Article
Neurosciences
Leah DeFlitch, Estibaliz Gonzalez-Fernandez, Ilan Crawley, Shin H. Kang
Summary: Oligodendrocyte population and changes in the adult hippocampus vary among subregions, with the CA3 and CA4 subregions showing the most prominent oligodendrogenesis. These subregion-dependent oligodendrocyte changes may be related to myelin plasticity and disease-associated vulnerability in the hippocampus.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Marion J. F. Levy, Beatriz Garcia-Diaz, Frederic Sedel, Anne Baron-Van Evercooren, Sabah Mozafari
Summary: Accumulating evidences suggest a strong correlation between metabolic changes and neurodegeneration in CNS demyelinating diseases such as multiple sclerosis (MS). Biotin or high-dose-biotin (MD1003) has been shown to increase the number and differentiation potential of murine and human oligodendrocytes, but without enhancing their myelination potential.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Julia Ghelman, Laureen Grewing, Farina Windener, Stefanie Albrecht, Alexander Zarbock, Tanja Kuhlmann
Summary: This study compared the intrinsic properties of oligodendroglial progenitor cells (OPCs) from the spinal cord and brain on both functional and transcriptional levels. It found differences in migration and differentiation capacity between the two populations, as well as differential expression of multiple genes. SKAP2 was identified as a novel regulator of oligodendroglial migration and myelin sheath formation, with its expression affecting OPC migration and morphological maturation.
Article
Neurosciences
Shuang-Ling Wu, Bin Yu, Yong-Jie Cheng, Shu-Yu Ren, Fei Wang, Lan Xiao, Jing-Fei Chen, Feng Mei
Summary: Alzheimer's disease (AD) is characterized by the presence of aggregated amyloid beta-protein (Aβ). Recent evidence suggests that inadequate myelinogenesis plays a role in AD-related functional deficits. The relationship between Aβ and myelinogenesis in AD brains, however, remains unclear.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Cell & Tissue Engineering
Kee-Pyo Kim, Cui Li, Daria Bunina, Hyun-Woo Jeong, Julia Ghelman, Juyong Yoon, Borami Shin, Hongryeol Park, Dong Wook Han, Judith B. Zaugg, Johnny Kim, Tanja Kuhlmann, Ralf H. Adams, Kyung-Min Noh, Steven A. Goldman, Hans R. Schoeler
Summary: By transducing an optimized transcription factor combination into a permissive donor phenotype, pericyte-derived iOPCs (PC-iOPCs) can overcome the limitations of inefficient generation and limited expansion and differentiation competence. PC-iOPCs are stably expandable and functionally myelinogenic with high differentiation competence.
Article
Neurosciences
Jun-Jie Zhi, Shuang-Ling Wu, Hao-Qian Wu, Qi Ran, Xing Gao, Jing-Fei Chen, Xing-Mei Gu, Tao Li, Fei Wang, Lan Xiao, Jian Ye, Feng Mei
Summary: Age-related decline in visual functions is a common health problem among elderly people, but there are currently no effective therapies available. The degeneration of axons and loss of myelin in optic nerves are age-dependent and result in functional deficits. Oligodendrocyte turnover in adult optic nerves is actively ongoing, but the longitudinal change and functional significance of this turnover in aging optic nerves remain largely unknown.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Biology
Adam R. Almeida, Wendy B. Macklin
Summary: Oligodendrocytes in the central nervous system exhibit variability in sheath number, with each cell initiating a variable number of ensheathments that are resolved through a consistent rate of loss. The repetitive ensheathment of the same axons before stable sheaths are formed is independent of neuronal activity. Disrupting membrane recycling affects the later stabilization phase, increasing the percentage of ensheathment loss.
Article
Pharmacology & Pharmacy
Anthony W. Harrington, Changlu Liu, Naomi Phillips, Diane Nepomuceno, Chester Kuei, Joseph Chang, Weixuan Chen, Steven W. Sutton, Daniel O'Malley, Ly Pham, Xiang Yao, Siquan Sun, Pascal Bonaventure
Summary: The study suggests that oxysterols, including 24S-HC, could be physiological activators for GPR17, regulating oligodendrocyte progenitor cell differentiation and myelination through receptor activation.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Neurosciences
V. T. Cheli, M. Sekhar, D. A. Santiago Gonzalez, C. G. Angeliu, G. E. Denaroso, Z. Smith, C. Wang, P. M. Paez
Summary: Ceruloplasmin (Cp) is crucial for cell iron efflux and its absence leads to neurodegeneration and brain iron accumulation. This study found that astrocytes express high levels of Cp and its iron efflux is essential for oligodendrocyte maturation and myelination. Deletion of astrocytic Cp during early postnatal stages resulted in hypomyelination, delayed oligodendrocyte maturation, and increased oxidative stress. Deletion of astrocytic Cp in older mice led to iron accumulation, neurodegeneration, myelin loss, and abnormal behavioral profiles. The study highlights the importance of astrocytic Cp in brain development, aging, and myelin integrity.
