Article
Biochemistry & Molecular Biology
Qing Ling, Lei Shen, Wei Zhang, DuoDuo Qu, Hongdong Wang, Bin Wang, Yong Liu, Jing Lu, Dalong Zhu, Yan Bi
Summary: The study revealed that plasmablasts may function as antigen-presenting cells and promote the activation and proinflammatory response of CD4(+) T cells, contributing to the T cell-mediated beta cell destruction. This suggests potential translational strategies for inhibiting T1D development.
MOLECULAR MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Qian Wu, Xiao Yue, Huashan Liu, Yaxi Zhu, Haoxian Ke, Xin Yang, Shi Yin, Zhihao Li, Yunfeng Zhang, Tuo Hu, Ping Lan, Xianrui Wu
Summary: Through next-generation sequencing, we identified MAP7D2 as a potential therapeutic target to improve the efficacy of immune checkpoint inhibitors (ICIs) for microsatellite stable (MSS) colorectal cancer (CRC) therapy. MAP7D2 expression was increased in MSS CRC and negatively correlated with the presence of antitumor T lymphocytes. Knockdown of MAP7D2 significantly enhanced CD8+ CTLs infiltration and improved the efficacy of ICIs in MSS CRC murine models. Targeting MAP7D2 may present a novel approach for antitumor immunotherapy in MSS CRC.
Article
Nanoscience & Nanotechnology
Jacqueline A. Burke, Xiaomin Zhang, Sharan Bobbala, Molly A. Frey, Carolina Bohorquez Fuentes, Helena Freire Haddad, Sean D. Allen, Reese A. K. Richardson, Guillermo A. Ameer, Evan A. Scott
Summary: This study demonstrates that subcutaneous delivery of rapamycin using a polymersome platform allows for control of the drug's biodistribution and activity on specific immune cells, changing its mechanism of action from immunosuppression to tolerance, reducing side effects and enhancing anti-inflammatory efficacy.
NATURE NANOTECHNOLOGY
(2022)
Article
Immunology
Arne Knoerck, Gertrud Schaefer, Dalia Alansary, Josephine Richter, Lorenz Thurner, Markus Hoth, Eva C. Schwarz
Summary: This study developed a FRET-based single cell fluorescent assay to compare the cytotoxic efficiency of effector memory CD8(+) T cells (T-EM) and central memory CD8(+) T cells (T-CM). The results showed that T-EM had higher cytotoxic efficiency compared to T-CM. This could be attributed to the higher expression levels of perforin and granzyme B in T-EM, which likely mediate the higher cytotoxic efficiency.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Vanaja Konduri, Damilola Oyewole-Said, Jonathan Vazquez-Perez, Scott A. Weldon, Matthew M. Halpert, Jonathan M. Levitt, William K. Decker
Summary: NK1.1 and its human homolog CD161 are expressed on various immune cells and play different roles in NK cells, T cells, and NKT cells. CD161-expressing CD8(+) T cells, initially studied in viral infections, have potential implications in tumor immunology, although their exact role is not well understood.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Jesus Paez-Mayorga, Jocelyn Nikita Campa-Carranza, Simone Capuani, Nathanael Hernandez, Hsuan-Chen Liu, Corrine Ying Xuan Chua, Fernanda Paola Pons-Faudoa, Gulsah Malgir, Bella Alvarez, Jean A. Niles, Lissenya B. Argueta, Kathryn A. Shelton, Sarah Kezar, Pramod N. Nehete, Dora M. Berman, Melissa A. Willman, Xian C. Li, Camillo Ricordi, Joan E. Nichols, A. Osama Gaber, Norma S. Kenyon, Alessandro Grattoni
