Review
Biochemistry & Molecular Biology
Weiyun Zhang, Peiyi Luo, Xiaohan Liu, Ruoxi Cheng, Shuxian Zhang, Xiao Qian, Fang Liu
Summary: Fibroblast growth factors (FGFs) have been extensively studied for their role in regulating essential cellular activities and have recently been found to play a crucial role in the formation of intricate connections within the nervous system. FGF and FGFR signaling pathways are important in axon guidance, where they act as chemoattractants or chemorepellents. This review provides an overview of the functions of FGFs in axonal navigation and discusses the mechanisms involved, including intracellular signaling integration and cytoskeleton dynamics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Jiajing Sheng, Jiehuan Xu, Kaixi Geng, Dong Liu
Summary: Vessels and nerves are closely associated in anatomy and functions. This study found that sema6D plays a role in regulating the patterning of both the vascular network and neural system in zebrafish embryos. Deficiency of sema6D led to path finding defects in both intersegmental vessels and primary motor neurons in zebrafish embryos.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Greta Limoni
Summary: The establishment and maintenance of neuronal circuits involve genetic regulations and environmental factors, maintaining a homeostatic balance throughout the lifespan. These processes include dendritic arborization, synaptic contact formation, and refinement.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Tian Wang, Yiming Li, Miao Guo, Xue Dong, Mengyu Liao, Mei Du, Xiaohong Wang, Haifang Yin, Hua Yan
Summary: Traumatic optic neuropathy (TON) is characterized by optic nerve damage resulting in vision loss, with limited treatment options. Pituitary adenylate cyclase-activating polypeptide 38 (PACAP38) has shown promise as a therapeutic agent. Using rat retinal ganglion cell (RGC) exosomes as delivery vesicles for PACAP38 (EXOPACAP38) demonstrated improved uptake efficiency and potential for promoting RGC survival, nerve fiber layer thickness, axon regeneration, and optic nerve function in a rat TON model. EXOPACAP38 may offer therapeutic implications for TON patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Ana C. Ayupe, Felipe Beckedorff, Konstantin Levay, Benito Yon, Yadira Salgueiro, Ramin Shiekhattar, Kevin K. Park
Summary: This study identifies specific lncRNAs expressed in different types of RGCs, some of which are altered in response to injury. The results suggest potential roles for lncRNAs in regulating neuronal survival and may provide insights into RGC type specification.
Article
Pharmacology & Pharmacy
Yuki Masuda, Hiroya Ohta, Yumiko Morita, Yoshiaki Nakayama, Ayumi Miyake, Nobuyuki Itoh, Morichika Konishi
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2015)
Article
Cell Biology
Yuki Masuda, Daiki Nawa, Yoshiaki Nakayama, Morichika Konishi, Hiroaki Nanba
JOURNAL OF LEUKOCYTE BIOLOGY
(2015)
Article
Pharmacology & Pharmacy
Kouya Yamaki, Masafumi Ueda, Kumiko Ueda, Noriaki Emoto, Nobuaki Mizutani, Koji Ikeda, Keiko Yagi, Masafumi Tanaka, Yasushi Habu, Yoshiaki Nakayama, Norihiko Takeda, Kensuke Moriwaki, Shuji Kitagawa
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN
(2016)
Article
Biochemistry & Molecular Biology
Mitsutaka Ogawa, Naosuke Nakamura, Yoshiaki Nakayama, Akira Kurosaka, Hiroshi Manya, Motoi Kanagawa, Tamao Endo, Koichi Furukawa, Tetsuya Okajima
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2013)
Review
Biochemistry & Molecular Biology
Ikuo Kimura, Yoshiaki Nakayama, Morichika Konishi, Kazuya Terasawa, Mitsuhiro Ohta, Nobuyuki Itoh, Masafumi Fujimoto
CURRENT PROTEIN & PEPTIDE SCIENCE
(2012)
Article
Biochemistry & Molecular Biology
Hiroyuki Miwa, Ayumi Miyake, Yuya Kouta, Akihiko Shimada, Yuki Yamashita, Yoshiaki Nakayama, Hajime Yamauchi, Morichika Konishi, Nobuyuki Itoh
Article
Developmental Biology
Yoshiaki Nakayama, Naosuke Nakamura, Tamiko Kawai, Eiichi Kaneda, Yui Takahashi, Ayumi Miyake, Nobuyuki Itoh, Akira Kurosaka
GENE EXPRESSION PATTERNS
(2014)
Article
Biochemistry & Molecular Biology
Yoshiaki Nakayama, Naosuke Nakamura, Sayoko Oki, Masaki Wakabayashi, Yasushi Ishihama, Ayumi Miyake, Nobuyuki Itoh, Akira Kurosaka
JOURNAL OF BIOLOGICAL CHEMISTRY
(2012)
Article
Biochemistry & Molecular Biology
Ikuo Kimura, Yoshiaki Nakayama, Morichika Konishi, Teruyuki Kobayashi, Masahiro Mori, Masaki Ito, Akira Hirasawa, Gozoh Tsujimoto, Mitsuhiro Ohta, Nobuyuki Itoh, Masafumi Fujimoto