Review
Neurosciences
Minxi Fang, Lixia Chen, Tao Tang, Mengsheng Qiu, Xiaofeng Xu
Summary: In the central nervous system, oligodendrocytes (OLs) play a crucial role in myelination and promote axonal conduction. Differentiation committed OPCs (COPs) serve as an intermediate population between OPCs and newly-formed OLs (NFOs), characterized by the expression of G-protein coupled receptor 17 (GPR17). Dysregulation of COPs can lead to remyelination failure and impaired myelin replacement, highlighting the importance of understanding COPs for developing strategies to promote myelin repair in demyelinating diseases.
Article
Neurosciences
Sheng Zhang, Yan Wang, Jie Xu, Bokyung Kim, Wenbin Deng, Fuzheng Guo
Summary: This study reveals the important role of HIF-alpha in developmental myelination, demonstrating its requirement in controlling OPC differentiation for efficient myelination. Contrary to previous beliefs, it was found that HIF-alpha's regulation of CNS myelination is independent of canonical Wnt signaling, and instead involves the HIF-alpha-Sox9 regulatory axis. This discovery represents a shift in understanding the mechanisms of HIF-alpha-regulated CNS myelination from a Wnt-dependent view to a Wnt-independent one.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Zongyan Yu, Zhiwen Yang, Guoru Ren, Yingjie Wang, Xiang Luo, Feiyan Zhu, Shouyang Yu, Lanlan Jia, Mina Chen, Paul F. Worley, Bo Xiao
Summary: GATOR2 plays a crucial role in the formation of myelin sheath in brain development, by regulating the signaling of amino acids and growth factors to mTORC1. Disruption of GATOR2 impairs the proliferation and differentiation of oligodendrocyte precursor cells, leading to defective myelination in the brain.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Lucas Baudouin, Noemie Ades, Kadia Kante, Antonny Czarnecki, Corinne Bachelin, Asha Baskaran, Dominique Langui, Aymeric Millecamps, Basile Gurchenkov, Yoan Velut, Kevin Duarte, Jean-Vianney Barnier, Brahim Nait Oumesmar, Lamia Bouslama-Oueghlani
Summary: Researchers have developed a reliable ex vivo model of myelination by seeding OPCs on cerebellar slices deprived of their endogenous oligodendrocytes. This model is an effective tool for studying the cellular and molecular mechanisms of OPC differentiation and myelination, and can aid in the development and validation of new therapies for myelin-related disorders such as multiple sclerosis and psychiatric diseases.
Review
Cell Biology
Belgin Yalcin, Michelle Monje
Summary: Developmental myelination is a prolonged process with cell-intrinsic mechanisms and microenvironmental interactions guiding every aspect of myelination. Neuron-oligodendroglial interactions fine-tune neural circuit dynamics and promote healthy neurological function during development and throughout adult life.
DEVELOPMENTAL CELL
(2021)
Review
Biology
Nadjet Gacem, Brahim Nait-Oumesmar
Summary: Myelination by oligodendrocytes is crucial for central nervous system development and function, with multiple sclerosis being a common neurodegenerative disease characterized by inflammation and demyelination. Current treatments for MS target the immune component of the disease, but there is ongoing research on pharmacological compounds that could enhance remyelination.
Review
Biochemistry & Molecular Biology
Kai-Hei Tse, Karl Herrup
JOURNAL OF NEUROCHEMISTRY
(2017)
Article
Multidisciplinary Sciences
Aifang Cheng, Teng Zhao, Kai-Hei Tse, Hei-Man Chow, Yong Cui, Liwen Jiang, Shengwang Du, Michael M. T. Loy, Karl Herrup
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Cell Biology
Hei-Man Chow, Aifang Cheng, Xuan Song, Mavis R. Swerdel, Ronald P. Hart, Karl Herrup
JOURNAL OF CELL BIOLOGY
(2019)
Article
Immunology
Chin Wai Hui, Xuan Song, Fulin Ma, Xuting Shen, Karl Herrup
JOURNAL OF NEUROINFLAMMATION
(2018)
Article
Chemistry, Medicinal
Beika Zhu, Yang Zhang, Karl Herrup
Article
Neurosciences
Xuan Song, Fulin Ma, OKarl Herrupu
JOURNAL OF NEUROSCIENCE
(2019)
Article
Biochemistry & Molecular Biology
Beika Zhu, Zhongrui Li, Pei-Yuan Qian, Karl Herrup
JOURNAL OF NEUROCHEMISTRY
(2020)
Article
Neurosciences
Hei-Man Chow, Meng Shi, Aifang Cheng, Yuehong Gao, Guimiao Chen, Xuan Song, Raphaella Wai Lam So, Jie Zhang, Karl Herrup
NATURE NEUROSCIENCE
(2019)
Article
Neurosciences
Yang Zhang, Xuan Song, Karl Herrup
MOLECULAR NEUROBIOLOGY
(2020)
Article
Cell Biology
Aifang Cheng, Kai-Hei Tse, Hei-Man Chow, Yunqiao Gan, Xuan Song, Fulin Ma, Yi Xuan Yvonne Qian, Weiyi She, Karl Herrup
Summary: ATM protein is associated with cellular organelles such as synaptic vesicles, endosomes, and lysosomes, with its deficiency impacting autophagy and lysosomal function in neurons. This disruption leads to impaired neuronal functions including synaptic maintenance, neuronal survival, and glucose uptake.
