Integrated genomic and transcriptomic analysis of human brain metastases identifies alterations of potential clinical significance

Emerging Strategies for Treating Brain Metastases from Breast Cancer

(2015) David P. Kodack et al.   CANCER CELL

Cell cycle control as a promising target in melanoma

(2015) Belinda Lee et al.   CURRENT OPINION IN ONCOLOGY

Quantitative HER2 and p95HER2 levels in primary breast cancers and matched brain metastases

(2015) R. Duchnowska et al.   NEURO-ONCOLOGY

Heregulin-HER3-HER2 signaling promotes matrix metalloproteinase-dependent blood-brain-barrier transendothelial migration of human breast cancer cell lines

(2015) Majid Momeny et al.   Oncotarget

The localization of HER4 intracellular domain and expression of its alternately-spliced isoforms have prognostic significance in ER+ HER2- breast cancer

(2015) Saori Fujiwara et al.   Oncotarget

Nuclear HER4 mediates acquired resistance to trastuzumab and is associated with poor outcome in HER2 positive breast cancer

(2015) Siti Norasikin Mohd Nafi et al.   Oncotarget

Incidence of central nervous system metastases in patients with HER2-positive metastatic breast cancer treated with pertuzumab, trastuzumab, and docetaxel: results from the randomized phase III study CLEOPATRA

(2014) S. M. Swain et al.   ANNALS OF ONCOLOGY

Serpins Promote Cancer Cell Survival and Vascular Co-Option in Brain Metastasis

(2014) Manuel Valiente et al.   CELL

Therapeutic Targeting of Cancers with Loss of PTEN Function

(2014) Lloye Dillon et al.   CURRENT DRUG TARGETS

Recommendations on Disease Management for Patients With Advanced Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer and Brain Metastases: American Society of Clinical Oncology Clinical Practice Guideline

(2014) Naren Ramakrishna et al.   JOURNAL OF CLINICAL ONCOLOGY

DNA Double-Strand Break Repair Genes and Oxidative Damage in Brain Metastasis of Breast Cancer

(2014) Stephan Woditschka et al.   JNCI-Journal of the National Cancer Institute

Convergent and Divergent Cellular Responses by ErbB4 Isoforms in Mammary Epithelial Cells

(2014) Vikram B. Wali et al.   MOLECULAR CANCER RESEARCH

Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S

(2014) Lisa Sevenich et al.   NATURE CELL BIOLOGY

The maintenance of chromosome structure: positioning and functioning of SMC complexes

(2014) Kristian Jeppsson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Human breast cancer metastases to the brain display GABAergic properties in the neural niche

(2014) J. Neman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ERBB3 is required for metastasis formation of melanoma cells

(2014) S Tiwary et al.   Oncogenesis

Targeting MET Amplification as a New Oncogenic Driver

(2014) Hisato Kawakami et al.   Cancers

Frequent Genetic Alterations in EGFR- and HER2-Driven Pathways in Breast Cancer Brain Metastases

(2013) Ina Hohensee et al.   AMERICAN JOURNAL OF PATHOLOGY

Pazopanib Inhibits the Activation of PDGFRβ-Expressing Astrocytes in the Brain Metastatic Microenvironment of Breast Cancer Cells

(2013) Brunilde Gril et al.   AMERICAN JOURNAL OF PATHOLOGY

Recommendations for Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer: American Society of Clinical Oncology/College of American Pathologists Clinical Practice Guideline Update

(2013) Antonio C. Wolff et al.   ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE

The prognostic value of Her4 receptor isoform expression in triple-negative and Her2 positive breast cancer patients

(2013) Anna Machleidt et al.   BMC CANCER

Estrogen receptor α is the major driving factor for growth in tamoxifen-resistant breast cancer and supported by HER/ERK signaling

(2013) Susan Thrane et al.   BREAST CANCER RESEARCH AND TREATMENT

Src Family Kinases as Novel Therapeutic Targets to Treat Breast Cancer Brain Metastases

