Review
Gastroenterology & Hepatology
Ghada Tafesh-Edwards, Ioannis Eleftherianos
Summary: The gut epithelia of animals house complex microbial communities that play a crucial role in maintaining immune and cellular homeostasis. These microbial populations have adapted to the gut environment and regulate intestinal stem cells, promoting a healthy gut barrier and epithelial self-renewal. Disruption of these populations is associated with inflammatory disorders and cancerous lesions of the intestine, but the molecular mechanisms controlling gut-microbe interactions are still not fully understood.
Article
Medicine, Research & Experimental
C. Pirozzi, N. Opallo, L. Coretti, A. Lama, C. Annunziata, F. Comella, S. Melini, E. Buommino, M. P. Mollica, G. Aviello, G. Mattace Raso, F. Lembo, R. Meli
Summary: This study evaluates the effect and protective mechanisms of a probiotic formulation containing Alkalihalobacillus clausii spores on antibiotic-induced intestinal injury (AIJ). The probiotic preserved colonic integrity, reduced tissue inflammation, and regulated the production of colonic cytokines. It also restored the gut microbiota composition and promoted epithelium repair and mucus synthesis.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Immunology
Mangalakumari Jeyanathan, Maryam Vaseghi-Shanjani, Sam Afkhami, Jensine A. Grondin, Alisha Kang, Michael R. D'Agostino, Yushi Yao, Shreya Jain, Anna Zganiacz, Zachary Kroezen, Meera Shanmuganathan, Ramandeep Singh, Anna Dvorkin-Gheva, Philip Britz-McKibbin, Waliul I. Khan, Zhou Xing
Summary: This study demonstrates that subcutaneous BCG vaccination can induce memory alveolar macrophages (AMs) and trained immunity in the lung. The induction of memory AMs is independent of circulating monocytes and is related to the distribution of mycobacteria, alterations in the intestinal microbiome, and changes in circulating and lung metabolites.
Review
Biochemistry & Molecular Biology
Minghui Zhu, Omer M. A. Dagah, Billton Bryson Silaa, Jun Lu
Summary: This review explores the role of gut microbiota dysbiosis in inducing oxidative stress in non-alcoholic fatty liver disease (NAFLD) and highlights the crucial interaction between gut microbiota dysbiosis and thiol-redox regulation. The paper also examines how dysbiosis affects the production of specific gut microbiota metabolites and how these metabolites impact liver inflammation, lipid metabolism, insulin resistance, and cellular damage through thiol-dependent redox signaling.
Review
Biochemistry & Molecular Biology
Claudia Kunst, Stephan Schmid, Marlen Michalski, Deniz Tuemen, Jonas Buttenschoen, Martina Mueller, Karsten Guelow
Summary: The human gastrointestinal tract houses a complex microbial community that plays a crucial role in the overall well-being of the body. The gut microbiota produces various metabolites that regulate biological processes, including immune system regulation. Maintaining a balance in the gut microbiome is essential for a stable REDOX equilibrium, as dysbiosis can disrupt this balance and directly impact the immune system and promote inflammation. In this article, we discuss the common reactive oxygen species (ROS), the transition from a balanced REDOX state to oxidative stress, and the role of the microbiota in maintaining REDOX homeostasis and regulating immune responses and inflammation.
Review
Immunology
Yuling Guo, Yujia Liu, Binqi Rui, Zengjie Lei, Xixi Ning, Yinhui Liu, Ming Li
Summary: The human gastrointestinal tract contains a large number of microorganisms that are involved in various physiological functions. Imbalance in the gut microbiota is closely related to the pathogenesis of several human diseases. Innate lymphoid cells (ILCs), including NK cells, ILC1s, ILC2s, ILC3s, and LTi cells, are a type of immune cells enriched in mucosal tissues and have gained extensive attention. The gut microbiota and its metabolites play important roles in intestinal mucosal diseases such as inflammatory bowel disease (IBD), allergic disease, and cancer. Therefore, studying the interaction between ILCs and the gut microbiota has great clinical significance in identifying potential pharmacotherapy targets for related diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Environmental Sciences
Zhenguang Yan, Jinzhe Du, Tianxu Zhang, Qianhang Sun, Binbin Sun, Yan Zhang, Shuo Li
Summary: The study found that TCC had toxic effects on the gut of zebrafish, leading to inflammation and changes in gut microbial composition, as well as damage to gut tissue.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Cell Biology
Kyoko Yamashita, Ayano Oi, Hina Kosakamoto, Toshitaka Yamauchi, Hibiki Kadoguchi, Takayuki Kuraishi, Masayuki Miura, Fumiaki Obata
Summary: Early-life immune activation in fruit flies triggers long-term physiological changes that result in altered starvation resistance, food intake, and lifespan in adult flies. The activation of the immune pathway Imd during larval development leads to sustained inflammatory responses in the gut, dysbiosis in gut microbiota, and shortened organismal lifespan in adulthood.
DISEASE MODELS & MECHANISMS
(2021)
Article
Genetics & Heredity
Taro Onuma, Toshitaka Yamauchi, Hina Kosakamoto, Hibiki P. Kadoguchi, Takayuki Kuraishi, Takumi P. Murakami, Hiroshi Mori, Masayuki P. Miura, Fumiaki Obata
Summary: Commensal microbes have a significant impact on tissue homeostasis, stress resistance, and ageing in animals. This study investigates the molecular mechanism behind how a specific gut bacterium shortens lifespan and promotes intestinal stem cell proliferation in fruit flies. The findings reveal that the bacterium induces the production of antimicrobial peptides and alters the balance between lifespan and host defence through peptidoglycan specificity.
Article
Dermatology
Marie-Ange Dagnelie, Stephane Corvec, Elise Timon-David, Amir Khammari, Brigitte Dreno
Summary: Skin microbiota plays a crucial role in inflammatory skin response, and maintaining a balance between bacterial communities is essential. Imbalance in skin microbiota can activate inflammation-related markers, especially with S. epidermidis having a more significant impact on IL-6 induction.
EXPERIMENTAL DERMATOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ludovico Abenavoli, Giuseppe Guido Maria Scarlata, Maria Rosaria Paravati, Luigi Boccuto, Francesco Luzza, Emidio Scarpellini
Summary: Liver transplantation is the preferred treatment for patients with certain liver conditions, but rejection after transplantation is a significant issue. The gut microbiota is involved in the gut-liver axis and can affect the immune response, potentially leading to graft rejection. Evaluating changes in the gut microbiota composition is essential for monitoring the success of liver transplantation and implementing appropriate preventive measures.
Review
Biotechnology & Applied Microbiology
Shaodong Wei, Martin Iain Bahl, Simon Mark Dahl Baunwall, Christian Lodberg Hvas, Tine Rask Licht
Summary: This paper lists various types of dysbiosis indexes identified in the literature, introduces their methodology, categorizes them, and discusses their potential descriptive and clinical applications as well as their limitations. The focus is on the methodological approaches available to determine and quantify the dysbiosis condition, rather than on the implications of dysbiosis for disease.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ibrahim Yusufu, Kehong Ding, Kathryn Smith, Umesh D. Wankhade, Bikash Sahay, G. Taylor Patterson, Rafal Pacholczyk, Satish Adusumilli, Mark W. Hamrick, William D. Hill, Carlos M. Isales, Sadanand Fulzele
Summary: This study investigated the impact of varied tryptophan diets on the gut microbiome and inflammatory responses in aged mice models, finding that tryptophan-deficient diets led to changes in gut bacterial abundance and increased levels of inflammatory cytokines IL-6, IL-17A, and IL-1a.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biotechnology & Applied Microbiology
Vandna Singh, Shruti Ahlawat, Hari Mohan, Sarvajeet Singh Gill, Krishna Kant Sharma
Summary: This article introduces the crucial role of ROS in gut health and discusses several sources of ROS production, as well as the role of probiotics in maintaining gut homeostasis and controlling ROS-related intestinal diseases.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Review
Immunology
Anjana, Santosh Kumar Tiwari
Summary: Lactic acid bacteria can cure diseases and modulate gut microbiota by producing bacteriocins, making them effective in treating various human disorders.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Fisheries
Ratiporn Thongsoi, Siriluk Maskaew, Panumas Puechpon, Benjaporn Noppradit, Napassawan Inaek, Prapaporn Utarabhand, Phanthipha Runsaeng
Summary: In this study, a PPAE gene called FmPPAE1 was cloned and analyzed in banana shrimp. FmPPAE1 plays a vital role in regulating the proPO system, exhibits antibacterial properties, and contributes to the suppression of bacterial proliferation.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Jishuang Tan, Paizelaiti Sahaer, Huan Li, Wei Han, Hongyan Sun
Summary: Circular RNAs (circRNA) are involved in gene expression and affect cellular processes such as transcription, splicing, and translation by interacting with microRNA and RNA binding proteins. A study identified circDNAJB6 as a circular RNA abundant in chicken macrophages after bacterial infection, and found that circDNAJB6 exacerbates cellular injury and interacts with multiple miRNAs and target genes, potentially impacting autophagy and MAPK signaling pathways.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Rodrigo Guabiraba, Damaris Ribeiro Rodrigues, Paul T. Manna, Melanie Chollot, Vincent Saint-Martin, Sascha Trapp, Marisa Oliveira, Clare E. Bryant, Brian J. Ferguson
Summary: The innate immune response relies on the ability of host cells to detect and respond to microbial nucleic acids. Toll-like receptors (TLRs) play a crucial role in this process by distinguishing self from non-self. This study focused on TLR21, an avian TLR that recognizes bacterial DNA motifs. The findings suggest that avian TLR21 shares similar activation mechanisms to mammalian TLR9, highlighting the conservation of nucleic acid sensing mechanisms across species.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Safieh Zeinali, Kate Sutton, Lonneke Vervelde
Summary: Chickens have a unique immune structure characterized by the absence of draining lymph nodes and the presence of well-developed mucosa-associated lymphoid tissue. The structure and development of chicken lymphoid tissues in the intestine, particularly Peyer's patches, have been poorly studied. However, the use of CSF1R-eGFP reporter transgenic chickens has allowed for the visualization and investigation of the development and distribution of these tissues. This research provides insights that could benefit mucosal vaccination strategies and the development of targeted vaccine delivery systems.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Retraction
Fisheries
G. -g. Li, Z. -z. Guo, X. -f. Ma, N. Cao, S. -n. Geng, Y. -q. Zheng, M. -j. Meng, H. -h. Lin, G. Han, G. -j. Du
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Jinyue Yang, Peng Zhou, Wanrong Wu, Qingxiang Zhang, Dong Chen, Rui Luo
Summary: This study cloned and characterized the full-length sequence of duck MRE11 (duMRE11) for the first time, and found that this protein plays an important role in the innate immune response of ducks.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Mengjiao Guo, Jiaqi Zhang, Mingtao Li, Xiaorong Zhang, Yantao Wu
Summary: rNLRC3 negatively regulates the NF -KB signaling pathway induced by P. multocida in rabbits by inhibiting the activation of NF -KB, reducing the expression of inflammatory cytokines, and interacting with rTRAF4 and rTRAF6. The NACHT-LRR domain is the functional domain of rNLRC3. These findings provide insights into the important role of rNLRC3 in combating P. multocida infection.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Yinan Li, Xingye Lian, Wenwen Yang, Jinyuan Leng, Jiejie Sun, Yu Liu, Siqi Fan, Lingling Wang, Linsheng Song
Summary: The DM9-containing protein CgDM9CP-7 plays an important role in the innate immune response of molluscs. It is constitutively expressed in various tissues and is up-regulated in haemocytes after stimulation by Vibrio splendidus and lipopolysaccharide (LPS). CgDM9CP-7 binds to various pathogens and exhibits antimicrobial activity, while also regulating the expression of CgMyD88 and CgIL-17.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Xiuwen Bao, Haoran Song, Liying He, Yong Li, Shuqi Niu, Jinlin Guo
Summary: This study focuses on the interaction between Hepialus xiaojinensis larvae and Ophiocordyceps sinensis during the infection process. The results show that the infected third instar larvae enhance antioxidant defense ability, while the infected fourth instar larvae reduce this ability and allocate more energy to growth and development.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)