Article
Polymer Science
Li Jun Ren, Hui Yun Zhou, Pei Yan Hao, Hui Jie Zheng, Jia Nan Tong, Ya Wei Chen, Hyun Jin Park
Summary: In this study, l-lysine (Lys), l-glutamate (Glu), and l-glutamine (Gln) grafted-chitosan (CS) polymers (AA-g-CS) were prepared using EDC/NHS as coupling agents. AA-g-CS/GP hydrogel showed improved thermosensitivity and had a dense three-dimensional network structure. The hydrogel loaded with berberine hydrochloride (BBH) demonstrated sustained release, with BBH@Lys-g-CS/GP hydrogel showing the best sustained release effect.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Chemistry, Applied
Jinjin Tong, Xiaolin Hou, Defeng Cui, Wu Chen, Hua Yao, Benhai Xiong, Lirong Cai, Hua Zhang, Linshu Jiang
Summary: This study prepared a novel berberine hydrochloride-carboxymethyl chitosan hydrogel (BH-CMCH) with excellent properties and demonstrated its antibacterial activity against Staphylococcus aureus in a rat mastitis model. Proteomics analysis indicated that BH-CMCH enhanced autolysosome degradation and activated the lysosomal pathway to promote the innate immune response.
CARBOHYDRATE POLYMERS
(2022)
Article
Medicine, Research & Experimental
Lili Wang, Shuyu Liu, Jia-mei Chen, Yan-xiang Wang, Changquan Calvin Sun
Summary: This study utilized structurally similar aliphatic dicarboxylic acids as coformers to obtain phase pure cocrystals with berberine chloride through a slow solvent evaporation method. The cocrystals exhibited higher melting points, improved powder dissolution and intrinsic dissolution rate, and lower hygroscopicity compared to BCl·2H2O, with melting points and IDRs showing an odd-even alternation with the carbon chain length of the acids.
MOLECULAR PHARMACEUTICS
(2021)
Article
Polymer Science
Ruifang Zhao, Pengfei Tan, Yanting Han, Feng Yang, Yidong Shi, Puxin Zhu, Lin Tan
Summary: This study verified the application prospects of berberine hydrochloride in antibacterial fibers, the coating modified polyurethane fiber showed good antibacterial properties, mechanical properties, and surface wettability, and is expected to be applied in the biomedical field.
Article
Chemistry, Physical
Hui Yun Zhou, Pei Yan Hao, Shuai Qiang Jiang, Wan Hui Zhang, Li Jun Ren, Hui Jie Zheng, Ya Wei Chen, Jun Liang Chen, Hyun Jin Park
Summary: In this paper, cyclodextrin-grafted-chitosan (CD-g-CS) with different degrees of substitution (DS) was successfully synthesized for the development of an injectable thermosensitive hydrogel. The hydrogel showed rapid gelation and had a three-dimensional porous structure. It exhibited good swelling ratio, degradable behavior, sustained drug release, and excellent antibacterial activity against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). The CD-g-CS/GP-SHC hydrogels have great potential in biomedical drug delivery systems and antibacterial materials.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Biochemistry & Molecular Biology
Zhaoxia Tang, Jiali Luo, Yahya Faqir, Yu Zhang, Wenqian Xue, Hongmei Zhao, Ali Murad Jakhar, Chengjia Tan, Jiahua Ma
Summary: This study aimed to treat mice with colitis using dung beetle chitosan (DCS)-transported berberine hydrochloride (BH). BH-loaded DCS/sodium alginate microspheres (SA-DCS-BH) were successfully prepared and characterized. The results showed that SA-DCS-BH had slow-release ability, reduced inflammation, modulated gut microbiota, and DCS was a more suitable carrier compared to commercial chitosan for intestinal drug delivery systems.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Pharmacology & Pharmacy
Jing Zhao, Ting Zhou, Jing-Ze Lu, Dan Ye, Sheng Mu, Xin-Hui Tian, Wei-Dong Zhang, Bing-Liang Ma
Summary: Primary plant metabolites can be used to prepare natural deep eutectic solvents (NADESs), which were found in Coptidis Rhizoma extract and shown to improve the pharmacokinetics of oral berberine hydrochloride (BBR) when diluted. The dilutions of NADES significantly enhanced the water solubility of BBR, reduced its efflux, and improved its metabolic stability.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Applied
Fanyong Yan, Zhonghui Sun, Shiying Luo, Hao Zhang
Summary: In this study, fluorescent carbon dots with rich carboxyl groups on the surface were synthesized and further modified to improve stability and quantum yield. These modified carbon dots were used for the rapid and effective determination of BRH, with successful detection of BRH concentration and a low limit of detection achieved under specific conditions.
