Article
Neurosciences
Siyi Liu, Ge Lin, Qiao Yang, Penghui Wang, Chao Ma, Xiaowei Qian, Xiaomei He, Zhangji Dong, Yan Liu, Mei Liu, Ronghua Wu, Liu Yang
Summary: This study aimed to evaluate the effects of SASH1 knockdown on functional recovery after SCI and investigate its mechanism in facilitating axonal growth. The results show that SASH1 downregulation improved hindlimb motor function and reduced glial activation. In cultured spinal astrocytes, SASH1 knockdown decreased interferon-gamma release and increased BDNF release, leading to increased axonal growth. Furthermore, SASH1 depletion maintained high levels of Nestin protein and increased BDNF release in differentiated NSCs.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Hung-Chieh Lee, Wei-Lin Lai, Cheng-Yung Lin, Chih-Wei Zeng, Jin-Chuan Sheu, Tze-Bin Chou, Huai-Jen Tsai
Summary: ANP32a plays a positive role in the regeneration of zebrafish spinal cord injury embryos, promoting spinal cord regeneration and resumption of swimming capability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Ciro De Luca, Assunta Virtuoso, Sohaib Ali Korai, Raffaella Cirillo, Francesca Gargano, Michele Papa, Giovanni Cirillo
Summary: The maladaptive response of the central nervous system following nerve injury is primarily linked to the activation of glial cells that produce an inflammatory reaction and remodeling. Glial acidic fibrillary protein (GFAP) is significantly upregulated in the spinal cord after nerve injury and may play a crucial role in neuroinflammation and morpho-functional-metabolic rewiring. Understanding the maladaptive changes in glial cells could open up new avenues for studying CNS diseases.
Article
Neurosciences
Tingting Fan, Ying Yu, Yong-long Chen, Pan Gu, Stanley Wong, Zheng-yuan Xia, Jessica Aijia Liu, Chi-wai Cheung
Summary: Diabetes patients with painful diabetic neuropathy (PDN) exhibit spinal atrophy and degeneration of astrocytes, leading to pain hypersensitivity. The impaired acetylation of STAT3 in astrocytes and aberrant activation of HDAC5 promote astrocyte deficiency, contributing to the development of PDN in a rat model of type 1 diabetes (T1D). Restoring STAT3 signaling or inhibiting HDAC5 rescues astrocyte deficiency and attenuates PDN, highlighting the therapeutic potential for targeting the HDAC5-STAT3 axis in diabetic spinal cord pathogenesis.
Article
Cell Biology
Anissa Elahi, Jacen Emerson, Jacob Rudlong, Jeffrey W. Keillor, Garrick Salois, Adam Visca, Peter Girardi, Gail V. W. Johnson, Christoph Proschel
Summary: The study revealed that deletion of TG2 from astrocytes significantly improved motor function in a spinal cord contusion injury (SCI) model, reducing astrocyte markers and SOX9 positive cell numbers. Activation of fatty acid metabolism and energy pathways promotes metabolic coupling between neurons and astrocytes.
Article
Biochemistry & Molecular Biology
Lubna A. H. Mansour, Gehad E. Elshopakey, Fatma M. Abdelhamid, Talat A. Albukhari, Samah J. Almehmadi, Bassem Refaat, Mohamed El-Boshy, Engy F. Risha
Summary: Naringenin (NRG), a naturally occurring flavonoid found in citrus species and tomatoes, has various biological activities including antioxidant, antitumor, antiviral, antibacterial, anti-inflammatory, antiadipogenic, and cardioprotective effects. This study investigated the protective role of NRG against liver and brain toxicity induced by lead acetate in rats. The findings suggest that NRG has potential hepato- and neuroprotective effects against lead acetate toxicity.
