Review
Immunology
Yang Liu, Yanling Mu, Zhe Li, Voon Wee Yong, Mengzhou Xue
Summary: This review explores the role of EMMPRIN in stroke and its pathological mechanisms. It discusses the regulation of matrix metalloproteinase expression, exacerbation of blood-brain barrier dysfunction and microvascular thrombosis, and promotion of neuroinflammation. Additionally, it summarizes various stroke treatments targeting the EMMPRIN signaling pathway, and suggests the potential of EMMPRIN as a biomarker of stroke injury.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Lin Lu, Jianjian Huang, Xia Xue, Ting Wang, Zhouqing Huang, Jianmin Li
Summary: Elevated expression of P2X7R and decreased levels of miR150-5p were observed in oxLDL-induced macrophages. Inhibition of AMPK-alpha and MAPK signaling pathways reversed the upregulation of EMMPRIN and MMP-9 expression mediated by P2X7R. Berberine treatment resulted in increased miR150-5p levels, downregulated P2X7R expression, and decreased levels of MMP-9 and EMMPRIN by suppressing AMPK-alpha and MAPK signaling.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yang Liu, Fei Wang, Zhe Li, Yanling Mu, Voon Wee Yong, Mengzhou Xue
Summary: This study found that chlorogenic acid (CGA) can provide neuroprotection in intracerebral hemorrhage (ICH) by inhibiting the expression of EMMPRIN and MMP-2/9, alleviating neuroinflammation, blood-brain barrier disruption, cell death, and brain injury.
Article
Biochemistry & Molecular Biology
Yihe Wang, Christine Y. Chuang, Clare L. Hawkins, Michael J. Davies
Summary: Matrix metalloproteinase-9 (MMP9) plays a crucial role in the degradation of extracellular matrix (ECM) proteins. This study demonstrates that MMP9 can be activated by both chloramines and oxidation. The activation of MMP9 and ECM degradation are interdependent processes that may contribute to the progression of diseases.
Review
Biotechnology & Applied Microbiology
Victor Alfonso Solarte David, Viviana Raquel Guiza-Argueello, Martha L. Arango-Rodriguez, Claudia L. Sossa, Silvia M. Becerra-Bayona
Summary: The absence or damage of tissue is a major cause of diseases, and novel therapeutic alternatives aim to recover lost functions through tissue regeneration. Chronic cutaneous lesions are common wounds that require regenerative medicine and tissue engineering interventions to develop bioactive medical products for proper healing and prevention of complications. The coordination of cells, extracellular matrix (ECM), and biomolecules is crucial in tissue repair and regeneration, with ECM acting as a biological platform for their interactions. Tissue engineering utilizes synthetic polymers and decellularized tissues to mimic native ECM and provide necessary functionalities for cell differentiation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Neurosciences
Yang Liu, Zhe Li, Suliman Khan, Ruiyi Zhang, Ruixue Wei, Yan Zhang, Mengzhou Xue, V. Wee Yong
Summary: The study demonstrates that minocycline plays a protective role in ICH by reducing EMMPRIN and MMP-9 expression, alleviating BBB disruption, inhibiting neuroinflammation, and decreasing neuronal degeneration and death.
NEUROSCIENCE LETTERS
(2021)
Review
Chemistry, Medicinal
Sanjib Das, Sk Abdul Amin, Tarun Jha
Summary: Matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) play significant roles in solid tumor invasion, metastasis, and angiogenesis, while their role in hematological malignancies is less understood. Recent studies have shown correlations between gelatinases and hematological malignancies, leading to the development of potential inhibitors for these conditions.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Engineering, Biomedical
Lindsay Piraino, Chiao Yun Chen, Tracey Moyston, Yuanhui Song, Andrew Shubin, Catherine E. Ovitt, Jared A. Mereness, Lisa A. DeLouise, Danielle S. W. Benoit
Summary: We developed a salivary gland tissue mimetic (SGm) for high-throughput drug screening. By tuning biochemical cues within the hydrogel matrix, we improved the maintenance of acinar cell phenotype and function. Slow-degrading MMP-sensitive peptide crosslinkers and adhesive peptides enhanced the secretory response and stability of the SGm over 14 days of culture.
