Editorial Material
Cell Biology
Triveni Menon, Rebecca D. Burdine
Summary: The asymmetric expression of transcription factor Pitx2 is crucial for proper organ asymmetry during development. A recent study in Science reveals that Pitx2 expression, independent of Nodal, functions as a brake to counteract BMP4 signaling on the right side, leading to gut tilting.
DEVELOPMENTAL CELL
(2022)
Article
Cell Biology
Xiangxiang Jiang, Yue Wang, Zhenyu Xiao, Long Yan, Shanshan Guo, Yiming Wang, Hao Wu, Xuehan Zhao, Xiaoyin Lu, Hongmei Wang
Summary: The placenta is a crucial but poorly understood organ. By analyzing the single-cell transcriptomes of trophoblast cells during mouse placentation, this study reveals new cell types and provides a roadmap of lineage differentiation. Transcription factors responsible for developmental processes are identified, and the origin of sinusoid trophoblast giant cells is determined. This comprehensive single-cell dataset serves as a valuable resource for future studies on the gene regulatory networks of hemochorial placentation.
Article
Toxicology
Samantha Lapehn, Scott Houghtaling, Kylia Ahuna, Leena Kadam, James W. MacDonald, Theo K. Bammler, Kaja Z. LeWinn, Leslie Myatt, Sheela Sathyanarayana, Alison G. Paquette
Summary: This study investigated changes in placental gene expression in response to exposure to the phthalate metabolite MEHP. The researchers found that MEHP affected gene expression in the placenta, with male placentas being more responsive to exposure. Pathway analysis identified several key metabolic pathways and transcription factors associated with MEHP exposure. This study provides new insights into the toxic effects of phthalates on placental gene expression and generates new hypotheses for further research.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Cell Biology
Niraimathi Govindasamy, Hongyan Long, Hyun-Woo Jeong, Ratish Raman, Burak Ozcifci, Simone Probst, Sebastian J. Arnold, Kristina Riehemann, Adrian Ranga, Ralf H. Adams, Britta Trappmann, Ivan Bedzhov
Summary: This study established a 3D biomimetic culture environment mimicking the murine implantation niche, allowing for direct analysis of trophoblast invasion and early interactions with maternal vasculature. The findings reveal that implantation is mediated by collective migration of trophoblast giant cells, which acquire expression of vascular receptors and adhesion molecules to communicate with maternal blood vessels, with Pdgf signaling playing a key role in establishing heterologous contacts.
DEVELOPMENTAL CELL
(2021)
Article
Biochemistry & Molecular Biology
Hyung Joo Lee, Yiran Hou, Ju Heon Maeng, Nakul M. Shah, Yujie Chen, Heather A. Lawson, Hongbo Yang, Feng Yue, Ting Wang
Summary: This study systematically investigates the epigenomic and transcriptomic profile of transposable elements (TEs) in zebrafish tissues. The results show that TEs significantly contribute to gene regulation in zebrafish, with a portion of TEs being in active regulatory states. Specific TE subfamilies are found to be enriched in different tissues, and TE-derived transcriptional units are expressed across tissues.
Review
Biochemistry & Molecular Biology
Henrieta Papuchova, Paulina A. Latos
Summary: The placenta is crucial for the development of the embryo and the success of pregnancy. It serves as a site for exchange between the mother and the embryo, has immune functions, and acts as an important endocrine organ. Specialized trophoblast cell types, including syncytiotrophoblast and extravillous trophoblast, are responsible for these diverse functions of the placenta. Transcription factors play a vital role in regulating the emergence, specialization, and identity of these cells, and their coordinated actions determine the specific characteristics of each cell type. This article provides an overview of transcription factors involved in the development and function of human trophoblast and discusses their similarities and differences to their counterparts in mice. The establishment of human in vitro models combined with -omics approaches has greatly advanced our understanding of the human trophoblast field.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Multidisciplinary Sciences
Ann Collier, Angela Liu, Jessica Torkelson, Jillian Pattison, Sadhana Gaddam, Hanson Zhen, Tiffany Patel, Kelly McCarthy, Hana Ghanim, Anthony E. Oro
Summary: This study identifies a protein called Gibbin as a key regulator of early epithelial morphogenesis. Gibbin interacts with multiple sequence-specific transcription factors and methyl-CpG-binding proteins to regulate the expression of mesoderm genes. The loss of Gibbin leads to increased DNA methylation at GATA3-dependent mesodermal genes, resulting in a loss of signaling between dermal and epidermal cell types.
