cJUN N-terminal kinase (JNK) activation mediates islet amyloid-induced beta cell apoptosis in cultured human islet amyloid polypeptide transgenic mouse islets

β-Cell Loss and β-Cell Apoptosis in Human Type 2 Diabetes Are Related to Islet Amyloid Deposition

(2011) Catherine A. Jurgens et al.   AMERICAN JOURNAL OF PATHOLOGY

Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan

(2011) Silvestre Alavez et al.   NATURE

Differences between amyloid toxicity in alpha and beta cells in human and mouse islets and the role of caspase-3

(2010) E. Law et al.   DIABETOLOGIA

Involvement of mitochondrial dysfunction in human islet amyloid polypeptide-induced apoptosis in INS-1E pancreatic beta cells: An effect attenuated by phycocyanin

(2010) Xiao-Ling Li et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Modulation of Bcl-2-related protein expression in pancreatic beta cells by pro-inflammatory cytokines and its dependence on the antioxidative defense status

(2010) Ilir Mehmeti et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

(2010) Seth L Masters et al.   NATURE IMMUNOLOGY

Beta cell apoptosis in diabetes

(2009) Helen E. Thomas et al.   APOPTOSIS

Bad News for  -Cell Apoptosis

(2009) H. E. Thomas et al.   DIABETES

Glucose Induces Pancreatic Islet Cell Apoptosis That Requires the BH3-Only Proteins Bim and Puma and Multi-BH Domain Protein Bax

(2009) M. D. McKenzie et al.   DIABETES

Cytokine-mediated induction of anti-apoptotic genes that are linked to nuclear factor kappa-B (NF-κB) signalling in human islets and in a mouse beta cell line

(2009) S. A. Sarkar et al.   DIABETOLOGIA

Amyloid formation in human IAPP transgenic mouse islets and pancreas, and human pancreas, is not associated with endoplasmic reticulum stress

(2009) R. L. Hull et al.   DIABETOLOGIA

JNK3 is abundant in insulin-secreting cells and protects against cytokine-induced apoptosis

(2009) S. Abdelli et al.   DIABETOLOGIA

Oxidative stress is induced by islet amyloid formation and time-dependently mediates amyloid-induced beta cell apoptosis

(2009) S. Zraika et al.   DIABETOLOGIA

Phycocyanin protects INS-1E pancreatic beta cells against human islet amyloid polypeptide-induced apoptosis through attenuating oxidative stress and modulating JNK and p38 mitogen-activated protein kinase pathways

(2009) Xiao-Ling Li et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Islet Graft Response to Transplantation Injury Includes Upregulation of Protective as Well as Apoptotic Genes

(2008) Silvia Rodríguez-Mulero et al.   CELL TRANSPLANTATION

Glucose and leptin induce apoptosis in human β-cells and impair glucose-stimulated insulin secretion through activation of c-Jun N-terminal kinases

(2008) Kathrin Maedler et al.   FASEB JOURNAL

Initiation and execution of lipotoxic ER stress in pancreatic  -cells

(2008) D. A. Cunha et al.   JOURNAL OF CELL SCIENCE