JOURNAL OF NEUROCHEMISTRY
(2010)
Article
Biochemistry & Molecular Biology
Paitoon Srimontri, Shogo Endo, Toshiro Sakamoto, Yoshiaki Nakayama, Akira Kurosaka, Shigeyoshi Itohara, Yoshio Hirabayashi, Keiko Kato
JOURNAL OF NEUROCHEMISTRY
(2014)
Article
Biochemical Research Methods
Yoshiaki Nakayama, Ayumi Wada, Rei Inoue, Kazuya Terasawa, Ikuo Kimura, Naosuke Nakamura, Akira Kurosaka
JOURNAL OF NEUROSCIENCE METHODS
(2014)
Article
Developmental Biology
Ayumi Miyake, Satoka Nihno, Yuino Murakoshi, Ayano Satsuka, Yoshiaki Nakayama, Nobuyuki Itoh
MECHANISMS OF DEVELOPMENT
(2012)
Article
Multidisciplinary Sciences
Ayumi Miyake, Tatsuya Chitose, Eriko Kamei, Atsuko Murakami, Yoshiaki Nakayama, Morichika Konishi, Nobuyuki Itoh
Review
Neurosciences
Ikuo Kimura, Yoshiaki Nakayama, Ying Zhao, Morichika Konishi, Nobuyuki Itoh
FRONTIERS IN NEUROSCIENCE
(2013)
Review
Cell Biology
Nobuyuki Itoh, Yoshiaki Nakayama, Morichika Konishi
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2016)
Review
Developmental Biology
Cheng Shi, Pengfei Jiao, Zhiyi Chen, Lan Ma, Siyue Yao
Summary: This review discusses the molecular etiology of congenital craniofacial abnormalities, with a focus on the role and mechanism of noncoding RNAs in regulating craniofacial development. Aberrant expression of noncoding RNAs has been implicated in the pathogenesis of craniofacial abnormalities, providing potential therapeutic targets.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Hideru Togashi, Steven Ray Davis, Makoto Sato
Summary: Tile patterns, regulated by cell adhesion molecules, are regular arrangements of cells that play important functional roles in multicellular organisms. The physical constraints and cell adhesion regulate both cell shape and tissue morphogenesis.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Armen Khanbabei, Lina Segura, Cynthia Petrossian, Aaron Lemus, Ithan Cano, Courtney Frazier, Armen Halajyan, Donnie Ca, Mariano Loza-Coll
Summary: This article investigates the genetic regulatory mechanisms of Drosophila intestinal stem cells. The study found that most target genes co-regulated by Esg and STAT show a consistent gene expression pattern. However, manipulating these validated targets in vivo rarely replicated the effects of manipulating Esg and STAT, suggesting the presence of complex genetic interactions among the downstream targets of these two master regulator genes.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Bayley J. Waters, Zoe R. Birman, Matthew R. Wagner, Julia Lemanski, Barak Blum
Summary: Researchers found that conditional deletion of Robo2 in adult mice led to a significant loss of islet architecture without affecting beta cell identity or function, suggesting that Robo2 plays a role in actively maintaining adult islet architecture. Understanding the factors required for islet architecture maintenance is crucial for developing future diabetes therapies.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Rhiannon Clements, Tyler Smith, Luke Cowart, Jennifer Zhumi, Alan Sherrod, Aidan Cahill, Ginger L. Hunter
Summary: Cell protrusions play a crucial role in regulating cell activities during development. By studying the regulation mechanism in fruit fly sensory bristle patterning, it was found that Myosin XV is essential for the dynamics of signaling filopodia and promotes long-range Notch signaling.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Margaret Keating, Ryan Hagle, Daniel Osorio-Mendez, Anjelica Rodriguez-Parks, Sarah I. Almutawa, Junsu Kang
Summary: Knock-in reporter (KI) animals are essential for studying gene expression in biomedical research. This study developed a new strategy using minicircle technology and a minimal promoter to enhance knock-in events and establish stable KI transgenic reporter lines. The study also highlighted the importance of selecting the proper KI line due to potential inappropriate influence of genome editing on reporter gene expression.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Christian Altbuerger, Meta Rath, Daniel Armbruster, Wolfgang Driever
Summary: This study reveals that Neurog1 and Olig2 transcription factors have differential requirements for the development of dopaminergic neurons, and they integrate local patterning signals and Notch neurogenic selection signaling to specify the progenitor population and initiate neurogenesis and differentiation.
DEVELOPMENTAL BIOLOGY
(2024)