Article
Biochemistry & Molecular Biology
Sehwan Jang, Sabzali Javadov
Summary: Cardiolipin is a unique phospholipid that plays vital roles in resisting osmotic rupture and stabilizing large membrane proteins in the inner mitochondrial membrane. It forms covalently bonded net-like structures through oxidative polymerization, which is essential for maintaining the complex geometry of the mitochondria and gluing the quaternary structure of large protein complexes.
Article
Biology
Arvydas Strazdauskas, Sonata Trumbeckaite, Valdas Jakstas, Justina Kamarauskaite, Liudas Ivanauskas, Rasa Baniene
Summary: This study analyzed the oxidation of cardiolipin during renal ischemia in vivo. The results showed that the levels of the dominant species of cardiolipin decreased after ischemia, and multiple cardiolipin oxidation products were produced. These findings suggest that cardiolipin levels are altered and harmful lipid signaling molecules may induce more damage to mitochondria during ischemia.
Article
Environmental Sciences
Patricia Rodrigues da Silva, Marcio Borges-Martins, Guendalina Turcato Oliveira
Summary: The study evaluated the impact of herbicide exposure on biomarkers and oxidative balance in Melanophryniscus admirabilis tadpoles. Results showed decreased glycogen levels, reduced lipoperoxidation, and lower levels of superoxide dismutase and catalase. Glutathione S-transferase activity increased in response to herbicide exposure.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Konstantinos C. Makris, Nikolaos Efthymiou, Corina Konstantinou, Elena Anastasi, Greet Schoeters, Marike Kolossa-Gehring, Andromachi Katsonouri
Summary: This study aimed to investigate the exposure of children to pesticides and their impact on DNA and lipid oxidative damage. The results showed a significant association between GLY, AMPA and DNA oxidative damage in the urine of Cypriot children.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Diogo Ferreira Bicca, Cristiano Chiapinotto Spiazzi, Juliana Bernera Ramalho, Melina Bucco Soares, Francielli Weber Santos Cibin
Summary: The study revealed that subchronic low dose of GBH could affect behavior and oxidative stress in mouse hippocampus. Quercetin treatment partly or fully improved these effects, but caution is needed regarding the potential independent effects of continuous quercetin supplementation.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Fernanda Bernardi, Juliana Roratto Lirola, Marta Margarete Cestari, Robie Allan Bombardelli
Summary: This study evaluated the effects of 2,4-D, glyphosate, and their mixture on oxidative stress, genotoxicity, and the rates of fertilization, hatching, and larval normality in silver catfish. The results showed that glyphosate and the mixture significantly decreased fertilization and hatching, while 2,4-D and the mixture caused genetic damage to the larvae.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Hong Jin, Li Zhang, Jun He, Min Wu, Li Jia, Jiabin Guo
Summary: Oxidative stress is a key mechanism in liver damage caused by various chemicals. The transcription factor FOXO3a plays a critical role in regulating redox imbalance, with its activity closely regulated by multiple post-translational changes and epigenetic processes. Depending on the chemical nature and subcellular context, the activation of FOXO3a by oxidative stress can induce multiple transcriptional programs that are crucial in liver oxidative injury.
Article
Horticulture
Cristiano Soares, Pedro Mateus, Fernanda Fidalgo, Ruth Pereira
Summary: This study aimed to investigate the role of soil organic matter (OM) in preventing glyphosate (GLY) phytotoxicity on tomato plants. The results suggest that soils with higher OM content (10% and 15%) can mitigate the non-target phytotoxicity of GLY, possibly by decreasing herbicide bioavailability and/or stimulating defense mechanisms, thereby improving crop growth and physiological performance.
SCIENTIA HORTICULTURAE
(2023)
Article
Biochemistry & Molecular Biology
Daiane Cattani, Paula Pierozan, Ariane Zamoner, Eva Brittebo, Oskar Karlsson
Summary: Concerns have been raised about the potential adverse health effects of glyphosate, a widely used herbicide. This study found that developmental exposure to a glyphosate-based herbicide (GBH) led to reduced serum melatonin levels, oxidative stress-related changes in the striatum, and increased neuron numbers in adult rats. Mechanistic studies also suggested that glyphosate could affect melatonin secretion and cell viability.
