Article
Hematology
Markus Spindler, Wolfgang Bergmeier, Theresia E. B. Stradal, Jinyi Zhang, Katherine A. Siminovitch, Leo Nicolai, Annegret Reinhold, Markus Bender
Summary: Mature bone marrow megakaryocytes produce platelets through a mechanism involving actin regulation and integrin activation. Defects in this process can lead to thrombocytopenia and ectopic release of platelet-like particles. This study identifies several proteins that are part of the same pathway regulating directional proplatelet formation, providing insights into the underlying mechanisms and potential therapeutic targets.
Review
Gastroenterology & Hepatology
Mathias K. -M. Herzog, Monica Cazzaniga, Audrey Peters, Nizar Shayya, Luca Beldi, Siegfried Hapfelmeier, Markus M. M. Heimesaat, Stefan Bereswill, Gad Frankel, Cormac G. M. Gahan, Wolf-Dietrich Hardt
Summary: Enteropathogenic bacteria are a major global cause of disease and death, but not all individuals naturally exposed to these bacteria develop disease. The gut microbiota and various barriers contribute to resistance against gastrointestinal infection. However, the mechanisms underlying inter-individual differences in resistance are still not fully understood.
Review
Pathology
Sonia Arely Garcia, Vincent Y. Ng, Masahiro Iwamoto, Motomi Enomoto-Iwamoto
Summary: Osteochondromas are the most common benign bone tumor in children, causing issues such as skeletal deformity and pain. Surgery is currently the only treatment option. Mouse models have been developed to study the pathology and origin of osteochondromas, with research focusing on potential therapeutic drugs.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Multidisciplinary Sciences
Yashpal Rawal, Lijia Jia, Aviv Meir, Shuo Zhou, Hardeep Kaur, Eliza A. Ruben, Youngho Kwon, Kara A. Bernstein, Maria Jasin, Alexander B. Taylor, Sandeep Burma, Robert Hromas, Alexander V. Mazin, Weixing Zhao, Daohong Zhou, Elizabeth V. Wasmuth, Eric C. Greene, Patrick Sung, Shaun K. Olsen
Summary: This study reports cryogenic electron microscopy reconstructions of human BCDX2 in apo and ssDNA-bound states. The structures reveal the participation of the amino-terminal domains of RAD51B, RAD51C and RAD51D in inter-subunit interactions for complex formation and ssDNA-binding specificity. Single-molecule DNA curtain analysis provides insights into how BCDX2 enhances RAD51-ssDNA nucleoprotein filament assembly. Additionally, the cryogenic electron microscopy and functional analyses explain how RAD51C alterations found in patients with cancer inactivate DNA binding and the HR mediator activity of BCDX2.
Review
Oncology
Sharad S. S. Singhal, Rachana Garg, Atish Mohanty, Pankaj Garg, Sravani Keerthi Ramisetty, Tamara Mirzapoiazova, Raffaella Soldi, Sunil Sharma, Prakash Kulkarni, Ravi Salgia
Summary: Animal models, especially genetically engineered mouse models and xenograft transplantation technologies, have greatly advanced our understanding of disease mechanisms, including cancer. These models have been used to evaluate specific genetic changes in carcinogenesis and provide insights into tumor biomarkers. The patient-derived xenograft model has revolutionized drug discovery and therapeutics.
Article
Biotechnology & Applied Microbiology
Xin Huang, Di Sun, Tianzhen Wu, Xing Liu, Shixia Xu, Guang Yang
Summary: This study identified genes related to obesity and cancer control in carnivores, which may have driven the diversifying evolution of body size in the order. The evolution of an effective mechanism to resist cancer in large carnivores provides molecular evidence for Peto's paradox. Additionally, changes in rapidly evolving genes in small carnivores were found to reduce body size.
Review
Oncology
Zachary D. Prudowsky, Jason T. Yustein
Summary: Osteosarcoma is the most common bone malignancy of childhood. Standard chemotherapy regimens work well for many patients, but there are minimal options for patients with progressive or resistant disease. A better understanding of therapy resistance is necessary to improve current treatments and design new strategies for future treatment options.
