Review
Immunology
Olga Sierawska, Paulina Niedzwiedzka-Rystwej
Summary: It is increasingly believed that diabetes in cats may belong to both metabolic and autoimmune diseases due to the involvement of the immune system and secretion of adipokines. Risk factors include age, sex, breed, obesity, and insulin resistance. Diagnosis of diabetes in cats is more complicated than in humans.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zsolt Szekeres, Barbara Sandor, Zita Bognar, Fadi H. J. Ramadan, Anita Palfi, Beata Bodis, Kalman Toth, Eszter Szabados
Summary: Obesity is a global public health issue associated with various diseases, particularly type 2 diabetes. Leptin plays a crucial role in regulating food intake and metabolism. Sodium glucose co-transport 2 inhibitors have beneficial effects and can be potent antihyperglycemic drugs. This study aimed to investigate the metabolic state and leptin level among obese and type 2 diabetic patients, as well as the impact of empagliflozin treatment. The results showed that empagliflozin treatment led to lower body mass index, body fat, visceral fat, and leptin levels compared to conventional antidiabetic treatments. Leptin levels were increased in both obese and type 2 diabetic patients. Empagliflozin treatment also resulted in lower body mass index, body fat, and visceral fat percentages, while preserving renal function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Leonardo Pazarin-Villasenor, Yessica Garcia-Salas, Francisco Gerardo Yanowsky-Escatell, Fermin Paul Pacheco-Moises, Jorge Andrade-Sierra, Tannia Isabel Campos-Bayardo, Daniel Roman-Rojas, Andres Garcia-Sanchez, Alejandra Guillermina Miranda-Diaz
Summary: This study investigated the oxidative stress status in peritoneal dialysis patients with type 2 diabetes mellitus. The levels of lipoperoxides and oxidative DNA damage markers were found to be significantly increased in patients with and without diabetes, while the activity of antioxidant enzymes was also increased. Antioxidant enzymes could be a promising therapeutic strategy for the management of chronic kidney diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Li-Ying He, Yong Li, Shu-Qi Niu, Jing Bai, Si-Jing Liu, Jin-Lin Guo
Summary: Diabetes mellitus is a metabolic disease characterized by high blood sugar levels. Oxidative stress plays a significant role in its development, especially in type 2 diabetes and metabolic syndrome. Natural polysaccharides, derived from plants, microorganisms, and marine organisms, have been found to have antioxidant activity and therapeutic effects in diabetes. This paper summarizes the natural polysaccharides with therapeutic potential for diabetes in the past 5 years, providing insights into their pharmacological mechanisms and identified structures, which can be valuable for the development of new diabetic drugs.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Amal Ahmed Mohamed, Dina M. Abo-Elmatty, Alaa S. Wahba, Omnia Ezzat Esmail, Hadeer Saied Mahmoud Salim, Wafaa Salah Mohammed Hegab, Mona Mostafa Farid Ghanem, Nadia Youssef Riad, Doaa Ghaith, Lamiaa Daker, Shorouk Issa, Noha Hassan Radwan, Eman Sultan, Omar Mohamoud Azzam, Ehab A. M. El-Shoura
Summary: This study investigated the association of serum leptin (LEP) levels and LEP gene polymorphisms with type 2 diabetes mellitus (T2DM) in Egyptian patients. The results showed that the LEP gene SNP rs7799039 was associated with an increased risk of T2DM, and serum LEP levels were significantly decreased in T2DM patients.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Katarzyna Piotrowska, Katarzyna Zgutka, Marta Tkacz, Maciej Tarnowski
Summary: Diabetes is a major healthcare problem, especially for pregnant women, and requires an appropriate approach. Gestational diabetes mellitus and type 2 diabetes mellitus share many similarities and induce oxidative stress and cellular stress signaling. The risk of diabetes during pregnancy can lead to complications for both the mother and fetus. Physical activity is not only important for treating the negative effects of diabetes, but also for preventing its progression and reversing changes. Regular training sessions have a positive effect on the immune status of diabetic patients, mothers, and fetuses, causing changes in immune cell levels, cytokine activation, production and secretion, as well as microRNA, which improve overall well-being.
Article
Biochemistry & Molecular Biology
Jelena Mirnic, Milanko Djuric, Tanja Veljovic, Ivana Gusic, Jasmina Katanic, Karolina Vukoje, Bojana Ramic, Ana Tadic, Snezana Brkic
Summary: Oxidative stress may serve as a link between diabetes mellitus and periodontitis. In this study, the salivary lipid peroxidation (LP) in periodontitis patients with and without type 2 diabetes was evaluated. The results showed that the improvement in clinical periodontal status following nonsurgical periodontal therapy is accompanied by a significant decrease in salivary LP in diabetes mellitus type 2 (DM2) patients, suggesting that periodontitis is the primary driver of the elevated salivary LP in this group.