Article
Microscopy
A. Ostrozka, Z. Tiffert, G. Wilczek, M. Rost-Roszkowska
Summary: This study evaluated the toxic potential of dimethoate on the midgut epithelium of freshwater shrimp Neocaridina davidi, and showed that different sensitivity exists in the midgut organs of freshwater crustaceans. It also demonstrated the possibility of midgut regeneration after insecticide exposure.
Article
Endocrinology & Metabolism
Chris E. Shannon, Mukundan Ragavan, Juan Pablo Palavicini, Marcel Fourcaudot, Terry M. Bakewell, Ivan A. Valdez, Iriscilla Ayala, Eunsook S. Jin, Muniswamy Madesh, Xianlin Han, Matthew E. Merritt, Luke Norton
Summary: Insulin resistance and altered hepatic mitochondrial function are key features of type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD). This study found that insulin sensitization with pioglitazone can mitigate mitochondrial dysfunction in the liver, which is independent of changes in hepatic lipid accumulation. The research highlights potential therapeutic targets for T2D and NAFLD, emphasizing the benefits of insulin sensitization in managing obesity-related diseases.
MOLECULAR METABOLISM
(2021)
Review
Medicine, Research & Experimental
Baoyuan Zhang, Xuesong Zhang, Moussa Omorou, Kai Zhao, Yang Ruan, Haiyan Luan
Summary: DIP2A, a protein expressed throughout the body and abundantly in the brain, plays a role in various biological processes and has been implicated in brain disorders. Regulation of DIP2A could offer new diagnostic and therapeutic approaches for brain disorders.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Marine & Freshwater Biology
Natalia Portruneli, Rocio Ines Bonansea, Maria Eugenia Valdes, Lais Conceicao Menezes da Silva, Natalia Prudencio Viana, Bianca Goulart, Iara da Costa Souza, Evaldo Luiz Gaeta Espindola, Cassiana Carolina Montagner, Daniel Alberto Wunderlin, Marisa Narciso Fernandes
Summary: This study revealed that the exposure of the neotropical fish Prochilodus lineatus to the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) and the insecticide fipronil caused bioconcentration and biochemical/morphological changes in the gills. The two pesticides had different effects on the fish, with the mixture of 2,4-D and fipronil showing antagonistic interaction.
AQUATIC TOXICOLOGY
(2021)
Article
Food Science & Technology
Miguel-Angel Barrios-Maya, Angelica Ruiz-Ramirez, Hector Quezada, Carlos L. Cespedes Acuna, Mohammed El-Hafidi
Summary: The release of cytochrome c from liver mitochondria into the cytosol is a key process in hepatocyte apoptosis involved in the progression of non-alcoholic fatty liver disease (NAFLD) to more severe conditions. The study found that palmitoyl-CoA-induced cytochrome c release is sensitive to cyclosporine A, indicating the involvement of mitochondrial membrane permeability transition (mMPT). Despite increased H2O2 generation, cytochrome c release from sucrose-fed (SF) rat mitochondria remains significantly lower than normal mitochondria, possibly due to the enrichment of cardiolipin molecular species with palmitic acid.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Review
Cell Biology
Katarzyna Glombik, Jan Detka, Boguslawa Budziszewska
Summary: Hormones play a crucial role in regulating neuronal and synaptic plasticity, neurogenesis, and metabolic activity in the brain, ensuring proper communication between the brain and the body. The influence of hormones on energy metabolism and mitochondrial function in the brain has gained significant attention, as excess or deficiency of hormones is associated with cell damage and loss of function in mitochondria.
