Review
Pharmacology & Pharmacy
Sumama Nuthana Kalva, Robin Augustine, Abdulla Al Mamun, Yogesh Bharat Dalvi, Namitha Vijay, Anwarul Hasan
Summary: Healing chronic diabetic ulcers, burn wounds, and large traumatic wounds is a significant clinical challenge, but submicron fiber-based membranes can mimic the natural extracellular matrix, promoting wound healing and tissue regeneration. Various active components can be incorporated into electrospun fibers to improve ECM mimetic features and provide additional advantages.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Engineering, Biomedical
Agustina Setiawati, Dongyoon Jang, Daeyon Cho, Shingyu Cho, Hayan Jeong, Sungmin Park, Jungsug Gwak, Soo Ryeon Ryu, Won Hee Jung, Bong-Gun Ju, Kwang-Hwan Jung, Oh-Sun Kwon, Kwanwoo Shin
Summary: The research introduces a new method to coat absorbable sutures with fibronectin, promoting cellular migration and adhesion while preventing infection. The modified suture also reduces friction with wounded tissue, enhancing overall healing outcomes.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Pharmacology & Pharmacy
Lin-Cui Da, Yi-Zhou Huang, Hui-Qi Xie, Bei-Hong Zheng, Yong-Can Huang, Sheng-Rong Du
Summary: Membranous extracellular matrix (ECM)-based scaffolds are promising biomaterials for skin wound healing, but they currently face limitations such as poor mechanical properties and uncontrollable degradation. Advances in scaffold modification, nanotechnology, and material manufacturing techniques have led to the development of new ECM-based membranes with improved properties for skin wound healing, making them promising candidates for future clinical translation.
Review
Biotechnology & Applied Microbiology
Walker D. D. Short, Oluyinka O. O. Olutoye, Benjamin W. W. Padon, Umang M. M. Parikh, Daniel Colchado, Hima Vangapandu, Shayan Shams, Taiyun Chi, Jangwook P. P. Jung, Swathi Balaji
Summary: Impaired wound healing is a significant financial and medical burden. Disruptions in ECM deposition, structure, and composition lead to impaired healing in diseased states, such as in diabetes. Valid measures include lack of bacterial contamination, good tissue perfusion, and reduced mechanical injury and strain. This review discusses bioengineering advances in detecting biologic and physiologic factors, visualizing and modeling the ECM, and efficiently evaluating wound data. It focuses on bioelectronics and biologic interfaces for real-time sensing and actuation, advanced imaging techniques, and computational modeling. These advancements have the potential to improve healing outcomes and guide decision-making in wound care.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Jiangjiang Ru, Qian Zhang, Shaowei Zhu, Junrong Cai, Yunfan He, Feng Lu
Summary: The study found that HEP-ADGF-AAM, a surface-modified heparin-loaded acellular adipose matrix (AAM) containing adipose-derived growth factors (ADGFs), can promote wound healing. HEP-ADGF-AAM not only induced adipocyte regeneration but also enhanced fibroblast migration, promoted vessel formation, accelerated wound closure, and enhanced wound epithelialization.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Engineering, Biomedical
Qiang Zhou, Victor H. Guaiquil, Matthea Wong, Alejandro Escobar, Evguenia Ivakhnitskaia, Ghasem Yazdanpanah, Hongwu Jing, Michael Sun, Joy Sarkar, Yuncin Luo, Mark Rosenblatt
Summary: The acellular porcine corneal stroma (APCS) hydrogel demonstrated optimal light transmittance and gelation properties, retaining critical corneal ECM components. It showed higher porosity, faster nutrition diffusion, improved proliferation of corneal cells, and enhanced viability and infiltration. The APCS-gel also improved corneal epithelial stemness and wound healing in vitro and in vivo, making it a promising option for clinical applications.
