Review
Chemistry, Multidisciplinary
Jia Li, Meng Zheng, Olga Shimoni, William A. Banks, Ashley I. Bush, Jennifer R. Gamble, Bingyang Shi
Summary: The blood-brain barrier is a crucial neurovascular unit that prevents harmful substances from entering the brain and maintains normal neuronal function. Disruption of BBB in diseases can contribute to disease progression, while restoration of BBB integrity is a biomarker for better clinical outcomes. The BBB also plays a role in facilitating communication between neuronal and circulatory systems, showing promising results for brain-targeted drug delivery.
Review
Pharmacology & Pharmacy
Lais Ribovski, Naomi M. Hamelmann, Jos M. J. Paulusse
Summary: Safe and reliable entry into the brain is crucial for successful treatment of central nervous system disorders, but remains challenging. Nano-sized systems as drug carriers show significant improvements in therapy delivery. Careful design of NP properties is essential for successful brain delivery, affecting the ability to overcome multiple barriers.
Review
Chemistry, Multidisciplinary
Fatemeh Madani, Seyedeh Sara Esnaashari, Thomas J. Webster, Masood Khosravani, Mahdi Adabi
Summary: This review discusses the challenges of delivering drugs through the blood-brain barrier (BBB) in glioblastoma (GBM) treatment and introduces the latest advances in using nanoparticles for this purpose. It also describes the development of drug delivery and combination modalities using natural and synthetic polymer nanoparticles, as well as adjuvant therapies for GBM treatment. Additionally, it explains the receptor-mediated endocytosis agents that exist in brain endothelial capillary cells and emphasizes future research directions.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Chemistry, Multidisciplinary
Ekta Jagtiani, Mihika Yeolekar, Shivraj Naik, Vandana Patravale
Summary: Understanding the BBB enables the development of new techniques for CNS medication and improvement of existing models. In vitro BBB models have been formed to study the pathology of BBB and its mechanism of action in CNS disorders. The microfluidics-based BBB-on-Chip model has been developed for realistic simulation and drug permeability testing. Evaluating in vitro BBB models is critical for developing CNS treatments with improved BBB penetrability.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Pharmacology & Pharmacy
Xue Du, Chunbao Chen, Lu Yang, Yu Cui, Bangxian Tan
Summary: This study visualized the scientific achievements and research trends of applying nanotechnology in glioma treatment. China had the highest number of publications in this field, and strong collaboration among research institutions was observed. Drug delivery was identified as a hot topic based on keyword frequency.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Obaydah Abd Alkader Alabrahim, Hassan Mohamed El-Said Azzazy
Summary: As the world's population ages, the incidence of Parkinson's disease continues to rise. Current therapies primarily target dopamine or its precursor, but the delivery of exogenous dopamine or levodopa is hindered by poor bioavailability and the blood-brain barrier. However, the fabrication of polymeric nanoparticles provides a new approach for drug delivery to the brain.
NANOSCALE ADVANCES
(2022)
Article
Chemistry, Multidisciplinary
Suyeong Seo, Seung-Yeol Nah, Kangwon Lee, Nakwon Choi, Hong Nam Kim
Summary: The study introduced an engineered 3D human glioblastoma in vitro platform integrated with a tricultured BBB, allowing for mimicking the physiological environment of brain tumors. The platform showed potential for studying the physiology of the BBB and monitoring drug responses based on the interaction between brain tumor cells and the BBB.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Engineering, Biomedical
Raleigh M. Linville, Alexander Komin, Xiaoyan Lan, Jackson G. DeStefano, Chengyan Chu, Guanshu Liu, Piotr Walczak, Kalina Hristova, Peter C. Searson
Summary: Melittin, a membrane active peptide found in bee venom, enables transient blood-brain barrier opening for delivery of therapeutics into the brain. Studies on endothelial and neuronal viability identified the effective concentration range for BBB opening, and a tissue-engineered model was used to optimize dosing and understand the mechanism. Melittin and other membrane active variants increase paracellular permeability temporarily by disrupting cell-cell junctions.
Review
Cell Biology
Md. Mominur Rhaman, Md. Rezaul Islam, Shopnil Akash, Mobasharah Mim, Md. Noor Alam, Eugenie Nepovimova, Martin Valis, Kamil Kuca, Rohit Sharma
Summary: In recent years, there has been a strong emphasis on using nanostructured materials technologies to improve medicine delivery to the central nervous system (CNS), particularly for the treatment of neurodegenerative diseases. Nanomaterials can target specific brain regions and enhance therapy success, offering advantages such as low toxicity and high stability. However, safety concerns need to be addressed before widespread clinical application can be realized.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Weisen Zhang, Ami Mehta, Ziqiu Tong, Lars Esser, Nicolas H. Voelcker
Summary: Polymeric nanoparticles have shown great potential in overcoming the blood-brain barrier for effective drug delivery, with their unique properties offering high tunability and ease of synthesis. Careful analysis of their performance in transporting drugs across the blood-brain barrier is essential for successful drug delivery to the central nervous system.
Article
Chemistry, Multidisciplinary
Liron L. Israel, Tao Sun, Oliver Braubach, Alysia Cox, Ekaterina S. Shatalova, Harun-Mohammad Rashid, Anna Galstyan, Zachary Grodzinski, Xue Ying Song, Oksana Chepurna, Vladimir A. Ljubimov, Antonella Chiechi, Sachin Sharma, Connor Phebus, Yizhou Wang, Julia Y. Ljubimova, Keith L. Black, Eggehard Holler
Summary: Delivery of therapeutic substances to the brain is challenging due to the blood-brain barrier, limited stability, and distribution in brain tissue. However, a study demonstrated efficient delivery of microRNA and antisense RNA specifically to neurons using a biodegradable, amphiphilic, and multivalent platform conjugated with a D3-peptide. This targeting approach, through the transcytosis pathway, shows promise in Alzheimer's disease mouse models.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Biotechnology & Applied Microbiology
Annu, Ali Sartaj, Zufika Qamar, Shadab Md, Nabil A. Alhakamy, Sanjula Baboota, Javed Ali
Summary: The blood-brain barrier hinders the delivery of therapeutic molecules to the brain, but nanotechnology, specifically the use of polymeric nanoparticles, shows great potential in overcoming this barrier and targeting therapeutics to the brain, improving intervention for CNS disorders.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Aziz Unnisa, Nigel H. H. Greig, Mohammad A. A. Kamal
Summary: Nanotechnology involves manipulating shape and size at the nanoscale to design and create structures, devices, and systems. It has shown great potential in improving drug delivery and overcoming the blood-brain barrier for treating brain disorders such as brain cancer and Alzheimer's disease. The use of nanomaterials in diagnostics and controlled drug delivery systems holds promise for enhancing the efficacy of treatments. However, further research is needed to ensure the safety and effectiveness of nanotechnology-assisted drugs.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Materials Science, Multidisciplinary
Tanveer A. Tabish, Roger J. Narayan
Summary: The article discusses the potential of graphene as a drug delivery system to cross the blood-brain barrier, and how it can improve, protect, or rescue brain energetics, with a specific focus on how graphene alters neuronal cell function.
Review
Pharmacology & Pharmacy
Aida Maaz, Ian S. Blagbrough, Paul A. De Bank
Summary: The nasal cavity is a promising route for drug delivery to the brain, with the potential to bypass the blood-brain barrier. However, challenges exist in depositing drug molecules in the olfactory region due to its limited surface area. Aerosolized particles have the potential to target the olfactory region, but specific deposition within this area is influenced by various factors such as formulation properties, delivery device, and patient physiology.