Article
Biochemistry & Molecular Biology
Amin Arif, Ruhul Quds, Samreen Salam, Riaz Mahmood
Summary: In this study, we found that dietary antioxidant esculin can protect human erythrocytes from oxidative damage caused by the insecticide bioallethrin. Bioallethrin induced oxidative stress, resulting in increased oxidative proteins and lipids, decreased amino groups and reduced to oxidized glutathione ratio in erythrocytes. It also increased the generation of reactive oxygen and nitrogen species, altered plasma membrane integrity, oxidized hemoglobin, and affected antioxidant enzyme activities and redox system. However, pretreatment with esculin significantly restored these parameters in a concentration-dependent manner. Therefore, esculin can be an effective chemoprotectant against xenobiotic-induced toxicity in human erythrocytes.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Article
Food Science & Technology
Jia-yi Zhou, Hua-lin Lin, Ying-chao Qin, Xiang-guang Li, Chun-qi Gao, Hui-chao Yan, Xiu-qi Wang
Summary: The study revealed that LC protects the intestine against DON by promoting differentiation of intestinal stem cells, improving cell proliferation and apoptosis, repairing intestinal damage, and enhancing antioxidant capacity.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Giuseppe Caruso, Cristina Benatti, Nicolo Musso, Claudia G. Fresta, Annamaria Fidilio, Giorgia Spampinato, Nicoletta Brunello, Claudio Bucolo, Filippo Drago, Susan M. Lunte, Blake R. Peterson, Fabio Tascedda, Filippo Caraci
Summary: The study showed that carnosine can protect macrophages from cell death and apoptosis induced by Aβ 1-42 oligomers, decrease oxidative stress, enhance macrophage phagocytic activity, and rescue fractalkine receptor CX3CR1. These new findings support the therapeutic potential of carnosine in the context of AD pathology, highlighting its multimodal mechanism of action.
Article
Biochemistry & Molecular Biology
Junjie Du, Dongmin Yu, Jinghang Li, Linjie Si, Dawei Zhu, Ben Li, Yizhou Gao, Lifu Sun, Xufeng Wang, Xiaowei Wang
Summary: Through mouse experiments and in vitro cell experiments, it was found that Asiatic acid (AA) enhances the survival of cardiomyocytes and alleviates cardiac dysfunction by protecting mitochondrial structure, reducing oxidative stress, inhibiting mitochondrial-dependent apoptosis pathway, and inhibiting the activation of the JNK pathway, which highlights its potential therapeutic value in chronic pressure overload-induced heart failure and oxidative stress-induced cardiomyocyte apoptosis.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Plant Sciences
Yanfen Cheng, Xiaoping Wu, Xin Nie, Yihan Wu, Chen Zhang, Simon Ming-Yuen Lee, Kongpeng Lv, George Pak-Heng Leung, Chaomei Fu, Jinming Zhang, Jingjing Li
Summary: Glycyrrhetinic acid (GA) protects against doxorubicin-induced cardiotoxicity by suppressing oxidative stress, mitochondrial dysfunction, and apoptosis via upregulating the Nrf2/HO-1 signaling pathway.
Article
Cell Biology
Alessia Remigante, Sara Spinelli, Elisabetta Straface, Lucrezia Gambardella, Daniele Caruso, Giuseppe Falliti, Silvia Dossena, Angela Marino, Rossana Morabito
Summary: Aging is a decline in physiological functions, closely related to oxidative stress (OS). Functional foods rich in flavonoids are effective in counteracting age-related changes. This study confirmed the protective role of Aca extract in a model of aging in human erythrocytes, reducing OS damage and restoring protein distribution alterations.
Article
Food Science & Technology
Jozaa Z. ALTamimi, Nora A. AlFaris, Ghedeir M. Alshammari, Reham Alagal, Dalal H. Aljabryn, Hussain Aldera, Bahauddeen M. Alrfaei, Mahmoud A. Alkhateeb, Mohammed A. Yahya
Summary: The study showed that EA can improve diabetic nephropathy in rats through antioxidant and anti-inflammatory effects. In STZ-induced diabetic rats, EA prevented renal damage, oxidative stress, inflammation, and apoptosis.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Cardiac & Cardiovascular Systems
Huijing Yu, Fang Zhang, Pengyi Yan, Shasha Zhang, Yingmei Lou, Zilong Geng, Zixuan Li, Yan Zhang, Yuejuan Xu, Yanan Lu, Chen Chen, Daowen Wang, Wei Zhu, Xinyang Hu, Jian'an Wang, Tao Zhuang, Yuzhen Zhang, Gengze Wu, Junling Liu, Chunyu Zeng, William T. Pu, Kun Sun, Bing Zhang
Summary: LARP7 plays a crucial role in mitochondrial biogenesis, energy production, and cardiac function by modulating SIRT1 homeostasis and activity. Reduction of LARP7 in diseased hearts contributes to heart failure pathogenesis, while restoring LARP7 in the injured heart confers myocardial protection, identifying the ATM-LARP7-SIRT1 pathway as a potential therapeutic target in heart failure.
