Article
Psychiatry
Gianluca Pandolfo, Giovanni Genovese, Antonio Bruno, Domenica Campolo, Valeria Tigano, Mariateresa Cristani, Marco Casciaro, Giovanni Pioggia, Sebastiano Gangemi
Summary: The pathophysiology of schizophrenia is still not well understood. Genetic factors and oxidative stress play key roles in its development and progression. Oxidative stress leads to the continuous production of oxidation products, such as AGEs and AOPPs, which interact with their receptors, amplifying the production of reactive oxygen species (ROS) and pro-inflammatory cytokines. In this study, plasma levels of AGEs and AOPPs were found to be significantly higher in schizophrenia patients compared to controls, confirming their involvement in mental disorders. Antioxidant nutraceuticals and a healthy lifestyle could reduce oxidative stress and alleviate schizophrenia symptoms.
PSYCHIATRY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Giuseppe Caruso, Anna Privitera, Miriam Wissam Saab, Nicolo Musso, Salvatore Maugeri, Annamaria Fidilio, Anna Provvidenza Privitera, Alessandra Pittala, Renaud Blaise Jolivet, Luca Lanzano, Giuseppe Lazzarino, Filippo Caraci, Angela Maria Amorini
Summary: The activity of microglia plays a crucial role in various physiological processes and its imbalance can lead to neurodegenerative disorders. Carnosine, a naturally occurring molecule, has antioxidant and anti-inflammatory activities, and can modulate immune cell response and energy metabolism. Understanding microglia characteristics and their response to environmental challenges is important for therapeutic strategies.
Review
Biochemistry & Molecular Biology
Carolina Di Fabrizio, Veronica Giorgione, Asma Khalil, Colin E. Murdoch
Summary: Human pregnancy can be affected by various pathologies, including gestational diabetes mellitus and hypertensive disorders, which can have severe consequences. Health issues during pregnancy and postpartum contribute significantly to maternal mortality and morbidity. This review focuses on the latest evidence on oxidative stress in pregnancy complications, early diagnosis, and potential therapies.
Article
Biochemistry & Molecular Biology
Gianni Paulis, Giovanni De Giorgio
Summary: This study describes three cases of Peyronie's disease patients who achieved complete resorption of plaque through antioxidant treatment, providing useful experience for urological clinical practice.
Review
Biochemistry & Molecular Biology
Fernando Bartolome, Eva Carro, Carolina Alquezar
Summary: Oxidative stress is the imbalance between reactive oxygen species (ROS) production and the antioxidant capacity of cells. The human brain is highly susceptible to oxidative stress, making it an essential component in the pathophysiology of neurodegenerative diseases such as tauopathies. However, there currently exist no effective therapies for these diseases. Although antioxidant therapies have shown promise in preclinical studies, clinical trials have been disappointing. To develop effective antioxidant therapies, a complete understanding of the molecular mechanisms underlying oxidative stress in tauopathies is crucial.
Review
Biochemistry & Molecular Biology
Izabela Korczowska-Lacka, Bartosz Slowikowski, Thomas Piekut, Mikolaj Hurla, Natalia Banaszek, Oliwia Szymanowicz, Pawel P. Jagodzinski, Wojciech Kozubski, Agnieszka Permoda-Pachuta, Jolanta Dorszewska
Summary: In diseases of the central nervous system, oxidative stress load commonly exceeds the body's antioxidant capacity. Endogenous antioxidants such as enzymes and exogenous antioxidants like vitamins and polyphenols play a significant role in preventing oxidative damage. However, the clinical efficacy and effectiveness of these antioxidants in neurological diseases need further research and definition.
Review
Biochemistry & Molecular Biology
Munsoo Han, Dabin Lee, Sang Hag Lee, Tae Hoon Kim
Summary: Oxidative stress plays a crucial role in redox metabolism in various physiological and pathological conditions, and antioxidants are important in treating associated diseases. Allergic rhinitis significantly impacts daily function and quality of life, with a high socioeconomic burden and prevalence, with recent studies focusing on the role of oxidative stress and antioxidants in this condition.
Article
Multidisciplinary Sciences
Danielli M. M. Dantas, Thiago B. Cahu, Carlos Yure B. Oliveira, Ricardo Abadie-Guedes, Nathalia A. Roberto, Werlayne M. Santana, Alfredo O. Galvez, Rubem C. A. Guedes, Ranilson S. Bezerra
Summary: Recent advances in microalgae biotechnology have shown that microorganisms like Chlorella vulgaris contain beneficial bioactive molecules that can be used in functional beverages to protect tissues from oxidative damage. In vitro and in vivo tests demonstrated the protective effects of a functional alcoholic beverage made from C. vulgaris biomass in rat brains. The beverage not only improved cortical spreading depression but also helped control weight gain in animals, suggesting a potential physiological role in protecting brain cells from the effects of alcohol consumption.
