Peroxisome Proliferator-activated Receptor γ (PPARγ) and Its Target Genes Are Downstream Effectors of FoxO1 Protein in Islet β-Cells

PPAR-γ Activation Increases Insulin Secretion through the Up-regulation of the Free Fatty Acid Receptor GPR40 in Pancreatic β-Cells

(2013) Hyo-Sup Kim et al.   PLoS One

The B55α-containing PP2A holoenzyme dephosphorylates FOXO1 in islet β-cells under oxidative stress

(2012) Ling Yan et al.   BIOCHEMICAL JOURNAL

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

Rosiglitazone Promotes PPARγ-Dependent and -Independent Alterations in Gene Expression in Mouse Islets

(2012) Hannah J. Welters et al.   ENDOCRINOLOGY

Increased DNA Methylation and Decreased Expression ofPDX-1in Pancreatic Islets from Patients with Type 2 Diabetes

(2012) Beatrice T. Yang et al.   MOLECULAR ENDOCRINOLOGY

PPAR-γ Activation Restores Pancreatic Islet SERCA2 Levels and Prevents β-Cell Dysfunction under Conditions of Hyperglycemic and Cytokine Stress

(2012) Tatsuyoshi Kono et al.   MOLECULAR ENDOCRINOLOGY

Research Resource: The Pdx1 Cistrome of Pancreatic Islets

(2012) Cynthia Khoo et al.   MOLECULAR ENDOCRINOLOGY

Control of Pancreatic β Cell Regeneration by Glucose Metabolism

(2011) Shay Porat et al.   Cell Metabolism

Altered Insulin Receptor Signalling and β-Cell Cycle Dynamics in Type 2 Diabetes Mellitus

(2011) Franco Folli et al.   PLoS One

Applications of post-translational modifications of FoxO family proteins in biological functions

(2011) Ying Zhao et al.   Journal of Molecular Cell Biology

Fuel-Stimulated Insulin Secretion Depends upon Mitochondria Activation and the Integration of Mitochondrial and Cytosolic Substrate Cycles

(2011) Gary W. Cline   Diabetes & Metabolism Journal

Physiologic and Pharmacologic Modulation of Glucose-Dependent Insulinotropic Polypeptide (GIP) Receptor Expression in  -Cells by Peroxisome Proliferator-Activated Receptor (PPAR)-  Signaling: Possible Mechanism for the GIP Resistance in Type 2 Diabetes

(2010) D. Gupta et al.   DIABETES

Dissociation of lipotoxicity and glucotoxicity in a mouse model of obesity associated diabetes: role of forkhead box O1 (FOXO1) in glucose-induced beta cell failure

(2010) O. Kluth et al.   DIABETOLOGIA

Regulation of insulin secretion: role of mitochondrial signalling

(2010) S. Jitrapakdee et al.   DIABETOLOGIA

Uncoupling of Acetylation from Phosphorylation Regulates FoxO1 Function Independent of Its Subcellular Localization

(2010) Li Qiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

(2010) Richa Saxena et al.   NATURE GENETICS

Thiazolidinediones in prediabetes and early type 2 diabetes: What can be learned about that disease’s pathogenesis

(2009) Jack L. Leahy   Current Diabetes Reports

Islet beta cell failure in the 60% pancreatectomised obese hyperlipidaemic Zucker fatty rat: severe dysfunction with altered glycerolipid metabolism without steatosis or a falling beta cell mass

(2009) V. Delghingaro-Augusto et al.   DIABETOLOGIA

Decreased levels of metabolic enzymes in pancreatic islets of patients with type 2 diabetes

(2009) M. J. MacDonald et al.   DIABETOLOGIA

Effect of forkhead box O1 (FOXO1) on beta cell development in the human fetal pancreas

(2009) M. Al-Masri et al.   DIABETOLOGIA

Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function

(2009) Luan Shu et al.   HUMAN MOLECULAR GENETICS

FOXO1 Transrepresses Peroxisome Proliferator-activated Receptor γ Transactivation, Coordinating an Insulin-induced Feed-forward Response in Adipocytes

(2009) WuQiang Fan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Pancreatic Juxtaductal Endocrine Cell Formation by FoxO1

(2009) T. Kitamura et al.   MOLECULAR AND CELLULAR BIOLOGY

Peroxisome Proliferator-Activated Receptor   Activation Restores Islet Function in Diabetic Mice through Reduction of Endoplasmic Reticulum Stress and Maintenance of Euchromatin Structure

(2009) C. Evans-Molina et al.   MOLECULAR AND CELLULAR BIOLOGY

Enhanced β-cell mass without increased proliferation following chronic mild glucose infusion

(2008) Thomas L. Jetton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Fat and Beyond: The Diverse Biology of PPARγ

(2008) Peter Tontonoz et al.   Annual Review of Biochemistry

The role of pyruvate carboxylase in insulin secretion and proliferation in rat pancreatic beta cells

(2008) J. Xu et al.   DIABETOLOGIA

In Vivoandin VitroStudies of a Functional Peroxisome Proliferator-activated Receptor γ Response Element in the Mousepdx-1Promoter

(2008) Dhananjay Gupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY