positively correlated with psychological well-being, life satisfaction, positive self-esteem, happiness, and negatively correlated with negative self-esteem. Search for meaning was negatively correlated with these variables and positively correlated with negative self-esteem. Women had higher scores on presence of meaning, while men had higher scores on self-esteem. The findings highlight the importance of promoting psychological well-being by fostering a sense of meaning in emerging adulthood.
CURRENT PSYCHOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Yuhan Zou, Xianzhong Yang, Lin Shen, Yiwen Su, Ziyan Chen, Xiang Gao, Jiang Zhou, Jingyu Sun
Summary: This review summarizes the emerging design strategies for directing the orientation of zinc deposition and elaborates on the mechanistic insights towards achieving highly reversible zinc anodes. The existing challenges and future outlook in this field are also proposed to envision the commercialization of AZIBs.
ENERGY & ENVIRONMENTAL SCIENCE
(2022)
Review
Oncology
Elena Astanina, Federico Bussolino, Gabriella Doronzo
Summary: TFEB is an emerging transcription factor in cancer biology, playing a crucial role in regulating tumor growth and development by controlling the autophagy-lysosomal pathway. Its dysregulation has been found to have a crucial pathogenic role in different tumors, promising potential new druggable vulnerabilities in cancer treatment.
MOLECULAR ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Elena Pontemezzo, Eleonora Foglio, Enza Vernucci, Alessandra Magenta, Marco D'Agostino, Sara Sileno, Elena Astanina, Federico Bussolino, Laura Pellegrini, Antonia Germani, Matteo Antonio Russo, Federica Limana
Summary: Recent research suggests that miR-200c-3p targets FSTL1 to regulate epicardial EMT and related processes, resulting in EMT, stemness, and migration of EMCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Peripheral Vascular Disease
Anna Gualandris, Alessio Noghero, Davide Cora', Elena Astanina, Marco Arese, Federico Bussolino
Summary: Embryonic stem cells can differentiate into endothelial cells with the help of FGF2 or BMP4 signaling pathways. TGF beta 1 and WNT6 are key regulators in FGF2 and BMP4-induced endothelial differentiation, respectively, as validated by loss-of-function experiments. These findings offer insights into the mechanisms of tumor angiogenesis and potential inhibition.
Article
Peripheral Vascular Disease
Camilla Ariano, Chiara Riganti, Davide Cora, Donatella Valdembri, Giulia Mana, Elena Astanina, Guido Serini, Federico Bussolino, Gabriella Doronzo
Summary: This article investigates the impact of oncogenic transcription factor EB (TFEB) on the adhesion of endothelial cells to the surrounding extracellular matrix (ECM). The study reveals that TFEB promotes turnover of ECM adhesion by regulating cholesterol metabolism, suggesting it may serve as a novel target for therapeutic control of pathological angiogenesis.
Review
Oncology
Valentina Foglizzo, Serena Marchio
Summary: Nanotechnology offers a solution to the limitations of conventional antitumor drugs by enabling targeted delivery and slow release of drugs, as well as development of cancer vaccines. Nanoparticle formulations have the potential to selectively kill cancer cells while sparing normal ones, making them promising tools for cancer therapy.
Article
Biochemistry & Molecular Biology
Elena Astanina, Federico Bussolino, Gabriella Doronzo
Summary: Transcription factor EB (TFEB) is an important transcription factor that not only has oncogenic activity, but also plays a role in regulating genetic programs in response to stress conditions and in cellular proliferation and motility. TFEB is considered as a hub in signaling networks involved in the development of many non-communicable diseases.
Review
Oncology
Valentina Foglizzo, Emiliano Cocco, Serena Marchio
Summary: Novel strategies for personalized cancer therapy are rapidly evolving. Researchers have developed model systems using patient-derived material to accurately represent the complexity of cancer, enhancing drug screening and treatment outcome prediction.
Article
Multidisciplinary Sciences
Elena Astanina, Gabriella Doronzo, Davide Cora, Francesco Neri, Salvatore Oliviero, Tullio Genova, Federico Mussano, Emanuele Middonti, Edoardo Vallariello, Chiara Cencioni, Donatella Valdembri, Guido Serini, Federica Limana, Eleonora Foglio, Andrea Ballabio, Federico Bussolino
Summary: This study investigates how the transcription factor EB (TFEB) regulates epithelial-mesenchymal transition (EMT) during heart development by tuning sensitivity to transforming growth factor (TGF) beta signaling. The authors find that TFEB activates the transcription of TGFβ/Smad pathway repressor Tgif1, promoting EMT. Furthermore, TFEB overexpression inhibits TGFβ-induced EMT, while loss of TFEB function enhances cellular sensitivity to TGFβ, leading to EMT.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Marco Arese, Federico Bussolino, Margherita Pergolizzi, Laura Bizzozero
Summary: This article provides an overview of the molecular cues and intracellular signaling involved in the interaction between cancer and the nervous system. These interactions occur through various mechanisms at different stages of tumor progression and share similarities with physiological processes of the nervous system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Elisabetta Marini, Marco Marino, Giulia Gionfriddo, Federica Maione, Marta Pandini, Daniele Oddo, Marta Giorgis, Barbara Rolando, Federica Blua, Simone Gastaldi, Serena Marchio, Sandra Kovachka, Francesca Spyrakis, Eleonora Gianquinto, Federica Di Nicolantonio, Massimo Bertinaria
Summary: In this study, a series of compounds were designed where the BRAF kinase inhibitor encorafenib was conjugated to pomalidomide through different linkers. The synthesized compounds maintained their ability to inhibit the kinase activity of mutated BRAF and showed inhibitory effects on tumor cell lines.
Article
Cell Biology
C. Ariano, F. Costanza, M. Akman, C. Riganti, D. Cora, E. Casanova, E. Astanina, V. Comunanza, F. Bussolino, G. Doronzo
Summary: Melanomas are characterized by dysregulation of MAPK pathway, glycolysis, and TCA cycle, and the oncogenic transcription factor EB (TFEB) controls melanoma tumor growth through regulating ERK1/2 activity and metabolism. TFEB negatively regulates DUSP-1, dephosphorylates ERK1/2, and inhibits melanoma cell proliferation. TFEB also influences glucose, glutamine, and cholesterol metabolism, affecting glycolysis, glutaminolysis, and oxidative phosphorylation. TFEB silencing impairs cholesterol synthesis, glucose and glutamine uptake, and reverses TCA cycle, leading to fatty acid production. In a melanoma model, TFEB silencing reduces tumor growth, increases DUSP-1 level, and inhibits ERK1/2 action, indicating the importance of TFEB in melanoma cell behavior and metabolic pathways.
CELL DEATH & DISEASE
(2023)
Article
Biology
Elena Astanina, Sara Petrillo, Tullio Genova, Federico Mussano, Federico Bussolino
Summary: X-ray computed microtomography (μCT) is a powerful tool for 3D visualization and morphometric analysis of tissues and organs. In this study, we present a method for μCT scanning of iodine-stained E15.5 mouse embryos to visualize and analyze the 3D structure of the embryonic heart.
Article
Biochemistry & Molecular Biology
Stefania Rosano, Sushant Parab, Alessio Noghero, Davide Cora, Federico Bussolino
Summary: Recent evidence suggests that noncoding RNAs are important for regulating angiogenesis. This study identified a noncoding RNA called LINC02802 that plays a critical role in regulating capillary sprouting. LINC02802 acts as a competing endogenous RNA with miR-486-5p to regulate the expression of the Mastermind-like-3 gene.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