Article
Oncology
Christine Stuerken, Volker Moebus, Karin Milde-Langosch, Sabine Schmatloch, Peter A. Fasching, Josef Rueschoff, Elmar Stickeler, Rolf-Peter Henke, Carsten Denkert, Lars Hanker, Christian Schem, Valentina Vladimirova, Thomas Karn, Valentina Nekljudova, Claus-Henning Koehne, Frederik Marme, Udo Schumacher, Sibylle Loibl, Volkmar Mueller
Summary: The study found that higher TGIF expression in breast cancer cells is associated with smaller tumor size, well-differentiated phenotype, and estrogen receptor-positive breast cancer. Patients with higher TGIF expression levels had longer disease-free and overall survival, but no significant association with the first site of relapse being bone metastasis. Reduced TGIF expression was linked to tumor progression, especially in HER2-negative breast cancer.
Article
Forestry
Qiqi Yang, Qicheng Li, Liyuan Gu, Peng Chen, Yu Zhang, Yonghua Li, Yun Chen, Xia Ye, Bin Tan, Xianbo Zheng, Jidong Li, Jiancan Feng
Summary: The study found that the TCP transcription factor ZjTCP16 in jujube may play a regulatory role in the interaction between jujube plants and JWB phytoplasma. Through overexpression and knock-down experiments, it was confirmed that ZjTCP16 regulates plant growth and cell size. Molecular experiments further revealed its influence on genes involved in leaf morphogenesis and cell proliferation.
Article
Multidisciplinary Sciences
Dandan Yang, Mao Zhang, Chang Su, Bin Dong, Yang Lu
Summary: The carbon source N-acetylglucosamine plays a role in modulating the balance between commensalism and pathogenesis in Candida albicans. N-acetylglucosamine enables C. albicans to balance between commensalism and pathogenesis, but its signaling is detrimental to commensalism. In addition to yeast-to-hypha morphogenesis, other factors such as Sod5 and Ofi1 contribute to the balance between commensalism and virulence.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Jennifer D. Kaminker, Alexander V. Timoshenko
Summary: This paper discusses the unique properties, regulation, and expression of galectin-16 gene (LGALS16) in human cells and tissues, focusing on its expression and role in placental cell lines in the context of trophoblastic differentiation. Through bioinformatics analysis, it is found that LGALS16 is detected in diverse human cells/tissues and shows altered expression associated with cancer, diabetes, and brain diseases. Molecular mechanisms of the transcriptional and post-transcriptional regulation of LGALS16 are also explored based on available bioinformatics resources.
Editorial Material
Biochemistry & Molecular Biology
Natalia Y. Martynova, Elena A. Parshina, Andrey G. Zaraisky
Summary: Zyxin, initially recognized as a minor actin cytoskeleton protein, not only regulates actin filaments assembly and repair but also plays a crucial role in gene expression and cell differentiation, particularly during embryogenesis process.
Article
Multidisciplinary Sciences
Weibing Yang, Sandra Cortijo, Niklas Korsbo, Pawel Roszak, Katharina Schiessl, Aram Gurzadyan, Raymond Wightman, Henrik Jonsson, Elliot Meyerowitz
Summary: Mitogens trigger cell division in animals, while in plants, cytokinins derived from adenine stimulate cell proliferation. Cytokinin signaling in Arabidopsis SAM is shown to regulate cell division by promoting nuclear shuttling of MYB3R4, a transcription factor activating mitotic gene expression. Rapid nuclear accumulation of MYB3R4 at G2-to-M transition, associated with a peak in cytokinin concentration, initiates a transcriptional cascade driving mitosis and cytokinesis, mimicking the effects of enhanced cell proliferation and meristem growth.
Article
Biochemistry & Molecular Biology
Ming-an Sun, Gernot Wolf, Yejun Wang, Anna D. Senft, Sherry Ralls, Jinpu Jin, Caitlin E. Dunn-Fletcher, Louis J. Muglia, Todd S. Macfarlan
Summary: The study identified numerous lineage-specific gene expression in different mammalian placentae, shedding light on the evolutionary process of placenta. The overlap between specific families of endogenous retroviruses and lineage-specific placental enhancers likely facilitates the lineage-specific evolution of the mammalian placenta.