Article
Medicine, General & Internal
Mohammad Reza Nazem, Mojgan Asadi, Maryam Adelipour, Niloofar Jabbari, Abdolamir Allameh
Summary: This study evaluated the effects of zinc supplementation on oxidative status and glycaemic parameters in overweight patients with type 2 diabetes mellitus (T2DM). The results showed that zinc supplementation for 8 weeks significantly improved the oxidative balance and controlled the glycaemic indices in these patients.
POSTGRADUATE MEDICAL JOURNAL
(2023)
Review
Pharmacology & Pharmacy
Khaled Benchoula, Aditya Arya, Ishwar S. Parhar, Wong Eng Hwa
Summary: This review discusses the importance of maintaining balanced glucose homeostasis in preventing or treating diabetes and obesity, as well as the complexity of activating and inhibiting glucose production. It focuses on the key role of FoxO1 in obesity-induced insulin susceptibility and provides potential therapeutic approaches.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
George-Alexandru Maftei, Maria-Alexandra Martu, Marius-Cristian Martu, Dora Popescu, Petra Surlin, Diana Tatarciuc, Cristina Popa, Liliana-Georgeta Foia
Summary: The study showed that various oxidative status markers and proinflammatory biomarkers in the saliva of diabetic patients were altered before and after tooth extraction, correlating with HbA1c levels and potentially serving as indicators of post-extraction healing status in the oral cavity.
Review
Oncology
Tiffany Scully, Abora Ettela, Derek LeRoith, Emily Jane Gallagher
Summary: Obesity and type 2 diabetes are both linked to increased cancer risk, with metabolic abnormalities playing a key role in the relationship and progression of cancer. Multiple mechanisms, including insulin signaling, lipid and glucose metabolism, as well as changes in adipose tissue, are proposed to be involved in the association between obesity, diabetes, and cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Adela-Viviana Sitar-Taut, Angela Cozma, Adriana Fodor, Sorina-Cezara Coste, Olga Hilda Orasan, Vasile Negrean, Dana Pop, Dan-Andrei Sitar-Taut
Summary: The study aimed to assess the relationship between adipokines such as leptin and ghrelin and their ratio with obesity and diabetes. Results showed that obese patients had higher leptin values and leptin/ghrelin ratios, with significant differences found in analyses stratified by obesity and gender. Obesity and diabetes were associated with changes in the levels of adipokines, even in overweight subjects, indicating a basis for early intervention in diabetic and obese patients.
Review
Biochemistry & Molecular Biology
Rosaria Vincenza Giglio, Anca Pantea Stoian, Martin Haluzik, Kalliopi Pafili, Angelo Maria Patti, Ali Abbas Rizvi, Marcello Ciaccio, Nikolaos Papanas, Manfredi Rizzo
Summary: Diabetes is a major risk factor for cardiovascular disease, with high blood glucose leading to increased reactive oxygen species and affecting endothelial function and atherosclerotic plaque formation. Biomarkers play a crucial role in screening, prediction, diagnosis, and monitoring of cardiovascular risks associated with diabetes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Food Science & Technology
Chandra Sekhar Arigela, Giribabu Nelli, Siew Hua Gan, Kuttulebbai Nainamohamed Salam Sirajudeen, Kumarathevan Krishnan, Nurhanan Abdul Rahman, Visweswara Rao Pasupuleti
Summary: Bitter gourd honey (BGH) shows potential anti-oxidative, anti-inflammatory, and anti-apoptotic effects in the treatment of diabetes, reducing liver and kidney damage and increasing levels of antioxidant enzymes.
Review
Biochemistry & Molecular Biology
Anju Singh, Ritushree Kukreti, Luciano Saso, Shrikant Kukreti
Summary: Oxidative stress is a metabolic dysfunction caused by the imbalance between reactive oxygen species production and the body's antioxidant defense system. It is closely related to the development of various noncommunicable diseases. Diabetes mellitus, especially type 2 diabetes, is significantly influenced by oxidative stress, which plays a crucial role in insulin signaling pathways.