Article
Biochemistry & Molecular Biology
Xueting Li, Ce Chen, Mingyue He, Lidong Yu, Renhao Liu, Chunmeng Ma, Yu Zhang, Jianbo Jia, Bingsheng Li, Li Li
Summary: Lead is an important raw material for industrial production, but it poses serious harm to aquatic ecosystems, especially causing spinal malformations in zebrafish embryos, which is mainly attributed to Pb2+-induced endoplasmic reticulum stress and apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Anesthesiology
Shiyun Jin, Resat Cinar, Xudong Hu, Yuhong Lin, Guoxiang Luo, David M. Lovinger, Ye Zhang, Li Zhang
Summary: The study reveals that ALDH2 in spinal astrocytes plays a crucial role in mediating ethanol metabolism and ethanol-induced analgesic effects by promoting GABA synthesis and transmission in the spinal cord.
BRITISH JOURNAL OF ANAESTHESIA
(2021)
Article
Environmental Sciences
Rui Yan, Jie Ding, Qianlei Yang, Xiaoyun Zhang, Junyu Han, Tingxu Jin, Shudi Shi, Xirui Wang, Yu Zheng, Heran Li, Hengdong Zhang, Yan An
Summary: This study investigated the skeletal toxicity of lead acetate (PbAc) in early life stages of zebrafish. The results showed that PbAc inhibited the differentiation and maturation of osteoblasts and cartilage matrix, promoted the formation of osteoclasts, disrupted the GH/IGF-1 axis, and ultimately induced cartilage defects and bone loss in zebrafish embryos.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Multidisciplinary Sciences
Xuchen Liu, Chengqiang Wang, Qingshan Peng, Birong Peng, Lixin Zhu
Summary: Pramipexole (PPX) has a neuroprotective effect in spinal cord injury (SCI) by inhibiting nerve cell apoptosis and regulating protein expression levels, which facilitates the recovery of motor function.
Article
Biochemistry & Molecular Biology
Yiyoung Kim, Eun Ji Roh, Hari Prasad Joshi, Hae Eun Shin, Hyemin Choi, Su Yeon Kwon, Seil Sohn, Inbo Han
Summary: BZA has shown neuroprotection and remyelination effects in central nervous system injuries. Research demonstrated that BZA could suppress inflammatory response, promote oligodendrocyte precursor cell differentiation, and reduce blood-spinal cord barrier disruption. BZA also improved locomotor recovery in rats with spinal cord injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Li Zhou, Chaoqin Zhang, Yu Qiang, Min Huang, Xiangmei Ren, Yuanhong Li, Jihong Shao, Lichun Xu
Summary: The study demonstrated that APSP can protect against lead-induced reproductive toxicity in male mice by attenuating testicular injury, improving sperm count and motility, reducing sperm abnormality rate, restoring antioxidant levels, inhibiting lipid peroxidation, and modulating the JNK signaling pathway.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Physiology
Yu Huang, Jin Lin, Xuanwei Chen, Jianhua Lin
Summary: This study evaluated the role of Pannexin-1 in the development of spinal cord injury, revealing that Panx1 exacerbates cell apoptosis and worsens secondary damage.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Environmental Sciences
Sibel Cigdem Tuncer, Serkan Ali Akarsu, Sefa Kucukler, Cihan Gur, Fatih Mehmet Kandemir
Summary: This study aimed to determine the effects of lead acetate (PbAc) and sinapic acid (SNP) on oxidative stress, apoptosis, inflammation, sperm quality, and histopathology in rat testicular tissue. PbAc administration increased oxidative stress and inflammation parameters, while SNP treatment inhibited these changes and improved sperm quality. Overall, PbAc caused histopathological damage and impaired spermatogenesis, whereas SNP treatment showed protective effects.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Markus Leo, Linda-Isabell Schmitt, Rebecca Steffen, Andrea Kutritz, Christoph Kleinschnitz, Tim Hagenacker
Summary: The study found that platinum-based chemotherapeutics activate spinal astrocytes and decrease the expression of excitatory amino acid transporter 1. The modulation of K-ir4.1 and EAAT1 proteins in astrocytes may be linked to the direct impact of the chemotherapy drugs, identifying spinal astrocytes as a potential target in the prevention and treatment of chemotherapy-induced neuropathy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)