MOLECULAR BIOLOGY AND EVOLUTION
(2021)
Article
Agriculture, Multidisciplinary
Shuangcheng He, Rong Ma, Zijin Liu, Da Zhang, Shixiang Wang, Yuan Guo, Mingxun Chen
Summary: This study reveals that overexpression of BnaAGL11 in Brassica napus results in smaller, curly leaves and accelerated leaf senescence. This is achieved through the regulation of multiple gene transcription, where BnaAGL11 indirectly controls leaf morphogenesis and senescence.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Review
Genetics & Heredity
David Wotton, Kenichiro Taniguchi
AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS
(2018)
Article
Cardiac & Cardiovascular Systems
Paolo Parini, Tiffany A. Melhuish, David Wotton, Lilian Larsson, Osman Ahmed, Mats Eriksson, Camilla Pramfalk
Review
Gastroenterology & Hepatology
Marc Hilmi, Laurent Bartholin, Cindy Neuzillet
WORLD JOURNAL OF GASTROENTEROLOGY
(2018)
Article
Cell Biology
Thomas G. Bird, Miryam Mueller, Luke Boulter, David F. Vincent, Rachel A. Ridgway, Elena Lopez-Guadamillas, Wei-Yu Lu, Thomas Jamieson, Olivier Govaere, Andrew D. Campbell, Sofia Ferreira-Gonzalez, Alicia M. Cole, Trevor Hay, Kenneth J. Simpson, William Clark, Ann Hedley, Mairi Clarke, Pauline Gentaz, Colin Nixon, Steven Bryce, Christos Kiourtis, Joep Sprangers, Robert J. B. Nibbs, Nico Van Rooijen, Laurent Bartholin, Steven R. McGreal, Udayan Apte, Simon T. Barry, John P. Iredale, Alan R. Clarke, Manuel Serrano, Tania A. Roskams, Owen J. Sansom, Stuart J. Forbes
SCIENCE TRANSLATIONAL MEDICINE
(2018)
Article
Cell Biology
Anant Shah, Tiffany A. Melhuish, Todd E. Fox, Henry F. Frierson, David Wotton
GENES & DEVELOPMENT
(2019)
Article
Oncology
Marc Hilmi, Benoit Rousseau, Romain Cohen, Angelique Vienot, Dewi Vernerey, Laurent Bartholin, Felix Blanc-Durand, Christophe Louvet, Anthony Turpin, Cindy Neuzillet
BULLETIN DU CANCER
(2019)
Article
Immunology
Toshiro Hirai, Yukari Zenke, Yi Yang, Laurent Bartholin, Lalit K. Beura, David Masopust, Daniel H. Kaplan
Article
Cell Biology
Elodie Roger, Sylvie Martel, Adrien Bertrand-Chapel, Arnaud Depollier, Nicolas Chuvin, Roxane M. Pommier, Karam Yacoub, Cassandre Caligaris, Victoire Cardot-Ruffino, Veronique Chauvet, Sophie Aires, Kayvan Mohkan, Jean-Yves Mabrut, Mustapha Adham, Tanguy Fenouil, Valerie Hervieu, Laura Broutier, Marie Castets, Cindy Neuzillet, Philippe A. Cassier, Richard Tomasini, Stephanie Sentis, Laurent Bartholin
CELL DEATH & DISEASE
(2019)
Article
Oncology
Shekhar Saha, Manjari Kiran, Canan Kuscu, Ajay Chatrath, David Wotton, Marty W. Mayo, Anindya Dutta
Article
Multidisciplinary Sciences
D. Larrieu, M. Brunet, C. Vargas, N. Hanoun, L. Ligat, L. Dagnon, H. Lulka, R. M. Pommier, J. Selves, B. E. Jady, L. Bartholin, P. Cordelier, M. Dufresne, J. Torrisani
SCIENTIFIC REPORTS
(2020)
Article
Multidisciplinary Sciences
Victoire Cardot-Ruffino, Veronique Chauvet, Cassandre Caligaris, Adrien Bertrand-Chapel, Nicolas Chuvin, Roxane M. Pommier, Ulrich Valcourt, David F. Vincent, Sylvie Martel, Sophie Aires, Bastien Kaniewski, Pierre Dubus, Philippe Cassier, Stephanie Sentis, Laurent Bartholin
SCIENTIFIC REPORTS
(2020)
Article
Developmental Biology
Victoire Cardot-Ruffino, Veronique Chauvet, Cassandre Caligaris, Adrien Bertrand-Chapel, Nicolas Chuvin, Roxane M. Pommier, Ulrich Valcourt, David Vincent, Sylvie Martel, Sophie Aires, Bastien Kaniewski, Pierre Dubus, Philippe Cassier, Stephanie Sentis, Laurent Bartholin
Review
Multidisciplinary Sciences
Guojun Sheng, Alfonso Martinez Arias, Ann Sutherland
Summary: The primitive streak is a transient embryonic structure that plays a crucial role in bilateral symmetry and spatial information during gastrulation. While its in vitro recapitulation can aid in deriving tissues and organs with complexity, it is not conserved or necessary for gastrulation in human development. It is viewed as part of a morphologically diverse yet molecularly conserved process of spatial coordinate acquisition, and its recapitulation is predicted to be dispensable for development in vitro.
