Article
Biochemistry & Molecular Biology
Hongjian Zhou, Shengjie Li, Shanshan Wu, Ping Jin, Fei Ma
Summary: The study reveals that lncRNA-CR11538 interacts with transcription factors to inhibit antimicrobial peptide expressions in Drosophila, affecting the Toll signaling pathway and helping to restore immune homeostasis in the later stages of the immune response. This provides new insights into understanding the complex regulatory mechanisms of animal innate immunity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Fisheries
Beixiang Liu, Xueying Cao, Jiaxue Li, Zuosheng Jiang, Wei Qin, Hongyu Wang, Chengxiang Zhou, Qian Ren, Xin Huang
Summary: Bursicon is a neuropeptide hormone in insects that regulates cuticle tanning and wing development, and also regulates the secretion of antimicrobial peptides. This study identified Mnburs alpha and Mnburs beta in Macrobrachium nipponense, showing their widespread expression in immune tissues and their upregulation in response to pathogen invasion. Knockdown and recombinant protein experiments suggest that Mnburs alpha and Mnburs beta play positive roles in AMP synthesis, with a mechanism involving the transcription factor Relish in innate immunity.
Article
Medicine, Research & Experimental
Zhenjia Li, Wenzhi Qu, Dongdong Zhang, Yue Sun, Dejing Shang
Summary: Excessive inflammatory responses contribute to high mortality in sepsis. Targeting macrophages and reducing proinflammatory cytokine release is a potential therapeutic strategy. Chensinin-1b, derived from Rana chensinensis skin secretion, effectively neutralizes LPS and alleviates LPS-induced inflammatory responses. It prolongs survival, reduces organ damage, and mitigates inflammatory responses in septic shock models.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Judith Bossen, Jan-Philip Kuehle, Thomas Roeder
Summary: The unique design of respiratory organs in multicellular organisms makes them vulnerable to infection by pathogens. Insects have evolved highly effective local immune systems in their tracheal system to cope with this vulnerability. Further research is needed to understand the architecture of tracheal immune systems and mechanisms that maintain immune homeostasis, especially in species other than Drosophila.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
Article
Fisheries
Yan-Mei Zhang, Wen-Bin Xu, Bang-Ze Li, Chen-Yang Lin, Yuan-Xin Cheng, Yi Xiao, Da-Yong Chen, Wei-Ren Dong, Miao-An Shu
Summary: In this study, the drosophila mothers against decapentaplegic protein gene 1 (Smad1) was identified and characterized from the Red Swamp Crayfish Procambarus clarkii. It was found that pcSmad1 played an important regulatory role in crayfish's immune response.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Fisheries
Chen-Yang Lin, Yan-Mei Zhang, Bang-Ze Li, Miao-An Shu, Wen-Bin Xu
Summary: In this study, two subtypes of MKK4, SpMKK4-1 and SpMKK4-2, were identified and their molecular characteristics and tissue distributions were analyzed. The expression of SpMKK4s was induced by WSSV and Vibrio alginolyticus challenges, and knocking down SpMKK4s resulted in decreased bacteria clearance capacity and antimicrobial peptide genes' expression. Moreover, overexpression of SpMKK4s activated the NF-κB signaling pathway. These findings provide insights into the role of MKK4s in the innate immunity of crabs.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Article
Veterinary Sciences
Qingqing Fu, Qian Lin, Daiwen Chen, Bing Yu, Yuheng Luo, Ping Zheng, Xiangbing Mao, Zhiqing Huang, Jie Yu, Junqiu Luo, Hui Yan, Jun He
Summary: In this study, the researchers investigated the role and mechanism of DEFB118 in alleviating inflammation and cell injury caused by ETEC in IPEC-J2 cells. They found that DEFB118 pretreatment increased cell viability, reduced expression of inflammatory cytokines, elevated the abundance of a tight-junction protein, and decreased the number of apoptotic cells. DEFB118 also downregulated the expression of caspase proteins and suppressed inflammation-associated signaling proteins in ETEC-challenged IPEC-J2 cells. This study suggests that DEFB118 can act as a novel anti-inflammatory agent.