Article
Endocrinology & Metabolism
Mariana Astiz, Olga Pernia, Vicente Barrios, Luis Miguel Garcia-Segura, Yolanda Diz-Chaves
NEUROENDOCRINOLOGY
(2017)
Article
Marine & Freshwater Biology
F. Arrighetti, E. Ambrosio, M. Astiz, A. Rodrigues Capitulo, S. Lavarias
AQUATIC TOXICOLOGY
(2018)
Review
Neurosciences
Mariana Astiz, Henrik Oster
Review
Biochemistry & Molecular Biology
Mariana Astiz, Isabel Heyde, Henrik Oster
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Pharmacology & Pharmacy
Nathalie Arnal, Gustavo Morel, Carlos A. Marra, Mariana Astiz
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2019)
Editorial Material
Physiology
Mariana Astiz, Henrik Oster
Review
Endocrinology & Metabolism
Estefania Acaz-Fonseca, Ana Ortiz-Rodriguez, Luis Miguel Garcia-Segura, Mariana Astiz
JOURNAL OF NEUROENDOCRINOLOGY
(2020)
Article
Cell Biology
Kornelia Johann, Anna Lena Cremer, Alexander W. Fischer, Markus Heine, Eva Rial Pensado, Julia Resch, Sebastian Nock, Samuel Virtue, Lisbeth Harder, Rebecca Oelkrug, Mariana Astiz, Georg Brabant, Amy Warner, Antonio Vidal-Puig, Henrik Oster, Anita Boelen, Miguel Lopez, Joerg Heeren, Jeffrey W. Dalley, Heiko Backes, Jens Mittag
Article
Genetics & Heredity
Yang Hu, Alejandra Korovaichuk, Mariana Astiz, Henning Schroeder, Rezaul Islam, Jon Barrenetxea, Andre Fischer, Henrik Oster, Henrik Bringmann
Article
Multidisciplinary Sciences
Mariana Astiz, Isabel Heyde, Mats Ingmar Fortmann, Verena Bossung, Claudia Roll, Anja Stein, Berthold Gruettner, Wolfgang Goepel, Christoph Haertel, Jonas Obleser, Henrik Oster
NATURE COMMUNICATIONS
(2020)
Article
Nutrition & Dietetics
Christoph Haertel, Juliane Spiegler, Ingmar Fortmann, Mariana Astiz, Henrik Oster, Bastian Siller, Dorothee Viemann, Thomas Keil, Tobias Banaschewski, Marcel Romanos, Egbert Herting, Wolfgang Goepel
Review
Neurosciences
Mariana Astiz, Henrik Oster
Summary: The circadian clock system adapts physiology and behavior to daily recurring changes in the environment. Recent findings suggest that the embryo/fetal molecular clock machinery is present and functional in several tissues early during gestation, entrained by maternal rhythmic signals. This highlights the complex interaction and coordination between maternal, placental, and embryo/fetal clocks in regulating the circadian system's development and response to external perturbations during critical times.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Developmental Biology
Cecile Demarez, Leonardo Vinicius Monteiro De Assis, Markus Krohn, Nahuel Ramella, Markus Schwaninger, Henrik Oster, Mariana Astiz
Summary: The trophoblast layer of the labyrinth zone in the mature mouse placenta harbors a functional clock by late gestation, regulating the expression and activity of the xenobiotic efflux pump ABCB1 in a circadian manner, potentially controlling the fetal exposure to drugs at certain times of the day. This finding may have implications in determining the timing of maternal treatments to achieve maximal/minimal drug availability to the fetus/mother.
Review
Neurosciences
Mariana Astiz, Lina Maria Delgado-Garcia, Laura Lopez-Mascaraque
Summary: Astrocytes have gained importance in building brain circuits and regulating complex behavior alongside neurons. The circadian system synchronizes physiological processes in mammals such as sleep-wake cycle and cognition. Recent breakthrough discoveries have implicated astrocytes as essential time-keepers in addition to neurons in the suprachiasmatic nucleus.
Article
Neurosciences
Alexander Dueck, Olaf Reis, Henrike Wagner, Katja Wunsch, Frank Haessler, Michael Koelch, Mariana Astiz, Johannes Thome, Christoph Berger, Henrik Oster
Summary: This study compared circadian rhythms at the behavioral, endocrine, and molecular levels between children with ADHD and age- and BMI-matched controls. Significant differences were found in sleep onset and duration, cortisol secretion profiles, and expression of clock genes in the ADHD group. The analysis of circadian molecular rhythms may provide a new approach for diagnosing ADHD in children and adults.