(2013) S. Zhang et al.   CANCER RESEARCH

Co-evolution of breast-to-brain metastasis and neural progenitor cells

(2013) Josh Neman et al.   CLINICAL & EXPERIMENTAL METASTASIS

CNS Metastases in Breast Cancer: Old Challenge, New Frontiers

(2013) N. U. Lin et al.   CLINICAL CANCER RESEARCH

Molecular Imaging of Death Receptor 5 Occupancy and Saturation Kinetics In Vivo by Humanized Monoclonal Antibody CS-1008

(2013) I. J. G. Burvenich et al.   CLINICAL CANCER RESEARCH

Carcinoma cells misuse the host tissue damage response to invade the brain

(2013) Han-Ning Chuang et al.   GLIA

ErbB3 downregulation enhances luminal breast tumor response to antiestrogens

(2013) Meghan M. Morrison et al.   JOURNAL OF CLINICAL INVESTIGATION

64Cu-DOTA-Trastuzumab PET Imaging in Patients with HER2-Positive Breast Cancer

(2013) K. Tamura et al.   JOURNAL OF NUCLEAR MEDICINE

Functional Imaging of Human Epidermal Growth Factor Receptor 2-Positive Metastatic Breast Cancer Using 64Cu-DOTA-Trastuzumab PET

(2013) J. E. Mortimer et al.   JOURNAL OF NUCLEAR MEDICINE

Massively-parallel sequencing assists the diagnosis and guided treatment of cancers of unknown primary

(2013) Richard W Tothill et al.   JOURNAL OF PATHOLOGY

Metastatic progression of breast cancer: insights from 50 years of autopsies

(2013) Margaret C Cummings et al.   JOURNAL OF PATHOLOGY

Pertuzumab, trastuzumab, and docetaxel for HER2-positive metastatic breast cancer (CLEOPATRA study): overall survival results from a randomised, double-blind, placebo-controlled, phase 3 study

(2013) Sandra M Swain et al.   LANCET ONCOLOGY

MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study

(2013) Paolo A Ascierto et al.   LANCET ONCOLOGY

HER4 and its cytoplasmic isoforms are associated with progression-free survival of malignant melanoma

(2013) Trine O. Nielsen et al.   MELANOMA RESEARCH

Reply to ‘Intratumoral heterogeneity of HER2 gene amplification in breast cancer: its clinicopathological significance’

(2013) Hee Jin Lee et al.   MODERN PATHOLOGY

Letter to the editor regarding ‘Seol H, Lee HJ, Choi Y, et al. Intratumoural heterogeneity of HER2 gene amplification in breast cancer: its clinicopathological significance’

(2013) Martin C Chang   MODERN PATHOLOGY

erbB3 Is an Active Tyrosine Kinase Capable of Homo- and Heterointeractions

(2013) M. P. Steinkamp et al.   MOLECULAR AND CELLULAR BIOLOGY

Mutational heterogeneity in cancer and the search for new cancer-associated genes

(2013) Michael S. Lawrence et al.   NATURE

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

IntOGen-mutations identifies cancer drivers across tumor types

(2013) Abel Gonzalez-Perez et al.   NATURE METHODS

Implementing personalized cancer genomics in clinical trials

(2013) Richard Simon et al.   NATURE REVIEWS DRUG DISCOVERY

Somatic Point Mutation Calling in Low Cellularity Tumors

(2013) Karin S. Kassahn et al.   PLoS One

The Small GTPase ARF6 Stimulates  -Catenin Transcriptional Activity During WNT5A-Mediated Melanoma Invasion and Metastasis

(2013) A. H. Grossmann et al.   Science Signaling

Blocking NRG1 and Other Ligand-Mediated Her4 Signaling Enhances the Magnitude and Duration of the Chemotherapeutic Response of Non-Small Cell Lung Cancer

(2013) G. V. Hegde et al.   Science Translational Medicine

Deciphering Signatures of Mutational Processes Operative in Human Cancer

(2013) Ludmil B. Alexandrov et al.   Cell Reports

Incidence and time trends of brain metastases admissions among breast cancer patients in Sweden

(2012) G Frisk et al.   BRITISH JOURNAL OF CANCER

Clinicopathologic features, patterns of recurrence, and survival among women with triple-negative breast cancer in the National Comprehensive Cancer Network

(2012) Nancy U. Lin et al.   CANCER

Combination of a MEK inhibitor at sub-MTD with a PI3K/mTOR inhibitor significantly suppresses growth of lung adenocarcinoma tumors in KrasG12D-LSL mice

(2012) Brett H. Simmons et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Dual Targeting of EGFR and HER3 with MEHD7945A Overcomes Acquired Resistance to EGFR Inhibitors and Radiation

(2012) S. Huang et al.   CANCER RESEARCH

PIK3CA Mutation H1047R Is Associated with Response to PI3K/AKT/mTOR Signaling Pathway Inhibitors in Early-Phase Clinical Trials

(2012) F. Janku et al.   CANCER RESEARCH

Mutational Processes Molding the Genomes of 21 Breast Cancers

(2012) Serena Nik-Zainal et al.   CELL

A Landscape of Driver Mutations in Melanoma

(2012) Eran Hodis et al.   CELL

Mapping the Hallmarks of Lung Adenocarcinoma with Massively Parallel Sequencing

(2012) Marcin Imielinski et al.   CELL

Androgen-independent prostate cancer cells circumvent EGFR inhibition by overexpression of alternative HER receptors and ligands

(2012) DOLORS CARRIÓN-SALIP et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Selumetinib plus docetaxel for KRAS-mutant advanced non-small-cell lung cancer: a randomised, multicentre, placebo-controlled, phase 2 study

(2012) Pasi A Jänne et al.   LANCET ONCOLOGY

Lapatinib plus capecitabine in patients with previously untreated brain metastases from HER2-positive metastatic breast cancer (LANDSCAPE): a single-group phase 2 study

(2012) Thomas Bachelot et al.   LANCET ONCOLOGY

Intratumoral heterogeneity of HER2 gene amplification in breast cancer: its clinicopathological significance

(2012) Hyesil Seol et al.   MODERN PATHOLOGY

The landscape of cancer genes and mutational processes in breast cancer

(2012) Philip J. Stephens et al.   NATURE

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

(2012) Andrew V. Biankin et al.   NATURE

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

Comprehensive genomic characterization of squamous cell lung cancers

(2012)   NATURE

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

(2012) Marco Gerlinger et al.   NEW ENGLAND JOURNAL OF MEDICINE

qpure: A Tool to Estimate Tumor Cellularity from Genome-Wide Single-Nucleotide Polymorphism Profiles

(2012) Sarah Song et al.   PLoS One

Burden of breast cancer with brain metastasis: a French national hospital database analysis

(2012) L. Benjamin et al.   JOURNAL OF MEDICAL ECONOMICS

Genomic analysis identifies unique signatures predictive of brain, lung, and liver relapse

(2011) J. Chuck Harrell et al.   BREAST CANCER RESEARCH AND TREATMENT

High frequency of complex TP53 mutations in CNS metastases from breast cancer

(2011) C Lo Nigro et al.   BRITISH JOURNAL OF CANCER

Whole genome sequencing of matched primary and metastatic acral melanomas

(2011) S. Turajlic et al.   GENOME RESEARCH

Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study

(2011) Karen A Gelmon et al.   LANCET ONCOLOGY

A framework for variation discovery and genotyping using next-generation DNA sequencing data

(2011) Mark A DePristo et al.   NATURE GENETICS

Neurosurgical management of metastases in the central nervous system

(2011) Elizabeth B. Claus   Nature Reviews Clinical Oncology

Lapatinib Distribution in HER2 Overexpressing Experimental Brain Metastases of Breast Cancer

