Article
Cardiac & Cardiovascular Systems
Morten Malmborg, Michelle D. S. Schmiegelow, Thomas Gerds, Morten Schou, Caroline Kistorp, Christian Torp-Pedersen, Gunnar Gislason
Summary: This study demonstrates that primary prevention with statins can reduce the risk of cardiovascular events or death in low-risk patients with T2D, with the greatest benefit seen in elderly patients and those with high adherence to statin treatment.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Immunology
Eleana Bolla, Nikolaos Tentolouris, Petros P. Sfikakis, Maria G. Tektonidou
Summary: This study aimed to evaluate the prevalence of Metabolic Syndrome (MetS) in antiphospholipid syndrome (APS) patients and its associations with cardiovascular risk biomarkers, physical activity, and subclinical atherosclerosis. The results showed that MetS was present in approximately one-fourth of APS patients and was associated with arterial thrombosis, cardiovascular risk biomarkers, physical activity, and subclinical atherosclerosis. This suggests that MetS plays an important role in cardiovascular risk stratification and management in APS.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Alessandro Mattina, Christiano Argano, Giuseppe Brunori, Umberto Lupo, Massimo Raspanti, Marika Lo Monaco, Raffaella Mallaci Bocchio, Giuseppe Natoli, Maria Ausilia Giusti, Salvatore Corrao
Summary: Diabetes mellitus is a rapidly growing health emergency with significant socioeconomic impact. It is associated with chronic kidney disease and increased cardiovascular risk. The management of patients with diabetes and comorbidities requires a proactive approach and integration of healthcare services. A multidimensional management model is proposed to enhance communication among care units.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Medicine, General & Internal
Yannick Degboe, Richard Koch, Laurent Zabraniecki, Benedicte Jamard, Guillaume Couture, Jean Bernard Ruidavets, Jean Ferrieres, Adeline Ruyssen-Witrand, Arnaud Constantin
Summary: Psoriatic arthritis (PsA) patients have a higher prevalence of cardiovascular risk factors and cardiovascular events compared to the control population. Correcting cardiovascular risk assessment equations for PsA patients increases their risk. Although there is a trend towards higher LDLc levels in PsA patients, there is no significant difference compared to the control group.
FRONTIERS IN MEDICINE
(2022)
Article
Nutrition & Dietetics
Karolina Drozdz, Katarzyna Nabrdalik, Weronika Hajzler, Hanna Kwiendacz, Janusz Gumprecht, Gregory Y. H. Lip
Summary: Non-alcoholic fatty liver disease (NAFLD) is a common condition associated with type 2 diabetes (T2DM) and cardiovascular disease (CVD). The new term metabolic-associated fatty liver disease (MAFLD) highlights the bidirectional relationships between NAFLD, T2DM, and CVD. Lifestyle changes and targeting the gut microbiota may be important for NAFLD treatment.
Article
Health Care Sciences & Services
Paolo Barbier, Edvige Palazzo Adriano, Daniela Lucini, Massimo Pagani, Gaspare Cusumano, Beatrice De Maria, Laura Adelaide Dalla Vecchia
Summary: The study found that dyslipidaemia may independently influence left atrial compliance in a population with a high prevalence of metabolic syndrome. Additionally, blood pressure and the total cholesterol/HDL cholesterol ratio also affect left atrial compliance.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Medicine, General & Internal
Jisun Bang, Sang Ah Lee, Gwanpyo Koh, Soyeon Yoo
Summary: This study investigated the association between glucagon to insulin ratio and metabolic syndrome in patients with type 2 diabetes. The results showed that the fasting glucagon to insulin ratio was inversely associated with metabolic syndrome, indicating a higher risk of metabolic syndrome with lower fasting glucagon to insulin ratio.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Yanglu Zhao, Pin Xiang, Blai Coll, J. Antonio G. Lopez, Nathan D. Wong
Summary: In statin-treated patients with ASCVD, the presence of diabetes mellitus was associated with a significantly higher risk of both initial and total recurrent ASCVD events compared to ASCVD alone. The impact of DM on events was influenced by various factors, with homocysteine and lipoprotein(a) having the strongest predictive value in patients with and without DM, respectively.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Florence Filisa-Kaphamtengo, Jonathan Ngoma, Victoria Mukhula, Zaithwa Matemvu, Deborah Kapute, Peter Banda, Tamara Phiri, Mwapatsa Mipando, Mina C. Hosseinipour, Kondwani G. H. Katundu
Summary: This study investigated the prevalence and biochemical characteristics of dyslipidaemia in individuals attending the diabetes clinic at Kamuzu Central Hospital in Malawi. The results showed a high prevalence of dyslipidaemia, with elevated low-density lipoprotein cholesterol being the most common abnormality. Overweight and obesity were also prevalent and positively associated with dyslipidaemia.
