期刊
ELECTROCHIMICA ACTA
卷 60, 期 -, 页码 95-101出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.electacta.2011.11.011
关键词
Furosemide; Multi-wall carbon nanotubes; Voltammetry; Pharmaceuticals; Urine
Electrochemical oxidation of loop diuretic furosemide (4-chloro-2-(furan-2-ylmethylamino)-5-sulfamoylbenzoic acid) was studied in 5.0 pH with 0.04 M Britton-Robinson buffer as supporting electrolyte at 25 +/- 0.1 degrees C at a multi-walled carbon nanotubes-paraffin oil paste electrode (CNTPE) using cyclic and differential-pulse voltammetric (DPV) techniques. The electrochemical process was observed to be adsorption controlled, irreversible and involving two-electron oxidation. Effects of anodic peak potential (E-pa), anodic peak current (I-pa) and heterogeneous rate constant (k(0)) have been discussed. Under optimal conditions, the peak current was proportional to furosemide concentration in the range of 8.0 x 10(-6) to 2.0 x 10(-4) M with a detection limit of 2.9 x 10(-7) M by differential pulse voltammetry. A differential pulse voltammetric method with good precision and accuracy was developed for the determination of furosemide in pharmaceutical formulations and urine as a real sample. (C) 2011 Elsevier Ltd. All rights reserved.
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