Summary: By using the Neovascularized Implantable Cell Homing and Encapsulation (NICHE) device, pancreatic islet transplantation for type 1 diabetes can achieve long-term reversal without the need for systemic immunosuppression, making it a promising approach for effective treatment.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Icia Santos-Zas, Jeremie Lemarie, Ivana Zlatanova, Marine Cachanado, Jean-Christophe Seghezzi, Hakim Benamer, Pascal Goube, Marie Vandestienne, Raphael Cohen, Maya Ezzo, Vincent Duval, Yujiao Zhang, Jin-Bo Su, Alain Bize, Lucien Sambin, Philippe Bonnin, Maxime Branchereau, Christophe Heymes, Corinne Tanchot, Jose Vilar, Clement Delacroix, Jean-Sebastien Hulot, Clement Cochain, Patrick Bruneval, Nicolas Danchin, Alain Tedgui, Ziad Mallat, Tabassome Simon, Bijan Ghaleh, Jean-Sebastien Silvestre, Hafid Ait-Oufella
Summary: This study reveals the detrimental role of CD8(+) T lymphocytes following acute myocardial infarction, showing that they release Granzyme B in the ischemic heart tissue leading to cardiomyocyte apoptosis, adverse ventricular remodeling, and deterioration of myocardial function. Depletion of CD8(+) T lymphocytes leads to reduced apoptosis, inhibited inflammatory response, limited myocardial injury, and improved heart function. Elevated circulating levels of GRANZYME B in AMI patients may predict increased risk of death at 1-year follow-up. Targeting pathogenic CD8(+) T lymphocytes could be a potential therapeutic strategy in the setting of acute myocardial infarction.
NATURE COMMUNICATIONS
(2021)
Article
Medicine, Research & Experimental
Claire Lhuillier, Nils-Petter Rudqvist, Takahiro Yamazaki, Tuo Zhang, Maud Charpentier, Lorenzo Galluzzi, Noah Dephoure, Cristina C. Clement, Laura Santambrogio, Xi Kathy Zhou, Silvia C. Formenti, Sandra Demaria
Summary: Radiotherapy upregulates the expression of genes containing immunogenic mutations, enhancing the therapeutic efficacy of neoantigen vaccination by promoting the killing of tumor cells through CD8 and CD4 T cells. CD4 T cells produce Th1 cytokines to promote epitope spread, while utilizing radiation to enhance the ability of MHC molecules and death receptors on tumor cells.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Oncology
Hans Raskov, Adile Orhan, Jan Pravsgaard Christensen, Ismail Gogenur
Summary: The functions and interactions between the innate and adaptive immune systems play a crucial role in anticancer immunity. Cytotoxic T cells with CD8 as the most effective effectors in the anticancer immune response form the basis of successful cancer immunotherapies. Advancements in genetically modified or synthetic receptors on cytotoxic T cells are being developed for future cancer treatment. Combinatory regimens may optimize treatment effects and reduce adverse events in cancer therapy.