Meeting Abstract
Gastroenterology & Hepatology
Thomas G. Bird, Miryam Mueller, Luke Boulter, David Vincent, Rachel Ridgway, Elena Lopez Guadamillas, Wei Lu, Olivier Govaere, Andrew Campbell, Sofia Gonzalez, Kenneth J. Simpson, Miari Clarke, Pauline Gentaz, Christos Kiourtis, Joep Sprangers, Robert Nibbs, Nico Van Rooijen, Laurent Bartholin, Stephen Mcgreal, Udayan Apte, Simon Barry, John P. Iredale, Manuel Serrano, Tania Roskams, Owen Sansom, Stuart J. Forbes
Article
Developmental Biology
Xin Fang, Nan Ni, Yang Gao, David F. Vincent, Laurent Bartholin, Qinglei Li
MOLECULAR HUMAN REPRODUCTION
(2018)
Review
Developmental Biology
Cheng Shi, Pengfei Jiao, Zhiyi Chen, Lan Ma, Siyue Yao
Summary: This review discusses the molecular etiology of congenital craniofacial abnormalities, with a focus on the role and mechanism of noncoding RNAs in regulating craniofacial development. Aberrant expression of noncoding RNAs has been implicated in the pathogenesis of craniofacial abnormalities, providing potential therapeutic targets.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Hideru Togashi, Steven Ray Davis, Makoto Sato
Summary: Tile patterns, regulated by cell adhesion molecules, are regular arrangements of cells that play important functional roles in multicellular organisms. The physical constraints and cell adhesion regulate both cell shape and tissue morphogenesis.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Armen Khanbabei, Lina Segura, Cynthia Petrossian, Aaron Lemus, Ithan Cano, Courtney Frazier, Armen Halajyan, Donnie Ca, Mariano Loza-Coll
Summary: This article investigates the genetic regulatory mechanisms of Drosophila intestinal stem cells. The study found that most target genes co-regulated by Esg and STAT show a consistent gene expression pattern. However, manipulating these validated targets in vivo rarely replicated the effects of manipulating Esg and STAT, suggesting the presence of complex genetic interactions among the downstream targets of these two master regulator genes.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Bayley J. Waters, Zoe R. Birman, Matthew R. Wagner, Julia Lemanski, Barak Blum
Summary: Researchers found that conditional deletion of Robo2 in adult mice led to a significant loss of islet architecture without affecting beta cell identity or function, suggesting that Robo2 plays a role in actively maintaining adult islet architecture. Understanding the factors required for islet architecture maintenance is crucial for developing future diabetes therapies.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Rhiannon Clements, Tyler Smith, Luke Cowart, Jennifer Zhumi, Alan Sherrod, Aidan Cahill, Ginger L. Hunter
Summary: Cell protrusions play a crucial role in regulating cell activities during development. By studying the regulation mechanism in fruit fly sensory bristle patterning, it was found that Myosin XV is essential for the dynamics of signaling filopodia and promotes long-range Notch signaling.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Margaret Keating, Ryan Hagle, Daniel Osorio-Mendez, Anjelica Rodriguez-Parks, Sarah I. Almutawa, Junsu Kang
Summary: Knock-in reporter (KI) animals are essential for studying gene expression in biomedical research. This study developed a new strategy using minicircle technology and a minimal promoter to enhance knock-in events and establish stable KI transgenic reporter lines. The study also highlighted the importance of selecting the proper KI line due to potential inappropriate influence of genome editing on reporter gene expression.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Christian Altbuerger, Meta Rath, Daniel Armbruster, Wolfgang Driever
Summary: This study reveals that Neurog1 and Olig2 transcription factors have differential requirements for the development of dopaminergic neurons, and they integrate local patterning signals and Notch neurogenic selection signaling to specify the progenitor population and initiate neurogenesis and differentiation.
DEVELOPMENTAL BIOLOGY
(2024)