BMC VETERINARY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Juan Zhang, Yue Sun, Yao Kang, Dejing Shang
Summary: Temporin-1CEa and its analogs LK2(6) and LK2(6)A(L) exhibit anti-inflammatory activity in LPS-stimulated murine macrophages by inhibiting key signaling pathways and reducing production of inflammatory mediators.
MOLECULAR IMMUNOLOGY
(2021)
Article
Immunology
Hongjian Zhou, Shengjie Li, Wanwan Pan, Shanshan Wu, Fei Ma, Ping Jin
Summary: In this study, a long noncoding RNA called lncRNA-CR33942 was found to play a positive regulatory role in the fruit fly's immune response to Gram-positive bacterial infection through interacting with Dorsal-related immunity factor/Dorsal. The lncRNA promotes the transcription of antimicrobial peptides, enhancing the Toll immune response in the fruit fly.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ho Am Jang, Bharat Bhusan Patnaik, Maryam Ali Mohammadie Kojour, Bo Bae Kim, Young Min Bae, Ki Beom Park, Yong Seok Lee, Yong Hun Jo, Yeon Soo Han
Summary: TmSpz-like, a cystine knot protein in T. molitor, plays a critical role in the innate immune response against E. coli infection by positively regulating AMP production and the expression of NF-κB-encoding genes. Its knockdown leads to downregulation of AMP-encoding genes and NF-κB expression, impacting the viability of infected larvae.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Mark A. Hanson, Bruno Lemaitre
Summary: Antimicrobial peptides (AMPs) play important roles in host defense and have been implicated in the clearance of aberrant cells and neurodegenerative syndromes. AMPs are produced in Drosophila downstream of Toll and Imd NF-κB pathways and have antimicrobial properties. Aging leads to upregulation of AMPs, potentially contributing to age-associated inflammatory diseases. However, the individual effects of AMPs on lifespan have been inconclusive. In this study, the researchers found no significant effect of individual AMPs on lifespan, except for Defensin. However, flies lacking seven AMP gene families displayed a reduced lifespan due to microbiome dysbiosis, and germ-free conditions extended their lifespan. Overall, AMPs collectively impact lifespan by preventing dysbiosis during aging.
DISEASE MODELS & MECHANISMS
(2023)
Article
Multidisciplinary Sciences
Li Wang, Lei Yu, Jian Shi, Feng Li, Caiyu Zhang, Haotian Xu, Xiangzhe Yin, Lixia Wang, Shihua Lin, Anastasiia Litvinova, Yanyan Ping, Shangwei Ning, Hongying Zhao
Summary: This study systematically investigated the functional regulations between genetic alteration-driven genes and drug target genes in breast cancer. Several gene pairs were identified as potential prognostic biomarkers and therapeutic targets for breast cancer.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Sara Bodahl, Samuel Cerps, Lena Uller, Bengt-Olof Nilsson
Summary: LL-37 enhances poly I:C-induced expression of TLR3 mRNA and protein, possibly through enhanced import of poly I:C. Dexamethasone reduces LL-37/poly I:C-induced TLR3 expression by attenuating NF-kappa B activity.
Article
Environmental Sciences
John D. Hansen, Keith A. Loftin, Zachary Laughrey, Ondrej Adamovsky
Summary: Various stressors can have profound impacts on immunity to pathogens, with little research into the effects of cyanobacterial toxins on disease resistance in mammals. Recent studies suggest that freshwater cyanotoxins may alter disease susceptibility parameters for fish, wildlife, and human health through interaction with specific components of innate immunity. However, the results of this study indicate that the tested toxins did not directly interact with key pathogen recognition receptors for innate immunity in humans.
Review
Oncology
Barbara Di Francesco, Daniela Verzella, Daria Capece, Davide Vecchiotti, Mauro Di Vito Nolfi, Irene Flati, Jessica Cornice, Monica Di Padova, Adriano Angelucci, Edoardo Alesse, Francesca Zazzeroni
Summary: Acute Myeloid Leukemia (AML) is an aggressive hematological malignancy with a high need for new therapeutic options. Constitutive NF-kappa B activation has been reported in around 40% of AML patients, making targeting the NF-kappa B pathway an attractive strategy to treat AML.