ACTA BIOMATERIALIA
(2021)
Article
Pharmacology & Pharmacy
Shenfang Zha, Yohanes Kristo Sugiarto Utomo, Li Yang, Guizhao Liang, Wanqian Liu
Summary: The study developed a biodegradable nanofibrous scaffold for diabetic wound healing, which showed excellent mechanical properties and biocompatibility. The scaffold provided a beneficial microenvironment for cell adhesion and growth, and promoted collagen deposition and re-vascularization, ultimately accelerating diabetic wound healing.
Article
Engineering, Biomedical
Zahra Bashiri, Motahareh Rajabi Fomeshi, Hatef Ghasemi Hamidabadi, Davod Jafari, Sanaz Alizadeh, Maryam Nazm Bojnordi, Gorka Orive, Alireza Dolatshahi-Pirouz, Maria Zahiri, Rui L. Reis, Subhas C. Kundu, Mazaher Gholipourmalekabadi
Summary: Extracellular matrix (ECM)-based bioinks are widely studied for 3D printing of native-like tissue constructs. In this study, a printable bioink biomimicking natural skin was prepared using different concentrations of placental ECM, sodium-alginate, and gelatin. The 5% ECM 3D printed scaffold showed the best deep wound regeneration, producing a skin replacement with a cellular structure comparable to native skin.
MATERIALS TODAY BIO
(2023)
Article
Materials Science, Textiles
Xiaofei Gao, Guohua Jiang, Liming Ruan, Yanfang Sun, Khaydar E. Yunusov, Yanting Jing, Uladzislau E. Aharodnikau, Sergey O. Solomevich
Summary: Electrospun nanofibers with adjustable properties and drug delivery capabilities have been developed as a potential wound healing material. The electrospun polycaprolactone and porcine acellular dermal matrix composite scaffolds showed enhanced thermal stability and cell adhesion. In vivo experiments demonstrated their ability to promote wound healing through enhanced expression of vascular factor and reduced inflammation.
FIBERS AND POLYMERS
(2023)
Article
Pharmacology & Pharmacy
Hengyue Song, Kewa Gao, Dake Hao, Andrew Li, Ruiwu Liu, Bryan Anggito, Boyan Yin, Qianyu Jin, Vanessa Dartora, Kit S. Lam, Lucas R. Smith, Alyssa Panitch, Jianda Zhou, Diana L. Farmer, Aijun Wang
Summary: The lack of vascularization associated with deep burns delays wound healing, increases infection risks, and leads to hypertrophic scars or disfigurement. To address this challenge, a multi-functional pro-angiogenic molecule, LXW7-DS-SILY (LDS), was fabricated and used to functionalize collagen-based Integra scaffolds. In a mouse burn wound model, LDS-modified Integra scaffolds loaded with endothelial cells (ECs) accelerated wound healing rate, re-epithelialization, vascularization, and collagen deposition. These scaffolds have the potential to reduce morbidity associated with open burn wounds and the need for autografting in patients with limited areas of harvestable skin.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Hyo-Sung Kim, Hyun-Jeong Hwang, Han-Jun Kim, Yeji Choi, Daehyung Lee, Hong-Hee Jung, Sun Hee Do
Summary: Mammalian tissue extracellular matrix (ECM) has been used as a scaffold for tissue repair. This study investigated the properties and effects of decellularized ECM (dECM) from human lung fibroblasts on wound remodeling. The fibroblast-derived dECM (fdECM) maintained important components and growth factors, and when applied to skin wounds, facilitated wound contraction, angiogenesis, and qualitative skin remodeling. The therapeutic efficacy was also observed in a diabetic ulcer model. In vitro experiments revealed that fdECM helps tissue remodeling by regulating growth factors and signaling pathways.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Sadia Perveen, Daniela Rossin, Emanuela Vitale, Rachele Rosso, Roberto Vanni, Caterina Cristallini, Raffaella Rastaldo, Claudia Giachino
