Article
Biochemistry & Molecular Biology
Ye Zhao, Qin Jiang, Xuefei Zhang, Xiaoxiao Zhu, Xia Dong, Linyuan Shen, Shunhua Zhang, Lili Niu, Lei Chen, Ming Zhang, Jun Jiang, Daiwen Chen, Li Zhu
Summary: l-Arginine has been shown to reduce muscle injury by regulating the SIRT1-Akt-Nrf2 and SIRT1-FOXO3a-mitochondria apoptosis signaling pathways as a potential nutraceutical.
Article
Orthopedics
Maria Giovanna Scioli, Filadelfo Coniglione, Chiara Greggi, Luca Evangelista, Elena Fiorelli, Luca Savino, Amedeo Ferlosio, Eleonora Piccirilli, Elena Gasbarra, Riccardo Iundusi, Umberto Tarantino, Augusto Orlandi
Summary: This study found that Ropivacaine has an oxidative stress-mediated myotoxic effect on human skeletal muscle tissue cell cultures. It is suggested that the use of the antioxidant ascorbic acid can mitigate the negative effects of Ropivacaine and promote functional recovery of skeletal muscle tissue in patients undergoing hip replacement surgery for osteoporotic bone fractures.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Kriti Sharma, Shiv Kumar, Ravi Prakash, Sonu Khanka, Tripti Mishra, Rajat Rathur, Arpon Biswas, Sarvesh Kumar Verma, R. S. Bhatta, T. Narender, Divya Singh
Summary: Chebulinic acid (CA), derived from Triphala, has been found to have anti-inflammatory, antioxidant, and anti-tumor effects. In an inflammatory bone loss condition, CA can prevent bone loss, improve bone micro-architectures, enhance bone regeneration, and maintain bone serum markers. CA also reduces the production of pro-inflammatory cytokines and attenuates inflammatory impairment to osteoblast cells through the suppression of the NFkB signaling pathway. These findings suggest that CA may be a potential novel therapeutic strategy for inflammatory diseases in bones.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Food Science & Technology
Yuan Xia, Wei Tan, Fangting Yuan, Mengjuan Lin, Hesheng Luo
Summary: Luteolin protects the intestines from excessive motility and diarrhea by regulating the Nrf2 signaling pathway and reducing oxidative stress damage. It inhibits colonic hypermobility, reduces ROS levels, upregulates Nrf2 and HO-1 protein expression levels, and promotes Nrf2 nuclear translocation.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Multidisciplinary Sciences
Shengsong Chen, Yu Bai, Jingen Xia, Yi Zhang, Qingyuan Zhan
Summary: This study used network pharmacology, bioinformatics, and molecular docking to predict the therapeutic targets and mechanisms of rutin in treating VILI. The results showed that rutin can alleviate VILI by regulating macrophage polarization and inhibiting the activation of inflammatory pathways.
Article
Cell Biology
Zhe Li, Tong Xu, Lin Peng, Xinyu Tang, Qianru Chi, Ming Li, Shu Li
Summary: Nanoplastics pollution poses a huge threat to the ecosystem, and this study found that polystyrene nanoplastics can aggravate lipopolysaccharide-induced renal cell apoptosis through oxidative stress.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Chemistry, Medicinal
Federica Sodano, Bice Avallone, Monica Tizzano, Chiara Fogliano, Barbara Rolando, Elena Gazzano, Chiara Riganti, Salvatore Magliocca, Mariarosaria Cuozzo, Stefania Albrizio, Antonio Calignano, Claudia Cristiano, Roberto Russo, Maria Grazia Rimoli
Summary: The ketorolac-galactose conjugate ketogal showed prolonged anti-inflammatory and analgesic activity with less gastric ulcerogenic effect and renal toxicity compared to its parent drug ketorolac. Ketogal demonstrated safer histopathological changes in the small intestine and liver, as well as lower cytotoxicity and oxidative stress parameters in Human Primary Colonic Epithelial cells, indicating it as a strategic alternative to ketorolac with improved efficacy and safety profiles.
Article
Endocrinology & Metabolism
Cheng-Chen Deng, Ji-Pan Zhang, Yuan-Nan Huo, Hong-Yan Xue, Wenxiu Wang, Jiao-Jiao Zhang, Xian-Zhong Wang
Summary: This study revealed the impact of heat stress on glucose metabolism in Sertoli cells and the protective mechanisms of melatonin on Sertoli cells under heat stress through different signaling pathways.
JOURNAL OF PINEAL RESEARCH
(2022)
Article
Immunology
Liyun Wu, Qiaozhen Chen, Bo Dong, Hancheng Geng, Yu Wang, Dong Han, Xiaoming Zhu, Haokun Liu, Zhimin Zhang, Yunxia Yang, Shouqi Xie, Junyan Jin
Summary: This study aimed to determine whether and how resveratrol (RES) can alleviate liver injury in lipopolysaccharide (LPS)-induced gibel carp. The results suggested that RES attenuated oxidative stress and inflammation by activating the Nrf2/Keap1 pathway and inhibiting the NF-kappa B pathway. Furthermore, RES cleared damaged mitochondria and enhanced mitochondrial biogenesis to mitigate reactive oxygen species (ROS) accumulation. Overall, RES alleviated LPS-induced oxidative stress and inflammation in gibel carp through mitochondria-related mechanisms.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Toxicology
Marta Justyna Koziel, Dominika Ewa Habrowska-Gorczynska, Kinga Anna Urbanek, Kamila Dominska, Agnieszka Wanda Piastowska-Ciesielska, Karolina Kowalska
Summary: This study found that alternariol may affect ovarian cancer cells by modulating estrogen receptor alpha, leading to apoptosis, oxidative stress, and decreased invasive ability.
