Article
Oncology
Simin Pan, Michael Cesarek, Carla Godoy, Cynthia M. Co, Catherine Schindler, Kelbi Padilla, Andrew Haskell, Heather Barreda, Christopher Story, Roy Poole, Alan Dabney, Carl A. Gregory
Summary: The study demonstrates that inhibiting Dkk-1 expression using DkkMo can reduce OS tumor expansion, uphold bone volume and structure, and induce tumor necrosis. These results suggest that administering DkkMo, with or without chemotherapy, can greatly enhance OS outcomes in terms of tumor growth and bone deterioration.
BRITISH JOURNAL OF CANCER
(2022)
Review
Oncology
Dakota Doucet, Connor Brubaker, Donald Turner, Carl A. A. Gregory
Summary: Dickkopf-1 (Dkk-1) has a dual role as either a driver or suppressor in tumor growth. The tissue origin of the tumor can predict the role of Dkk-1 in tumor progression. Dkk-1 is more likely to serve as a suppressor in ectodermal and endodermal tumors, while it is more likely to serve as a driver in mesodermal tumors. High Dkk-1 expression is generally associated with poor prognosis.
FRONTIERS IN ONCOLOGY
(2023)
Article
Endocrinology & Metabolism
Margarita M. Ivanova, Julia Dao, Neil Kasaci, Andrew Friedman, Lauren Noll, Ozlem Goker-Alpan
Summary: This study revealed that elevated levels of sclerostin in GD patients are associated with bone pain, BMI, and EM flask deformity. Most patients with elevated sclerostin also have osteopenia. Additionally, sclerostin levels increase with age in GD patients, and are higher compared to healthy controls in the same age group.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell & Tissue Engineering
Quan-Wen Liu, Yan-Min Ying, Jia-Xin Zhou, Wen-Jie Zhang, Zhao-Xiao Liu, Bing-Bing Jia, Hao-Cheng Gu, Chu-Yu Zhao, Xiao-Hui Guan, Ke-Yu Deng, Hong-Bo Xin
Summary: This study demonstrated that human amniotic mesenchymal stem cells (hAMSCs) attenuated liver fibrosis by inhibiting the activation of hepatic stellate cells (HSCs) through the depression of the Wnt/β-catenin signaling pathway.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Pharmacology & Pharmacy
Naisarg Gamit, Arun Dharmarajan, Gautam Sethi, Sudha Warrier
Summary: Nuclear receptor related 1 (Nurr1) is a transcription factor that regulates midbrain dopaminergic (mDA) neuronal development. Defects in Nurr1 can lead to neurodegeneration and motor function impairment, causing Parkinson's disease (PD). Nurr1 also regulates the expression of alpha-synuclein (alpha-SYN), and mutations in Nurr1 can result in alpha-SYN overexpression, increasing the risk of PD. The Wnt signaling pathway, which plays a role in neurogenesis, modulates Nurr1 and is involved in the downregulation of alpha-SYN. This review explores the interaction between Nurr1 and Wnt signaling pathways in mDA neuronal development, and proposes the modulation of the Wnt pathway as a potential treatment for PD using its antagonist, secreted frizzled related proteins (sFRPs).
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Cell Biology
Min Hee Park, Jae Hun Shin, Alfred L. M. Bothwell, Wook-Jin Chae
Summary: The human body encounters various challenges, and tissue repair and regeneration processes are enhanced after tissue injury to restore tissue homeostasis, with the Wnt pathway and Wnt ligands playing crucial roles in this process. DKK family proteins, acting as immunomodulators, are important in chronic inflammatory diseases, offering novel insights for therapeutic intervention.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Xiang Chen, Jia Hu, Yunfei Wang, Younghee Lee, Xiaohong Zhao, Huiping Lu, Gengzhen Zhu, Hui Wang, Yu Jiang, Fan Liu, Yongzhen Chen, Byung-Seok Kim, Qinghua Zhou, Xindong Liu, Xiaohu Wang, Seon Hee Chang, Chen Dong
Summary: Forkhead box O transcription factors, especially FoxO1 and FoxO3a, play important roles in immune responses. This study reveals the inhibitory role of another member, FoxO4, in Th1 cell's production of interferon-gamma. Conditional deletion of FoxO4 enhances CD4+ T cell's response to Listeria monocytogenes infection. The study also highlights the importance of the FoxO4/DKK3 axis in Th1 cell differentiation.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Review
Biology
Lorenzo Manfreda, Elena Rampazzo, Luca Persano
Summary: The involvement of Wnt signaling in normal tissue homeostasis and disease, particularly in neoplastic malignancies, has been summarized. The impact of aberrant Wnt pathway activation on brain tumorigenesis and tumor aggressiveness, as well as the interdependency between Wnt signaling components and the brain tumor microenvironment, has been emphasized. Furthermore, the latest therapeutic approaches targeting Wnt signaling in cancer treatment have been extensively reviewed and discussed. This review provides evidence that Wnt signaling could be a relevant target in brain tumors, but requires further investigation and overcoming potential concerns for clinical application.