Summary: Myocardial infarction is a leading cause of heart-related deaths worldwide, and the potential of acellular scaffolds in treating MI is significant, as they can improve cardiac regeneration, limit adverse LV remodelling, and enhance heart function recovery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biotechnology & Applied Microbiology
Hamed Nosrati, Reza Aramideh Khouy, Ali Nosrati, Mohammad Khodaei, Mehdi Banitalebi-Dehkordi, Korosh Ashrafi-Dehkordi, Samira Sanami, Zohreh Alizadeh
Summary: The skin serves as the body's primary barrier against external pathogens and maintaining homeostasis. Damage to the skin can have significant impacts on health and quality of life. Tissue engineering aims to enhance tissue regeneration, with improving angiogenesis being one of the most effective treatments for skin tissue regeneration.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Polymer Science
Igor Slivac, Emilija Zdraveva, Fran Ivancic, Bojan Zunar, Tamara Holjevac Grguric, Visnja Gaurina Srcek, Ivan-Kresimir Svetec, Tamara Dolenec, Emi Govorcin Bajsic, Mirna Tominac Trcin, Budimir Mijovic
Summary: This study compared the structural and biological characteristics of cell scaffolds made of synthetic polyester and natural protein-based extracellular matrix, showing that the differences between the two matrices did not affect cell growth and transfection efficiency. The results suggest that PCL electrospun mats can be a viable option for producing simple, cell carrying structures that adequately simulate the natural scaffold.
Review
Pharmacology & Pharmacy
Anna Yusuf Aliyu, Oluwatoyin A. Adeleke
Summary: Chronic wounds in poorly managed diabetics are difficult to heal due to long-term uncontrolled blood glucose levels. To prevent complications, special medical care is needed. Nanofibrous scaffolds are a promising treatment due to their flexibility, ability to load bioactive compounds, and biomimetic environment for cell proliferation.
Article
Biochemical Research Methods
Silvia M. Becerra-Bayona, Victor Alfonso Solarte, Juan David Alviar Rueda, Claudia L. Sossa, Martha L. Arango-Rodriguez
Summary: This study evaluates the impact of human platelet-rich plasma on human adipose-derived mesenchymal stem cells. The results show that culturing the stem cells in media supplemented with platelet-rich plasma leads to changes in cell morphology and gene expression, as well as promotion of osteogenic differentiation in the absence of differentiation medium.
Article
Oncology
Virginia Abello, William Armando Mantilla, Henry Idrobo, Claudia Lucia Sossa, Luis Antonio Salazar, Angela Pena, Juan Manuel Herrera, Paola Guerrero, Daniel Espinosa, Guillermo Enrique Quintero-Vega, Isabel Munevar, Kenny Galvez, Alicia Henao, Rigoberto Gomez, Jose Domingo Saavedra, Lina Maria Gaviria, Monica Osuna, Maria Victoria Mateos
Summary: This study provides an overview of clinical characteristics and outcomes of multiple myeloma patients in Colombia, highlighting the impact of access barriers on diagnosis and treatment outcomes. The data shows that despite the availability of novel drugs, advanced stage diagnosis and low transplantation rates in Latin American countries significantly affect survival.
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2022)
Review
Medicine, General & Internal
Claudia Lucia Sossa Melo, Carlos Alberto Orozco Orozco, Angela Maria Pena Castellanos, Maria Alejandra Rueda Perea, Cristian Orlando Porras Bueno, Carlos Ivan Romero Diaz, Helga Natalia Rojas Rodriguez
Summary: This case report describes a patient initially presenting with ischemic priapism in the emergency department, later diagnosed with chronic myeloid leukemia in the postoperative period. Priapism is a rare manifestation of chronic myeloid leukemia, often caused by hyperleukocytosis leading to thrombus formation and venous outflow obstruction in the corpora cavernosa. It is considered a medical emergency requiring immediate treatment to prevent irreversible cell damage and fibrosis.