Article
Rheumatology
R. M. Gamal, W. Gaber, S. Sayed, A. M. Mohey, S. H. Goma, M. S. E. Mohamed
AKTUELLE RHEUMATOLOGIE
(2016)
Meeting Abstract
Rheumatology
N. Hammam, R. M. Gamal, A. M. Rashed, E. Mosad, E. M. Khedr
ANNALS OF THE RHEUMATIC DISEASES
(2015)
Article
Immunology
Rania M. Gamal, Walid M. Gamal, Abeer M. Ghandour, Hanan Sayed M. Abozaid, Mona Embarek Mohamed, Yasser Emad, Ahmed Abdel Galeel
IMMUNOLOGICAL INVESTIGATIONS
(2018)
Article
Rheumatology
Rania M. Gamal, Nevin Hammam, Madeha M. Zakary, Marwa Mahmoud Abdelaziz, Mohamed Raouf Abdel Razek, Mona Sallam Embarek Mohamed, Yaser Emad, Mohamed Galal Elnaggar, Daniel E. Furst
CLINICAL RHEUMATOLOGY
(2018)
Article
Clinical Neurology
Rania M. Gamal, Mona Embarek Mohamed, Nevin Hammam, Noha Abo El Fetoh, Ahmed M. Rashed, Daniel E. Furst
Article
Rheumatology
Eman M. Khedr, Noha Abo El Fetoh, Rania M. Gamal, Mona H. Elzohri, Nashwa Mostafa A. Azoz, Daniel E. Furst
CLINICAL RHEUMATOLOGY
(2020)
Article
Rheumatology
Marwa Mahmoud Abdelaziz, Rania M. Gamel, Nadia M. Ismail, Raghda A. Lafy, Helal F. Hetta
Summary: The study evaluated the role of anti-CD74 antibodies in the diagnosis of axSpA, finding significantly higher levels in axSpA patients compared to control groups. CD74 autoantibodies showed promise as a diagnostic tool for supporting the clinical diagnosis of axSpA, with high sensitivity and specificity.
Article
Immunology
Naglaa K. Idriss, Rania M. Gamal, Marwa A. Gaber, Eman H. El-Hakeim, Nevin Hammam, Abeer M. Ghandour, Marwa Mahmoud Abdelaziz, Samar H. Goma
CENTRAL EUROPEAN JOURNAL OF IMMUNOLOGY
(2020)
Article
Rheumatology
Rania M. Gamal, Hanan Sayed M. Abozaid, Mohmed Zidan, Mohamed Aboel-Kassem F. Abdelmegid, Mohmed Raouf Abdel-Razek, Sahar Abdel-Rahman Alsayed, Amr F. Mourad, Nashwa Mostafa A. Azoz, Lobna Abdel-Wahid Mohram, Daniel E. Furst
ARTHRITIS RESEARCH & THERAPY
(2019)
Article
Rheumatology
Y. Emad, T. Gheita, H. Darweesh, P. Klooster, R. Gamal, H. Fathi, N. El-Shaarawy, M. Gamil, M. Hawass, R. M. El-Refai, H. Al-Hanafi, S. Abd-Ellatif, A. Ismail, J. Rasker
Article
Neurosciences
Reda Badry, Rania M. Gamal, Manal M. Hassanien, Mohamed Abd El Hamed, Nevin Hammam, Bastawy M. El Fawal
EGYPTIAN JOURNAL OF NEUROLOGY PSYCHIATRY AND NEUROSURGERY
(2018)
Article
Orthopedics
Hanan Sayed M. Abozaid, Reham Alaa El-Din Hassan, Waleed A. Elmadany, Mohamed Aly Ismail, Dalia S. Elgendy, Sahar A. Elsayed, Rania M. Gamal, Osama S. Daifallah, Esam M. Abu Alfadl
CLINICAL MEDICINE INSIGHTS-ARTHRITIS AND MUSCULOSKELETAL DISORDERS
(2018)
Article
Anesthesiology
Eman H. El-Hakeim, Abdelraheem Elawamy, Emad Zarief Kamel, Samar H. Goma, Rania M. Gamal, Abeer M. Ghandour, Ayman M. Osman, Khalid M. Morsy
Article
Rheumatology
Rania M. Gamal, Safaa A. Mahran, Noha Abo El Fetoh, Fadwa Janbi
EGYPTIAN RHEUMATOLOGIST
(2016)
Article
Rheumatology
Nevin Hammam, Rania M. Gamal, Ahmed Mohammed Rashed, Noha Abo Elfetoh, Eman Mosad, Eman M. Khedr
REUMATOLOGIA CLINICA
(2020)