ACTA BIOMATERIALIA
(2023)
Article
Clinical Neurology
Giuseppe Cosentino, Vincenzo Di Stefano, Rosalia Lo Presti, Maria Montana, Massimiliano Todisco, Matteo Gastaldi, Andrea Cortese, Enrico Alfonsi, Cristina Tassorelli, Brigida Fierro, Gregorio Caimi, Filippo Brighina
Summary: This study found that the plasmatic levels of MMPs and TIMPs were significantly altered in patients with CIDP, with higher concentrations of MMP-9, downregulation of TIMP-1, and lower concentration of MMP-2. These new biomarkers may have potential usefulness in the clinical setting and further studies are needed to confirm their utility.
NEUROLOGICAL SCIENCES
(2021)
Article
Oncology
Han-Soo Kim, Ha Jeong Kim, Mi Ra Lee, Ilkyu Han
Summary: The study found that the expression level of EMMPRIN in osteosarcoma is associated with metastasis-free survival, and EMMPRIN plays an important role in osteosarcoma metastasis by regulating the production of MMP and VEGF.
Article
Biochemistry & Molecular Biology
Laura Tomasello, Maria Pitrone, Valentina Guarnotta, Carla Giordano, Giuseppe Pizzolanti
Summary: This study investigated the contributions of adipose progenitors (ASCs) and adipocytes (AMCs) to TNF-alpha-induced extracellular matrix (ECM) remodeling and the potential involvement of irisin in AT impairment in obesity. The results showed that inflamed adipocytes exhibited impaired protein metabolism and lipid storage ability, accompanied by increased matrix metalloproteinase activity. In vitro and ex vivo measurements revealed a positive correlation between inflammation, adipose secretion of irisin, and circulating irisin levels in patients with visceral obesity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Xiaofang Xu, Dianhua Qiao, Chenyang Dong, Morgan Mann, Roberto P. Garofalo, Sunduz Keles, Allan R. Brasier
Summary: The SMARCA4 complex is found to play a crucial role in the response of airway epithelial cells to RSV infection, with its depletion leading to cellular state transition and chromatin opening that affect gene expression within cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, Research & Experimental
Liang Shan, Fengling Wang, Dandan Zhai, Xiangyun Meng, Jianjun Liu, Xiongwen Lv
Summary: Liver fibrosis is a consequence of chronic liver injuries, characterized by the imbalance of extracellular matrix production and degradation. Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) are crucial in collagen synthesis and lysis. This article reviews experimental studies on liver fibrosis based on MMPs/TIMPs and highlights the potential of targeting this interaction as a therapeutic strategy for hepatic fibrosis. The article also summarizes drugs, including natural products, that have been found to reduce liver fibrosis by altering the ratio of MMPs/TIMPs.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Hengameh Bakhtiar, Sarah Rajabi, Mohammad Pezeshki-Modaress, Mohammad Reza Ellini, Mahsa Panahinia, Solmaz Alijani, Amir Mazidi, Amir Kamali, Amir Azarpazhooh, Anil Kishen
Summary: The study aimed to characterize the effects of various decellularization protocols on bovine dental pulp ECM. Results showed successful decellularization in all groups, with protocol P7 (12E-0S-1T) demonstrating the highest retention of glycosaminoglycan and minimal DNA content. Overall, the tested treatments hold potential for producing xenogeneic dental pulp ECM scaffolds, with P7 being a promising option due to its minimal structural damage and acceptable host immune response.
JOURNAL OF ENDODONTICS
(2021)
Article
Chemistry, Physical
Xiaoqian Ge, Xueqi Xu, Qi Cai, Hejian Xiong, Chen Xie, Yi Hong, Xiaofei Gao, Yao Yao, Robert Bachoo, Zhenpeng Qin
Summary: The pan-ECM method enables live imaging of the entire brain extracellular matrix, providing insights into its heterogeneity and changes in neurological disorders. This novel approach has the potential to advance our understanding of brain function and neurological diseases.
