Article
Immunology
Eric Malmhall-Bah, Karin M. E. Andersson, Malin C. Erlandsson, Murali K. Akula, Mikael Brisslert, Clotilde Wiel, Ahmed E. El Zowalaty, Volkan I. Sayin, Martin O. Bergo, Maria I. Bokarewa
Summary: This study discovers an unexpected role of macrophages in stimulating the development of pro-inflammatory thymic Tregs and reveals that the activation of Rho-GTPases is behind their arthritogenic phenotype.
JOURNAL OF AUTOIMMUNITY
(2022)
Review
Cell Biology
Oona Paavolainen, Emilia Peuhu
Summary: The mammary gland undergoes dynamic remodeling during postnatal development and reproductive cycles, influenced by integrin adhesion receptors. Studies suggest that mechanosensing plays a crucial role in regulating mammary gland morphogenesis.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Physical
Mainak Chatterjee, Anirban Sain
Summary: Dynamic pattern formations in multicellular systems and embryos at their single-cell stage can be modeled using reaction-diffusion networks.
JOURNAL OF CHEMICAL PHYSICS
(2022)
Review
Oncology
Pontus Aspenstrom
Summary: For many years, the role of RHO GTPases in cancer has been overlooked, but recent studies have shown that they are altered in many cancer types and may have oncogenic effects. This review article summarizes the current knowledge of these mutant RHO GTPases, focusing on how their kinetics can contribute to cancer progression.
Article
Veterinary Sciences
Aolei Chen, Shaotang Ye, Jiahui Zheng, Jichao Li, Zejia Chen, Yashan Zhang, Shoujun Li
Summary: In this study, a cancerous HER2-enriched myoepithelial cell line from canine mammary tumor and a mammosphere developed from myoepithelial cells were successfully established. This novel cell line and its associated mammospheres could be used as a model to investigate the role of myoepithelial cells in the development of mammary tumors.
BMC VETERINARY RESEARCH
(2023)
Article
Multidisciplinary Sciences
Fabio Falleroni, Ulisse Bocchero, Simone Mortal, Yunzhen Li, Zhongjie Ye, Dan Cojoc, Vincent Torre
Summary: There is growing evidence that the mechanical properties of neurons play a crucial role in cellular processes. This study found that neurons are able to distinguish the magnitude of mechanical stimuli and respond with changes in intracellular calcium levels. Mechanically evoked responses require the influx of extracellular calcium through transmembrane ion channels. Furthermore, mechanical stimulation activates certain proteins involved in cellular signaling.
Article
Developmental Biology
Joana Paes de Faria, Raquel S. Vale-Silva, Reinhard Fassler, Hauke B. Werner, Joao B. Relvas
Summary: Pinch2 plays a crucial role in central nervous system myelination, preventing excessive myelin wrapping and promoting myelin stability. Loss of Pinch2 results in hypermyelination and pathological myelin outfoldings.
Article
Chemistry, Multidisciplinary
Huiping He, Chengjian Zhou, Xi Chen
Summary: This article introduces a targeted protein degradation method based on the autophagy pathway, which overcomes the limitations of current small-molecule degraders and can degrade unligandable proteins. By designing an intelligent nanobody chimera called ATNC, researchers have successfully achieved selective degradation of intracellular targets and demonstrated its therapeutic potential in suppressing ovarian cancer cell proliferation and migration.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Review
Immunology
Rana El Masri, Jerome Delon
Summary: Ras homology (RHO) GTPases play crucial roles in triggering multiple immune functions through interactions with effectors and kinases, and recent discoveries of new partners and genetic mutations in RHO GTPase signaling hubs offer novel therapeutic opportunities.
NATURE REVIEWS IMMUNOLOGY
(2021)
Article
Immunology
Robin Caire, Elisa Dalix, Marwa Chafchafi, Mireille Thomas, Marie-Therese Linossier, Myriam Normand, Alain Guignandon, Laurence Vico, Hubert Marotte
Summary: This study reveals the critical role of transcription co-factors YAP/TAZ in the signaling of pro-inflammatory cytokine TNF, and their involvement in biological effects associated with cancer and inflammatory disorders.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Chao Mei, Chong Liu, Ying Gao, Wen-Ting Dai, Wei Zhang, Xi Li, Zhao-Qian Liu
Summary: This study revealed that eIF3a is overexpressed in colorectal cancer tissues, and its high expression is associated with tumor metastasis and overall survival. Downregulation of eIF3a significantly inhibits the proliferation and migration of malignant cells. Mechanistically, eIF3a regulates Cdc42 and RhoA expression to promote actin cytoskeleton remodeling, facilitating cancer cell migration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Rocio G. Sampayo, Mason Sakamoto, Madeline Wang, Sanjay Kumar, David V. Schaffer
Summary: During the process of cell differentiation into tissues, cells are influenced by mechanical signals from the extracellular matrix (ECM), which regulate their fate. The activation of Rho GTPases plays a key role in sensing these cues, but the regulation and integration of the activation dynamics is still unclear. This study found that ECM stiffness cues not only alter the magnitude but also the temporal frequency of RhoA and Cdc42 activation in adult neural stem cells (NSCs). Further experiments using optogenetics showed that the frequency of RhoA and Cdc42 activation drives astrocytic versus neuronal differentiation, highlighting the functional significance of these dynamics.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Neurosciences