Article
Biotechnology & Applied Microbiology
Tian-heng Gao, Ming-ming Han, Hui Zhou, Chen-xi Zhu, Ying Yang, Zakaria Zuraini, Yan-Xia Guo, Qi-chen Jiang
Summary: This study investigated the molecular response of the crab Charybdis japonica to berberine hydrochloride exposure using transcriptome sequencing. It was found that berberine hydrochloride activated the immune complement system, increased the survival rate of crabs, and promoted the activity of certain immune enzymes.
Article
Engineering, Chemical
Chengde Liu, Wanting Du, Luyao Jiang, Yizheng Li, Cheng Liu, Xigao Jian
Summary: A crosslinked chitosan/gelatin hybrid hydrogel with antibacterial and adhesive properties was developed by introducing berberine hydrochloride and adhesive prepolymerized gallic acid. The hydrogel showed enhanced antibacterial and antibiofilm capabilities and strong adhesion to various surfaces. It has potential applications in biomedicine, particularly in wound dressing and surface modification of medical implants.
POLYMER ENGINEERING AND SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Ayca Gungor Ak, Inci Turan, Hale Sayan Ozacmak, Aysegul Karatas
Summary: This study aimed to enhance the oral bioavailability and gastrointestinal stability of berberine chloride (BER) by preparing chitosan nanoparticles using an ionotropic gelation method. The BER-loaded chitosan nanoparticles showed an encapsulation efficiency of 31.5%, a zeta potential of 41.6 mV, a particle size of 406 nm, and a polydispersity index of 0.462. Stability studies demonstrated that the nanoparticles improved the stability of BER in simulated gastrointestinal fluids.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Ting Zhang, Meng Li, Xiaolu Han, Guangjun Nie, Aiping Zheng
Summary: The study explored the effects of novel absorption enhancers on the nasal absorption of nalmefene hydrochloride. The results showed that DDM had the strongest enhancement effect and good safety profile, making it a promising nasal absorption enhancer.
Article
Chemistry, Applied
Danyang Wang, Yongjuan Zou, Ning Wang, Jie Wu
Summary: We developed an emulsion using chitosan hydrochloride salt (CSCL) as stabilizer, which effectively loaded antigens and slowed down antigen release. The emulsion showed strong immune responses and generated memory T cells in adaptive immunity.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Applied
Xi Xiang, Qiaomei Sun, Na Gan, Zili Suo, Shuangshuang Zhang, Shun Yao, Hongzhao Xiang, Na Yuan, Hui Li
Summary: Heat treatment causes conformational and morphological changes in proteins. This study examined the differences between native and heated proteins, as well as their binding mechanism with berberine hydrochloride (BH). Results showed that heat treatment resulted in a more compact secondary structure and a change in the morphology of protein nanoparticles. The interaction mechanism between beta-lg and BH was found to involve static quenching with energy transfer under electrostatic and hydrophobic forces, with a binding stoichiometric ratio of 1:1. Mollecular simulation confirmed the experimental results and highlighted the importance of heat treatment in food processing.
FOOD HYDROCOLLOIDS
(2022)
Article
Chemistry, Analytical
Madiha Melha Yahoum, Selma Toumi, Hichem Tahraoui, Sonia Lefnaoui, Mohammed Kebir, Abdeltif Amrane, Aymen Amin Assadi, Jie Zhang, Lotfi Mouni
Summary: This study aimed to prepare xanthan gum microspheres using ionotropic gelation for the encapsulation of metformin hydrochloride. The obtained microspheres, based on different fractions of xanthan gum, showed an average size ranging from 110.96 μm to 208.27 μm. The encapsulation efficiency reached 93.11% at a 1.25% biopolymer concentration. The swelling study demonstrated significant swelling in the gastric and intestinal environments, with release profiles showing sustained release kinetics.