Article
Agriculture, Dairy & Animal Science
Xiaoxing Xu, Birendra Mishra, Ning Qin, Xue Sun, Shumin Zhang, Jinzeng Yang, Rifu Xu
ANIMAL BIOTECHNOLOGY
(2019)
Review
Endocrinology & Metabolism
Birendra Mishra, Ulrike Luderer
NATURE REVIEWS ENDOCRINOLOGY
(2019)
Review
Agriculture, Dairy & Animal Science
Sanjeev Wasti, Nirvay Sah, Birendra Mishra
Article
Biotechnology & Applied Microbiology
Nirvay Sah, Donna Lee Kuehu, Vedbar Singh Khadka, Youping Deng, Rajesh Jha, Sanjeev Wasti, Birendra Mishra
Summary: This study identified novel genes involved in egg-white synthesis and secretion, along with well-known functional genes. These findings help to understand the mechanisms involved in albumen biosynthesis.
Article
Agriculture, Dairy & Animal Science
Sudhir Yadav, Kayla D. Caliboso, Jannel E. Nanquil, Jiachao Zhang, Helmut Kae, Kabi Neupane, Birendra Mishra, Rajesh Jha
Summary: Commercial chickens showed higher diversity in cecal bacteria, while feral chickens had more unique bacterial species but lower diversity, with a more functional microbiota. This may be attributed to the scavenging behavior of feral birds, diverse feed ingredients, and distinct rearing localities.
Article
Agriculture, Dairy & Animal Science
Sanjeev Wasti, Nirvay Sah, Amit K. Singh, Chin N. Lee, Rajesh Jha, Birendra Mishra
Summary: The study suggests that dietary supplementation of dried plum effectively improves growth performance and gut health parameters in heat-stressed broiler chickens.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Sanjeev Wasti, Nirvay Sah, Chin N. Lee, Rajesh Jha, Birendra Mishra
Summary: Heat stress negatively impacts chicken growth and performance, but dietary supplementation of alpha-lipoic acid can mitigate these effects by improving body weight, intestinal health, and microbiota diversity.
Article
Agriculture, Dairy & Animal Science
Xue Sun, Xiaotian Niu, Ning Qin, Xuesong Shan, Jinghua Zhao, Chang Ma, Rifu Xu, Birendra Mishra
Summary: LATS2 plays a crucial role in the development of hen prehierarchical follicles by regulating GC proliferation, differentiation, steroidogenesis, and follicle selection. The study revealed differential expression of LATS2 in various sized follicles and GCs, affecting the expression of genes involved in these processes.
Review
Biology
Karim El-Sabrout, Sarah Aggag, Birendra Mishra
Summary: The global demand for table eggs is growing, requiring advances in hen genetics, nutrition, and husbandry procedures. Improving hens' welfare and egg quality, as well as incorporating functional and designer foods, are important to consumers. Modifications in hen diets can impact egg nutritional composition and quality. Enriched egg products have shown potential benefits to human health. However, producers face challenges in optimizing breeding, housing, and dietary strategies.
Review
Agriculture, Dairy & Animal Science
Karim El-Sabrout, Ayman Khalifah, Birendra Mishra
Summary: The poultry industry faces challenges such as feedstuff availability, banning of antibiotics, and environmental stressors. To sustain the industry, it is necessary to include nutraceuticals in the diet. Botanical products, such as fenugreek seeds and ginger roots, have gained popularity due to their benefits in nutrition and therapeutic properties.
Article
Agriculture, Dairy & Animal Science
Ajay Chaudhary, Pravin Mishra, Sadid Al Amaz, Prem Lal Mahato, Razib Das, Rajesh Jha, Birendra Mishra
Summary: Heat stress in poultry is a serious concern, but supplementing their diet with microalgae can improve their health and productivity. This study aimed to investigate the effects of microalgae supplementation on heat-stressed broilers. The results showed that microalgae supplementation improved the growth performance and gene expression of heat-stressed broilers, as well as increased microbial diversity.
Article
Agriculture, Dairy & Animal Science
Pravin Mishra, Razib Das, Ajay Chaudhary, Birendra Mishra, Rajesh Jha
Summary: This study evaluated the effects of microalgae with or without xylanase supplementation on the growth performance and gut health of broiler chickens. The results showed that adding microalgae with or without xylanase could promote the growth performance and improve gut health parameters of broilers.