BMC CARDIOVASCULAR DISORDERS
(2023)
Review
Endocrinology & Metabolism
Uazman Alam, Dalal Y. Al-Bazz, Handrean Soran
Summary: Bempedoic acid, a novel molecule that inhibits cholesterol biosynthesis through a similar pathway as statins, shows promise in preventing atherosclerotic cardiovascular disease, particularly as an alternative option for patients intolerant to statins.
Article
Cardiac & Cardiovascular Systems
Arnaud D. Kaze, Prasanna Santhanam, Solomon K. Musani, Rexford Ahima, Justin B. Echouffo-Tcheugui
Summary: Metabolic dyslipidemia and low HDL-C are associated with higher risks of cardiovascular disease outcomes in overweight/obese individuals with type 2 diabetes mellitus.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Nutrition & Dietetics
Manuela Casula, Alberico Luigi Catapano, Paolo Magni
Summary: The focus on nutraceutical products in international guidelines for the management of cardio-metabolic diseases is limited. Some guidelines mention their potential usefulness for mild dyslipidaemia, but evidence for their effects on hard endpoints is lacking. For obesity and type 2 diabetes, no safe and effective nutraceutical products are currently available.
Review
Biochemistry & Molecular Biology
Itay Aizenbud, Asaf Wilensky, Galit Almoznino
Summary: Periodontal disease is a chronic inflammatory condition that leads to bone and tooth loss. It has been linked to various systemic diseases, including diabetes and obesity. These diseases are part of the metabolic syndrome cluster, which significantly increases the risk of cardiovascular diseases, diabetes, and stroke. This review aims to investigate the correlation between periodontal disease and the components and outcomes of the metabolic syndrome cluster, providing insights into the fundamental mechanisms that link each condition with the metabolic syndrome. Understanding this interplay can lead to more effective treatments considering the broader impact of managing periodontal disease on systemic disease treatment, and vice versa.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Maria S. Hershey, Mercedes Sotos-Prieto, Miguel Ruiz-Canela, Costas A. Christophi, Steven Moffatt, Miguel Angel Martinez-Gonzalez, Stefanos N. Kales
Summary: The study found that adherence to traditional Mediterranean lifestyle habits, as measured by the MEDLIFE index, was associated with a lower prevalence of metabolic syndrome and a more favorable cardiometabolic profile in a non-Mediterranean working population.
CLINICAL NUTRITION
(2021)
Review
Endocrinology & Metabolism
Bashir Ahmad Laway, Mohammad Salem Baba
Summary: Sheehan syndrome caused by postpartum hemorrhage leads to pituitary hormone deficiency, resulting in various abnormalities including lipid and glucose abnormalities, increased body fat, insulin resistance, coagulation abnormalities, increased leptin concentration, low-grade inflammation, and endothelial dysfunction. Replacement with growth hormone in addition to standard hormone replacement improves the cardiometabolic profile of patients with Sheehan syndrome.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Immunology
Rocio Montejano, Fernando de la Calle-Prieto, Maria Velasco, Carlos Guijarro, Javier Queiruga-Parada, Maria Jimenez-Gonzalez, Patricia Gonzalez-Ruano, Patricia Martinez, Ane Josune Goikoetxea, Marta Ibarrola, Marianela Ciudad, Angela Gutierrez, Miguel Torralba, Ana Diaz-Brasero, Pablo Ryan, Cristina Marcelo, Cristina Diez, Sofia Ibarra, Esperanza Merino, Vicente Estrada, Javier Marcos, Maria Novella, Maria A. Rivera, Manuel Ruiz-Munoz, Marta de Miguel, Llanos Soler, Mikel Del Alamo, Santiago Moreno, Antonio J. Carcas, Alberto M. Borobia, Jose R. Arribas
Summary: This study aimed to evaluate the effectiveness of tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) treatment in high-risk patients with severe COVID-19. The results showed that TDF/FTC did not provide significant benefits, while the beneficial effect of baricitinib, as established by prior clinical trials, was confirmed.
