Article
Dermatology
Ruchi Roy, Janet Zayas, F. Mohamed Mohamed, Anahita Aboonabi, Kaylee Delgado, Jennillee Wallace, Mohammad Bayat, Timothy M. Kuzel, Jochen Reiser, Sasha H. Shafikhani
Summary: Persistent inflammation is a major hindrance to healing in diabetic chronic wounds. However, the diabetic wound environment during the acute healing phase exhibits reduced macrophage response due to inadequate expression of CCL2 proinflammatory cytokine. In this study, it was found that short-term exposure to high glucose leads to rapid monocyte reprogramming through increased expression and secretion of IL-10, which transforms monocytes into an anti-inflammatory phenotype. Increased IL-10 expression in diabetic wounds during the acute healing phase inhibits toll-like receptor signaling and proinflammatory cytokine production, delaying macrophage and leukocyte responses and impairing healing. Blocking IL-10 signaling during the acute healing phase can improve toll-like receptor signaling, increase proinflammatory cytokine production, enhance macrophage and leukocyte responses, and stimulate healing in diabetic wounds.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Review
Medicine, Research & Experimental
Shahriar Sharifi, Mohammad Javad Hajipour, Lisa Gould, Morteza Mahmoudi
Summary: Chronic wounds pose challenges due to poor healing, bacterial infection, and inflammation imbalance. Current therapies have limitations, but nanomedicine offers promise by stimulating cellular and molecular mechanisms in the wound microenvironment. Incorporating nanomedicine into chronic wound management may provide opportunities for improved outcomes.
MOLECULAR PHARMACEUTICS
(2021)
Article
Endocrinology & Metabolism
Takayuki Nabeshima, Manabu Tsukamoto, Ke-Yong Wang, Yosuke Mano, Daisuke Arakawa, Kenji Kosugi, Takafumi Tajima, Yoshiaki Yamanaka, Hitoshi Suzuki, Makoto Kawasaki, Soshi Uchida, Eiichiro Nakamura, Kagaku Azuma, Akinori Sakai
Summary: The effect of COPD pathogenesis on bone fracture healing is unclear. This study found that delayed bone healing and impaired nuclear translocation of Nrf2 are involved in the delayed cortical bone healing in COPD mice. Sulforaphane, an Nrf2 activator, improved the delayed cortical bone healing in the mice model. These findings suggest that Nrf2 may be a potential target for bone fracture treatment in COPD patients.
Article
Hematology
Mansour Alkobtawi, Maria Sbeih, Karim Souaid, Qui Trung Ngo, Dany Nassar, Hugo Arbes, Henri Guillet, Anoosha Habibi, Pablo Bartolucci, Mathieu Castela, Selim Aractingi, Benedicte Oules
Summary: Leg ulcers are a major complication of sickle cell disease (SCD), and effective treatment options are limited. However, the study found that fetal microchimeric cells (FMC) can improve the healing of these ulcers by promoting angiogenesis. This suggests that FMC could be utilized as a potential therapy for post-partum SCD patients with leg ulcers.
Article
Pharmacology & Pharmacy
Jessica Salvo, Cristian Sandoval, Carolina Schencke, Francisca Acevedo, Mariano del Sol
Summary: This study aimed to investigate the effects of medical-grade honey with copper nanoparticles on the healing of infected or non-infected wounds. The results showed that the selected formulation had the same antibacterial potency as the medical-grade honey alone, and the addition of copper nanoparticles improved the maturation of collagen fibers and regulated the inflammatory process.
Review
Genetics & Heredity
Lei Yu, Jianxin Qin, Jiajun Xing, Zihao Dai, Tingting Zhang, Feng Wang, Jin Zhou, Xiaobai Zhang, Xia Chen, Yunjuan Gu
Summary: The morbidity of diabetes mellitus is increasing, leading to a growing economic burden of diabetic foot ulcers as a common complication. However, there is currently no standardized clinical treatment for this complication, and the efficacy of current treatments is unsatisfactory. Recent studies have shown that exosomes, which have low immunogenicity, high stability, and easy storage, promote diabetic wound healing through various pathways, such as promoting angiogenesis, collagen fiber deposition, and inhibiting inflammation. This article reviews the specific roles and mechanisms of different cell- or tissue-derived exosomes in wound healing and discusses the potential obstacles and solutions for future research on exosomes in the management of diabetic foot ulcers, aiming to provide novel insights and approaches for treatment.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Review
Endocrinology & Metabolism
Xiaoping Yu, Pan Liu, Zheng Li, Zhengdong Zhang
Summary: Diabetes is a global public health problem, with diabetic foot being one of its severe complications that have a significant impact on patients' economic burden and quality of life. Recent studies have shown that mesenchymal stem cells (MSCs) can effectively treat diabetic foot ulcers by promoting angiogenesis and re-epithelialization, regulating the immune response, and reducing inflammation. MSCs from different sources have similar characteristics and subtle differences, and understanding their features is crucial for improving the therapeutic effect of diabetic foot ulcers.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Dermatology
Raquel Marques, Marcos Lopes, Paulo Ramos, Joao Neves-Amado, Paulo Alves
Summary: This study aimed to identify prognostic factors for delayed healing of complex wounds, including pressure ulcers/injuries, venous leg ulcers, critical limb-threatening ischaemia, or diabetic foot ulcers. A total of 42 original peer-reviewed articles in the past 5 years were eligible for this scoping review. The most frequent prognostic factors found were gender, renal disease, diabetes, peripheral arterial disease, decline in activities of daily life, wound duration, wound area, wound location, high-stage WIfI classification, gangrene, infection, previous ulcers, and low ankle brachial index.
