Effects of chronic exposure of clonal β-cells to elevated glucose and free fatty acids on incretin receptor gene expression and secretory responses to GIP and GLP-1

Effects of lipotoxicity on a novel insulin-secreting human pancreatic β-cell line, 1.1B4

(2013) Srividya Vasu et al.   BIOLOGICAL CHEMISTRY

Pharmacology, Physiology, and Mechanisms of Incretin Hormone Action

(2013) Jonathan E. Campbell et al.   Cell Metabolism

Peroxisome Proliferator-activated Receptor γ (PPARγ) and Its Target Genes Are Downstream Effectors of FoxO1 Protein in Islet β-Cells

(2013) Dhananjay Gupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMPK Is Involved in the Regulation of Incretin Receptors Expression in Pancreatic Islets under a Low Glucose Concentration

(2013) Kazuki Tajima et al.   PLoS One

Genetic Variation in the Glucose-Dependent Insulinotropic Polypeptide Receptor Modifies the Association between Carbohydrate and Fat Intake and Risk of Type 2 Diabetes in the Malmö Diet and Cancer Cohort

(2012) Emily Sonestedt et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Regulation of GIP and GLP1 Receptor Cell Surface Expression by N-Glycosylation and Receptor Heteromerization

(2012) Gina M. Whitaker et al.   PLoS One

Development and Functional Characterization of Insulin-releasing Human Pancreatic Beta Cell Lines Produced by Electrofusion

(2011) Jane T. McCluskey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adipocyte expression of the glucose-dependent insulinotropic polypeptide receptor involves gene regulation by PPARγ and histone acetylation

(2011) Su-Jin Kim et al.   JOURNAL OF LIPID RESEARCH

Two incretin hormones GLP-1 and GIP: Comparison of their actions in insulin secretion and β cell preservation

(2011) Daisuke Yabe et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Acute and long-term effects of metformin on the function and insulin secretory responsiveness of clonal β-cells

(2010) Joan M. McKiney et al.   BIOLOGICAL CHEMISTRY

Physiologic and Pharmacologic Modulation of Glucose-Dependent Insulinotropic Polypeptide (GIP) Receptor Expression in  -Cells by Peroxisome Proliferator-Activated Receptor (PPAR)-  Signaling: Possible Mechanism for the GIP Resistance in Type 2 Diabetes

(2010) D. Gupta et al.   DIABETES

Effects of metformin on BRIN-BD11 beta-cell insulin secretory desensitization induced by prolonged exposure to sulphonylureas

(2010) N. Irwin et al.   DIABETES OBESITY & METABOLISM

Therapeutic potential of the original incretin hormone glucose-dependent insulinotropic polypeptide: diabetes, obesity, osteoporosis and Alzheimer's disease?

(2010) Nigel Irwin et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Acute and Long-term Effects of Peroxisome Proliferator-activated Receptor-γ Activation on the Function and Insulin Secretory Responsiveness of Clonal Beta-Cells

(2010) N. Irwin et al.   HORMONE AND METABOLIC RESEARCH

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

(2010) Richa Saxena et al.   NATURE GENETICS

Molecular mechanism by which pioglitazone preserves pancreatic β-cells in obese diabetic mice: evidence for acute and chronic actions as a PPARγ agonist

(2009) Yukiko Kanda et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Recent Advances in Antidiabetic Drug Therapies Targeting the Enteroinsular Axis

(2009) P. Flatt et al.   CURRENT DRUG METABOLISM

Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function

(2009) Luan Shu et al.   HUMAN MOLECULAR GENETICS