Pamela J. Urrutia, Felipe Bodaleo, Daniel A. Borquez, Yuta Homma, Victoria Rozes-Salvador, Cristopher Villablanca, Cecilia Conde, Mitsunori Fukuda, Christian Gonzalez-Billault
Summary: The acquisition of neuronal polarity is a complex process depending on cytoskeletal dynamics and membrane traffic regulation. A positive feedback loop between Rab8a and Cdc42, coupled by Tuba, plays a crucial role in ensuring single axon generation. These findings suggest Tuba coordinates vesicular traffic and cytoskeleton dynamics during neuronal polarization.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Cell Biology
Andrew J. Neumann, Rytis Prekeris
Summary: The regulation of machinery involved in cell migration is crucial for maintaining proper organism function. Among the various structures involved, the actin cytoskeleton plays a vital role in providing the forces necessary for cells to migrate. While the Rho family of GTPases are considered the major regulators, other proteins such as the Rab40 family have also been identified as modulators of actin structures and cell migration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Michael M. Sofroniou, Christopher A. Lemmon
Summary: Autocrine TGF-81 plays a critical role in FN fibril assembly in MCF10A epithelial cells, while malignant MDA-MB-231 cells assemble less FN into fibrils despite expressing and secreting more soluble FN.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2023)
Article
Dermatology
Van Tuan Nguyen, Dany Nassar, Frederic Batteux, Karine Raymond, Pierre-Louis Tharaux, Selim Aractingi
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2016)
Article
Developmental Biology
A. Lempereur, P. Y. Canto, C. Richard, S. Martin, J. Thalgott, K. Raymond, F. Lebrin, C. Drevon, T. Jaffredo
DEVELOPMENTAL BIOLOGY
(2018)
Article
Developmental Biology
Mejdi Moumen, Aurelie Chiche, Stephanie Cagnet, Valerie Petit, Karine Raymond, Marisa M. Faraldo, Marie-Ange Deugnier, Marina A. Glukhova
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
(2011)
Article
Biochemistry & Molecular Biology
S. Cagnet, M. M. Faraldo, M. Kreft, A. Sonnenberg, K. Raymond, M. A. Glukhova
Review
Cell Biology
Karine Raymond, Marisa M. Faraldo, Marie-Ange Deugnier, Marina A. Glukhova
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2012)
Article
Cardiac & Cardiovascular Systems
Jeremy H. Thalgott, Damien Dos-Santos-Luis, Anna E. Hosman, Sabrina Martin, Noel Lamande, Diane Bracquart, Samly Srun, Georgios Galaris, Hetty C. de Boer, Simon Tual-Chalot, Steven Kroon, Helen M. Arthur, Yihai Cao, Repke J. Snijder, Frans Disch, Johannes J. Mager, Ton J. Rabelink, Christine L. Mummery, Karine Raymond, Franck Lebrin
Article
Cell & Tissue Engineering
Mathilde Romagnoli, Stephanie Cagnet, Aurelie Chiche, Laura Bresson, Sylvain Baulande, Pierre de la Grange, Adele De Arcangelis, Maaike Kreft, Elisabeth George-Labouesse, Arnoud Sonnenberg, Marie-Ange Deugnier, Karine Raymond, Marina A. Glukhova, Marisa M. Faraldo
Correction
Cell & Tissue Engineering
Mathilde Romagnoli, Stephanie Cagnet, Aurelie Chiche, Laura Bresson, Sylvain Baulande, Pierre de la Grange, Adele De Arcangelis, Maaike Kreft, Elisabeth Georges-Labouesse, Arnoud Sonnenberg, Marie-Ange Deugnier, Karine Raymond, Marina A. Glukhova, Marisa M. Faraldo
Article
Cell & Tissue Engineering
Marga J. Bouma, Christian Freund, Adriaan P. IJzerman, Dorret I. Boomsma, Christine L. Mummery, Karine Raymond
STEM CELL RESEARCH
(2019)
Article
Cell & Tissue Engineering
Veronika Ramovs, Ignacia Fuentes, Christian Freund, Harald Mikkers, Christine L. Mummery, Karine Raymond
Summary: Fibroblasts from patients with a specific mutation were used to generate hiPSCs, which were then genetically corrected using CRISPR-Cas9 editing. The resulting cells showed typical morphology, expressed pluripotency-associated markers, had the ability for in vitro differentiation, and will facilitate modeling of KLHL24-associated conditions.
STEM CELL RESEARCH
(2021)
Article
Cell & Tissue Engineering
Veronika Ramovs, Hans Janssen, Ignacia Fuentes, Amandine Pitaval, Walid Rachidi, Susana M. Chuva de Sousa Lopes, Christian Freund, Xavier Gidrol, Christine L. Mummery, Karine Raymond
Summary: This study successfully generated hair-bearing skin organoids from hiPSC cells and characterized their epidermal-dermal junction (EDJ). The researchers found that the EDJs in the organoids lack type VII collagen, which should be considered when using these organoids for modeling epidermolysis bullosa.
Article
Microbiology
Pengfei Li, Spyridon T. Pachis, Guige Xu, Rick Schraauwen, Roberto Incitti, Annemarie C. de Vries, Marco J. Bruno, Maikel P. Peppelenbosch, Intikhab Alam, Karine Raymond, Qiuwei Pan
Summary: This study establishes human skin organoids as a robust experimental model for studying MPXV infection, mapping virus-host interactions, and testing therapeutics.
NATURE MICROBIOLOGY
(2023)
Meeting Abstract
Dermatology
S. Martin, G. Hasle, V. Nguyen, D. Baum, M. Oster, N. Lamande, S. Aractingi, F. Lebrin, K. Raymond
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2014)
Article
Dermatology
Karine Raymond, Sabrina Martin, Selim Aractingi, Franck Lebrin
EUROPEAN JOURNAL OF DERMATOLOGY
(2013)