Article
Biology
Marianne E. Emmert, Parul Aggarwal, Kritton Shay-Winkler, Se-Jin Lee, Qingnian Goh, Roger Cornwall
Summary: Neonatal brachial plexus injury (NBPI) leads to muscle contractures, and the study reveals sex dimorphism in the regulation of neonatal longitudinal muscle growth and contractures. It provides insights into finding potential muscle-specific therapeutic targets for contracture prevention and highlights the importance of sex as a biological variable in the pathophysiology of neuromuscular disorders.
Article
Critical Care Medicine
Sumika Osa, Yuki Enoki, Taichi Miyajima, Masahiro Akiyama, Yukio Fujiwara, Kazuaki Taguchi, Yun-Gi Kim, Kazuaki Matsumoto
Summary: This study verified the association between skeletal muscle atrophy induced by sciatic denervation (DN) and poor prognosis after CLP-induced sepsis. The results showed that the DN group had a lower survival rate, higher bacterial count in the blood, and increased kidney damage markers in comparison to the sham group. Additionally, skeletal muscle atrophy led to alterations in cytokine levels and the accumulation of nitrative stress.
Article
Pharmacology & Pharmacy
Anand Kumar, Priyanka Prajapati, Gurvinder Singh, Dinesh Kumar, Vikas Mishra, Seong-Cheol Kim, Chaitany Jayprakash Raorane, Vinit Raj, Sapana Kushwaha
Summary: This study aimed to evaluate the effect of salbutamol on skeletal muscle atrophy in diabetic rats. The findings demonstrated that salbutamol treatment improved muscle strength, muscle coordination, and lean muscle mass in diabetic rats. By impacting metabolites related to muscle inflammation and oxidative stress, salbutamol could be explored as an intervention in diabetic-associated skeletal muscle atrophy.
Article
Physiology
Xiaoming Yang, Ming Li, Yanan Ji, Yinghao Lin, Lai Xu, Xiaosong Gu, Hualin Sun, Wei Wang, Yuntian Shen, Hua Liu, Jianwei Zhu
Summary: Peripheral nerve injury can cause skeletal muscle atrophy and dysfunction. Transcription factors play a key role in this process. The current study identified differentially expressed transcription factors that are mainly involved in immune response, providing insights into the regulatory mechanisms and potential therapeutic targets for muscle atrophy following peripheral nerve injury.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yuta Ozaki, Koji Ohashi, Naoya Otaka, Hayato Ogawa, Hiroshi Kawanishi, Tomonobu Takikawa, Lixin Fang, Minako Tatsumi, Mikito Takefuji, Takashi Enomoto, Mohamed Darwish, Yoko Iijima, Takatoshi Iijima, Toyoaki Murohara, Noriyuki Ouchi
Summary: Neuron-derived neurotrophic factor (NDNF) prevents skeletal muscle atrophy by reducing the expression of ubiquitin E3 ligases. Injections of NDNF increase muscle weight and reverse the decrease in myotube diameter caused by DEX stimulation. Therefore, NDNF could be a potential therapeutic target for muscle atrophy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Cell Biology
Roberta Sartori, Adam Hagg, Sandra Zampieri, Andrea Armani, Catherine E. Winbanks, Lais R. Viana, Mouna Haidar, Kevin Watt, Hongwei Qian, Camilla Pezzini, Pardis Zanganeh, Bradley J. Turner, Anna Larsson, Gianpietro Zanchettin, Elisa S. Pierobon, Lucia Moletta, Michele Valmasoni, Alberto Ponzoni, Shady Attar, Gianfranco Da Dalt, Cosimo Sperti, Monika Kustermann, Rachel E. Thomson, Lars Larsson, Kate L. Loveland, Paola Costelli, Aram Megighian, Stefano Merigliano, Fabio Penna, Paul Gregorevic, Marco Sandri
Summary: The study showed that diminished BMP signaling is associated with cancer-induced muscle wasting, and increasing BMP signaling could prevent muscle wasting. This presents an attractive strategy to counteract the loss of functional musculature in cancer patients.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Svenia Schmid, Barbara Heim-Kupr, Joaquin Perez-Schindler, Shivani Mansingh, Markus Beer, Nitish Mittal, Nikolaus Ehrenfeuchter, Christoph Handschin
Summary: This study reveals the role of PGC-1β in the regulation of catabolic pathways in muscle-specific loss-of-function mouse models. PGC-1β plays a crucial role in protein breakdown, muscle mass preservation, and function.
MOLECULAR METABOLISM
(2022)
Article
Critical Care Medicine
Dandan Yin, Dawei Lin, Yunbin Xie, Aihua Gong, Peng Jiang, Jin Wu
Summary: The study suggests that NRG-1beta can alleviate sepsis-induced skeletal muscle atrophy by inhibiting autophagy via the AKT/mTOR signaling pathway.