CLINICAL INFECTIOUS DISEASES
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
F. Aaysha Cader, Cristina Gavina
ARQUIVOS BRASILEIROS DE CARDIOLOGIA
(2023)
Review
Endocrinology & Metabolism
Miguel Melo, Mara Ventura, Luis Cardoso, Adriana Gaspar da Rocha, Isabel Paiva, Manuel Sobrinho-Simoes, Paula Soares
Summary: The term non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) was incorporated as a new entity in the World Health Organization (WHO) classification of tumours of endocrine organs in 2017, and there has been ongoing debate regarding its histological criteria, the need for molecular studies, and the risk of metastasis or recurrence. The concept of NIFTP has evolved to include both small and large tumours and oncocytic lesions. However, concerns have been raised regarding the follow-up of NIFTP patients with thyroid follicular nodular disease or frequent coexistence of malignant tumours.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Pere Rehues, Josefa Girona, Montse Guardiola, Nuria Plana, Roberto Scicali, Salvatore Piro, Ovidio Muniz-Grijalvo, Jose Luis Diaz-Diaz, Lluis Recasens, Marta Pinyol, Roser Rosales, Yaiza Esteban, Nuria Amigo, Lluis Masana, Daiana Ibarretxe, Josep Ribalta
Summary: This study evaluated the effects of iPCSK9 on glycoproteins A, B, and F, and found that iPCSK9 therapy not only reduced LDL cholesterol, but also decreased 1H-NMR glycoprotein signals, which correlated with a decrease in triglycerides and apoC-III.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Biomedical
Nathan Lagneau, Pierre Tournier, Fabien Nativel, Yves Maugars, Jerome Guicheux, Catherine Le Visage, Vianney Delplace
Summary: Currently, there is no curative treatment for osteoarthritis (OA), but using mesenchymal stromal cells (MSCs) to alleviate the inflammatory symptoms of OA is gaining attention. MSCs can respond to the pro-inflammatory microenvironment of an OA joint and secrete factors that have anti-inflammatory, anti-apoptotic, immunomodulatory, and pro-regenerative effects. However, the microenvironment of MSCs greatly influences their survival and bioactivity, and using tailored biomaterial scaffolds is crucial for the success of intra-articular MSC-based therapies.
Article
Cell Biology
Anais Defois, Nina Bon, Alexandre Charpentier, Melina Georget, Nicolas Gaigeard, Frederic Blanchard, Antoine Hamel, Denis Waast, Jean Armengaud, Ophelie Renoult, Claire Pecqueur, Yves Maugars, Marie-Astrid Boutet, Jerome Guicheux, Claire Vinatier
Summary: This study reveals a strong association between inflammation and metabolic dysregulation in osteoarthritic chondrocytes. Inflammation affects metabolic-related genes and leads to increased glycolysis and decreased mitochondrial respiration in osteoarthritic chondrocytes. These findings provide important insights for further understanding the mechanisms of osteoarthritis.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Cardiac & Cardiovascular Systems
Leopoldo Perez de Isla, Jose L. Diaz-Diaz, Manuel J. Romero, Ovidio Muniz-Grijalvo, Juan D. Mediavilla, Rosa F. Argueso, Juan F. Sanchez Munoz-Torrero, Patricia Rubio, Pilar Alvarez-Banos, Paola Ponte, Dolores Manas, Lorena Suarez Gutierrez, Jose Maria Cepeda, Marta Casanas, Francisco Fuentes, Carlos Guijarro, Miguel Angel Barba, Adriana Saltijeral Cerezo, Teresa Padro, Pedro Mata
Summary: This study aimed to assess the effect of alirocumab on coronary plaque burden and its characteristics in patients with familial hypercholesterolemia. The results showed that treatment with alirocumab in addition to high-intensity statin therapy resulted in significant improvement in coronary plaque burden and characteristics after 78 weeks.