Article
Neurosciences
Yang Zhang, Beika Zhu, Fulin Ma, Karl Herrup
Summary: Experiments in primary culture have revealed that neurons undergoing cell cycle-related death may resemble precursor-like cells with differences in morphology and expression. These cells predominantly give rise to astrocytes instead of neurons or oligodendrocytes. This suggests a reexamination of previous reports on stimuli leading to neuronal cell cycle-related death in primary cultures is warranted.
Article
Neurosciences
Xuan Song, Jacqueline T. M. Aw, Fulin Ma, Ming Fung Cheung, Danny Leung, Karl Herrup
Summary: Research suggests that failure to repair DNA damage can lead to sterile inflammation in neurodegenerative diseases, sourced from transcriptionally inactive genomic regions and actively exported to the cytoplasm for degradation through a CRM1-dependent mechanism.
JOURNAL OF NEUROSCIENCE
(2021)
Editorial Material
Neurosciences
Karl Herrup
Article
Neurosciences
Fulin Ma, Himanshu Akolkar, Jianquan Xu, Yang Liu, Dina Popova, Jiaan Xie, Mark M. Youssef, Ryad Benosman, Ronald P. Hart, Karl Herrup
Summary: It has been found that glutamate stimulation of neuronal activity leads to an increase in APP gene expression, which in turn affects the structure and function of neurons. APP is associated with the AIS structure protein in neurons, and increased levels of APP protein in AD patients result in AIS shortening and changes. These findings contribute to a reevaluation of the relationship between APP and AD.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Public, Environmental & Occupational Health
Seiko Goto, Yuki Morota, Congcong Liu, Minkai Sun, Bertram Emil Shi, Karl Herrup
HERD-HEALTH ENVIRONMENTS RESEARCH & DESIGN JOURNAL
(2020)
Review
Developmental Biology
Cheng Shi, Pengfei Jiao, Zhiyi Chen, Lan Ma, Siyue Yao
Summary: This review discusses the molecular etiology of congenital craniofacial abnormalities, with a focus on the role and mechanism of noncoding RNAs in regulating craniofacial development. Aberrant expression of noncoding RNAs has been implicated in the pathogenesis of craniofacial abnormalities, providing potential therapeutic targets.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Hideru Togashi, Steven Ray Davis, Makoto Sato
Summary: Tile patterns, regulated by cell adhesion molecules, are regular arrangements of cells that play important functional roles in multicellular organisms. The physical constraints and cell adhesion regulate both cell shape and tissue morphogenesis.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Armen Khanbabei, Lina Segura, Cynthia Petrossian, Aaron Lemus, Ithan Cano, Courtney Frazier, Armen Halajyan, Donnie Ca, Mariano Loza-Coll
Summary: This article investigates the genetic regulatory mechanisms of Drosophila intestinal stem cells. The study found that most target genes co-regulated by Esg and STAT show a consistent gene expression pattern. However, manipulating these validated targets in vivo rarely replicated the effects of manipulating Esg and STAT, suggesting the presence of complex genetic interactions among the downstream targets of these two master regulator genes.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Bayley J. Waters, Zoe R. Birman, Matthew R. Wagner, Julia Lemanski, Barak Blum
Summary: Researchers found that conditional deletion of Robo2 in adult mice led to a significant loss of islet architecture without affecting beta cell identity or function, suggesting that Robo2 plays a role in actively maintaining adult islet architecture. Understanding the factors required for islet architecture maintenance is crucial for developing future diabetes therapies.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Rhiannon Clements, Tyler Smith, Luke Cowart, Jennifer Zhumi, Alan Sherrod, Aidan Cahill, Ginger L. Hunter
Summary: Cell protrusions play a crucial role in regulating cell activities during development. By studying the regulation mechanism in fruit fly sensory bristle patterning, it was found that Myosin XV is essential for the dynamics of signaling filopodia and promotes long-range Notch signaling.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Margaret Keating, Ryan Hagle, Daniel Osorio-Mendez, Anjelica Rodriguez-Parks, Sarah I. Almutawa, Junsu Kang
Summary: Knock-in reporter (KI) animals are essential for studying gene expression in biomedical research. This study developed a new strategy using minicircle technology and a minimal promoter to enhance knock-in events and establish stable KI transgenic reporter lines. The study also highlighted the importance of selecting the proper KI line due to potential inappropriate influence of genome editing on reporter gene expression.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Christian Altbuerger, Meta Rath, Daniel Armbruster, Wolfgang Driever
Summary: This study reveals that Neurog1 and Olig2 transcription factors have differential requirements for the development of dopaminergic neurons, and they integrate local patterning signals and Notch neurogenic selection signaling to specify the progenitor population and initiate neurogenesis and differentiation.
DEVELOPMENTAL BIOLOGY
(2024)