Article
Public, Environmental & Occupational Health
Allison L. Dauner, Theron C. Gilliland, Indrani Mitra, Subhamoy Pal, Amy C. Morrison, Robert D. Hontz, Shuenn-Jue L. Wu
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2015)
Article
Infectious Diseases
Allison L. Dauner, Indrani Mitra, Theron Gilliland, Sajeewane Seales, Subhamoy Pal, Shih-Chun Yang, Carolina Guevara, Jiann-Hwa Chen, Yung-Chuan Liu, Tadeusz J. Kochel, Shuenn-Jue L. Wu
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2015)
Article
Microbiology
Subhamoy Pal, Allison L. Dauner, Andrea Valks, Brett M. Forshey, Kanya C. Long, Butsaya Thaisomboonsuk, Gloria Sierra, Victor Picos, Sara Talmage, Amy C. Morrison, Eric S. Halsey, Guillermo Comach, Chadwick Yasuda, Michael Loeffelholz, Richard G. Jarman, Stefan Fernandez, Ung Sam An, Tadeusz J. Kochel, Louis E. Jasper, Shuenn-Jue L. Wu
JOURNAL OF CLINICAL MICROBIOLOGY
(2015)
Article
Medicine, General & Internal
Subhamoy Pal, Jason H. Richardson, Jittawadee R. Murphy, Panadda Krairojananan, Patcharee Kongtak, Boonsong Jaichapor, Prasan Kankaew, Sajeewane Ekanayake, Timothy J. Davis, David L. Maserang, David H. F. Teng, Robert J. Crisp, Shuenn-Jue L. Wu, Russell E. Coleman, James C. McAvin, James A. Swaby
Article
Medicine, General & Internal
Subhamoy Pal, Louis E. Jasper, Kendra L. Lawrence, Maureen Walter, Theron Gilliland, Allison L. Dauner, Thomas J. Palys, Shuenn-Jue L. Wu
Editorial Material
Biochemistry & Molecular Biology
Javier Robalino, Louisa Wu
TRENDS IN MICROBIOLOGY
(2016)
Article
Immunology
Ashley E. Nazario-Toole, Javier Robalino, Kwame Okrah, Hector Corrada-Bravo, Stephen M. Mount, Louisa P. Wu
JOURNAL OF IMMUNOLOGY
(2018)
Article
Immunology
Thomas Luke, Richard S. Bennett, Dawn M. Gerhardt, Tracey Burdette, Elena Postnikova, Steven Mazur, Anna N. Honko, Nicholas Oberlander, Russell Byrum, Dan Ragland, Marisa St Claire, Krisztina B. Janosko, Gale Smith, Gregory Glenn, Jay Hooper, John Dye, Subhamoy Pal, Kimberly A. Bishop-Lilly, Theron Hamilton, Kenneth Frey, Laura Bollinger, Jiro Wada, Hua Wu, Jin-an Jiao, Gene G. Olinger, Bronwyn Gunn, Galit Alter, Surender Khurana, Lisa E. Hensley, Eddie Sullivan, Peter B. Jahrling
JOURNAL OF INFECTIOUS DISEASES
(2018)
Article
Cell Biology
Aprajita Garg, Louisa P. Wu
CELLULAR MICROBIOLOGY
(2014)
Article
Biochemistry & Molecular Biology
Elizabeth A. Gonzalez, Aprajita Garg, Jessica Tang, Ashley E. Nazario-Toole, Louisa P. Wu
Article
Developmental Biology
Bhupendra V. Shravage, Jahda H. Hill, Christine M. Powers, Louisa Wu, Eric H. Baehrecke
Article
Multidisciplinary Sciences
Subhamoy Pal, Allison L. Dauner, Indrani Mitra, Brett M. Forshey, Paquita Garcia, Amy C. Morrison, Eric S. Halsey, Tadeusz J. Kochel, Shuenn-Jue L. Wu
Article
Virology
Peifang Sun, Karolis Bauza, Subhamoy Pal, Zhaodong Liang, Shuenn-jue Wu, Charmagne Beckett, Timothy Burgess, Kevin Porter
Article
Cell Biology
Anubhab Nandy, Lin Lin, Panagiotis D. Velentzas, Louisa P. Wu, Eric H. Baehrecke, Neal Silverman
Meeting Abstract
Public, Environmental & Occupational Health
Zhuoyu Ni, Regina Heineman, Theron Gilliland, Allison Dauner, Subhamoy Pal, Robert D. Hontz, Shuenn-Jue Wu
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2015)
Article
Fisheries
Ratiporn Thongsoi, Siriluk Maskaew, Panumas Puechpon, Benjaporn Noppradit, Napassawan Inaek, Prapaporn Utarabhand, Phanthipha Runsaeng
Summary: In this study, a PPAE gene called FmPPAE1 was cloned and analyzed in banana shrimp. FmPPAE1 plays a vital role in regulating the proPO system, exhibits antibacterial properties, and contributes to the suppression of bacterial proliferation.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Jishuang Tan, Paizelaiti Sahaer, Huan Li, Wei Han, Hongyan Sun