Article
Engineering, Biomedical
Fabien Nativel, Audrey Smith, Jeremy Boulestreau, Charles Lepine, Julie Baron, Melanie Marquis, Caroline Vignes, Yoan Le Guennec, Joelle Veziers, Julie Lesoeur, Francois Loll, Boris Halgand, Denis Renard, Jerome Abadie, Benoit Legoff, Frederic Blanchard, Olivier Gauthier, Claire Vinatier, Anne des Rieux, Jerome Guicheux, Catherine Le Visage
Summary: Osteoarthritis is an inflammatory joint disease affecting cartilage, subchondral bone, and joint tissues. In this study, human adipose stromal cells were successfully encapsulated in alginate microgels and shown to retain their metabolic activity and ability to respond to inflammatory stimuli. When injected into a rabbit model of post-traumatic OA, the encapsulated cells exhibited properties matching those of non-encapsulated cells and showed a tendency toward decreased OA severity. These findings demonstrate the feasibility, safety, and efficacy of injecting cells encapsulated in microgels for long-term treatment of OA.
MATERIALS TODAY BIO
(2023)
Article
Chemistry, Multidisciplinary
Pierre Tournier, Garance Saint-Pe, Nathan Lagneau, Francois Loll, Boris Halgand, Arnaud Tessier, Jerome Guicheux, Catherine Le Visage, Vianney Delplace
Summary: This study introduces a new biomaterial concept, clickable dynamic bioinks. These bioinks use dynamic hydrogels that can be 3D-bioprinted and chemically modified via click and bioorthogonal reactions to allow a variety of post-printing modifications. These modifications include adjusting the bioink composition and stiffness, as well as promoting cell adhesion, and can be controlled over time and space for 4D bioprinting applications.
Article
Medical Laboratory Technology
Teresa Arrobas Velilla, Carlos Guijarro, Raquel Campuzano Ruiz, Manuel Rodriguez Pinero, Jose FranciscoValderrama Marcos, Antonio Perez M. Perez, Antonio M. Botana Lopez, Ana Morais Lopez, Jose Antonio Garcia Donaire, Juan Carlos Obaya, Luis Castilla Guerra, Vicente Pallares Carratala, Isabel Egocheaga Cabello, Mercedes Salgueira Lazo, Maria Mar Castellanos Rodrigo, Jose Maria Mostaza Prieto, Juan Jose Gomez Doblas, Antonio Buno Soto
Summary: Cardiovascular diseases remain the leading cause of death in our country, with the control of lipid metabolism disorders posing a key challenge. However, there is significant heterogeneity in the reporting of lipid metabolism from Spanish clinical laboratories, contributing to poor control. To address this issue, a working group composed of major scientific societies has prepared a consensus proposal on determining the basic lipid profile in cardiovascular prevention, providing recommendations for implementation and standardizing criteria for incorporating appropriate lipid control goals into laboratory reports.
ADVANCES IN LABORATORY MEDICINE-AVANCES EN MEDICINA DE LABORATORIO
(2023)
Review
Cell & Tissue Engineering
Emilie Hascoet, Frederic Blanchard, Claudine Blin-Wakkach, Jerome Guicheux, Philippe Lesclous, Alexandra Cloitre
Summary: Rheumatoid arthritis (RA) and periodontitis are chronic inflammatory diseases that lead to increased bone resorption. They have immunopathogenic similarities and a common inflammatory environment. Periodontal dysbiosis, triggered by periodontal pathogens, can promote or sustain bone resorption in inflamed joints in RA. Understanding the pathogenic mechanisms of osteoclasts and their precursors in these diseases could lead to the identification of new therapeutic targets for inflammatory bone resorption.
