Article
Environmental Sciences
Feng Zhao, Mengyu Guo, Mengna Zhang, Manman Duan, Junyue Zheng, Yinchi Liu, Lihong Qiu
Summary: This study investigated the effects of sublethal concentrations of metamifop on gut health in zebrafish. The results showed that metamifop induces inflammation and reduction of goblet cells in the gut, decreases the activities of digestive enzymes, impairs lipid absorption, and reduces the expression of lipid transportation-related genes. Metamifop exposure also increases the inflammatory response and intestinal permeability, and disrupts the composition of gut microbiota.
Article
Environmental Sciences
Shaolin Xie, Aiguo Zhou, Tianli Wei, Siying Li, Bing Yang, Guohuan Xu, Jixing Zou
Summary: This study found that spherical polystyrene MPs and NPs induced gut microbiota dysbiosis in zebrafish, with NPs increasing gut flora diversity. After 21 days of exposure, both MPs and NPs significantly altered the abundance of certain phyla, with NPs also increasing mRNA levels of inflammation-related genes in the gut.
BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ibrahim Yusufu, Kehong Ding, Kathryn Smith, Umesh D. Wankhade, Bikash Sahay, G. Taylor Patterson, Rafal Pacholczyk, Satish Adusumilli, Mark W. Hamrick, William D. Hill, Carlos M. Isales, Sadanand Fulzele
Summary: This study investigated the impact of varied tryptophan diets on the gut microbiome and inflammatory responses in aged mice models, finding that tryptophan-deficient diets led to changes in gut bacterial abundance and increased levels of inflammatory cytokines IL-6, IL-17A, and IL-1a.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Jefferson Luiz da Silva, Lia Vezenfard Barbosa, Camila Figueiredo Pinzan, Viviani Nardini, Irislene Simoes Brigo, Cassia Aparecida Sebastiao, Jefferson Elias-Oliveira, Vania Brazao, Jose Clovis do Prado Junior, Daniela Carlos, Cristina Ribeiro de Barros Cardoso
Summary: Dysbiosis and disturbances in gut homeostasis can lead to dysregulated responses in inflammatory bowel diseases. Melatonin has shown potential as a therapeutic option due to its interactions with immune responses and gut microbiota. In this study, MLT treatment increased inflammation in acute colitis and delayed recovery during remission.
Article
Fisheries
Fei Luo, Kaige Song, Weichao Chen, Xiaozhou Qi, Yong Zhang, Gaoxue Wang, Fei Ling
Summary: The gut microbiota of vertebrates, specifically in fish, plays a critical role in resisting viral infections. However, the relationship between gut microbes and the highly destructive Spring Viremia of Carp (SVC) virus is not well understood. This study examined the changes in gut microbiota in zebrafish following SVC virus infection, highlighting the potential of gut microbiota as a diagnostic biomarker and therapeutic target for SVC.
Review
Food Science & Technology
Clara Noguera-Navarro, Diana Navas-Carrillo, Esteban Orenes-Pinero
Summary: Multiple sclerosis is a chronic inflammatory disease that may be positively impacted by modifying the gut microbiota.
FOOD REVIEWS INTERNATIONAL
(2023)
Review
Pharmacology & Pharmacy
Jing Ren, Huimin Li, Guixing Zeng, Boxian Pang, Qiuhong Wang, Junping Wei
Summary: Chronic low-grade inflammation is linked to aging and age-related diseases, and dysregulation of the gut flora plays a major role in triggering this inflammation. Changes in gut flora composition and exposure to related metabolites impact the host's inflammatory system, leading to crosstalk between the gut barrier and immune system, contributing to chronic low-grade inflammation and compromised health. Probiotics can improve gut microbiota diversity, protect the gut barrier, and regulate gut immunity, thereby reducing inflammation. Using probiotics is a promising strategy to modulate the immune system and protect the gut barrier through gut microbiota, which can positively influence common inflammatory diseases in the elderly.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Sriram Ayyaswamy, Huanan Shi, Bojun Zhang, Robert M. M. Bryan, David J. J. Durgan
Summary: Obstructive sleep apnea (OSA) is an independent risk factor for hypertension. OSA induces gut dysbiosis, which contributes to hypertension. This study explores the mechanisms linking gut dysbiosis to blood pressure regulation, demonstrating that OSA induces inflammation in the gut and brain, which involves interleukin-17a signaling.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Nutrition & Dietetics
Sonia Croci, Lina Ilaras D'Apolito, Valeria Gasperi, Maria Valeria Catani, Isabella Savini
Summary: This passage discusses the relationship between metabolic syndrome and gut microbiota, indicating that dysbiosis may play a role in the pathogenesis of various chronic diseases; certain metabolites derived from microorganisms can trigger subclinical inflammatory processes related to MetS.