INTERNATIONAL WOUND JOURNAL
(2023)
Review
Pharmacology & Pharmacy
Jitao Chen, Penghui Ye, Rifang Gu, Huan Zhu, Wenjie He, Xingrui Mu, Xingqian Wu, Huiwen Pang, Felicity Han, Xuqiang Nie
Summary: This paper reviews the regulatory characteristics of neuropeptide substance P (SP) in normal and diabetic wound healing. SP actively regulates wound healing-related cells, exhibiting strong inflammatory properties, promoting cell proliferation and migration, and restoring skin cell activity and paracrine ability under diabetic conditions. Additionally, SP not only regulates healing-related cells but also orchestrates the immune environment, presenting unique and promising application prospects in wound intervention, particularly for diabetic foot ulcers (DFU) treatment.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Bao Hou, Yuanyuan Wen, Xuerui Zhu, Mengting Qi, Weiwei Cai, Bin Du, Haijian Sun, Liying Qiu
Summary: This study developed nanoparticles combining chitosan, vaccarin, and hypaphorine, which were effective in promoting the healing of chronic wounds.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Dermatology
Daniel Bormann, Alfred Gugerell, Hendrik Jan Ankersmit, Michael Mildner
Summary: Cell secretomes play an important role in wound healing by promoting regeneration. This study reviews the mechanisms of action of cell secretomes in wound healing, important preconditioning strategies to enhance therapeutic efficacy, and clinical trials on secretome-based wound healing.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Review
Emergency Medicine
Jessica Salvo, Cristian Sandoval
Summary: This review aims to explore the importance of copper nanoparticles in wound healing. Copper nanoparticles combat infection through multiple mechanisms and play a significant role in various stages of wound healing by modulating cytokines and growth factors.
Review
Cell Biology
Jiawei Feng, Jialin Wang, Yuqing Wang, Xiaoting Huang, Tengteng Shao, Xiaofei Deng, Yemin Cao, Mingmei Zhou, Cheng Zhao
Summary: This review explores the pathological mechanisms of delayed wound healing in diabetic ulcers, revealing the potential association between ferroptosis and diabetic ulcer healing delay, and proposes new treatment strategies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiaodan Hu, Lin Wang, Jiangzhi Deng, Haoyue Xu, Kai Song, Lingxue Bu, Baoxing Pang
Summary: Dietary nitrate can accelerate the healing of infected skin wounds by increasing microvascular density, promoting collagen deposition, and re-epithelialization. Our study found that 1 mmol/kg/d nitrate has a better therapeutic effect by increasing blood perfusion and promoting the formation of new blood vessels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Orthopedics
Xinyu Nie, Xiaocong Kuang, Guangwei Liu, Zhaowei Zhong, Yi Ding, Jie Yu, Jie Liu, Shanlang Li, Liexun He, Hongjie Su, Wencong Qin, Jinmin Zhao, Qikai Hua, Yan Chen
Summary: The study demonstrates that using distraction osteogenesis (TTT) can promote the healing of non-diabetic leg ulcers, reducing healing time and showing effectiveness compared to conventional surgeries.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2021)
Letter
Respiratory System
Raphael Porcher, Philippe Ravaud, Matthieu Resche-Rigon, Pierre-Louis Tharaux, Xavier Mariette, Olivier Hermine
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Cell Biology
Loic Louvet, Gaelle Lenglet, A. Michaela Krautzberger, Romuald Mentaverri, Frederic Hague, Clara Kowalewski, Nassim Mahtal, Julie Lesieur, Anne-Laure Bonnet, Caroline Andrique, Celine Gaucher, Cathy Gomila, Heinrich Schrewe, Pierre-Louis Tharaux, Said Kamel, Catherine Chaussain, Isabelle Six
Summary: In this study, we investigated the role of Vasn expression in vascular function. Vasn knockout mice showed decreases in blood pressure, angiotensin II levels, and vessel contractibility. In vitro experiments revealed that Vasn deficiency resulted in SMC contractile phenotype switching, changes in intracellular calcium levels, and impaired NO signaling. These findings highlight the importance of Vasn SMC expression in maintaining vascular functions.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Review
Urology & Nephrology
Nassim Mahtal, Olivia Lenoir, Claire Tinel, Dany Anglicheau, Pierre-Louis Tharaux
Summary: MicroRNAs (miRNAs) play important roles in the development of kidney diseases, including acute kidney injury, chronic kidney disease, and allograft injury. Dysregulation of miRNAs is involved in the pathophysiology of these conditions. miRNAs can serve as biomarkers for graft function and kidney disease development, and targeting specific miRNAs may be a promising therapeutic strategy.