Review
Oncology
Reihaneh Alsadat Mahmoudian, Moein Farshchian, Fatemeh Fardi Golyan, Parvaneh Mahmoudian, Ali Alasti, Vahid Moghimi, Mina Maftooh, Majid Khazaei, Seyed Mahdi Hassanian, Gordon A. Ferns, Hanie Mahaki, Soodabeh Shahidsales, Amir Avan
Summary: Preclinical models in cancer research can be manipulated to mimic human behavior and conditions through environmental, genomic, molecular, organ system, and physical activity modifications. Recent developments in genetic engineering, such as CRISPR/Cas9, transposable elements, epigenome modifications, and liquid biopsies, have advanced the creation of mouse models for studying cancer. This review focuses on the production and usage of xenografts, chemical-induced models, and genetically engineered mouse models (GEMMs), specifically for esophageal cancer research, and briefly discusses potential gene-editing tools.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Review
Endocrinology & Metabolism
Mengyu Zhang, Wen Jiang, Ganghua Lu, Ru Wang, Zhongwei Lv, Dan Li
Summary: Hyperthyroidism is a condition characterized by excessive production of thyroid hormones, with Graves' disease being the most common cause. Disease models have been established, and novel treatments for Graves' disease and Graves' orbitopathy have been discovered. Potential therapeutic targets have also been identified in mouse models of Graves' orbitopathy. Human placental mesenchymal stem cells, fucoxanthin, and icariin may provide alternative therapies in addition to existing drugs.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Microbiology
Jessica M. Ochoa, Todd O. Yeates
Summary: Bacterial microcompartments are organelle-like structures composed entirely of proteins that enhance metabolic functions. Recent studies have highlighted nuanced variations in microcompartment shell proteins, showing how variation and specialization enable complex molecular machine construction. Engineering synthetic miniaturized microcompartment shells provides additional frameworks for dissecting principles of microcompartment structure and assembly.
CURRENT OPINION IN MICROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Melanie Korbelius, Katharina B. Kuentzel, Ivan Bradic, Nemanja Vujic, Dagmar Kratky
Summary: Lysosomal acid lipase (LAL) is an essential enzyme for degrading neutral lipids in the lysosome. Mutations in the LAL-encoding LIPA gene can cause rare lysosomal lipid storage disorders, leading to reduced or absent LAL activity. This review discusses the impact of defective LAL-mediated lipid hydrolysis on cellular lipid homeostasis, epidemiology, and clinical presentation. Early detection of LAL deficiency (LAL-D) is crucial for disease management and survival. Enzyme replacement therapy, sometimes in combination with hematopoietic stem cell transplantation (HSCT), is currently the only therapy available for LAL-D. New technologies such as mRNA and viral vector gene transfer are being explored as potential therapeutic strategies.
TRENDS IN MOLECULAR MEDICINE
(2023)
Article
Chemistry, Applied
Abeeda Mushtaq, Sajad Mohd Wani, A. R. Malik, Amir Gull, Seema Ramniwas, Gulzar Ahmad Nayik, Sezai Ercisli, Romina Alina Marc, Riaz Ullah, Ahmed Bari
Summary: The increasing demand for healthy diet by consumers has led to the adoption of cutting-edge methods for maintaining the quality of fruits and vegetables without preservatives. Emulsion based coating approach is considered a viable way to extend the shelf life of fresh produce. The developing field of nanoemulsions has created new opportunities in industries such as medicines, cosmetics, and food, as they efficiently encapsulate active ingredients and improve biological activity.
Article
Biology
Lili Wang, Haoran Zhang, Panjing Lv, Yan Li, Maikun Teng, Yahui Liu, Donghai Wu
Summary: Intracellular fatty acid-binding proteins are highly conserved proteins with important functions in regulating fatty acid uptake and intracellular transport. This study reveals the unique structural features of mouse H-FABP, providing a basis for the development of small-molecule inhibitors for H-FABP.
Review
Fisheries
Ling-ke Liu, Man-jun Liu, Dong-Li Li, Hai-peng Liu
Summary: White spot syndrome virus (WSSV) is the most severe viral pathogen for farmed crustaceans, causing significant economic losses globally. Research on WSSV is hindered by the lack of suitable crustacean cell lines for propagation and incomplete host genomes annotations. Recent studies in crayfish have revealed new cellular events related to WSSV infection and immune responses, providing insights for potential antiviral drug development in crustacean farming.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Anas Khawaja, Miriam Cipullo, Annika Krueger, Joanna Rorbach
Summary: This review summarizes the biogenesis of mitochondrial ribosomal subunits, mtSSU and mtLSU, based on structural findings, and discusses potential crosstalk between mtSSU and mtLSU assembly pathways as well as coordination between mitoribosome biogenesis and other processes involved in mitochondrial gene expression.
TRENDS IN BIOCHEMICAL SCIENCES
(2023)
Article
Anesthesiology
Sietske M. K. Bakker, Rudolf Stienstra
ANESTHESIA AND ANALGESIA
(2018)
Article
Anesthesiology
Sietske M. K. Bakker, Maaike G. E. Fenten, Daan J. Touw, Bart J. F. van den Bemt, Petra J. C. Heesterbeek, Gert-Jan Scheffer, Rudolf Stienstra
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2018)
Article
Anesthesiology
M. G. E. Fenten, S. M. K. Bakker, G. J. Scheffer, A. B. Wymenga, R. Stienstra, P. J. C. Heesterbeek
BRITISH JOURNAL OF ANAESTHESIA
(2018)
Meeting Abstract
Oncology
Jean-Philippe F. Coppe, Pan Bo, Carolien van der Borden, Nina Koemans, Changjun Wang, Denise Wolf, Christina Yau, Sietske Bakker, Marij Hartog, Miki Mori, Ana Ruiz-Saenz, Zhongzhong Chen, Aleksandra Olow, Pei Rong, Evelyn Lee, Laura van't Veer
Article
Multidisciplinary Sciences
Johanna Flach, Sietske T. Bakker, Mary Mohrin, Pauline C. Conroy, Eric M. Pietras, Damien Reynaud, Silvia Alvarez, Morgan E. Diolaiti, Fernando Ugarte, E. Camilla Forsberg, Michelle M. Le Beau, Bradley A. Stohr, Juan Mendez, Ciaran G. Morrison, Emmanuelle Passegue
Article
Chemistry, Medicinal
Uday Kiran Velagapudi, Marie-France Langelier, Cristina Delgado-Martin, Morgan E. Diolaiti, Sietske Bakker, Alan Ashworth, Bhargav A. Patel, Xuwei Shao, John M. Pascal, Tanaji T. Talele
JOURNAL OF MEDICINAL CHEMISTRY
(2019)
Meeting Abstract
Oncology
A. Freeman, S. Bakker, A. Weeks, M. E. Diolaiti, D. Quigley, J. S. Chapman, L. M. Chen, A. Ashworth
GYNECOLOGIC ONCOLOGY
(2019)
Article
Immunology
Theodore T. Ho, Paul Dellorusso, Evgenia V. Verovskaya, Sietske T. Bakker, Johanna Flach, Lucas K. Smith, Patrick B. Ventura, Olivia M. Lansinger, Aurelie Herault, Si Yi Zhang, Yoon-A Kang, Carl A. Mitchell, Saul A. Villeda, Emmanuelle Passegue
Summary: The study indicated that despite the rejuvenating effects of young blood on aged tissues, the aged blood system and old hematopoietic stem cells (HSCs) are not significantly affected by exposure to young blood. Old HSC function is not improved by exercise, calorie restriction, or exposure to young niches, while young HSCs are resistant to systemic proaging conditions.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Anesthesiology
Sietske M. K. Bakker, Nienke M. Kosse, Sakib Crnic, Ger-Jan Scheer, Rudolf Stienstra
TURKISH JOURNAL OF ANAESTHESIOLOGY AND REANIMATION
(2019)
Article
Anesthesiology
M. G. E. Fenten, S. M. K. Bakker, D. J. Touw, B. J. F. van den Bemt, G. J. Scheffer, P. J. C. Heesterbeek, R. Stienstra
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2017)