Article
Cell Biology
Yan Che, Zhaopeng Wang, Yuan Yuan, Heng Zhou, Haiming Wu, Shasha Wang, Qizhu Tang
Summary: Corosolic acid (CRA) has shown protective effects against doxorubicin (Dox)-induced cardiotoxicity by promoting transcription factor EB (TFEB) nuclear translocation, reducing apoptosis, and decreasing oxidative stress. CRA activates TFEB in an AMPK alpha 2-dependent manner to protect against Dox cardiotoxicity by restoring autophagic flux and improving mitochondrial structure and function.
CELL BIOLOGY AND TOXICOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ivana Jukic, Nikolina Kolobaric, Ana Stupin, Anita Matic, Natasa Kozina, Zrinka Mihaljevic, Martina Mihalj, Petar Susnjara, Marko Stupin, Zeljka Breskic Curic, Kristina Selthofer-Relatic, Aleksandar Kibel, Anamarija Lukinac, Luka Kolar, Gordana Kralik, Zlata Kralik, Aleksandar Szechenyi, Marija Jozanovic, Olivera Galovic, Martina Medvidovic-Kosanovic, Ines Drenjancevic
Summary: Carnosine is a dipeptide synthesized in the body with beneficial antioxidant properties, mainly found in the brain, muscle, and gastrointestinal tissues. Its component beta-alanine can serve as a dietary supplement to increase muscle carnosine and improve exercise effectiveness. While widely used among athletes, carnosine is less commonly utilized in cardiovascular or diabetic patients.
Article
Biochemistry & Molecular Biology
Kaori Suyama, Daisuke Sakai, Shogo Hayashi, Ning Qu, Hayato Terayama, Daisuke Kiyoshima, Kenta Nagahori, Masahiko Watanabe
Summary: In this study, we found that Bag-1 binds to HSP70 but not to Raf-1 in NP cells, and this interaction enhances cell viability and mitochondrial function while suppressing p38/MAPKs phosphorylation during oxidative stress. However, inhibition of the Bag-1 C-terminal binding site decreases cell viability and mitochondrial function. In addition, the phosphorylation of ERK/MAPKs is significantly increased in the absence of H2O2 treatment, while the phosphorylation of Raf-1 is not affected by Bag-1.
Article
Medicine, Research & Experimental
Sahib Zada, Trang Minh Pham, Jin Seok Hwang, Mahmoud Ahmed, Trang Huyen Lai, Omar Elashkar, Jung-Hwan Kim, Dong Hee Kim, Deok Ryong Kim
Summary: The study demonstrates that chlorogenic acid (CGA) protects human chondrocytes against H2O2-induced apoptosis by decreasing apoptosis markers, increasing anti-apoptotic markers, and activating antioxidant response proteins through autophagy induction.
Article
Biochemistry & Molecular Biology
Qianqian Wang, Yasutaka Kuroda, Lingli Yang, Sylvia Lai, Yukiko Mizutani, Arunasiri Iddamalgoda, Jiao Guo, Asako Yamamoto, Daiki Murase, Yoshito Takahashi, Leihong Xiang, Shintaro Inoue, Daisuke Tsuruta, Ichiro Katayama
Summary: Glycoprotein non-metastatic melanoma protein B (GPNMB) is an important transmembrane glycoprotein involved in cancer metastasis and osteoblast differentiation, with protective effects on melanocytes from oxidative stress. Decreased GPNMB expression was observed in vitiligo and rhododendrol-induced leukoderma, suggesting a potential role in their pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Reem S. Alruhaimi
Summary: This study aimed to evaluate the protective activity of betulinic acid (BA) against chlorpyrifos (CPF) cardiotoxicity in rats by mitigating oxidative stress, inflammation, and apoptosis, and enhancing Nrf2 and antioxidants. The results showed that BA can ameliorate tissue injury, decrease oxidative stress, inflammation and apoptosis, and increase antioxidants.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Plant Sciences
Tomoki Oshita, Joongeun Sim, Taufika Islam Anee, Hanako Kiyono, Chihiro Nozu, Nobuhiro Suzuki
Summary: This study investigated the effects of heat, cadmium (Cd), and their combination on the growth and physiological characteristics of Arabidopsis thaliana. The combination of heat and Cd stress had more negative effects on Arabidopsis plants compared to individual stresses, despite similar Cd accumulation. This stress combination caused a reduction in photosynthetic proteins and increased lipid peroxidation, indicating oxidative damage. Interestingly, mutants deficient in jasmonic acid (JA) synthesis showed reduced negative effects of the stress combination on growth and photosystem II efficiency.
JOURNAL OF PLANT PHYSIOLOGY
(2023)