NATURE REVIEWS NEPHROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jose Luis Morgado-Pascual, Beatriz Suarez-Alvarez, Vanessa Marchant, Pamela Basantes, Pierre-Louis Tharaux, Alberto Ortiz, Carlos Lopez-Larrea, Marta Ruiz-Ortega, Sandra Rayego-Mateos
Summary: This study found that the use of iBET drugs can reduce collagen accumulation in experimental glomerulosclerosis by inhibiting the accumulation and overexpression of collagen IV. The study also found that SOX9 plays an important role in kidney fibrosis, and iBET drugs can prevent the translocation of SOX9 into the nucleus. These findings provide further research evidence for the application of iBET drugs in the treatment of glomerulosclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Qian Wu, Euclides Sacomboio, Lara Valente de Souza, Rui Martins, Jamil Kitoko, Silvia Cardoso, Temitope W. Ademolue, Tiago Paixao, Jaakko Lehtimaki, Ana Figueiredo, Caren Norden, Pierre-Louis Tharaux, Guenter Weiss, Fudi Wang, Susana Ramos, Miguel P. Soares
Summary: Iron recycling is important in preventing anemia, and its role in preventing anemia during infection is unclear. In severe Plasmodium falciparum malaria, acute kidney injury (AKI) is associated with life-threatening anemia. A study using a rodent model shows that renal proximal tubule epithelial cells (RPTECs) have the ability to store and recycle iron during P. chabaudi chabaudi (Pcc) infection, preventing the onset of life-threatening malarial anemia.
Editorial Material
Urology & Nephrology
Olivia Lenoir, Tobias B. Huber, Pierre -Louis Tharaux
KIDNEY INTERNATIONAL
(2023)
Article
Hematology
Brigitte Ranque, Mor Diaw, Abdoul Karim Dembele, Claudine Lapoumeroulie, Lucile Offredo, Oumar Tessougue, Serigne Mourtalla Gueye, Dapa Diallo, Saliou Diop, Yves Colin-Aronovicz, Xavier Jouven, Olivier Blanc-Brude, Pierre-Louis Tharaux, Sylvain Le Jeune, Philippe Connes, Marc Romana, Caroline Le Van Kim
Summary: This study investigated the associations between microvascular function, haemolysis markers, blood viscosity, and various types of SCA-related organ damage in a multicenter sub-Saharan African cohort. Among the 235 patients studied, no specific pattern of SCA-related complications was identified, and new biomarkers are needed to predict SCA clinical expression in resource-limited settings, such as Africa.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Pierre Nivoit, Thomas Mathivet, Junxi Wu, Yann Salemkour, Devanarayanan Siva Sankar, Veronique Baudrie, Jennifer Bourreau, Anne-Laure Guihot, Emilie Vessieres, Mathilde Lemitre, Cinzia Bocca, Jeremie Teillon, Morgane Le Gall, Anna Chipont, Estelle Robidel, Neeraj Dhaun, Eric Camerer, Pascal Reynier, Etienne Roux, Thierry Couffinhal, Patrick W. F. Hadoke, Jean-Sebastien Silvestre, Xavier Guillonneau, Philippe Bonnin, Daniel Henrion, Joern Dengjel, Pierre-Louis Tharaux, Olivia Lenoir
Summary: Dysregulated autophagy is associated with cardiovascular and metabolic diseases. Our study reveals the complex mechanisms by which autophagy regulates endothelial functions and demonstrates its crucial role in flow-mediated outward arterial remodeling, prevention of neointima formation, and recovery after myocardial infarction. These findings highlight the fundamental role of autophagy in endothelial function and its connection to cellular proteostasis and mechanosensing.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Medicine, Research & Experimental
Nuria Dolade, Sandra Rayego-Mateos, Alicia Garcia-Carrasco, Maryse Guerin, Jose-Luis Martin-Ventura, Marta Ruiz-Ortega, Pierre -Louis Tharaux, Jose Manuel Valdivielso
Summary: In chronic kidney disease (CKD), atherosclerotic cardiovascular disease is accelerated, but the specific CKD-related risk factors for atherosclerosis are unknown. This study found that down-regulation of BTLA may be associated with the incidence and progression of atherosclerosis in CKD patients.