Article
Cell Biology
Satya Srirama Karthik Divvela, Eric Bekoe Offei, Florian Suerland, David Revuelta Garcia, Julia Kwiatkowski, Ajeesh Balakrishnan-Renuka, Pauline Bohne, Marion Boing, Gabriela Morosan-Puopolo, Melanie D. Mark, Beate Brand-Saberi
Summary: This study demonstrates the significance of Atoh8 in both myogenesis and the maintenance of skeletal muscle. The results show that Atoh8 regulates myoblast proliferation and muscle fiber type through signaling pathways, playing a crucial role in muscle development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lisa A. Walter, Lauren P. Blake, Yann S. Gallot, Charles J. Arends, Randall S. Sozio, Stephen M. Onifer, Kyle R. Bohnert
Summary: This study investigates the molecular mechanisms controlling skeletal muscle atrophy following denervation. It shows that transection of the sciatic nerve leads to significant skeletal muscle atrophy in rats, while having little effect on the neuromuscular junction. The study also reveals the activation of the unfolded protein response in denervated skeletal muscle, with ATF4 and ATF6 elevated in the cytoplasm and XBP1 elevated in the nuclei. These findings suggest a potential role of the unfolded protein response and XBP1 in maintaining skeletal muscle and the neuromuscular junction after peripheral nerve injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Takuto Hayashi, Takashi Kudo, Ryo Fujita, Shin-ichiro Fujita, Hirona Tsubouchi, Sayaka Fuseya, Riku Suzuki, Michito Hamada, Risa Okada, Masafumi Muratani, Dai Shiba, Takafumi Suzuki, Eiji Warabi, Masayuki Yamamoto, Satoru Takahashi
Summary: The study shows that NRF2 plays a key role in maintaining slow-type muscle fibers in the soleus muscle during space flight, impacting the transition of muscle fiber types. These findings provide important insights into the mechanism of skeletal muscle atrophy in microgravity environments.
COMMUNICATIONS BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Hiroshi Kumagai, Ana Raquel Coelho, Junxiang Wan, Hemal H. Mehta, Kelvin Yen, Amy Huang, Hirofumi Zempo, Noriyuki Fuku, Seiji Maeda, Paulo J. Oliveira, Pinchas Cohen, Su-Jeong Kim
Summary: MOTS-c, a mitochondrial-derived peptide, reduces high-fat-diet-induced muscle atrophy signaling by decreasing myostatin expression. The CK2-PTEN-mTORC2-AKT-FOXO1 pathways play key roles in MOTS-c action on myostatin expression.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Review
Biochemistry & Molecular Biology
Tomohiko Shirakawa, Aki Miyawaki, Tatsuo Kawamoto, Shoichiro Kokabu
Summary: Skeletal muscle in the maxillofacial region plays a crucial role in healthy life, with distinct differences from other regions. Changes in gene expression during muscle remodeling and pros and cons of denervation-induced skeletal muscle atrophy model are discussed. Newly discovered beneficial effects of natural compounds on skeletal muscle atrophy are also highlighted.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Abdurrahman Aslan, Lauren Harlow, Xin-Hua Liu, Rita De Gasperi, William A. Bauman, Marco Brotto, Christopher P. Cardozo
Summary: Skeletal muscle undergoes rapid and extensive atrophy following nerve transection, but the mechanisms behind this process are not fully understood. This study investigated the role of Notch signaling and Numb expression in denervation atrophy. The results showed that nandrolone treatment increased Numb expression and reduced Notch signaling in denervated muscle. However, neither nandrolone nor nandrolone plus testosterone changed the rate of denervation atrophy. Furthermore, conditional knockout of Numb in myofibers had no effect on denervation atrophy. These findings suggest that Numb does not alter the course of denervation atrophy and that upregulation of Numb and inhibition of Notch signaling do not change the progression of denervation atrophy.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Myung-Hun Lee, Jin-Ho Lee, Wan-Joong Kim, Seo Ho Kim, Sun-Young Kim, Han Sung Kim, Tack-Joong Kim
Summary: This study aimed to identify the antioxidant mechanism of linoleic acid (LA) in muscle atrophy caused by oxidative stress. The results showed that cells treated with LA were able to recover from oxidative damage, suggesting that LA may be a candidate substance for preventing muscle atrophy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Behavioral Sciences
