Article
Nutrition & Dietetics
Napapan Kangwan, Wasana Pratchayasakul, Aphisek Kongkaew, Komsak Pintha, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: The study found that PSO and metformin can effectively improve gut dysbiosis, inflammation, and metabolic disturbance in HFD-fed rats, with metformin showing greater benefits.
Review
Biochemistry & Molecular Biology
Kamila P. Liput, Adam Lepczynski, Magdalena Ogluszka, Agata Nawrocka, Ewa Polawska, Agata Grzesiak, Brygida Slaska, Chandra S. Pareek, Urszula Czarnik, Mariusz Pierzchala
Summary: It is recommended to reduce saturated fatty acids (SFA) and increase polyunsaturated fatty acids (PUFAs) n-3 and n-6 in the diet to lower the risk of metabolic disorders. Western-type diet often contains excessive n-6 PUFAs and a high n-6/n-3 ratio. Oxylipins derived from n-3 and n-6 PUFAs play a role in inflammation, while PUFAs have varying effects on cell growth, proliferation, and neoplastic lesion progression, as observed in in vitro studies, animal models, and epidemiological studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Physiology
Jing Li, Heng Zhang, Yongqiang Dong, Xian Wang, Guang Wang
Summary: Homocysteine (Hcy) activates the NLRP3 inflammasome in adipose tissue, leading to the development of insulin resistance. Diets high in omega-3 fatty acids can alter serum and adipose lipid profiles, potentially reducing adipose tissue inflammation and alleviating insulin resistance.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Nutrition & Dietetics
Domenico Sergi, Juana Maria Sanz, Stefano Lazzer, Gloria Brombo, Giovanni Zuliani, Gianni Biolo, Bostjan Simunic, Rado Pisot, Edoardo Dalla Nora, Angelina Passaro
Summary: Dietary lipids play a crucial role in modulating metabolic inflammation, and interleukin 18 (IL-18) has been consistently linked to obesity and insulin resistance. This study aimed to assess if the quality of lipid intake affects IL-18 plasma levels and its implications on insulin resistance. The study confirmed that IL-18 is positively correlated with insulin resistance, and individuals with higher HOMA-IR levels displayed elevated IL-18 levels. The quality of dietary lipids, particularly the ratio between different fatty acids and the intake of omega-3, showed a negative correlation with IL-18 levels.
Article
Nutrition & Dietetics
Roberta Dourado Cavalcante da Cunha de Sa, Jussara de Jesus Simao, Viviane Simoes da Silva, Talita Mendes de Farias, Maysa Mariana Cruz, Vitor Jaco Antraco, Lucia Armelin-Correa, Maria Isabel Alonso-Vale
Summary: This study found that different ratios of EPA and DHA have different impacts on adipose tissue metabolism, with fish oil rich in EPA instead of DHA effectively reversing changes induced by obesity.
Article
Biochemistry & Molecular Biology
Min Xu, Yu-Meng Wang, Wan-Qing Li, Cheng-Long Huang, Jun Li, Wen-Hua Xie, Hong-Xiang Zeng, Lin-Fen Tao, Xi Li
Summary: This study found that Ccrl2 expression is increased in visceral adipose tissue of obese mice. Deletion of Ccrl2 gene exacerbates obesity and insulin resistance, resulting in increased visceral adipose tissue inflammation and M1/M2 macrophage ratio.
Review
Nutrition & Dietetics
Ivana Djuricic, Philip C. Calder
Summary: Oxidative stress and inflammation are important contributors to chronic non-communicable diseases. Different types of fatty acids have varying effects on chronic diseases, with moderate intake of Ω-6 fatty acids lowering the risk of cardiovascular diseases and Ω-3 fatty acids helping to reduce inflammation levels.
Article
Biochemistry & Molecular Biology
Viswanathan Saraswathi, Narendra Kumar, Weilun Ai, Thiyagarajan Gopal, Saumya Bhatt, Edward N. Harris, Geoffrey A. Talmon, Cyrus Desouza
Summary: The intake of myristic acid (MA) exacerbates obesity-associated insulin resistance, partially mediated by increased adipose tissue inflammation and secretion of resistin.