Summary: Circular RNAs (circRNA) are involved in gene expression and affect cellular processes such as transcription, splicing, and translation by interacting with microRNA and RNA binding proteins. A study identified circDNAJB6 as a circular RNA abundant in chicken macrophages after bacterial infection, and found that circDNAJB6 exacerbates cellular injury and interacts with multiple miRNAs and target genes, potentially impacting autophagy and MAPK signaling pathways.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Rodrigo Guabiraba, Damaris Ribeiro Rodrigues, Paul T. Manna, Melanie Chollot, Vincent Saint-Martin, Sascha Trapp, Marisa Oliveira, Clare E. Bryant, Brian J. Ferguson
Summary: The innate immune response relies on the ability of host cells to detect and respond to microbial nucleic acids. Toll-like receptors (TLRs) play a crucial role in this process by distinguishing self from non-self. This study focused on TLR21, an avian TLR that recognizes bacterial DNA motifs. The findings suggest that avian TLR21 shares similar activation mechanisms to mammalian TLR9, highlighting the conservation of nucleic acid sensing mechanisms across species.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Safieh Zeinali, Kate Sutton, Lonneke Vervelde
Summary: Chickens have a unique immune structure characterized by the absence of draining lymph nodes and the presence of well-developed mucosa-associated lymphoid tissue. The structure and development of chicken lymphoid tissues in the intestine, particularly Peyer's patches, have been poorly studied. However, the use of CSF1R-eGFP reporter transgenic chickens has allowed for the visualization and investigation of the development and distribution of these tissues. This research provides insights that could benefit mucosal vaccination strategies and the development of targeted vaccine delivery systems.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Retraction
Fisheries
G. -g. Li, Z. -z. Guo, X. -f. Ma, N. Cao, S. -n. Geng, Y. -q. Zheng, M. -j. Meng, H. -h. Lin, G. Han, G. -j. Du
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Jinyue Yang, Peng Zhou, Wanrong Wu, Qingxiang Zhang, Dong Chen, Rui Luo
Summary: This study cloned and characterized the full-length sequence of duck MRE11 (duMRE11) for the first time, and found that this protein plays an important role in the innate immune response of ducks.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Mengjiao Guo, Jiaqi Zhang, Mingtao Li, Xiaorong Zhang, Yantao Wu
Summary: rNLRC3 negatively regulates the NF -KB signaling pathway induced by P. multocida in rabbits by inhibiting the activation of NF -KB, reducing the expression of inflammatory cytokines, and interacting with rTRAF4 and rTRAF6. The NACHT-LRR domain is the functional domain of rNLRC3. These findings provide insights into the important role of rNLRC3 in combating P. multocida infection.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Yinan Li, Xingye Lian, Wenwen Yang, Jinyuan Leng, Jiejie Sun, Yu Liu, Siqi Fan, Lingling Wang, Linsheng Song
Summary: The DM9-containing protein CgDM9CP-7 plays an important role in the innate immune response of molluscs. It is constitutively expressed in various tissues and is up-regulated in haemocytes after stimulation by Vibrio splendidus and lipopolysaccharide (LPS). CgDM9CP-7 binds to various pathogens and exhibits antimicrobial activity, while also regulating the expression of CgMyD88 and CgIL-17.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Xiuwen Bao, Haoran Song, Liying He, Yong Li, Shuqi Niu, Jinlin Guo
Summary: This study focuses on the interaction between Hepialus xiaojinensis larvae and Ophiocordyceps sinensis during the infection process. The results show that the infected third instar larvae enhance antioxidant defense ability, while the infected fourth instar larvae reduce this ability and allocate more energy to growth and development.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)