Review
Biochemistry & Molecular Biology
Gianni Paulis, Giovanni De Giorgio, Luca Paulis
Summary: The article provides a narrative review of the current literature on antioxidant therapy for Peyronie's disease. The results demonstrate the positive effects of antioxidant treatment on the disease, although further randomized controlled studies are needed for confirmation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
F. Timoteo-Ferreira, D. Abreu, S. Mendes, L. Matos, A. R. Rodrigues, H. Almeida, E. Silva
Summary: The age of women having their first child is increasing, posing a major health challenge to society. Advanced maternal age is associated with decreased fertility, pregnancy complications, and offspring health issues. Ovarian aging, due to a decline in follicle number and oocyte quality, is a key contributor to female reproductive decline.
AGEING RESEARCH REVIEWS
(2021)
Review
Biochemistry & Molecular Biology
Karolina Pierzynowska, Lidia Gaffke, Zuzanna Cyske, Grzegorz Wegrzyn, Brigitta Buttari, Elisabetta Profumo, Luciano Saso
Summary: Mucopolysaccharidoses (MPS) are metabolic diseases caused by gene mutations, with oxidative stress being a major factor influencing disease progression. Available treatments such as enzyme replacement therapy and stem cell transplantation are limited in effectiveness, leading to discussions on the potential use of molecules with antioxidative activities as accompanying drugs for MPS management.
Review
Nutrition & Dietetics
Umberto Rodella, Claudia Honisch, Claudio Gatto, Paolo Ruzza, Jana D'Amato Tothova
Summary: This review discusses the delicate balance between the physiological production of reactive oxygen species and the role of antioxidant nutraceutical molecules in managing radicals in the eye. Various molecules and enzymes with reducing and antioxidant potential are present in different parts of the eye. Some are endogenously produced while others must be obtained through the diet. When the equilibrium between radical production and scavenging is disrupted, oxidative stress-related eye disorders can occur. The efficacy of antioxidant supplementation in preventing these disorders has been mixed, indicating a need for further research.
Review
Chemistry, Multidisciplinary
Young Geon Kim, Yunjung Lee, Nohyun Lee, Min Soh, Dokyoon Kim, Taeghwan Hyeon
Summary: The field of nanocatalytic therapy, which employs catalytic reactions mediated by nanomaterials to intervene in disease-critical biomolecular processes, has gained increasing interest in the last 20 years. Ceria nanoparticles have shown unique scavenging properties against biologically noxious free radicals, making them potential candidates for self-regenerating antioxidative and anti-inflammatory agents in disease therapy. This review provides an overview of the characteristics of ceria nanoparticles, their scavenging mechanisms, and recent therapeutic applications, as well as the challenges and future research directions.
ADVANCED MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Angelica Rodriguez-Nino, Diego O. Pastene, Adrian Post, M. Yusof Said, Antonio W. Gomes-Neto, Lyanne M. Kieneker, M. Rebecca Heiner-Fokkema, Tuba Esatbeyoglu, Gerald Rimbach, Peter Schnuelle, Benito A. Yard, Stephan J. L. Bakker
Summary: High urinary carnosinase-1 concentrations are associated with increased risk of graft failure in kidney transplant recipients, potentially due to decreased urinary carnosine levels. Further studies are needed to explore the potential of carnosine supplementation in these patients.
Article
Biochemistry & Molecular Biology
Cristiano Soares, Pedro Nadais, Bruno Sousa, Edgar Pinto, Isabel M. P. L. V. O. Ferreira, Ruth Pereira, Fernanda Fidalgo
Summary: The foliar application of silicon, either as bulk or nano forms, was found to enhance Solanum lycopersicum L. tolerance to glyphosate by reducing oxidative stress and upregulating antioxidant enzymes. Both sources of silicon showed potential in alleviating glyphosate-induced toxicity, with no significant differences in efficacy observed.
Article
Physiology
Dijana Dumancic, Ana Stupin, Maja Kozul, Vatroslav Seric, Aleksandar Kibel, Nandu Goswami, Bianca Brix, Zeljko Debeljak, Rudolf Scitovski, Ines Drenjancevic
Summary: The aim of this study was to investigate the effect of a 7-day high salt diet on the reactivity of the middle cerebral artery to orthostatic challenge in healthy individuals. The results demonstrated that high salt diet altered the vascular reactivity of the middle cerebral artery, leading to increased cerebrovascular resistance and reduced sympathetic activity.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Nutrition & Dietetics
Martina Kos, Tihana Nad, Lorena Stanojevic, Matea Lukic, Ana Stupin, Ines Drenjancevic, Silvija Puseljic, Erna Davidovic Cvetko, Zrinka Mihaljevic, Dijana Dumancic, Ivana Jukic
Summary: This study investigated salt consumption in normotensive and hypertensive children and found that hypertensive children have significantly higher salt intake compared to normotensive children, which is positively associated with blood pressure and body mass index. Cardiovascular disease prevention in childhood should focus on reducing salt intake and preventing overweight/obesity, as these are two important modifiable risk factors for hypertension.