Article
Immunology
Akira Shikuma, Daisuke Kami, Ryotaro Maeda, Yosuke Suzuki, Arata Sano, Toshihiko Taya, Takehiro Ogata, Anne Konkel, Satoaki Matoba, Wolf-Hagen Schunck, Satoshi Gojo
Summary: EEQ-A exhibits potent anti-inflammatory and immunomodulatory properties, improving survival rate and reducing organ damage in sepsis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Nutrition & Dietetics
Valeria Policastro, Dario Righelli, Lucilla Rava, Pamela Vernocchi, Marzia Bianchi, Cristina Vallone, Fabrizio Signore, Melania Manco
Summary: In this study, the association between dietary fatty acids and pro- and anti-inflammatory molecules in pregnant women was investigated. Several associations were found, including those between adiponectin and specific fatty acids, endotoxin and specific fatty acids, MCP-1 and a specific fatty acid, and ICAM-1 and a specific fatty acid. Additionally, cytokines such as leptin were associated with maternal body weight, smoking habits, and gestational diabetes.
Article
Pharmacology & Pharmacy
Jiali Yang, Yunhui Ran, Yonghui Yang, Shuyi Song, Yahong Wu, Yuanming Qi, Yanfeng Gao, Guodong Li
Summary: The study found that 4-HIL can inhibit obesity-related insulin resistance by reducing inflammation and regulating the state of macrophages associated with obesity.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Roberta Cardim Lessa, Fabio de Abreu Alves, Erika Fortunati, Jun Lu
Summary: Oral mucositis (OM) is a painful condition caused by cancer treatments, impacting patients' quality of life and recovery. Current management strategies are insufficient, necessitating a search for new approaches. Utilizing ω-3 fatty acids to manage OM may be an effective strategy based on preliminary evidence.
Article
Biochemistry & Molecular Biology
Jiaomei Li, Yi Wan, Zhaohong Zheng, Huaqi Zhang, Yang Li, Xiaofei Guo, Kelei Li, Duo Li
Summary: Our study found that a maternal diet rich in n-3 PUFAs significantly reduces the risk of offspring developing mammary cancer, and supplementation of maternal n-3 PUFAs can also alter the composition of offspring's gut microbiota and decrease the levels of inflammatory factors.
Article
Biochemistry & Molecular Biology
Tomohiko Shimizu, Tsugumichi Saito, Haruka Aoki-Saito, Shuichi Okada, Hiroyuki Ikeda, Takashi Nakakura, Hayato Fukuda, Syota Arai, Kouichi Fujiwara, Yasuyo Nakajima, Kazuhiro Horiguchi, Sayaka Yamada, Emi Ishida, Takeshi Hisada, Satoshi Shuto, Masanobu Yamada
Summary: The study showed that resolvin E3 (RvE3) may improve insulin sensitivity and enhance glucose uptake in adipocytes by activating the PI3K/Akt signaling pathways, potentially regulating glucose homeostasis and serving as a therapeutic target for treating obesity-associated diabetes.
Article
Biochemistry & Molecular Biology
Pratik Aryal, Ismail Syed, Jennifer Lee, Rucha Patel, Andrew T. Nelson, Dionicio Siegel, Alan Saghatelian, Barbara B. Kahn
Summary: FAHFAs have specific biological actions including enhancing glucose stimulated insulin secretion, insulin sensitivity, and anti-inflammatory effects. Some FAHFAs activate G protein-coupled receptor 40 and attenuate chemokine and cytokine expression and secretion in immune cells. The study suggests that FAHFAs with unsaturated acyl chains and higher branched structures are more likely to enhance insulin secretion, while those with lower branching are more likely to have anti-inflammatory effects.
JOURNAL OF LIPID RESEARCH
(2021)
Article
Nutrition & Dietetics
Ester S. Oh, Kristina S. Petersen, Penny M. Kris-Etherton, Connie J. Rogers
Summary: The study found that consuming a medium-dose spice blend for four weeks reduced fasting plasma IL-6 and postprandial plasma IL-1 beta, IL-8, and TNF-alpha levels, as well as altering monocyte function.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Review
Nutrition & Dietetics
Janhavi J. Damani, Mary Jane De Souza, Hannah L. VanEvery, Nicole C. A. Strock, Connie J. Rogers
Summary: This article reviews the potential role of prunes in improving bone health, highlighting evidence that prunes can protect bone by modulating oxidative and inflammatory pathways. Osteoporosis is a common condition in postmenopausal women, and prunes are being studied as a nonpharmaceutical intervention.
ADVANCES IN NUTRITION
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Emily Van Syoc, Connie J. Rogers, Erika Ganda
Meeting Abstract
Biochemistry & Molecular Biology
Janhavi J. Damani, Nicole C. A. Strock, Mary Jane De Souza, Connie J. Rogers
Article
Nutrition & Dietetics
Muzi Na, Yanxiu Wang, Xinyuan Zhang, Christopher Sarpong, Penny M. Kris-Etherton, Ming Gao, Aijun Xing, Shouling Wu, Xiang Gao
Summary: The DASH dietary pattern is associated with lower nighttime blood pressure variability in elderly adults, independent of sleep parameters and other factors.