Article
Medicine, Research & Experimental
Rosa Elvira Alarcon Yempen, Raphaelly Venzel, Maria Clara Paulino Campos, Larissa Pessoa de Oliveira, Rodrigo Vasquez Dan Lins, Andre Moreira Pessoni, Gustavo Bernardes Fanaro, Anderson de Oliveira Souza, Karin da Costa Calaza, Jose Luiz de Brito Alves, Marinaldo Pacifico Cavalcanti-Neto
Summary: Diabetic Retinopathy is a major complication of Diabetes Mellitus that severely impacts individuals of working age, being one of the main causes of blindness worldwide. Current therapies focus on alleviating clinical signs associated with microvasculature in advanced stages, prompting the need for alternative therapies to improve glycemic parameters and quality of life for patients with DR. Recent evidence suggests that dysbiosis in the gut microbiota can lead to inflammation, directly affecting the development of DM and its complications like DR, highlighting the potential of targeting the gut-retina axis for therapeutic purposes.
Article
Engineering, Environmental
Biran Zhu, Lei Lei, Yumiao Sun, Xiongjie Shi, Kaiyu Fu, Jianghuan Hua, Christopher J. Martyniuk, Jian Han, Lihua Yang, Bingsheng Zhou
Summary: This study examined the accumulation and distribution of niclosamide in different tissues of adult male zebrafish fed a normal diet or high-fat diet. The results showed that the liver accumulated the highest concentration of niclosamide, followed by the brain and gonads. High-fat diet increased the burden of niclosamide in the liver and brain compared to the normal diet. Niclosamide effectively controlled weight gain and improved insulin and glucose levels in high-fat diet-fed fish. However, it also had potential effects on the liver-gut axis, disrupting mitochondrial energy production, inhibiting glycemic and triacylglycerol biosynthesis, impairing the physical barrier of the intestine, and causing inflammatory, oxidative stress, and microbiota dysbiosis. These findings emphasize the importance of evaluating the potential impacts of niclosamide on the health of wild animals and humans.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Environmental Sciences
Yi Huang, Yuhang Hong, Shu Wu, Xiaozhen Yang, Qiang Huang, Yanzhen Dong, Dayong Xu, Zhiqiu Huang
Summary: The present study investigated the toxic effects of IMI on the brain and gut of zebrafish by analyzing the transcriptome and microbiome. The results showed that prolonged darkness improved survival rate and attenuated oxidative stress induced by IMI exposure. Microbiome analysis also revealed changes in gut bacterial community structure and tryptophan metabolism pathway inhibition, which were alleviated in the prolonged darkness group.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Immunology
Mohammad S. Alam, Jayanthi Gangiredla, Nur A. Hasan, Tammy Barnaba, Carmen Tartera
Summary: Aging and L. monocytogenes infection impact the gut microbiota of mice differently, with infected old mice showing increased colonization of Listeria and inflammatory bacterial species, while beneficial commensals diminish. This study suggests that aging may alter gut microbiota composition and increase susceptibility to invasive L. monocytogenes infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Nutrition & Dietetics
Paola Gualtieri, Rossella Cianci, Giulia Frank, Erica Pizzocaro, Gemma Lou De Santis, Silvia Giannattasio, Giuseppe Merra, Giovanni Butturini, Antonino De Lorenzo, Laura Di Renzo
Summary: The incidence of pancreatic cancer, particularly pancreatic ductal adenocarcinoma (PDAC), is increasing worldwide and is associated with chronic inflammation. Imbalance in the gut microbiota composition, known as dysbiosis, can lead to chronic inflammation and potentially promote PDAC development. Nutrition plays a modulatory role in the immunological processes of PDAC, influencing the gut microbiota composition and inflammation levels, thereby affecting the pathogenesis and progression of PDAC.
Article
Biochemistry & Molecular Biology
Shin Young Park, Sang Pyung Lee, Dongin Kim, Woo Jin Kim
Summary: A stroke is a serious condition that occurs when blood vessels in the brain are blocked or burst. This study aimed to explore the differences in gut microbiota between stroke patients and healthy controls. The results showed taxonomic and functional dysbiosis in stroke patients, suggesting a possible link between malnutrition and stroke. Manipulation of nutrition could potentially alleviate gut dysbiosis and improve the prognosis, disability, and mortality of stroke management.
Article
Fisheries
Shuo Li, Jiafang Li, Nan Wang, Tianxu Zhang, Yaqi Xu, Jinsheng Sun
FISH & SHELLFISH IMMUNOLOGY
(2018)
Review
Environmental Sciences
Xin Zheng, Zhenguang Yan, Peiyuan Liu, Juntao Fan, Shuping Wang, Pengyuan Wang, Tianxu Zhang
BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
(2019)
Article
Marine & Freshwater Biology
Tianxu Zhang, Zhenguang Yan, Xin Zheng, Juntao Fan, Shuping Wang, Yongjie Wei, Lixin Yang, Pengyuan Wang, Shaojuan Guo
AQUATIC TOXICOLOGY
(2019)
Article
Chemistry, Multidisciplinary
Zhen-Guang Yan, Jun-Tao Fan, Xin Zheng, Shu-Ping Wang, Xiao-Shan Guo, Tian-Xu Zhang, Su-Wen Yang, Yi-Zhang Zhang
JOURNAL OF CHEMISTRY
(2019)
Review
Environmental Sciences
Pengyuan Wang, Zhenguang Yan, Suwen Yang, Shuping Wang, Xin Zheng, Juntao Fan, Tianxu Zhang
BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
(2019)
Article
Environmental Sciences
Zhenguang Yan, Xin Zheng, Juntao Fan, Yizhang Zhang, Shuping Wang, Tianxu Zhang, Qianhang Sun, Yi Huang
Article
Biochemistry & Molecular Biology
Shuo Li, Xiaoli Chen, Jiafang Li, Xuejing Li, Tianxu Zhang, Gaixiang Hao, Jinsheng Sun
Article
Environmental Sciences
Tianxu Zhang, Yan Zhang, Jiayun Xu, Zhenguang Yan, Qianhang Sun, Yi Huang, Shuping Wang, Shuo Li, Binbin Sun
Summary: Ammonia stress was found to negatively impact intestinal inflammation, antioxidant system, and microbiome of the Asian clam, leading to tissue damage. Inflammatory responses were more severe and antioxidant system damage was more pronounced, while ammonia stress altered intestinal microbial diversity and composition, particularly affecting Proteobacteria and Aeromonas.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Yi Huang, Shuping Wang, Juntao Fan, Jinfen Pan, Quan Zhou, Jiayun Xu, Jie Wang, Tianxu Zhang, Zhenguang Yan
Summary: The NF-xB signaling pathway is crucial in innate immunity, and Cactus is the primary cytoplasmic inhibitor of NF-xB. This study revealed that ammonia exposure can induce the expression of Cactus in a dose-dependent manner, with the highest expression in the gill of Corbicula fluminea. The study also found an inhibitory effect between up-regulated Cactus and Dorsal, which regulate the expression of pro-inflammatory cytokines.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Engineering, Environmental
Tianxu Zhang, Sujuan Zhao, Fengfeng Dong, Yibo Jia, Xin Chen, Yumeng Sun, Lingyan Zhu
Summary: In this study, it was found that exposure to 6:6 PFPiA led to anxiety-like symptoms in zebrafish, which may be related to gut inflammation caused by gut microbiome imbalance. In addition, PFPiA also damaged the blood-brain barrier, stimulated neuroinflammation, and caused apoptosis and neural injury in the brain. The use of an inhibitor reduced inflammatory responses and anxiety-like behavior, highlighting the key role of the gut-brain axis in the neurotoxicity of PFPiA.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Environmental Sciences
Toshimi Nakajima, Mao Kuragano, Makoto Yamada, Ryo Sugimoto
Summary: This study compared the contribution of submarine groundwater discharge (SGD) to river nutrient budgets at nearshore and embayment scales, and found that SGD-derived nutrients become more important at larger spatial scales.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Fan Liu, Lei Zhang, Chongyang Zhang, Ziguang Chen, Jingguang Li
Summary: NO2 emissions from wall-mounted gas stoves used for household heating have become a significant source of indoor pollution in Chinese urban areas. The high indoor concentration of NO2 poses potential health risks to residents. It is urgently necessary to establish relevant regulations and implement emission reduction technologies to reduce NO2 emissions from wall-mounted gas stoves.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Letter
Environmental Sciences
Hans Peter H. Arp, Raoul Wolf, Sarah E. Hale, Sivani Baskaran, Juliane Gluege, Martin Scheringer, Xenia Trier, Ian T. Cousins, Harrie Timmer, Roberta Hofman-Caris, Anna Lennquist, Andre D. Bannink, Gerard J. Stroomberg, Rosa M. A. Sjerps, Rosa Montes, Rosario Rodil, Jose Benito Quintana, Daniel Zahn, Herve Gallard, Tobias Mohr, Ivo Schliebner, Michael Neumann
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Philomina Onyedikachi Peter, Binessi Edouard Ifon, Francois Nkinahamira, Kayode Hassan Lasisi, Jiangwei Li, Anyi Hu, Chang-Ping Yu
Summary: This study investigates the relationship between dissolved organic matter (DOM) and Rare Earth Elements (REEs) in sediments from Yundang Lagoon, China. The results show four distinct fluorescent components, with protein-like substances being the most prevalent. Additionally, the total fluorescence intensity and LREE concentrations exhibit a synchronized increase from Outer to Inner to Songbai Lake core sediments. The findings demonstrate a strong correlation between DOM content and pollution levels.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Surya Gupta, Pasquale Borrelli, Panos Panagos, Christine Alewell
Summary: The objective of this study is to incorporate soil hydraulic properties into the erodibility factor (K) of USLE-type models. By modifying and improving the existing equations for soil texture and permeability, the study successfully included information on saturated hydraulic conductivity (Ksat) into the calculation of K factor. Using the Random Forest machine learning algorithm, two independent K factor maps with different spatial resolutions were generated. The results show that the decrease in K factor values has a positive impact on the modeling of soil erosion rates.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jesmin Akter, Wendy J. M. Smith, Yawen Liu, Ilho Kim, Stuart L. Simpson, Phong Thai, Asja Korajkic, Warish Ahmed
Summary: The choice of workflow in wastewater surveillance has a significant impact on SARS-CoV-2 concentrations, while having minimal effects on HF183 and no effect on HAdV 40/41 concentrations. Certain components in the workflow can be interchangeable, but factors such as buffer type, chloroform, and homogenization speed can affect the recovery of viruses and bacteria.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yu Luo, Xueting Yang, Diwei Wang, Hongmei Xu, Hongai Zhang, Shasha Huang, Qiyuan Wang, Ningning Zhang, Junji Cao, Zhenxing Shen
Summary: Atmospheric PM2.5, which can generate reactive oxygen species (ROS), is associated with cardiorespiratory morbidity and mortality. The study found that both the mass concentration of PM2.5 and the DTT activity were higher during the heating season than during the nonheating season. Combustion sources were the primary contributors to DTT activity during the heating season, while secondary formation dominated during the nonheating season. The study also revealed that biomass burning had the highest inherent oxidation potential among all sources investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Erin L. Murphy, Leah R. Gerber, Chelsea M. Rochman, Beth Polidoro
Summary: Plastic pollution has devastating consequences for marine organisms. This study uses a trait-based framework to develop a vulnerability index for marine mammals, seabirds, and sea turtles in Hawai'i. The index ranks 63 study species based on their vulnerability to macroplastic pollution, providing valuable information for species monitoring and management priorities.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Kenji Maurice, Amelia Bourceret, Sami Youssef, Stephane Boivin, Liam Laurent-Webb, Coraline Damasio, Hassan Boukcim, Marc-Andre Selosse, Marc Ducousso
Summary: Growing pressure from climate change and agricultural land use is destabilizing soil microbial community interactions. Little is known about microbial community resistance and adaptation to disturbances, hindering our understanding of recovery latency and implications for ecosystem functioning. This study found that anthropic disturbance and natural disturbance have different effects on the topology and stability of soil microbial networks.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yunhao Li, Yali Feng, Haoran Li, Yisong Yao, Chenglong Xu, Jinrong Ju, Ruiyu Ma, Haoyu Wang, Shiwei Jiang
Summary: Deep-sea mining poses a serious threat to marine ecosystems and human health by disturbing sediment and transmitting metal ions through the food chain. This study developed a new regenerative adsorption material, OMN@SA, which effectively removes metal ions. The adsorption mechanism and performance of the material for metal ion fixation were investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Antonio Medici, Margherita Lavorgna, Marina Isidori, Chiara Russo, Elena Orlo, Giovanni Luongo, Giovanni Di Fabio, Armando Zarrelli
Summary: Valsartan, a widely used antihypertensive drug, has been detected in high concentrations in surface waters due to its unchanged excretion and incomplete degradation in wastewater treatment plants. This study investigated the degradation of valsartan and identified 14 degradation byproducts. The acute and chronic toxicity of these byproducts were evaluated in key organisms in the freshwater trophic chain.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jiang Lin, Lianbao Chi, Qing Yuan, Busu Li, Mingbao Feng
Summary: This study investigated the photodegradation behavior and product formation of two representative pharmaceuticals in simulated estuary water. The study found that the formed transformation products of these pharmaceuticals have potential toxicity on marine organisms, including oxidative stress and damage to cellular components.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Hua Fang, Dongdong Jiang, Ye He, Siyi Wu, Yuehong Li, Ziqi Zhang, Haoting Chen, Zixin Zheng, Yan Sun, Wenxiang Wang
Summary: This study revealed that exposure to lower levels of air pollutants led to decreased pregnancy rates, with PM10, NO2, SO2, and CO emerging as the four most prominent pollutants. Individuals aged 35 and above exhibited heightened susceptibility to pollutants.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Ali Shaan Manzoor Ghumman, Rashid Shamsuddin, Amin Abbasi, Mohaira Ahmad, Yoshiaki Yoshida, Abdul Sami, Hamad Almohamadi
Summary: In this study, inverse vulcanized polysulfides (IVP) were synthesized by reacting molten sulfur with 4-vinyl benzyl chloride, and then functionalized using N-methyl D-glucamine (NMDG). The functionalized IVP showed a high mercury adsorption capacity and a machine learning model was developed to predict the amount of mercury removed. Furthermore, the functionalized IVP can be regenerated and reused, providing a sustainable and cost-effective adsorbent.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Rita Bonfiglio, Renata Sisto, Stefano Casciardi, Valeria Palumbo, Maria Paola Scioli, Erica Giacobbi, Francesca Servadei, Gerry Melino, Alessandro Mauriello, Manuel Scimeca
Summary: This study investigated the presence of aluminum in human colon cancer samples and its potential association with biological processes involved in cancer progression. Aluminum was found in tumor areas of 24% of patients and was associated with epithelial to mesenchymal transition (EMT) and cell death. Additional analyses revealed higher tumor mutational burden and mutations in genes related to EMT and apoptosis in aluminum-positive colon cancers. Understanding the molecular mechanisms of aluminum toxicity may improve strategies for the management of colon cancer patients.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)