CLINICAL CASE REPORTS
(2021)
Review
Hematology
Federica R. Achini-Gutzwiller, John A. Snowden, Selim Corbacioglu, Raffaella Greco
Summary: Although modern clinical management strategies have improved the outcome of paediatric patients with severe autoimmune and inflammatory diseases, a proportion will still experience ongoing or recurrent/relapsing disease activity. Autologous and allogeneic haematopoietic stem cell transplantation (HSCT) have been successfully used to induce disease control and cure in children with severe treatment-refractory autoimmune diseases. However, the long-term outcomes and balancing risks of HSCT against other non-transplant options are challenging. Further research is needed to establish the position of HSCT in paediatric autoimmune diseases.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Cell & Tissue Engineering
Martha L. Arango-Rodriguez, Victor Alfonso Solarte-David, Silvia M. Becerra-Bayona, Eduardo Callegari, Maria D. Paez, Claudia L. Sossa, Miguel Enrique Ochoa Vera, Ligia C. Mateus, Sergio Eduardo Serrano, Andrea K. Ardila-Roa, Lady T. Girata Viviescas
Summary: This study aimed to evaluate the safety and efficacy profile of allogeneic bone marrow mesenchymal stromal cells derivatives (allo-hBM-MSCDs) relative to conventional treatment in patients with grade 1 and 2 diabetic foot ulcers (DFUs). The results showed that patients treated with allo-hBM-MSCDs achieved better outcomes in terms of ulcer closure, skin regeneration, and ulcer-free survival compared to those receiving conventional treatment.
Review
Cell & Tissue Engineering
Laura Lozano Navarro, Xueyi Chen, Lady Tatiana Girata Viviescas, Andrea K. Ardila-Roa, Maria L. Luna-Gonzalez, Claudia L. Sossa, Martha L. Arango-Rodriguez
Summary: Peripheral arterial disease affects hundreds of millions of people worldwide and can lead to limb amputation or death. Revascularization is crucial for preventing amputation, but a significant portion of patients are not suitable for traditional surgical treatment, resulting in higher amputation rates. Mesenchymal stem cells have emerged as a promising cell-based therapy for peripheral arterial disease due to their regenerative properties.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Polymer Science
Viviana R. Guiza-Arguello, Victor A. Solarte-David, Angie Pinzon-Mora, Jhair E. Avila-Quiroga, Silvia M. Becerra-Bayona
Summary: Diabetic foot ulcers are a common complication of diabetes, leading to significant healthcare costs and amputations. Current clinical treatments have limited effectiveness, necessitating the development of novel strategies. Hydrogels, with their unique properties, show promise for improved DFU treatment.
Article
Parasitology
Claudia Marcela Chalela, Angela Maria Pena, Angela Maria Roa, David L. Reyes, Jennifer Paola Rueda, Luis Antonio Salazar, Manuel Rosales, Edgar David Gomez, Edgar Augusto Bernal, Claudia Lucia Sossa Melo
Summary: Chagas disease, caused by Trypanosoma cruzi, can reactivate through drug-induced immunosuppression during transplantation. A case of a 62-year-old man with Hodgkin lymphoma who tested positive for CD pre-transplantation exhibited fever and elevated inflammatory markers before and after SCT, with evidence of trypomastigotes in a Micro-Strout test. Following treatment with benznidazole, the patient tested negative and post-transplantation seropositive patients should be screened for possible reactivation.
REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL
(2021)
Article
Engineering, Biomedical
Ahmad S. Arabiyat, Silvia Becerra-Bayona, Timothy Kamaldinov, Dany J. Munoz-Pinto, Mariah S. Hahn
Summary: Cell traction forces, biochemical signals, and cell metabolism play crucial roles in regulating mesenchymal stem cell (MSC) differentiation. This study indicates that hydrogel elastic modulus and mesh size can regulate MSC differentiation by modulating the activity of the metabolic enzyme GAPDH.
REGENERATIVE ENGINEERING AND TRANSLATIONAL MEDICINE
(2021)