BRITISH JOURNAL OF CANCER
(2021)
Article
Immunology
Dawei Chen, Dimitri Kakabadse, Sigal Fishman, Hadas Weinstein-Marom, Joanne Davies, Joanne Boldison, Terri C. Thayer, Li Wen, Gideon Gross, F. Susan Wong
Summary: This study proposes a novel therapeutic approach using B lymphocytes to attract and regulate specific T cells, thereby preventing the development of autoimmune diabetes. By expressing chimeric MHC-peptide constructs in B cells, the engineered cells successfully inhibited cytotoxicity of antigen-specific CD8(+) T cells and induced regulatory markers in antigen-specific CD4+ T cells. Furthermore, these engineered B cells protected mice from autoimmune diabetes induced by transfer of antigen-specific T cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell & Tissue Engineering
Nopmanee Taechangam, Naomi J. Walker, Dori L. Borjesson
Summary: The study showed that feline adipose-derived mesenchymal stem cells (ASCs) alter the functional characteristics of CD8+ T cells, shifting their phenotype towards terminally differentiated proinflammatory effector cells and enhancing their cytotoxic potential.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Immunology
Xiang Zhao, Liang-Zhe Wu, Esther K. Y. Ng, Kerisa W. S. Leow, Qianru Wei, Nicholas R. J. Gascoigne, Joanna Brzostek
Summary: Co-agonist pMHC class I complexes recruit CD8-bound Lck to the immune synapse to modulate CD8(+) T cell signaling pathways, enhancing effector functions and proliferation. Furthermore, co-agonism can boost T cell proliferation through an extrinsic mechanism, priming neighboring CD8(+) T cells for enhanced Akt pathway activation and proliferation.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Mouhamad Al Moussawy, Hossam A. Abdelsamed
Summary: Cytotoxic CD8 T cells play a crucial role in immune responses, but they can also have non-cytotoxic functions through interactions with immune and non-immune cells. The new classification provides a comprehensive understanding of CD8 T cell functions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Jin Wang, Dongbo Jiang, Xiaoqi Zheng, Wang Li, Tian Zhao, Di Wang, Huansha Yu, Dongqing Sun, Ziyi Li, Jian Zhang, Zhe Zhang, Likun Hou, Gening Jiang, Ke Fei, Fan Zhang, Kun Yang, Peng Zhang
Summary: This study reveals the adaptive characteristics of the tumor microenvironment (TME) in early lung adenocarcinoma, including high CD4(+) T cell infiltration, high B-cell activation, and low CD8(+) T cell infiltration. Multiplex immunohistochemistry staining confirms the formation of tertiary lymphoid structures (TLS) and the enrichment of follicular regulatory T cells (Tfr) in TLS follicles, which may contribute to the attenuated anti-tumor immunity in early lung adenocarcinoma.
Article
Cell Biology
Karolin I. Wagner, Laura M. Mateyka, Sebastian Jarosch, Vincent Grass, Simone Weber, Kilian Schober, Monika Hammel, Teresa Burrell, Behnam Kalali, Holger Poppert, Henriette Beyer, Sophia Schambeck, Stefan Holdenrieder, Andrea Strotges-Achatz, Verena Haselmann, Michael Neumaier, Johanna Erber, Alina Priller, Sarah Yazici, Hedwig Roggendorf, Marcus Odendahl, Torsten Tonn, Andrea Dick, Klaus Witter, Hrvoje Mijocevic, Ulrike Protzer, Percy A. Knolle, Andreas Pichlmair, Claudia S. Crowell, Markus Gerhard, Elvira D'Ippolito, Dirk H. Busch
Summary: This study isolated TCR repertoires specific for SARS-CoV-2 epitopes restricted to common HLA class I molecules in convalescent individuals. SARS-CoV-2-specific CD8(+) T cells were found to be detectable up to 12 months after infection. The TCR repertoires were diverse, with heterogeneous functional avidity and cytotoxicity towards virus-infected cells.