TOXICOLOGY LETTERS
(2023)
Article
Cell Biology
Dong Gil Lee, Bo Ra Nam, Jae-Won Huh, Dong-Seok Lee
Summary: Excessive microglial cell activation in the brain can lead to neurodegenerative processes due to the production of neurotoxic factors. Recent research indicates that mitochondrial dynamics play a role in regulating inflammatory response. Isoliquiritigenin (ISL) has been found to reduce LPS-induced pro-inflammatory response by inhibiting ERK/p38/NF-kappa B activation and mitochondrial fission. ISL also protects against microglial apoptosis by inhibiting dephosphorylation of Drp1 and reducing the levels of cleaved caspase3/PARP.
Article
Plant Sciences
Yuan Feng, Wan Dai, Junyu Ke, Yong Cui, Shuang Li, Jingjing Ma, Wenfeng Guo, Gang Chen, Ning Li, Yanwu Li
Summary: Valerian extract capsule (VEC) is an effective Chinese patent medicine used for gastrointestinal diseases and has shown potential gastroprotective effects.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Chemistry, Medicinal
Hafiza Maida Arshad, Fiaz-ud-Din Ahmad, Arslan Hussain Lodhi
Summary: The crude extract of Aerva javanica leaves exhibited pharmacological activities against LPS-induced depressive-like behavior in mice. The extract showed antioxidant potential and potential to modulate oxidative stress, neuro-inflammation, and catecholamines, resulting in the improvement of depressive-like behavior.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Plant Sciences
Weimin Xue, Yaqiang Li, Mei Zhang
Summary: The study demonstrated that pristimerin ameliorated neuronal injury by regulating the PI3K/Akt signaling pathway in mice with sepsis-induced brain injuries, improving cognitive function and reducing neurological dysfunction.
PHARMACEUTICAL BIOLOGY
(2021)
Article
Environmental Sciences
Sitong Yao, Wei Wei, Rui Cao, Lin Lu, Shijin Liang, Mingjun Xiong, Chen Zhang, Xiaohuan Liang, Yongjiang Ma
Summary: This study investigated the effects of the mycotoxin zearalenone on decidualization of human endometrial stromal cells, revealing that ZEA inhibits the decidualization process through nuclear translocation of ER alpha. However, this inhibitory effect can be attenuated by an estrogen receptor antagonist, and resveratrol administration can restore impaired decidualization by inducing the antioxidative gene GPX3.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Virology
Soran Amin Hamalaw, Ali Hattem Bayati, Muhammed Babakir-Mina, Domenico Benvenuto, Silvia Fabris, Michele Guarino, Marta Giovanetti, Massimo Ciccozzi
Summary: Early detection and prompt response are crucial in preventing and controlling outbreaks. This study evaluates the performance of the Communicable Disease Surveillance System (CDSS) in the Kurdistan region of Iraq, finding deficiencies in surveillance guiding manuals, data analysis, epidemic preparedness, feedback, and standard guidelines. Strengthening the CDSS in this region requires continuous feedback, supervision, well-trained staff, and coordination between researchers and physicians.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Review
Cell Biology
Francesco Valentini, Giulia Rocchi, Umberto Vespasiani-Gentilucci, Michele Pier Luca Guarino, Annamaria Altomare, Simone Carotti
Summary: Fetal life and the first few months after birth are crucial periods for adaptation to environmental conditions and can have long-term metabolic consequences and impact on gut microbiota composition, thus affecting future health.
Review
Microbiology
Giulia Rocchi, Marta Giovanetti, Francesca Benedetti, Alessandra Borsetti, Giancarlo Ceccarelli, Davide Zella, Annamaria Altomare, Massimo Ciccozzi, Michele Pier Luca Guarino
Summary: The SARS-CoV-2 pandemic has caused an unprecedented global crisis. The virus primarily infects the lungs by binding to the ACE-2 cell receptor on the surface of alveolar epithelial cells. Interestingly, this receptor is also found in the epithelial cells of the intestinal tract. Recent data suggests that the gut microbiota may play a role in modulating inflammation. Gastrointestinal symptoms, including diarrhea, are often observed in infected individuals, and there is evidence that the virus can spread through fecal-oral transmission.
Article
Medicine, General & Internal
Annamaria Pronio, Francesco Covotta, Lucia Pallotta, Rossella Palma, Danilo Badiali, Maria Carlotta Sacchi, Antonietta Lamazza, Carola Severi
Summary: The study aims to compare collagen deposition and cytokine expression involved in the fibrogenic response in patients with eosinophilic esophagitis (EoE) and celiac disease. The results show that the inflammatory pathway in EoE is different from celiac disease, and fibrosis mainly occurs in the distal esophagus.