Article
Urology & Nephrology
Yann Salemkour, Dilemin Yildiz, Lea Dionet, Daan C. 't Hart, Kim A. T. Verheijden, Ryuta Sato, Nassim Mahtal, Jean-Daniel Delbet, Emmanuel Letavernier, Marion Rabant, Alexandre Karras, Johan van der Vlag, Tom Nijenhuis, Pierre-Louis Tharaux, Olivia Lenoir
Summary: This study reveals a new mechanism linking TRPC6 and calpain activity to impaired podocyte autophagy, podocyte injury, and proteinuria in diabetic kidney disease. Targeting TRPC6 and/or calpain to restore podocyte autophagy may offer a promising therapeutic strategy for diabetic kidney disease.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Medicine, General & Internal
Alexandre Loupy, Valentin Goutaudier, Alessia Giarraputo, Fariza Mezine, Erwan Morgand, Blaise Robin, Karen Khalil, Sapna Mehta, Brendan Keating, Amy Dandro, Anais Certain, Pierre-Louis Tharaux, Navneet Narula, Renaud Tissier, Sebastien Giraud, Thierry Hauet, Harvey Pass, Aurelie Sannier, Ming Wu, Adam Griesemer, David Ayares, Vasishta Tatapudi, Jeffrey Stern, Carmen Lefaucheur, Patrick Bruneval, Massimo Mangiola, Robert A. Montgomery
Summary: We conducted a comprehensive phenotyping of pig kidney xenografts transplanted to deceased humans. Our findings suggest early signs of antibody-mediated rejection, characterized by microvascular inflammation, endothelial cell activation, and positive xenoreactive crossmatches.
Article
Microbiology
Pengfei Li, Spyridon T. Pachis, Guige Xu, Rick Schraauwen, Roberto Incitti, Annemarie C. de Vries, Marco J. Bruno, Maikel P. Peppelenbosch, Intikhab Alam, Karine Raymond, Qiuwei Pan
Summary: This study establishes human skin organoids as a robust experimental model for studying MPXV infection, mapping virus-host interactions, and testing therapeutics.
NATURE MICROBIOLOGY
(2023)
Meeting Abstract
Peripheral Vascular Disease
Sebastien Rubin, Aurelien Lorthioir, Jean Michel Halimi, Pierre Louis Tharaux, Cremer Antoine, Stephane Debeugny, Alexandre Persu, Gosse Philippe, Boulestreau Romain
JOURNAL OF HYPERTENSION
(2023)
Article
Immunology
Candie Joly, Delphine Desjardins, Raphael Porcher, Helene Pere, Thomas Bruneau, Qian Zhang, Paul Bastard, Aurelie Cobat, Lea Resmini, Olivia Lenoir, Laurent Savale, Camille Lecuroux, Celine Verstuyft, Anne-Marie Roque-Afonso, David Veyer, Gabriel Baron, Matthieu Resche-Rigon, Philippe Ravaud, Jean-Laurent Casanova, Roger Le Grand, Olivier Hermine, Pierre-Louis Tharaux, Xavier Mariette
Summary: This study examined the relationship between blood IFN-alpha 2 level, plasma SARS-CoV-2 viral load, and subsequent death in patients with severe and critical COVID-19. The findings suggest that patients with higher blood IFN-alpha 2 levels have higher viral loads, while the presence of neutralizing anti-IFN-alpha 2 auto-antibodies is associated with lower IFN-alpha 2 levels. Patients with a rapid decline in blood IFN-alpha 2 are at higher risk of death, and a high level of plasma SARS-CoV-2 RNA is associated with death risk in patients with severe COVID-19.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Raphael Degrave, Juliette Murris, Anais Charles-Nelson, Olivier Hermine, Raphael Porcher, Philippe Ravaud, Xavier Mariette, Pierre-Louis Tharaux, Matthieu Resche-Rigon, Olivier Sanchez, Sandrine Katsahian, Jean-Benoit Arlet
Summary: This study found that diabetes and high CRP level were risk factors for arterial and venous thromboses in COVID-19 pneumonia patients hospitalized in general wards. Obesity was not associated with a higher risk of thrombosis. Higher doses of anticoagulants could be considered in these high-risk patients, opening up opportunities for interventional studies.
POSTGRADUATE MEDICAL JOURNAL
(2023)