Review
Cell Biology
Benjamin Steventon, Lara Busby, Alfonso Martinez Arias
Summary: The emergence of a conserved body plan in vertebrate embryos through gastrulation involves gene regulatory networks and multicellular interactions. Stem cell models of early embryogenesis from different species show similar structures in culture, with the main difference being the boundary conditions of multicellular ensembles. The mechanical and geometric boundary conditions of different embryos before gastrulation reveal a morphogenetic ground state in stem-cell-based models of embryo development.
DEVELOPMENTAL CELL
(2021)
Article
Immunology
Qian Huang, Chao-Cai Wang, Yun-Guang Liu, Chang-Ming Zhao, Tian-Ping Zhang, Yan Liu, Hua Wang
Summary: This study evaluated the association between WNT signaling pathway gene variants and the risk of pulmonary tuberculosis (PTB) in the Chinese Han population. The results showed that the genetic variations in WNT signaling pathway genes were not significantly associated with PTB susceptibility. However, specific genetic variations in WNT3A, CTNNB1, WIF-1, DKK-1, LRP5, and LRP6 genes might be closely related to certain clinical characteristics of PTB patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Maris Teder-Laving, Mart Kals, Anu Reigo, Riin Ehin, Telver Objaertel, Mariliis Vaht, Tiit Nikopensius, Andres Metspalu, Kulli Kingo
Summary: Acne vulgaris is a common skin disorder characterized by inflammatory lesions on the face and upper torso. A genome-wide association study identified 23 risk loci, including 19 previously implicated and 4 novel loci. These loci explained 9.4% of the phenotypic variance of acne. Individuals with high genetic risk had a significantly increased risk of acne. The Wnt and MAPK pathways, as well as lipid biosynthesis, play key roles in the genetic predisposition to acne vulgaris.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Biochemistry & Molecular Biology
Ardavan Farhadi, Shaobin Fang, Yin Zhang, Wenxiao Cui, Huan Fang, Mhd Ikhwanuddin, Hongyu Ma
Summary: In this study, the wingless-type MMTV integration site family member-4 (Wnt4) gene was cloned and functionally studied in mud crab (Scylla paramamosain). The expression of Sp-Wnt4 was found to play crucial roles in ovarian development, with differential expression levels in different tissues and developmental stages. Unilateral eyestalk ablation also affected the expression of Sp-Wnt4 in testis and gill of female crabs. In situ hybridization assay revealed the localization of Sp-Wnt4 transcripts in the cytoplasm of oocyte cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Tianju Liu, Francina Gonzalez De los Santos, Mitchell Hirsch, Zhe Wu, Sem H. Phan
Summary: The study revealed significantly higher levels of Wnt11 expression in cells from patients with idiopathic pulmonary fibrosis, bleomycin-treated mice, and TGF beta-treated mouse lung fibroblasts, inducing myofibroblast differentiation. Additionally, the activation of noncanonical Wnt signaling by Wnt3a may play a significant role in pulmonary fibrosis.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Nathaniel T. Carpena, So-Young Chang, Ji-Eun Choi, Jae Yun Jung, Min Young Lee
Summary: This study focused on the effects of the Wnt signaling pathway on stem cell differentiation, finding that a Wnt agonist can enhance enucleation and otic organoid formation, as well as lead to spontaneous movement in EBs if activation is prolonged. Optimizing Wnt enhancement is necessary for differentiating specific cells in the inner ear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Irina Giralt, Gabriel Gallo-Oller, Natalia Navarro, Patricia Zarzosa, Guillem Pons, Ainara Magdaleno, Miguel F. Segura, Constantino Sabado, Raquel Hladun, Diego Arango, Jose Sanchez de Toledo, Lucas Moreno, Soledad Gallego, Josep Roma