Article
Agriculture, Dairy & Animal Science
Sanjeev Wasti, Nirvay Sah, Donna L. Kuehu, Yong S. Kim, Rajesh Jha, Birendra Mishra
ANIMAL SCIENCE JOURNAL
(2020)
Review
Veterinary Sciences
Birendra Mishra, Rajesh Jha
FRONTIERS IN VETERINARY SCIENCE
(2019)
Review
Veterinary Sciences
Rajesh Jha, Amit Kumar Singh, Sudhir Yadav, Julio Francisco Diaz Berrocoso, Birendra Mishra
FRONTIERS IN VETERINARY SCIENCE
(2019)
Article
Agriculture, Dairy & Animal Science
Mehak Nisar, Shafayat Ahmad Beigh, Abdul Qayoom Mir, Syed Ashaq Hussain, Aijaz Ahmad Dar, Iqbal Yatoo, Adil Mehraj Khan
Summary: This study aimed to evaluate the role of vitamin D in redox balance, insulin resistance, and its predicting value for subclinical pregnancy toxemia (SPT) in pregnant ewes. The results showed that ewes with insufficient vitamin D had significantly lower total antioxidant capacity (TAC) compared to ewes with sufficient vitamin D, and there were significant differences in metabolite concentrations between the two groups. Additionally, vitamin D was positively correlated with fructosamine, calcium, and TAC, and negatively correlated with non-esterified fatty acid (NEFA) and total oxidant status (TOS). Ewes with insufficient vitamin D had a higher risk of developing SPT two weeks prior to lambing and at lambing.
DOMESTIC ANIMAL ENDOCRINOLOGY
(2024)
Article
Agriculture, Dairy & Animal Science
L. G. Gonzalez-Arostegui, A. Munoz-Prieto, C. P. Rubio, J. J. Ceron, L. Bernal, I. Rubic, V. Mrljak, J. C. Gonzalez-Sanchezc, A. Tvarijonaviciute
Summary: This study investigated changes in the saliva and serum proteome of dogs with hypothyroidism using TMT labelling and LC-MS/MS. The findings showed that this disease induces alterations in the saliva and serum proteome, reflecting physiological and pathological changes in the immune system, metabolism, skin, and coagulation. The downregulation of LDH in saliva may serve as a potential biomarker for canine hypothyroidism.
DOMESTIC ANIMAL ENDOCRINOLOGY
(2024)
Article
Agriculture, Dairy & Animal Science
Camila R. C. Brito, Agatha D. Cordeiro, Pricila Baldessar, Carolini Schultz, Monike Quirino, Rafael R. Ulguim, Paulo B. D. Goncalves, Thomaz Lucia Jr, Ivan Bianchi, Bernardo G. Gasperin
Summary: This study tested synchronization protocols without progestogens during the luteal phase in gilts. The results showed that the protocols based on PGF and hCG were effective in reducing the interval between estrus in gilts. Additionally, the hCG2 protocol had negative effects on the number of piglets born alive and total litter size.
DOMESTIC ANIMAL ENDOCRINOLOGY
(2024)
Article
Agriculture, Dairy & Animal Science
F. Frers, J. Delarocque, K. Feige, K. Huber, T. Warnken
Summary: This study aimed to investigate the relationship between insulin dysregulation and the expression and phosphorylation of key proteins in the insulin signaling cascade in different tissues of horses. The results showed enhanced phosphorylation of the insulin receptor and protein kinase B in response to stimulation, while phosphorylation of adenosine monophosphate protein kinase alpha decreased after glucose administration. Interestingly, horses with insulin dysregulation had significantly higher phosphorylation of mechanistic target of rapamycin in muscle tissue. These findings suggest that insulin signaling is maintained in horses, but post-receptor alterations may occur.
DOMESTIC ANIMAL ENDOCRINOLOGY
(2024)
Article
Agriculture, Dairy & Animal Science
Patrice Dufour, Vincent Frisee, Goulven Rigaux, Flore Brutinel, Sophie Egyptien, Philippe Bossaert, Jessica Deleersnyder, Stefan Deleuze, Stephanie Peeters, Caroline Le Goff, Jerome Ponthier, Etienne Cavalier
Summary: This report describes the method of measuring progesterone and estrone-sulfate using Liquid Chromatography coupled with Mass Spectrometry in American Bison feces. This method provides an alternative to serum assay for studying the pregnancy-related evolution of these hormones in American Bison.
DOMESTIC ANIMAL ENDOCRINOLOGY
(2024)