Abby Adamczyk, Rebeca Mejias, Kogo Takamiya, Jennifer Yocum, Irina N. Krasnova, Juan Calderon, Jean Lud Cadet, Richard L. Huganir, Mikhail V. Pletnikov, Tao Wang
BEHAVIOURAL BRAIN RESEARCH
(2012)
Article
Medicine, Research & Experimental
Eva Andres-Mateos, Heinrich Brinkmeier, Tyesha N. Burks, Rebeca Mejias, Daniel C. Files, Martin Steinberger, Arshia Soleimani, Ruth Marx, Jessica L. Simmers, Benjamin Lin, Erika Finanger Hedderick, Tom G. Marr, Brian M. Lin, Christophe Hourde, Leslie A. Leinwand, Dietmar Kuhl, Michael Foeller, Silke Vogelsang, Ivan Hernandez-Diaz, Dana K. Vaughan, Diego Alvarez de la Rosa, Florian Lang, Ronald D. Cohn
EMBO MOLECULAR MEDICINE
(2013)
Article
Neurosciences
Ran Xu, Eva Andres-Mateos, Rebeca Mejias, Elizabeth M. MacDonald, Leslie A. Leinwand, Dana K. Merriman, Rainer H. A. Fink, Ronald D. Cohn
EXPERIMENTAL NEUROLOGY
(2013)
Article
Multidisciplinary Sciences
Eva Andres-Mateos, Rebeca Mejias, Arshia Soleimani, Brian M. Lin, Tyesha N. Burks, Ruth Marx, Benjamin Lin, Richard C. Zellars, Yonggang Zhang, David L. Huso, Tom G. Marr, Leslie A. Leinwand, Dana K. Merriman, Ronald D. Cohn
Article
Multidisciplinary Sciences
Rebeca Mejias, Abby Adamczyk, Victor Anggono, Tejasvi Niranjan, Gareth M. Thomas, Kamal Sharma, Cindy Skinner, Charles E. Schwartz, Roger E. Stevenson, M. Daniele Fallin, Walter Kaufmann, Mikhail Pletnikov, David Valle, Richard L. Huganir, Tao Wang
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2011)
Article
Cell Biology
Tyesha N. Burks, Eva Andres-Mateos, Ruth Marx, Rebeca Mejias, Christel Van Erp, Jessica L. Simmers, Jeremy D. Walston, Christopher W. Ward, Ronald D. Cohn
SCIENCE TRANSLATIONAL MEDICINE
(2011)
Article
Neurosciences
Rebeca Mejias, Shu-Ling Chiu, Mei Han, Rebecca Rose, Ana Gil-Infante, Yifan Zhao, Richard L. Huganir, Tao Wang
NEUROBIOLOGY OF DISEASE
(2019)
Review
Oncology
Congcong Zhang, Rina M. Oetjengerdes, Julian Roewe, Rebeca Mejias, Andrea L. J. Marschall
Article
Psychiatry
Rebeca Mejias, Juan J. Rodriguez-Gotor, Minae Niwa, Irina N. Krasnova, Abby Adamczyk, Mei Han, Gareth M. Thomas, Zheng-Xiong Xi, Richard L. Huganir, Mikhail Pletnikov, Akira Sawa, Jean-Lud Cadet, Tao Wang
Summary: This study explores the role of zdhhc15 gene in novelty-seeking behaviors and impulsivity by using knockout mice as experimental models. The research reveals that the absence of zdhhc15 gene may lead to elevated locomotion and extracellular dopamine levels in response to novel environments, suggesting a novel regulatory mechanism of dopamine in the striatum.
TRANSLATIONAL PSYCHIATRY
(2021)
Review
Oncology
Angela Fontan-Lozano, Sara Morcuende, Ma America Davis-Lopez de Carrizosa, Beatriz Benitez-Temino, Rebeca Mejias, Esperanza R. Matarredona
FRONTIERS IN ONCOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Juan F. Cervilla-Martinez, Juan J. Rodriguez-Gotor, Krzysztof J. Wypijewski, Angela Fontan-Lozano, Tao Wang, Enrique Santamaria, William Fuller, Rebeca Mejias
Summary: Through data-mining of palmitome in the cerebral cortex of PD patients and controls, the study identified 150 proteins with altered palmitoylation, which are predicted to impact cytoskeleton, mitochondrial and fibrinogen functions, as well as cell survival. The research suggests that protein palmitoylation may play a role in the pathophysiology of PD, and comprehensive palmitoyl-proteomics is a powerful approach for exploring novel cellular pathways involved in this neurodegenerative disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Eleftheria Koropouli, Qiang Wang, Rebeca Mejias, Randal Hand, Tao Wang, David D. Ginty, Alex L. Kolodkin
Summary: The secretion of Sema3F inhibits dendritic spine formation by palmitoylation of Nrp2, while the secretion of Sema3A enhances basal dendrite extension by palmitoylation of Nrp1. These findings demonstrate the essential role of palmitoylation in establishing neuronal structure and functional responses to guidance cues.
Editorial Material
Physiology
William Fuller, Rebeca Mejias
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Behavioral Sciences
Mei Han, Rebeca Mejias, Shu-Ling Chiu, Rebecca Rose, Abby Adamczyk, Richard Huganir, Tao Wang
BEHAVIOURAL BRAIN RESEARCH
(2017)