Article
Allergy
Marian Szczepanik, Monika Majewska-Szczepanik, Florence S. Wong, Paulina Kowalczyk, Chandrashekhar Pasare, Li Wen
CONTACT DERMATITIS
(2018)
Article
Endocrinology & Metabolism
Anna E. Long, Isabel V. Wilson, Dorothy J. Becker, Ingrid M. Libman, Vincent C. Arena, F. Susan Wong, Andrea K. Steck, Marian J. Rewers, Liping Yu, Peter Achenbach, Rosaura Casas, Johnny Ludvigsson, Alistair J. K. Williams, Kathleen M. Gillespie
Article
Endocrinology & Metabolism
Larissa C. Da Rosa, Joanne Boldison, Evy De Leenheer, Joanne Davies, Li Wen, F. Susan Wong
Article
Endocrinology & Metabolism
Wendy E. Powell, Stephanie J. Hanna, Claire N. Hocter, Emma Robinson, Joanne Davies, Gareth J. Dunseath, Stephen Luzio, Daniel Farewell, Li Wen, Colin M. Dayan, David A. Price, Kristin Ladell, F. Susan Wong
Article
Immunology
Elke Gulden, Chen Chao, Ningwen Tai, James A. Pearson, Jian Peng, Monika Majewska-Szczepanik, Zhiguang Zhou, F. Susan Wong, Li Wen
JOURNAL OF AUTOIMMUNITY
(2018)
Article
Endocrinology & Metabolism
James A. Pearson, Dimitri Kakabadse, Joanne Davies, Jian Peng, Jeremy Warden-Smith, Simone Cuff, Mark Lewis, Larissa Camargo da Rosa, Li Wen, F. Susan Wong
Editorial Material
Endocrinology & Metabolism
F. Susan Wong, Li Wen
NATURE REVIEWS ENDOCRINOLOGY
(2020)
Review
Immunology
James Alexander Pearson, Florence Susan Wong, Li Wen
Review
Immunology
M. Battaglia, J. H. Buckner, M. K. Levings, S. J. Richardson, F. S. Wong, T. I. Tree
Summary: The story of Achilles' heel serves as a metaphor for vulnerability and weakness that may go unnoticed until it causes failure. Various cells and elements have been proposed as potential Achilles' heels for type 1 diabetes, each playing a role in the pathogenesis of the disease.Experts continue to study and present arguments to identify the specific Achilles' heel of T1D.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Joanne Boldison, Terri C. Thayer, Joanne Davies, F. Susan Wong
Summary: Naturally protected NOD mice exhibit unique characteristics in their pancreatic islet morphology and immune infiltrate, with features such as increased frequency of insulin-containing, smaller-sized islets and regulatory T and B cell phenotypes. Despite being diabetes free, they still have significant immune infiltrate, indicating a distinct islet signature and providing new insights into regulatory mechanisms in pancreatic islets.
Article
Endocrinology & Metabolism
James A. Pearson, Heyuan Ding, Changyun Hu, Jian Peng, Brittany Galuppo, F. Susan Wong, Sonia Caprio, Nicola Santoro, Li Wen
Summary: The study suggests that IgM-bound gut microbiota may play a crucial role in the immunopathogenesis of obesity and type 2 diabetes, providing a novel link between IgM and these conditions in both mice and humans.
Article
Medicine, General & Internal
Raffaella Buzzetti, Ernesto Maddaloni, Jason Gaglia, R. David Leslie, F. Susan Wong, Bernhard O. Boehm
Summary: Adult-onset autoimmune diabetes is often misdiagnosed as type 2 diabetes and has a slow progression. Proper care aims to prevent complications and improve quality of life. Choosing the right therapy for this disease is challenging due to its heterogeneity.
NATURE REVIEWS DISEASE PRIMERS
(2022)
Article
Endocrinology & Metabolism
Sha Sha, James A. Pearson, Jian Peng, Youjia Hu, Juan Huang, Yanpeng Xing, Luyao Zhang, Ying Zhu, Hongyu Zhao, F. Susan Wong, Li Chen, Li Wen
Summary: TLR9 in B cells modulates T1D susceptibility by changing the frequency and function of IL-10-producing B cells, leading to near-complete protection from diabetes development in NOD mice.
Article
Endocrinology & Metabolism
Terri C. Thayer, Joanne Davies, James A. Pearson, Stephanie J. Hanna, Li Wen, F. Susan Wong
Summary: Our results suggest that a loss of NOD-LNSC MHC-independent suppressive mechanisms may contribute to diabetes development. In contrast, non-MHC-matched, control C57BL/6 mouse LNSC suppressed T-cell receptor engagement by anti-CD3/CD28 via MHC-independent mechanisms, modifying antigen sensitivity and effector function.
Article
Medicine, Research & Experimental
Qiyuan Tan, Ningwen Tai, Yangyang Li, James Pearson, Sean Pennetti, Zhiguang Zhou, F. Susan Wong, Li Wen