JOURNAL OF NUTRITION
(2022)
Article
Multidisciplinary Sciences
Callum R. K. Arnold, Sreenidhi Srinivasan, Sophie Rodriguez, Natalie Rydzak, Catherine M. Herzog, Abhinay Gontu, Nita Bharti, Meg Small, Connie J. Rogers, Margeaux M. Schade, Suresh Kuchipudi, Vivek Kapur, Andrew F. Read, Matthew J. Ferrari
Summary: This study found that university students had a higher seroprevalence rate compared to community residents, indicating a potential source of transmission. Contact with known positive individuals and attendance at small gatherings were significant predictors of antibody detection among students.
SCIENTIFIC REPORTS
(2022)
Article
Nutrition & Dietetics
Mary Jane De Souza, Nicole C. A. Strock, Nancy Williams, Hang Lee, Kristen J. Koltun, Connie Rogers, Mario G. Ferruzzi, Cindy H. Nakatsu, Connie Weaver
Summary: This study evaluated the effects of prune consumption on bone mineral density in postmenopausal women and found that a daily dose of 50 grams of prunes can prevent a decrease in hip bone mineral density. This effect persisted for 12 months with high compliance and retention rates.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Medicine, General & Internal
Connie J. Rogers, Kristina Petersen, Penny M. Kris-Etherton
MEDICAL CLINICS OF NORTH AMERICA
(2022)
Letter
Cardiac & Cardiovascular Systems
Kamil F. Faridi, Penny M. Kris-Etherton, Karen E. Aspry
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Immunology
Janhavi J. Damani, Mary Jane De Souza, Nicole C. A. Strock, Kristen J. Koltun, Nancy Williams, Connie Weaver, Connie J. Rogers
Summary: This study aimed to investigate the association between circulating inflammatory markers and bone outcomes in postmenopausal women. The findings showed a negative correlation between inflammatory markers and bone density, geometry, and strength, suggesting that inflammatory markers may play an important role in postmenopausal bone loss.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Review
Nutrition & Dietetics
Tricia L. Hart, Kristina S. Petersen, Penny M. Kris-Etherton
Summary: This study conducted a systematic review of the effects of cottonseed oil on lipid metabolism and found that cottonseed oil can improve lipid/lipoprotein levels compared with olive oil. The predictive equations suggest that cottonseed oil can be incorporated into a healthy dietary pattern without significantly affecting lipids/lipoproteins.
Article
Sport Sciences
Dan Lin, Cheryl L. Thompson, Djibril M. Ba, Joshua E. Muscat, Shouhao Zhou, Connie J. Rogers, Kathleen M. Sturgeon
Summary: The study revealed an inverse association between leisure-time physical activity level and white blood cell count, as well as neutrophil-to-lymphocyte ratio, suggesting that higher levels of physical activity may lead to lower levels of inflammation, which could be important for future chronic disease outcomes.
SPORTS MEDICINE-OPEN
(2023)
Article
Biochemistry & Molecular Biology
Abigayle M. R. Simpson, Mary Jane De Souza, Janhavi Damani, Connie Rogers, Nancy I. Williams, Connie Weaver, Mario G. Ferruzzi, Sydney Chadwick-Corbin, Cindy H. Nakatsu
Summary: This study aims to characterize the effect of prune supplementation on the gut microbiome of postmenopausal women. The results show that prune consumption leads to a decrease in gut microbiome diversity, and different doses of prunes have different effects on the gut microbiome. In addition, prune consumption may enrich beneficial bacterial taxa and correlate with urinary phenolic metabolites and inflammatory markers. These findings suggest that prunes may exert health effects by modulating the gut microbiome.
Meeting Abstract
Geriatrics & Gerontology
M. J. De Souza, N. C. Strock, N. I. Williams, H. Lee, K. J. Koltun, C. Rogers, M. G. Ferruzzi, C. H. Nakatsu, C. Weaver
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Medicine, Research & Experimental
Mary Jane De Souza, Nicole C. A. Strock, Connie J. Rogers, Nancy I. Williams, Mario G. Ferruzzi, Cindy H. Nakatsu, Abigayle M. R. Simpson, Connie Weaver
Summary: This study is a randomized controlled trial aiming to investigate the effects of daily prune consumption on bone density, immune function, inflammation, and cardiovascular health in postmenopausal women. It also includes detailed phenolic and gut microbiota analyses. The findings will provide insights into the clinical implications and underlying mechanisms of prune as a functional food therapy.
CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS
(2022)