Article
Biochemistry & Molecular Biology
Stana Tokic, Maja Jirous, Vera Pluzaric, Martina Mihalj, Marija Sola, Maja Tolusic Levak, Kristina Glavas, Peter Balogh, Mario Stefanic
Summary: Psoriasis vulgaris (PV) is an autoinflammatory dermatosis of unknown etiology. Gamma delta T cells play a pathogenic role in PV, and differential miRNA expression is related to the composition of these cells. This study found a decrease in miR-20a and an increase in miR-92b in PV patients, which may contribute to PV pathogenesis by affecting mRNA/miRNA transcriptional circuits in gamma delta T cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ivana Tolj, Ana Stupin, Ines Drenjancevic, Petar Susnjara, Leon Peric, Marko Stupin
Summary: This study aimed to investigate the specific role of nitric oxide (NO) in micro- and macrovascular response to a 7-day high-salt (HS) diet in healthy individuals. It found that the HS diet resulted in impaired NO-mediated endothelial vasodilation, with increased eNOS, decreased nNOS, and unchanged iNOS concentration and NO serum level. The study also failed to support the concept of non-osmotic sodium storage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Nikolina Kolobaric, Martina Mihalj, Natasa Kozina, Anita Matic, Zrinka Mihaljevic, Ivana Jukic, Ines Drenjancevic
Summary: High salt intake leads to hemodynamic changes and immune response, causing pro-inflammatory conditions. In this study, knock-out mice showed lower levels of inflammatory response compared to wild-type mice after salt-loading.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Analytical
Mirela Samardzic, Mateja Persic, Aleksandar Szechenyi, Marija Jozanovic, Iva Pukles, Mateja Budetic
Summary: The aim of this research was to develop a solid-contact sensor for the potentiometric determination of Promethazine hydrochloride (PM). The membrane composition for the new PM sensor was optimized by varying different membrane plasticizers and the content of the sensing material. The best analytical performances were obtained using a sensor with 2-nitrophenyl phenyl ether (NPPE) as the plasticizer and 4% of the sensing material.
Article
Chemistry, Analytical
Nikola Sakac, Dubravka Madunic-Cacic, Dean Markovic, Marija Jozanovic
Summary: The behavior of a new DODI-TPB surfactant sensor was analyzed in single and complex mixtures of QACs commonly used in COVID-19 disinfectants. The results showed that the DODI-TPB sensor performed well and can accurately distinguish different components in the mixtures. The sensor was also successfully tested in ten different COVID-19 disinfectant formulations.
Article
Nutrition & Dietetics
Petar Susnjara, Zrinka Mihaljevic, Ana Stupin, Nikolina Kolobaric, Anita Matic, Ivana Jukic, Zlata Kralik, Gordana Kralik, Andelina Miloloza, Tihana Pavosevic, Vatroslav Seric, Zdenko Loncaric, Darko Kerovec, Olivera Galovic, Ines Drenjancevic
Summary: The present study aimed to evaluate the effects of enriched hen egg consumption on endothelium-dependent vasodilation (EDV) in young healthy individuals. The results suggest that consumption of enriched eggs improves microvascular EDV in healthy young subjects.
Review
Agriculture, Dairy & Animal Science
Kristina Gvozdanovic, Zlata Kralik, Zarko Radisic, Manuela Kosevic, Gordana Kralik, Ivona Djurkin Kusec
Summary: The addition of bioactive compounds to chicken feed improves the health and production traits of the animals. Nutrigenomics helps understand the molecular relationship between nutrients in the feed and the genes that affect desired phenotypes. This knowledge can be used to produce high-quality chicken products that positively impact human health.
Article
Chemistry, Multidisciplinary
Zeljka Breskic Curic, Ana Stupin, Ana Marija Masle, Petar Susnjara, Natasa Kozina, Zrinka Mihaljevic, Ivana Jukic, Aleksandar Kibel, Nikolina Kolobaric, Brankica Juranic, Diana Nejasmic, Anita Sporec, Marija Lovric, Kristina Selthofer-Relatic, Ines Drenjancevic
Summary: The aim of this clinical study was to investigate the impact of chicken eggs enriched with n-3 polyunsaturated fatty acids, selenium, vitamin E, and lutein on vascular dilation, inflammation, and oxidative stress levels in patients with chronic coronary syndrome. The study found that enriched eggs significantly improved vascular dilation, reduced inflammation, and improved lipid profiles in patients with chronic coronary syndrome.
APPLIED SCIENCES-BASEL
(2023)