Article
Peripheral Vascular Disease
Teresa Arrobas Velilla, Carlos Guijarro, Raquel Campuzano Ruiz, Manuel Rodriguez Pinero, Jose Francisco Valderrama Marcos, Antonio Perez Perez, Manuel Antonio Botana Lopez, Ana Morais Lopez, Jose Antonio Garcia Donaire, Juan Carlos Obaya, Luis Castilla Guerra, Vicente Pallares Carratala, Isabel Egocheaga Cabello, Mercedes Salgueira Lazo, Maria Mar Castellanos Rodrigo, Jose Maria Mostaza Prieto, Juan Jose Gomez Doblas, Antonio Buno Soto
Summary: Cardiovascular diseases remain the leading cause of death in our country. The control of lipid metabolism disorders is a key challenge in cardiovascular prevention that has not been achieved in clinical practice. The heterogeneity in lipid metabolism reports from Spanish clinical laboratories may contribute to inadequate control. Therefore, a working group has proposed a consensus on the determination of the basic lipid profile, recommendations for implementation, and unification of criteria for lipid control goals in laboratory reports.
CLINICA E INVESTIGACION EN ARTERIOSCLEROSIS
(2023)
Article
Endocrinology & Metabolism
Ana Carreira, Pedro Castro, Filipe Mira, Miguel Melo, Pedro Ribeiro, Lelita Santos
Summary: The study aimed to assess the impact of acute kidney injury (AKI) and its severity and duration on the risk of hypoglycaemia in hospitalized patients with type 2 diabetes (T2D). The results showed that AKI increased the risk of hypoglycaemia in hospitalized patients with T2D, and the duration of AKI was the main risk factor.
ACTA DIABETOLOGICA
(2023)
Article
Medical Laboratory Technology
Teresa Arrobas Velilla, Carlos Guijarro, Raquel Campuzano Ruiz, Manuel Rodriguez Pinero, Jose Francisco Valderrama Marcos, Antonio Perez Perez, Manuel Antonio Botana Lopez, Ana Morais Lopez, Jose Antonio Garcia Donaire, Juan Carlos Obaya, Luis Castilla Guerra, Vicente Pallares Carratala, Isabel Egocheaga Cabello, Mercedes Salgueira Lazo, Maria Mar Castellanos Rodrigo, Jose Maria Mostaza Prieto, Juan Jose Gomez Doblas, Antonio Buno Soto
Summary: Cardiovascular diseases continue to be the leading cause of death in our country, and controlling lipid metabolism abnormalities is a major challenge in cardiovascular prevention. In order to address the heterogeneity in lipid metabolism reports from Spanish clinical laboratories, a working group of scientific societies has prepared a document proposing basic consensus on lipid profile determination and recommendations for incorporating appropriate lipid control objectives in laboratory reports for patients at vascular risk.
ADVANCES IN LABORATORY MEDICINE-AVANCES EN MEDICINA DE LABORATORIO
(2023)
Article
Urology & Nephrology
Alberto Ortiz, Borja Quiroga, Javier Diez, Francisco Javier Escalada San Martin, Leblic Ramirez, Manuel Perez Maraver, M. Lourdes Martinez-Berganza Asensio, Jose Angel Arranz Arija, Jose Luis Alvarez-Ossorio Fernandez, Raul Cordoba, Franscisco Brotons Munto, Maria Jesus Cancelo Hidalgo, Joan Carles Reverter, Chamaida Plasencia-Rodriguez, Juana Carretera Gomez, Carlos Guijarro, M. del Mar Freijo Guerrero, Patricia de Sequera
Summary: The 2021 guidelines on the prevention of vascular disease emphasize the role of chronic kidney disease screening in preventing vascular disease. Vascular risk is categorized based on glomerular filtration rate and albumin to creatinine ratio, with different levels requiring different therapeutic actions. The guidelines recommend starting vascular risk assessment with the measurement of eGFR and ACR.