Review
Nutrition & Dietetics
Claudia Di Rosa, Annamaria Altomare, Elena Imperia, Chiara Spiezia, Yeganeh Manon Khazrai, Michele Pier Luca Guarino
Summary: Inflammatory bowel diseases, including Chron's disease and ulcerative colitis, are chronic immune-mediated diseases of the intestinal tract. Dietary therapy has been shown to be crucial in managing symptoms and pathology of IBD, although there is currently no specific therapeutic diet. Further research is needed to determine the appropriate amount and type of fiber intake for IBD patients.
Article
Gastroenterology & Hepatology
Alessandra Lo Presti, Federica Del Chierico, Annamaria Altomare, Francesca Zorzi, Giovanni Monteleone, Lorenza Putignani, Silvia Angeletti, Michele Cicala, Michele Pier Luca Guarino, Massimo Ciccozzi
Summary: This study investigated the phylogenetic dynamics of P. copri in patients with IBS, IBD, and healthy volunteers. Results showed longer genetic distances between IBD and healthy volunteers, as well as between IBD and IBS, indicating higher genetic variability in P. copri sequences within IBD. Different strains of P. copri were found in IBS patients, and a correlation between isolates and disease grading was observed. Understanding the phylogenetic characteristics of P. copri is important for better understanding the interactions between microbiota and the pathophysiology of IBD and IBS.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2023)
Article
Medicine, General & Internal
Rosa Vaccaro, Arianna Casini, Carola Severi, Antonietta Lamazza, Annamaria Pronio, Rossella Palma
Summary: This study examined biopsy samples of normal gastrointestinal mucosa and ulcerative colitis (UC) patients, and found a decrease in the concentration of 5-HT+ cells in UC patients and an increase in the expression of melatonin-secreting cells in severe cases of the disease.
Article
Nutrition & Dietetics
Alessio Molfino, Sara Emerenziani, Giuseppe Tonini, Daniele Santini, Antonietta Gigante, Michele Pier Luca Guarino, Chiara Nuglio, Giovanni Imbimbo, Annalisa La Cesa, Michele Cicala, Maurizio Muscaritoli
Summary: This study evaluated the prevalence of anorexia, hypophagia, and cachexia in patients with gastrointestinal or lung cancer at time of diagnosis. The results showed that 68% of patients had cachexia, 57% had anorexia, and 48% had hypophagia. These conditions had negative impacts on patients' nutritional intake, indicating a need for early multimodal strategies to improve food intake.
FRONTIERS IN NUTRITION
(2023)
Review
Nutrition & Dietetics
Claudia Di Rosa, Annamaria Altomare, Vittoria Terrigno, Florencia Carbone, Jan Tack, Michele Cicala, Michele Pier Luca Guarino
Summary: Irritable bowel syndrome (IBS) is a chronic gastrointestinal disorder characterized by abdominal pain and altered bowel habits. The exact cause of IBS is not fully understood, but it is believed to involve a combination of factors such as abnormal gut motility, inflammation, increased intestinal permeability, and sensitivity. Diet and gut microbiota have also been identified as important contributors to IBS. This review examines the effects of dietary components, functional foods, prebiotics, probiotics, and symbiotics on symptoms and gut microbiota in individuals with IBS-C.
Article
Biochemistry & Molecular Biology
Lucia Pallotta, Vittoria Cammisotto, Valentina Castellani, Alessia Gioia, Margherita Spigaroli, Dominga Carlomagno, Simona Bartimoccia, Cristina Nocella, Martina Cappelletti, Stefano Pontone, Roberto Carnevale, Francesco Violi, Rosa Vona, Carla Giordano, Pasquale Pignatelli, Carola Severi
Summary: This study assessed the pathogenesis and potential therapeutic targets of diverticular disease (DD) using circulating biomarkers. It was found that DD patients had decreased antioxidant capacity and increased levels of sNox2-dp, H2O2, and isoprostanes, along with increased TNF-a levels and markers of gut permeability and LPS translocation. These markers were correlated with the severity of DD, suggesting that circulating biomarkers could be used as tools for monitoring disease progression and testing new therapeutic strategies.
Meeting Abstract
Gastroenterology & Hepatology
A. Altomare, C. Di Rosa, L. Putignani, S. Emerenziani, S. Fabris, M. Ristori, S. Crucilla, C. Calo, R. Nicolo, M. Ciccozzi, M. Cicala, M. P. L. Guarino
DIGESTIVE AND LIVER DISEASE
(2022)
Meeting Abstract
Gastroenterology & Hepatology
A. Altomare, G. Rocchi, F. Zorzi, F. Del Chierico, A. Lo Presti, S. Emerenziani, C. Nuglio, L. Pica, M. Ciccozzi, L. Putignani, M. Cicala, M. P. L. Guarino
DIGESTIVE AND LIVER DISEASE
(2022)