Summary: The study demonstrates the therapeutic potential of DKK-1 pharmaceutical inhibition in rhabdomyosarcoma, resulting in beta-catenin activation and modulation of focal adhesion kinase, with positive effects on myogenic marker expression and a reduction in proliferation and invasion. In addition, the chemical inhibitor WAY-262611 was able to impair tumor cell survival in vivo, suggesting DKK-1 as a potential molecular target for novel therapeutic strategies in RMS patients, especially those with high DKK-1 expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Yuki Masuda, Hiroya Ohta, Yumiko Morita, Yoshiaki Nakayama, Ayumi Miyake, Nobuyuki Itoh, Morichika Konishi
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2015)
Article
Cell Biology
Yuki Masuda, Daiki Nawa, Yoshiaki Nakayama, Morichika Konishi, Hiroaki Nanba
JOURNAL OF LEUKOCYTE BIOLOGY
(2015)
Article
Pharmacology & Pharmacy
Kouya Yamaki, Masafumi Ueda, Kumiko Ueda, Noriaki Emoto, Nobuaki Mizutani, Koji Ikeda, Keiko Yagi, Masafumi Tanaka, Yasushi Habu, Yoshiaki Nakayama, Norihiko Takeda, Kensuke Moriwaki, Shuji Kitagawa
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN
(2016)
Article
Biochemistry & Molecular Biology
Mitsutaka Ogawa, Naosuke Nakamura, Yoshiaki Nakayama, Akira Kurosaka, Hiroshi Manya, Motoi Kanagawa, Tamao Endo, Koichi Furukawa, Tetsuya Okajima
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2013)
Review
Biochemistry & Molecular Biology
Ikuo Kimura, Yoshiaki Nakayama, Morichika Konishi, Kazuya Terasawa, Mitsuhiro Ohta, Nobuyuki Itoh, Masafumi Fujimoto
CURRENT PROTEIN & PEPTIDE SCIENCE
(2012)
Article
Biochemistry & Molecular Biology
Hiroyuki Miwa, Ayumi Miyake, Yuya Kouta, Akihiko Shimada, Yuki Yamashita, Yoshiaki Nakayama, Hajime Yamauchi, Morichika Konishi, Nobuyuki Itoh
Article
Developmental Biology
Yoshiaki Nakayama, Naosuke Nakamura, Tamiko Kawai, Eiichi Kaneda, Yui Takahashi, Ayumi Miyake, Nobuyuki Itoh, Akira Kurosaka
GENE EXPRESSION PATTERNS
(2014)
Article
Biochemistry & Molecular Biology
Yoshiaki Nakayama, Naosuke Nakamura, Sayoko Oki, Masaki Wakabayashi, Yasushi Ishihama, Ayumi Miyake, Nobuyuki Itoh, Akira Kurosaka
JOURNAL OF BIOLOGICAL CHEMISTRY
(2012)
Article
Biochemistry & Molecular Biology
Ikuo Kimura, Yoshiaki Nakayama, Morichika Konishi, Teruyuki Kobayashi, Masahiro Mori, Masaki Ito, Akira Hirasawa, Gozoh Tsujimoto, Mitsuhiro Ohta, Nobuyuki Itoh, Masafumi Fujimoto
JOURNAL OF NEUROCHEMISTRY
(2010)
Article
Biochemistry & Molecular Biology
Paitoon Srimontri, Shogo Endo, Toshiro Sakamoto, Yoshiaki Nakayama, Akira Kurosaka, Shigeyoshi Itohara, Yoshio Hirabayashi, Keiko Kato
JOURNAL OF NEUROCHEMISTRY
(2014)
Article
Biochemical Research Methods
Yoshiaki Nakayama, Ayumi Wada, Rei Inoue, Kazuya Terasawa, Ikuo Kimura, Naosuke Nakamura, Akira Kurosaka
JOURNAL OF NEUROSCIENCE METHODS
(2014)
Article
Multidisciplinary Sciences
Ayumi Miyake, Tatsuya Chitose, Eriko Kamei, Atsuko Murakami, Yoshiaki Nakayama, Morichika Konishi, Nobuyuki Itoh
Review
Neurosciences
Ikuo Kimura, Yoshiaki Nakayama, Ying Zhao, Morichika Konishi, Nobuyuki Itoh
FRONTIERS IN NEUROSCIENCE
(2013)
Review
Cell Biology
Nobuyuki Itoh, Yoshiaki Nakayama, Morichika Konishi
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2016)