(2011) Kunal S. Taskar et al.   PHARMACEUTICAL RESEARCH

Treatment of Brain Metastases: Chemotherapy

(2011) Sean A. Grimm   Current Oncology Reports

Management of Brain Metastasis: Past Lessons, Modern Management, and Future Considerations

(2011) Eugene Koay et al.   Current Oncology Reports

Epidemiology of Brain Metastases

(2011) Lakshmi Nayak et al.   Current Oncology Reports

Biodistribution of 89Zr-trastuzumab and PET Imaging of HER2-Positive Lesions in Patients With Metastatic Breast Cancer

(2010) E C Dijkers et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

(2010) A. McKenna et al.   GENOME RESEARCH

The brain microenvironment and cancer metastasis

(2010) Isaiah J. Fidler et al.   MOLECULES AND CELLS

Genome remodelling in a basal-like breast cancer metastasis and xenograft

(2010) Li Ding et al.   NATURE

Distant metastasis occurs late during the genetic evolution of pancreatic cancer

(2010) Shinichi Yachida et al.   NATURE

Resource Utilization in Patients with Brain Metastases Managed with Best Supportive Care, Radiotherapy and/or Surgical Resection: A Markov Analysis

(2010) Carsten Nieder et al.   ONCOLOGY

The role of HER3, the unpretentious member of the HER family, in cancer biology and cancer therapeutics

(2010) Dhara N. Amin et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Pindel: a pattern growth approach to detect break points of large deletions and medium sized insertions from paired-end short reads

(2009) K. Ye et al.   BIOINFORMATICS

Fast and accurate short read alignment with Burrows-Wheeler transform

(2009) H. Li et al.   BIOINFORMATICS

HER/ErbB receptor interactions and signaling patterns in human mammary epithelial cells

(2009) Yi Zhang et al.   BMC CELL BIOLOGY

Brain Metastasis: Opportunities in Basic and Translational Research

(2009) E. A. Maher et al.   CANCER RESEARCH

WNT/TCF Signaling through LEF1 and HOXB9 Mediates Lung Adenocarcinoma Metastasis

(2009) Don X. Nguyen et al.   CELL

HER Family Receptor Abnormalities in Lung Cancer Brain Metastases and Corresponding Primary Tumors

(2009) M. Sun et al.   CLINICAL CANCER RESEARCH

The role of stereotactic radiosurgery in the management of patients with newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline

(2009) Mark E. Linskey et al.   JOURNAL OF NEURO-ONCOLOGY

Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution

(2009) Sohrab P. Shah et al.   NATURE

Genes that mediate breast cancer metastasis to the brain

(2009) Paula D. Bos et al.   NATURE

Real-time imaging reveals the single steps of brain metastasis formation

(2009) Yvonne Kienast et al.   NATURE MEDICINE

Genome Alteration Print (GAP): a tool to visualize and mine complex cancer genomic profiles obtained by SNP arrays

(2009) Tatiana Popova et al.   GENOME BIOLOGY

A Central Role for HER3 in HER2-Amplified Breast Cancer: Implications for Targeted Therapy

(2008) S. T. Lee-Hoeflich et al.   CANCER RESEARCH

HER3 Is a Determinant for Poor Prognosis in Melanoma

(2008) M. Reschke et al.   CLINICAL CANCER RESEARCH

Brain metastases: current management and new developments

(2008) Riccardo Soffietti et al.   CURRENT OPINION IN ONCOLOGY

Heregulin-induced activation of ErbB3 by EGFR tyrosine kinase activity promotes tumor growth and metastasis in melanoma cells

(2008) Yoko Ueno et al.   INTERNATIONAL JOURNAL OF CANCER

Molecular Basis of Metastasis

(2008) Anne C. Chiang et al.   NEW ENGLAND JOURNAL OF MEDICINE